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| 1 | Beta-blocker therapy in elderly patients with renal dysfunction and heart failure显示文摘OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 years.METHODS AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^2.We analyzed the relationship between treatment with BB and mortality or cardiovascular events.The mean age of our population was 82.6±4.1 years.Mean ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,and<30 m L/min per 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving BB.The median follow-up was28.04(IR:19.41-36.67)months.During the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better prognosis.Use of BB should be encouraged when possible. | Juan Martínez-Milla Marcelino Cortés García Julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón | 2021 | Journal of Geriatric Cardiology2021，18，1： | 3 |
| 2 | 128 case of myasthenia gravis treated with huperzine A 显示文摘 | CHENG Y S LUC Z YING Z L | 1956 | Chin J New Drugs Clin Rem1956，5，4： | 1 |
| 3 | Patents and innoration counts as measures of regional production Of new knowledge显示文摘 | Acs Z J Anselin Luc Varga Attila | 2002 | Research Policy2002，31，： | 1 |
| 4 | Patents and Inno- vation Counts as Measures of Regional Production of New Knowledge显示文摘 | Acs Z J Anselin Luc Varga Attila | 2002 | Research Policy2002，，31： | 1 |
| 5 | Patents and Innovation Counts as Measures of Regional Production of New Knowledge显示文摘 | Acs Z J Anselin Luc Varga Attila | 2002 | Research Policy2002，，31： | 1 |
| 6 | Patents and innovation counts as measures of regional production of new knowledge 显示文摘 | Acs Z J and Anselin Luc and Varga Attila | 2002 | Research Policy2002，31，： | 1 |
| 7 | Patents and Innovation Counts as Measures of Regional Production of New Knowledge 显示文摘 | Acs Z J Luc Anselin A Varga | 2002 | Research Policy2002，，31： | 1 |
| 8 | Patents and Innovation Counts as Measures of Regional Production of New Knowledge显示文摘 | ACS Z J ANSELIN LUC VARGA ATTILA | 2002 | Research Policy2002，3，1： | 1 |
| 9 | Patents and Innovation Counts as Measures of Regional Production of New Knowledge 显示文摘 | Acs Z J Anselin Luc Varga Attila | 2002 | Research Policy2002，，31： | 1 |
| 10 | Comparative mapping of QTLs for agronomic traits of rice cross environments by using a doubled-haploid population显示文摘 | Luc Shen L Tan Z | 1997 | Theor Appl Genet1997，94，： | 1 |
| 11 | Patents and innovation counts as measures of regional production of new knowledge显示文摘 | ACS Z J ANSELIN Luc VARGA Attila | 2002 | Research Policy2002，，31： | 1 |
| 12 | Patents and innovation counts as measures of regional production of New knowledge显示文摘 | Aes Z J Luc A Attila V | 2002 | Research Policy2002，，31： | 1 |
| 13 | Covalent surface modification of oxide surfaces显示文摘 | Sidharam P P Luc S Antonius T M M Han Z | 2014 | Angewandte Chemie International Edition2014，53，： | 1 |
| 14 | Patent and innovation counts as measures of regional production of new knowledge 显示文摘 | ACS Z J ANSELIN LUC VARGA ATTILA | 2002 | Re- search Policy2002，，31： | 1 |
| 15 | Electrical and magnetic properties of polyaniline/ Fe3O4 nanostructures显示文摘 | Long Y Chen Z J Jean Luc Duvail | 2005 | Physica B2005，370，： | 1 |
| 16 | Patents and innovation counts as measure of regional production of new knowledge显示文摘 | ACS Z J LUC A | 2002 | Research Policy2002，，31： | 1 |
| 17 | Patents and innovation counts as measures of regional production of new knowledge 显示文摘 | ACS Z J ANSELIN LUC VARGA ATTILA | 2002 | Research Policy2002，，31： | 1 |
| 18 | Comparison of the diagnostic accuracy of brain natriuretic peptide (BNP) and the N-terlninal part of the propeptide of BNP immunoassays in chronic and acute heart failurc 显示文摘 | Aldo C Marianna F Luc Z | 2007 | Clin Chem2007，53，5： | 1 |
| 19 | Patents and innovation counts as measures of regional production of new knowledge显示文摘 | ACSA Z J LUC A L | 2002 | Research Policy2002，31，： | 1 |
| 20 | Patents and innovation counts as measures of regional production of new knowledge 显示文摘 | ACS Z J ANSELIN LUC VARGA ATTILA | 2002 | Research Policy2002，31，： | 1 |
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