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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin显示文摘 | Lundberg J A Franco-cereceda A Hua X Y | 1985 | Eur J pharmacol1985，108，3： | 2 |
| 3 | Spelenthems and climate:a special issue of the Holocene显示文摘 | Lundberg J | 1999 | The Holocene1999，9，6： | 1 |
| 4 | Auditory function after spinal anesthesia显示文摘 | Wang LP Magnusson M Lundberg J | 1993 | Reg Anesth1993，18，3： | 1 |
| 5 | Seasonal and diurnal body-mass fluctuations for two nonhoarding species ofparus in Sweden modeled using path analysis显示文摘 | Rintamaki P T Stone J R Lundberg S A | 2003 | Auk2003，120，3： | 1 |
| 6 | Nitrate, bacteria and human health 显示文摘 | Lundberg J O Weitzberg E Cole J A | 2004 | Nature Reviews Microbiology2004，2，7： | 1 |
| 7 | Characteristics of the bottom simulating reflectors near mud diapirs: offshore southwestern Taiwan显示文摘 | Chow J Lundberg N Lee J S | 2000 | Geo-Marine Letters2000，20，： | 1 |
| 8 | Trypsin stimulates production of cytokines from peritoneal maerophages in vitro and ivivo显示文摘 | Lundberg AH Eubanks JW Ⅲ Henry J | 2000 | Pancreas2000，21，1： | 1 |
| 9 | Separation of lipid classes from marine particulate material by HPLC on a polyvinyl alcohol-bonded stationary phase using dual-channel evaporative light-scattering detection 显示文摘 | Nordback J Lundberg E Christie W W | 1998 | Marine Chemistry1998，60，： | 1 |
| 10 | Increased amount of nitric oxidein exhaled air of asthmatics显示文摘 | Alving K Weitzberg E Lundberg J M | 1993 | Eur Respir 11993，6，9： | 1 |
| 11 | Methylation of the pl6INKgA promoter is associated with malignant behavior in abdominal extra- adrenal paragangliomas but not pheochromocytomas 显示文摘 | Kiss N Geli J Lundberg F | 2008 | Endocr Relat Cancer2008，15，2： | 1 |
| 12 | Rapid Quaternary emergence,uplift,and denudation of the Coastal Range,eastern Taiwan显示文摘 | Lundberg N Dorsey R J | | 0，，18： | 1 |
| 13 | Euler Angle Dilution of Precision in GPS Attitude Determination显示文摘 | Yoon S P Lundberg J B | 2001 | IEEE2001，37，3： | 1 |
| 14 | Preparation of calcium alginate nanoparticles using water-in-oil ( W/O ) nanoemulsions 显示文摘 | Machado AHE Lundberg D Ribeiro A J | 2012 | Langmuir: the ACS Journal of Surfaces and Colloids2012，28，9： | 1 |
| 15 | The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics显示文摘 | LUNDBERG J O WEITZBERG E GLADWIN MT | 2008 | Nat Rev Drug Discov2008，7，： | 1 |
| 16 | Extension or combination of an autologous latissimus dorsi flap in breast reconstruction显示文摘 | LUNDBERG J | 2009 | Scand J Plast Reconstr Surg Hand Surg2009，45，1： | 1 |
| 17 | Neuropeptide Y and sympathetic vascular control in man显示文摘 | Lundberg J M Torsse U L Sollevi A | 1985 | Regul Rept1985，13，1： | 1 |
| 18 | Specific binding of sterically stabilized ant-B-cell immunoliposomes and cytotoxicity of entrapped doxorubicin显示文摘 | Lundberg B B Griffiths G Hansen H J | 2000 | Int J Pharm2000，205，12： | 1 |
| 19 | Non-motorized Transport and University Populations:An Analysis of Connectivity and Network Perceptions显示文摘 | LUNDBERG B WEBER J | 2014 | Journal of Transport Geography2014，，39： | 1 |
| 20 | Calibration of the speleothom delta function:an absolute temperature record for the Holocene in northern Norway显示文摘 | Lundberg J | 1999 | The Holocene1999，9，6： | 1 |
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