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| 1 | Effects of Qizhukangxian granules on idiopathic pulmonary fibrosis:a randomized,double blind,placebo-controlled and multicenter clinical pilot trial显示文摘OBJECTIVE:To evaluate the effects of Qizhukangxian granules(QG)on idiopathic pulmonary fibrosis(IPF).METHODS:This is a randomized,double blind,placebo-controlled and multicenter clinical pilot trial.Six medical centers in Tianjin,China,participated in the study.A total of 120 IPF patients were enrolled and randomized into two groups,with 60 patients in each group.The treatment group was treated with QG,while the control group received a Qizhukangxian placebo.The pharmacological treatment lasted for 48 weeks from the enrollment date.The indexes of patients were recorded on the admission day and at the end of the 24th and 48th weeks.Data were analyzed to study the effects of QG;forced vital capacity,change in forced vital capacity and maximal 6-min walk test(6MWT)distance were the primary endpoints.Secondary endpoints were percentage of patients with episodes of acute exacerbation of IPF,pulmonary function,changes in pulse oxygen saturation during the 6MWT,dyspnea score,St.George's respiratory questionnaire score,arterial blood gas analyses and the total Traditional Chinese Medicine symptom pattern score.RESULTS:After 24 weeks of treatment,QG showed greater efficacy than the placebo in certain parameters,including the dyspnea score,Traditional Chinese Medicine symptom pattern score and some indicators in the St.George's respiratory questionnaire score.Analysis of the indexes obtained from all patients at the end of the 48th week showed that the therapeutic effects in the treatment group were significantly better than those in the control group because remarkable differences were observed in most of the primary and secondary endpoints between the two groups,except for the maximal distance of the 6MWT and arterial blood gas analyses.No adverse reaction was observed in either group during the 48-week trial treatment period.CONCLUSION:QG could effectively treat IPF patients by ameliorating pulmonary function,improving the quality of life and lowering the percentage of acute exacerbations. | Guo Sijia Song Yalin Feng Jihong Liu Shuang Li Yuechuan Liu Min Wei Luqing Zhang Xian Xie Hui Sun Zengtao | 2020 | Journal of Traditional Chinese Medicine2020，40，4： | 3 |
| 2 | The synchronization of spontaneous BOLD activity predicts extraversion and neuroticism显示文摘 | Luqing Wei Xujun Duan Yang Yang Wei Liao Qing Gao Ju-rong Ding Zhiqiang Zhang Weixi Zeng Yuan Li Guangming Lu Huafu Chen | 2011 | Brain Research2011，，： | 2 |
| 3 | Microprocessor-based adaptive governor with variable PID parameters for a hydroelectric generating unit显示文摘 | Ye Luqing Wei Shouping | 1984 | Mini and Microcomputers and Their Applications1984，，6： | 1 |
| 4 | An intelligent self- improving control strategy and its microprocessor-based implementation for application to a hydro-turbine governing system 显示文摘 | Ye Luqing Wei Shouping Li Zhaohui | 1990 | CanJ Elect & Comp Eng1990，15，4： | 1 |
| 5 | Variable structure and time-varying parameter control for hydroelectric generating unit显示文摘 | Ye Luqing Wei Shouping Xu Haibo | 1989 | IEEE Trans on Energy Conversion1989，4，3： | 1 |
| 6 | Variable Structure and Time-varying Parameter Control for Hydroelectric Generating Unit显示文摘 | YE Luqing WEI Shouping XU Haibo | 1989 | IEEE Transaction on Energy Conversion1989，4，3： | 1 |
| 7 | Fault tolerance aspects of a highly reliable microprocessor-based wa- ter turbine governor显示文摘 | LI ZHAOHUI YE LUQING WEI SHOUPING | 1992 | IEEE Trans on Energy Conversion1992，7，1： | 1 |
| 8 | An intelligent self-improving strategy and its microprocessor-based implementation to a hydro-turbine governor 显示文摘 | YE Luqing WEI Shouping LI Zhaohui | 1990 | Canadian J of Electrical and Computer Engineering1990，15，4： | 1 |
| 9 | Variable structure and time-varying parameter control for hydroelectric unit显示文摘 | Wei Shouping Xu Haibo | 1989 | IEEE Trans on Energy Conversion1989，4，3： | 1 |
| 10 | Retrospective analysis of diffuse interstitial lung disease in 10 hospitals in Tianjin显示文摘Objective:To investigate the constituent ratio and clinical features of diffuse interstitial lung disease(DILD)in Tianjin,and to identify the existing problems of its diagnosis and treatment.Methods:Data of all patients diagnosed as DILD in ten comprehensive hospitals in Tianjin from 2003 to 2009 was collected.The disease constituent ratio of DILD to all kinds of diseases in the respiration department or in the whole hospital,the clinical manifestation,lung function,the result of blood gas analysis,and biopsy were analyzed.Results:A total of 804 DILD patients were included in the study aged(69.28±12.09)years with a male/female ratio of 1.32.The disease constituent ratios of DILD were 4.52‰in respiratory department and 0.31‰in the whole hospital in 2003,which increased to 35.9‰and 1.51‰respectively in 2009.Reticular abnormality(43.1%),ground glass(25.6%)and honeycombing(11.4%)were the predominant imaging manifestations.26.7%patients’lung function were tested,and 10.3%had diffusion function tests.Most patients presented with hypoxemia,and the average oxygenation index was(281±98.3)mmHg.Only 4.0%of patients underwent bronchoalveolar lavage,and 3.5%had pathologic data.Conclusion:The disease constituent ratio of DILD increased progressively from 2003 to 2009.A definite diagnosis of DILD demands cooperation of physicians,radiologists and pathologists.Doctors should attach more importance on lung function test,bronchoalveolar lavage and biopsy. | SHOUCHUN PENG LUQING WEI JIE CAO GUIYING LIU YANPING LAI WEI JIA HONG ZHENG LIYU LI YUYAN XIAO NAN LI NAXIN ZHANG | 2013 | Family Medicine and Community Health2013，1，2： | 0 |
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