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| 1 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 2 | Long-term outcomes of interventions for radiation-induced xerostomia:A review显示文摘Xerostomia, or dry mouth, is a significant problem affecting quality of life in patients treated with radiation therapy for head and neck cancer. Strategies for reduction of xerostomia burden vary widely, with options including: sialagogue medications, saliva substitutes, acupuncture, vitamins, hyperbaric oxygen,submandibular gland transfer, and acupuncture or associated treatments. In this review, we sought to evaluate long-term outcomes of patients treated with various interventions for radiation-induced xerostomia. A literature search was performed using the terms 'xerostomia' and 'radiation' or 'radiotherapy'; all prospective clinical trials were evaluated, and only studies that reported 1 year follow up were included. The search results yielded 2193 studies, 1977 of which were in English. Of those, 304 were clinical trials or clinical studies. After abstract review, 23 trials were included in the review evaluating the following treatment modalities: pilocarpine(three); cevimeline(one); amifostine(eleven);submandibular gland transfer(five); acupuncture like transcutaneous electrical nerve stimulation(ALTENS)(one); hyperbaric oxygen(one); and acupuncture(one). Pilocarpine, cevimeline, and amifostine have been shown in some studies to improve xerostomia outcomes, at the cost of toxicity. ALTENS has similar efficacy with fewer side effects. Submandibular gland transfer is effective but requires an elective surgery, and thus may not always be appropriate or practical.The use of intensity-modulated radiation therapy, in addition to dose deescalation in select patients, may result in fewer patients with late xerostomia,reducing the need for additional interventions. | Sung Jun Ma Charlotte I Rivers Lucas M Serra Anurag K Singh | 2019 | World Journal of Clinical Oncology2019，10，1： | 4 |
| 3 | Effectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma:An up-to-date meta-analysis显示文摘BACKGROUND Gastric mucosa-associated lymphoid tissue(MALT)lymphoma(GML)is usually a low-grade B-cell neoplasia strongly associated with Helicobacter pylori(H.pylori)-induced chronic gastritis.Clinical practice guidelines currently recommend H.pylori eradication as the preferred initial treatment for early-stage GML.To determine the practical effect of bacterial eradication as the sole initial therapy for early-stage GML,an updated analysis and review of available evidence is imperative.AIM To perform a meta-analysis to assess the rate of complete remission(CR)of H.pylori-positive early-stage GML following bacterial eradication.METHODS We performed independent,computer-assisted literature searches using the PubMed/MEDLINE,Embase,and Cochrane Central databases through September 2022.Prospective and retrospective observational studies evaluating the CR of early-stage GML following bacterial eradication in H.pylori-positive patients.The risk of bias was assessed using Joanna Briggs Institute(JBI)Critical Appraisal Tools.The pooled estimate of the complete histopathological remission rate and respective confidence intervals(95%CI)were calculated following the random-effects model.Heterogeneity and inconsistency were assessed using Cochran’s Q test and I2 statistic,and heterogeneity was defined as P<0.01 and I²>50%,respectively.Subgroup and meta-regression analyses were conducted to explore potential sources of heterogeneity.RESULTS The titles and abstracts of 1576 studies were screened;96 articles were retrieved and selected for full-text reading.Finally,61 studies were included in the proportional meta-analysis(P-MA).Forty-six were prospective and fifteen were retrospective uncontrolled,single-arm,observational studies.The overall risk of bias was low to moderate in all but a single report,with an average critical appraisal score across all studies of 79.02%.A total of 2936 H.pylori-positive early-stage GML patients,in whom H.pylori was successfully eradicated,were included in the analysis.The pooled CR of H.pylori-positive early-stage GML after bacterial eradication was 75.18%(95%CI:70.45%-79.91%).P-MA indicated the substantial heterogeneity in CR reported across studies(I2=92%;P<0.01).Meta-regression analysis identified statistically significant effect modifiers,including the proportion of patients with t(11;18)(q21;q21)-positive GML and the risk of bias in each study.CONCLUSION Comprehensive synthesis of available evidence suggests that H.pylori eradication is effective as the sole initial therapy for early-stage GML.Although the substantial heterogeneity observed across studies limits the interpretation of the pooled overall CR,the present study is a relevant to informing clinical practice. | Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Mariana Santos Calmon Marcel Silva Luz Samuel Luca Rocha Pinheiro Clara Faria Souza Mendes dos Santos Gabriel Lima Correa Santos Hanna Santos Marques Henrique Affonso Delgado Kádima Nayara Teixeira Cláudio Lima Souza Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2023 | World Journal of Gastroenterology2023，29，14： | 2 |
| 4 | 术前检测患者血液中总蛋白、白蛋白与白细胞介素-1受体拮抗剂作为切口疝修补术后是否出现血清肿的预测指标显示文摘患者切口疝修补术后出现血清肿是非常常见的,约占20%~30%,其中10%的患者渗液量超过50ml。出现血清肿并不一定出现并发症,但血清肿患者术后容易出现疼痛不适,尤其是补片感染导致修补手术失败,切口疝复发。对某些患者及时使用细针抽液,甚至是手术治疗都是必要的。 | Klink CD Binnebosel M Lucas AH Schachtrupp A Grommes J Conze J Klinge U Neumann U Junge K 宗振(译) 陈双(校) | 2012 | 中华疝和腹壁外科杂志(电子版)2012，6，2： | 2 |
| 5 | Changes in mieroeystin production by Microcystis aeruginosa exposed to phytoplanktivorous and omnivorous fish 显示文摘 | JANGM H HA K LUCAS MC | 2004 | Aquatic Toxicology2004，68，1： | 1 |
| 6 | Market knowledge dimensions and cross-functional collaboration:Examining the different routes to product innovation performance显示文摘 | Luca L M D Atuahene-Gima K | 2007 | Journal of Marketing2007，71，1： | 1 |
| 7 | Mechanical properties of the ice I-magnesium sulfate eutectic: A comparison with freshwater ice in reference to Europa显示文摘 | Golding N Burks C E Lucas K N | 2013 | Cold Region Science and Technology2013，，225： | 1 |
| 8 | Fieldvalidation of antioxidant enzyme biomarkers in mussels(Perna viridis)and clams(Ruditapes phillippinaum)transplanted in Hong Kongcoastal waters显示文摘 | LUCA A S B RICHARDSON B J MCCLELLAN K E | 2005 | Marine Pollution Pulletin2005，，812： | 1 |
| 9 | LRFD for Steel and Composite Beams with Web Openings 显示文摘 | Darwin D Lucas W K | 1990 | Journal of Structural Engineering1990，116，6： | 1 |
| 10 | The contingent value of marketing strategy innovativeness for product development performance in Chinese new technology ventures显示文摘 | Atuahene-Gima K Li H Y de Luca L M | | 0，，03： | 1 |
| 11 | Market Knowledge Dimensions and Cross-Functional Collab- oration: Examining the Different Routes to Product Innovation Performance显示文摘 | DE LUCA L M ATUAHENE-GIMA K | 2007 | Journal of Marketing2007，71，1： | 1 |
| 12 | Enzymatic production of acetaldehyde from ethanol in rat brain tissue显示文摘 | GILL K MENEZ J F LUCAS D | 1992 | Alcohol Clin Exp Res1992，16，： | 1 |
| 13 | Nanocrystales as destructive adsorbents for mimics of chemical warfare agents显示文摘 | Lucas E M Klabunde K J | 1999 | Nanostructured Material1999，，12： | 1 |
| 14 | Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy显示文摘 | Jellett AP Jenks K Lucas M | 2015 | Epilepsy Res2015，110，2： | 1 |
| 15 | Steady-State and dynamic modeling of gas-phase polypropylene processes using stirred-bed reactors显示文摘 | KHARE N P LUCA B SEAVEY K C | 2004 | Ind Eng Chem Res2004，43，4： | 1 |
| 16 | Introduction:Accountability through participation:Developing workable partnership models in the health sector显示文摘 | Cornwall· A Lucas· H & Pasteur· K | 2000 | IDS Bulletin2000，31，： | 1 |
| 17 | The endoplasmic reticulum is a key component of the plasma cell death pathway 显示文摘 | Pelletier N Casamayor-Pallejt M De Luca K | 2006 | J Immunol2006，176，3： | 1 |
| 18 | Null mutation of the prolactin receptor gene produces a defect in maternal behavior显示文摘 | Lucas B K Ormandy C J Binart N | 1998 | Endocrinology1998，139，10： | 1 |
| 19 | Development of multiple calcium channel types in cultured mouse hippocampal neurons显示文摘 | Chameau P Lucas P Melliti K | 1999 | Neuroscience1999，90，2： | 1 |
| 20 | Economic Viability of biogas technology in a Bangladesh village显示文摘 | Biswas W K and Lucas N J D | 1997 | Energy1997，22，8： | 1 |
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