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| 1 | Molecular cloning and characterization of antimicrobial peptides from skin of Hylarana guentheri显示文摘把抗菌剂肽(安培) 编码为 Hylarana guentheri 的皮肤的 cDNAs 被识别,也就是 temporin (五肽,称为的 temporin-GHa-GHd 和 temporin-GUa ) , brevinin-1 (一肽, brevinin-1GUb ) ,并且 brevinin-2 (八肽, brevinin-2GHd-2GHj,和 brevinin-2GHb ) 。14 肽中的十一个有新奇主要结构。综合 temporin GHa-GHd 有用途广泛的抗菌剂对克积极的细菌(葡萄球菌 aureus 和杆菌 subtilis ) 的活动,克否定的细菌(Escherichia coli, Vibrio alginolyticus,和 Pseudomonas aeruginosa ) ,以及真菌(Candida albicans ) 。在这些测试紧张之中, S。aureus 对有禁止的集中(MIC ) 在 6.8 和 12.9 M 之间珍视的最小的 temporin-GHa-GHd 最敏感。他们也对 Methicillin 抵抗的 S 展出了抗菌剂活动。有从 12.7 ~ 51.7 M 的 MIC 的 aureus。有趣地,第二等的结构预言证明在 temporin-GHb 没有螺旋,它说明那个螺旋没为 temporin-GHb 的抗菌剂活动被要求。NaCl (在 0.15-2 M 的最后的集中) 减少 temporin-GHa-GHd 的抗菌剂活动稍微,当时人的浆液和 S。aureus V8 朊酶没在抗菌剂活动有效果。扫描 E 的电子显微镜学图象。coli 和 S。aureus 证明微生物引起的房间的表面在有在 37 畲獧的 temporin-GHa-GHd 的处理的 1 h 以后更加不平、忏悔吗? | Zhu Dong Wenjie Luo Hengren Zhong Manchuriga Wang Yanting Song Shiming Deng Yingxia Zhang | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 3 |
| 2 | Cloning of the key genes in maize oxylipins pathways and their roles in herbivore induced defense显示文摘To gain an understanding of the molecular ba-sis of signaling pathways in herbivore-induced maize plant defense, three key genes, ZmAOS, ZmAOC and ZmHPL, which are involved in the biosynthesis of oxylipin signals, have been cloned using RT-PCR in this study. Beet army-worm (BAW) infestation induced the systemic expression of the key genes involved in the biosynthesis of oxylipin signals similar to exogenous methyl jasmonate (MeJA). Moreover, the systemic expression patterns of maize defense-related genes were similar between maize leaves induced by jas-monic acid (JA) and damaged by BAW. Previous treatment with salicyhydroxamic acid (SHAM), an inhibitor of jas-monates (JAs) signal pathway followed by BAW infestation did not induce the systemic expression of the defense-related genes. Exposure to the vapors of green leafy volatiles (GLVs, (Z)-3-hexen-1-ol, (E)-2-hexenal, (E)-3-hexenal) and β-oci- mene induced the expression of the defense-related genes, as well as the key genes involved in biosynthesis of JAs. How-ever, previous treatment with SHAM clearly decreased the transcript levels of the defense genes induced by (Z)-3-hexen-1-ol, (E)-2-hexenal and (E)-3- hexenal. These results demonstrate the major role of oxylipin signal path-way in herbivore-induced maize chemical defense. JA was the endogenous signal in the process of herbivore-induced maize systemic defense. GLVs, another group of oxylipin, played an important role in the process of herbivore-induced systemic defense outside the plant. Furthermore, the expres-sion of defense-related genes induced by GLVs was partially dependent on JAs signal pathway, while β-ocimene induction was independent of JAs signal pathway. | XU Tao WANG Jianwu LUO Shiming | 2005 | Chinese Science Bulletin2005，50，21： | 2 |
| 3 | Phenotypic similarities in pigs with SOX10^(c.321dupC)and SOX10^(c.325A>T)mutations implied the correlation of SOX10 haploinsufficiency with Waardenburg syndrome显示文摘SOX10 is a causative gene of Waardenburg syndrome(WS)that is a rare genetic disorder characterized by hearing loss and pigment disturbance.More than 100 mutations of SOX10 have been found in patients with Type 2 WS(WS2),Type 4 WS(WS4),and more complex syndromes.However,no mutation hotspot has been detected in SOX10,and most cases are sporadic,making it difficult to establish a correlation between the high phenotypic and genetic variability.In this study,a duplication of the 321th cytosine(c.321dupC)was introduced into SOX10 in pigs,which induced premature termination of the translation of SOX10(p.K108QfsX45).The premature stop codon in Exon 3 triggered the degradation of mutant mRNA through nonsense-mediated mRNA decay.However,SOX10^(c.321dupC) induced a highly similar phenotype of WS2 with heterogeneous inner ear malformation compared with its adjacent missense mutation SOX10^(c.325A>T).In addition,a site-saturation mutation analysis of the SOX10 N-terminal nuclear localization signal(n-NLS),where these two mutations located,revealed the correlation between SOX10 haploinsufficiency and WS by an in vitro reporter assay.The analysis combining the in vitro assay with clinical cases may provide a clue to clinical diagnoses. | Tingting Lin Lihua Luo Weiwei Guo Wei Ren Chuanhong Liu Hong Wei Shiming Yang Yong Wang | 2020 | Journal of Genetics and Genomics2020，47，12： | 2 |
| 4 | Management of Maillard reaction-derived reactive carbonyl species and advanced glycation end products by tea and tea polyphenols显示文摘Tea as the most consumed beverage in the world has received enormous attention for its promoting health benefits.The deleterious effect ofα-dicarbonyls and AGEs formed in Maillard reaction is also a longterm challenge.The connection between the two topics was the main aim of this review,to address and update the antiglycation effect and mechanism of tea and tea polyphenols.By analyzing recent publications,we have covered across chemistry models,cell lines and animal studies.Tea polyphenols,particularly catechins,showed outstanding antiglycation effect by trappingα-dicarbonyl compounds and impeding AGEs formation.Reduction of carbonyl stress brought alleviation to aging,diabetes,and collagen related diseases or complications through regulation of RAGE expression and subsequent MAPK and TGF-βpathway.Therefore,tea polyphenols can serve as promising natural candidates in the treatment and/or prevention of nephropathy,retinopathy,hepatopathy,hyperglycemia and obesity among others,by their potent antiglycation effect.Further studies need to address on aspects like exact mechanisms,solution of detection obstacles,balance of practical usage and harmful effects such as potential flavor damage and toxicity in food,to gain a comprehensive understanding of antiglycation activities of tea polyphenols and its actual application. | Yue Luo Jianan Zhang Chi-Tang Ho Shiming Li | 2022 | Food Science and Human Wellness2022，11，3： | 2 |
| 5 | Hydrogen-rich gas from catalytic steam gasification of municipal solid waste (MSW): influence of catalyst and temperature on yield and product composition 显示文摘 | He Maoyun Hu Zhiquan Xiao Bo Li Jianfen Guo Xianjun Luo Siyi Yang Fan Feng Yu Yang Guangjun Liu Shiming | 2009 | International Journal of Hydrogen Energy2009，34，1： | 1 |
| 6 | Experimental study on combustion of biomass micron fuel (BMF) in cyclone furnace显示文摘 | Siyi Luo Bo Xiao Zhiquan Hu Shiming Liu Maoyun He | 2010 | Energy Conversion and Management2010，，11： | 1 |
| 7 | Physio- logical and cytological mechanisms of silicon-induced re- sistance in rice against blast disease 显示文摘 | CAI Kunzheng GAO Dan LUO Shiming | 2008 | Physiol Plant2008，134，2： | 1 |
| 8 | Physiological and cytological mechanisms of silicon-induced resistance in rice against blast disease显示文摘 | Kunzheng Cai Dan Gao Shiming Luo | | 0，，02： | 1 |
| 9 | Allelopathy of Aspergillus japonicus on crops 显示文摘 | Zeng Rensen Luo shiming Shi Mubiao | 2001 | Agronomy Journal2001，93，1： | 1 |
| 10 | Physiological and biochemical mechanism of allelopathy of seealonic acid on higher plants 显示文摘 | Zeng Rensen Luo shiming Shi yuehong | 2001 | Agronomy Journal2001，93，1： | 1 |
| 11 | Syngas production from pyrolysis of municipal solid waste (MSW) with dolomite as downstream catalysts显示文摘 | Maoyun He Bo Xiao Shiming Liu Zhiquan Hu Xianjun Guo Siyi Luo Fan Yang | 2010 | Journal of Analytical and Applied Pyrolysis2010，，2： | 1 |
| 12 | Steam catalytic gasification of municipal solid waste for producing tar-free fuel gas显示文摘 | Guan Yanwen Luo Siyi Liu Shiming | 2009 | International Journal of Hydrogen Energy2009，34，： | 1 |
| 13 | Influence of particle size on pyrolysis and gasification performance of municipal solid waste in a fixed bed reactor显示文摘 | Siyi Luo Bo Xiao Zhiquan Hu Shiming Liu Yanwen Guan Lei Cai | 2010 | Bioresource Technology2010，，16： | 1 |
| 14 | Allelopathy of Aspergillus japonicus on crops 显示文摘 | ZENG RENSEN LUO SHIMING SHI MUBIAO | 2001 | Agronomy Journal2001，93，1： | 1 |
| 15 | Dynamic data driven application system: Recent development and future perspective 显示文摘 | Ouyang Ying Zhang Jiaen Luo Shiming | 2007 | Ecological Modelling2007，204，12： | 1 |
| 16 | Highly efficient top-emitting white organic light-emitting diodes with improved contrast and reduced angular dependence for active matrix displays显示文摘 | Guohua Xie Zhensong Zhang Qin Xue Shiming Zhang Li Zhao Yang Luo Ping Chen Baofu Quan Yi Zhao Shiyong Liu | 2010 | Organic Electronics2010，，12： | 1 |
| 17 | Thiostrepton alleviates experimental colitis by promoting RORγt ubiquitination and modulating dysbiosis显示文摘Thiostrepton(TST)is a natural antibiotic with pleiotropic properties.This study aimed to elucidate the therapeutic effect of TST on experimental colitis and identify its targets.The effect of TST on colon inflammation was evaluated in a dextran sulfate sodium(DSS)-induced colitis model and a T-cell transfer colitis model.The therapeutic targets of TST were investigated by cytokine profiling,immunophenotyping and biochemical approaches.The effect of TST on the gut microbiota and its contribution to colitis were evaluated in mice with DSS-induced colitis that were subjected to gut microbiota depletion and fecal microbiota transplantation(FMT).Alterations in the gut microbiota caused by TST were determined by 16S rDNA and metagenomic sequencing.Here,we showed that TST treatment significantly ameliorated colitis in the DSS-induced and T-cell transfer models.Specifically,TST targeted the retinoic acid-related orphan nuclear receptor RORγt to reduce the production of IL-17A byγδT cells,type 3 innate lymphoid cells(ILC3s)and Th17 cells in mice with DSS-induced colitis.Similarly,TST selectively prevented the development of Th17 cells in the T-cell transfer colitis model and the differentiation of naïve CD4^(+)T cells into Th17 cells in vitro.Mechanistically,TST induced the ubiquitination and degradation of RORγt by promoting the binding of Itch to RORγt.Moreover,TST also reversed dysbiosis to control colonic inflammation.Taken together,these results from our study describe the previously unexplored role of TST in alleviating colonic inflammation by reducing IL-17A production and modulating dysbiosis,suggesting that TST is a promising candidate drug for the treatment of IBD. | Ya Luo Cheng Liu Yuan Luo Xianglian Zhang Jing Li Changjiang Hu Shiming Yang | 2023 | Cellular & Molecular Immunology2023，20，11： | 0 |
| 18 | Image editing by object-aware optimal boundary searching and mixed-domain composition显示文摘When combining very different images which often contain complex objects and backgrounds,producing consistent compositions is a challenging problem requiring seamless image editing. In this paper, we propose a general approach, called objectaware image editing, to obtain consistency in structure,color, and texture in a unified way. Our approach improves upon previous gradient-domain composition in three ways. Firstly, we introduce an iterative optimization algorithm to minimize mismatches on the boundaries when the target region contains multiple objects of interest. Secondly, we propose a mixeddomain consistency metric for measuring gradients and colors, and formulate composition as a unified minimization problem that can be solved with a sparse linear system. In particular, we encode texture consistency using a patch-based approach without searching and matching. Thirdly, we adopt an objectaware approach to separately manipulate the guidance gradient fields for objects of interest and backgrounds of interest, which facilitates a variety of seamless image editing applications. Our unified method outperforms previous state-of-the-art methods in preserving global texture consistency in addition to local structure continuity. | Shiming Ge Xin Jin Qiting Ye Zhao Luo Qiang Li | 2018 | Computational Visual Media2018，4，1： | 0 |
| 19 | 前额叶皮质中兴奋性神经元集合编码短期记忆显示文摘文章简介短期记忆(STM)对于动物在一小段时间内保存信息来说至关重要。已经知道,持续性或复发性的神经活动和神经振荡在细胞水平上编码STM。然而,微回路级的编码机制仍然是一个谜。在本文中,我们对行为小鼠进行了双光子成像以监测神经元微回路的活动。 | Yonglu Tian Chaojuan Yang Yaxuan Cui Feng Su Yongjie Wang Yangzhen Wang Peijiang Yuan Shujiang Shang Hao Li Jizong Zhao Desheng Zhu Shiming Tang Peng Cao Yunbo Liu Xunli Wang Liecheng Wang Wenbo Zeng Haifei Jiang Fei Zhao Minhua Luo Wei Xiong 仇子龙 李相尧 张晨 | 2019 | 科学新闻2019，0，2： | 0 |
| 20 | Cellularmetabolism: A key player in cancer ferroptosis显示文摘Cellular metabolism is the fundamental process by which cells maintain growth and self-renewal.It produces energy,furnishes raw materials,and intermedi-ates for biomolecule synthesis,and modulates enzyme activity to sustain normal cellular functions.Cellular metabolism is the foundation of cellular life processes and plays a regulatory role in various biological functions,including pro-grammed cell death.Ferroptosis is a recently discovered form of iron-dependent programmed cell death.The inhibition of ferroptosis plays a crucial role in tumorigenesis and tumor progression.However,the role of cellular metabolism,particularly glucose and amino acid metabolism,in cancer ferroptosis is not well understood.Here,we reviewed glucose,lipid,amino acid,iron and sele-nium metabolism involvement in cancer cell ferroptosis to elucidate the impact of different metabolic pathways on this process.Additionally,we provided a detailed overview of agents used to induce cancer ferroptosis.We explained that the metabolism of tumor cells plays a crucial role in maintaining intracellu-lar redox homeostasis and that disrupting the normal metabolic processes in these cells renders them more susceptible to iron-induced cell death,resulting in enhanced tumor cell killing.The combination of ferroptosis inducers and cel-lular metabolism inhibitors may be a novel approach to future cancer therapy and an important strategy to advance the development of treatments. | Xianjie Jiang Qiu Peng Mingjing Peng Linda Oyang Honghan Wang Qiang Liu Xuemeng Xu Nayiyuan Wu Shiming Tan Wenjuan Yang Yaqian Han Jinguan Lin Longzheng Xia Yanyan Tang Xia Luo Jie Dai Yujuan Zhou Qianjin Liao | 2024 | Cancer Communications2024，44，2： | 0 |
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