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| 1 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 2 | Recent development of a refined multiple air pollutant emission inventory of vehicles in the Central Plains of China显示文摘Central Plains region of China,represented by Henan Province,is facing serious air pollution problems.Vehicular exhaust emissions had adverse impacts on the atmospheric environment.The first comprehensive and novel vehicle emission inventory for Henan Province using vehicle kilometers traveled,localized emission factors,and activity data at city-level was developed.Furthermore,3 km×3 km gridded emission and temporal variations were determined by using localized information.Results show that the total emissions of sulfur dioxide(SO2),nitrogen oxides(NOx),carbon monoxide(CO),particular matter with aerodynamic diameter<10μm(PM10),aerodynamic diameter<2.5μm(PM2.5),volatile organic compounds(VOCs),VOCs-evaporation and ammonia in 2015 were 9.1,533.4,1190.7,23.7,21.6,150.8,31.5 and 10.4 Gg,respectively,and the emission intensities of the above pollutants were 0.05,2.7,6.0,0.1,0.1,0.8,0.2 and 0.05 g/km,respectively.Vehicles meeting the Primary China 1,China 3 and China 4 contributed 89.1%,82.7%,75.3%,75.5%,75.5%,68.2%,68.4%and 82.3%for SO2,NOx,CO,PM10,PM2.5,VOCs,VOCs-evaporation and ammonia emissions,respectively.Zhengzhou,Zhoukou,Nanyang,Luoyang,Shangqiu and Xinyang showed relatively higher emissions and contributed more than 50%of each pollutant.The spatial distribution indicated obvious characteristics of the road network,and high-level emission was concentrated in the downtown areas.Additionally,the ozone formation potential(OFP)based on the estimated speciated VOC emissions was 569.6 Gg in Henan Province.Aliphatic and aromatic hydrocarbons were the main species of VOCs,whereas olefins contributed the largest proportion of OFP,with 42.2%. | Xingke Gu Shasha Yin Xuan Lu Huan Zhang Lingling Wang Ling Bai Chen Wang Ruiqin Zhang Minghao Yuan | 2019 | Journal of Environmental Sciences2019，31，10： | 11 |
| 3 | Characteristics of ozone pollution and the sensitivity to precursors during early summer in central plain, China显示文摘In this study,we conducted an observation experiment from May 1 to June 30,2018 in Zhengzhou,a major city in central China,where ground ozone(O3)pollution has become serious in recent years.The concentrations of O3 and its precursors,as well as H2O_(2) and meteorological data were obtained from the urban site(Yanchang,YC),suburban(Zhengzhou University,ZZU)and background sites(Ganglishuiku,GLSK).Result showed that the rates of O3 concentration exceeded Chinese National Air Quality Standard GradeⅡ(93.3 ppbv)were 59.0%,52.5%,and 55.7%at the above three sites with good consistency,respectively,indicating that O3 pollution is a regional problem in Zhengzhou.The daily peak O3 appeared at 15:00-16:00,which was opposite to VOCs,NOx,and CO and consistent with H2O_(2).The exhaustive statistical analysis of meteorological factors and chemical effects on O3 formation at YC was advanced.The high concentration of precursors,high temperature,low relative humidity,and moderately high wind speed together with the wind direction dominated by south and southeast wind contribute to urban O3 episodes in Zhengzhou.O3 formation analysis showed that reactive alkenes such as isoprene and cis-2-butene contributed most to O3 formation.The VOCs/NOx ratio and smog production model were used to determine O3-VOC-NOx sensitivity.The O3 formation in Zhengzhou during early summer was mainly under VOC-limited and transition regions alternately,which implies that the simultaneous emission reduction of alkenes and NOx is effective in reducing O3 pollution in Zhengzhou. | Yasong Li Shasha Yin Shijie YU Ling Bai Xudong Wang Xuan Lu Shuangliang Ma | 2021 | Journal of Environmental Sciences2021，33，1： | 10 |
| 4 | Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells显示文摘RNase III DROSHA is upregulated in multiple cancers and contributes to tumor progression by hitherto unclear mechanisms.Here,we demonstrate that DROSHA interacts withβ-Catenin to transactivate STC1 in an RNA cleavage-independent manner,contributing to breast cancer stem-like cell(BCSC)properties.DROSHA mRNA stability is enhanced by N6-methyladenosine(m^(6)A)modification which is activated by AURKA in BCSCs.AURKA stabilizes METTL14 by inhibiting its ubiquitylation and degradation to promote DROSHA mRNA methylation.Moreover,binding of AURKA to DROSHA transcript further strengthens the binding of the m^(6)A reader IGF2BP2 to stabilize m^(6)A-modified DROSHA.In addition,wild-type DROSHA,but not an m^(6)A methylation-deficient mutant,enhances BCSC stemness maintenance,while inhibition of DROSHA m^(6)A modification attenuates BCSC traits.Our study unveils the AURKA-induced oncogenic m^(6)A modification as a key regulator of DROSHA in breast cancer and identifies a novel DROSHA transcriptional function in promoting the BCSC phenotype. | Fei Peng Jie Xu Bai Cui Qilan Liang Sai Zeng Bin He Hong Zou Manman Li Huan Zhao Yuting Meng Jin Chen Bing Liu Shasha Lv Peng Chu Fan An Zifeng Wang Junxiu Huang Yajing Zhan Yuwei Liao Jinxin Lu Lingzhi Xu Jin Zhang Zhaolin Su Zhiguang Li Fangjun Wang Eric W-FLam Quentin Liu | 2021 | Cell Research2021，31，3： | 9 |
| 5 | A Hybrid Inexact Optimization Model for Land-use Allocation of China显示文摘Land scarcity has become the prominent obstacle on the way to sustainable development for China. Under the constraints of land shortage, how to allocate the finite land resources to the multiple land users in China considering various political, environmental, ecological and economic conditions have become research topics with great significance. In this study, an interval fuzzy national-scale land-use model(IFNLM) was developed for optimizing land systems of China. IFNLM is based on an integration of existing interval linear programming(ILP), and fuzzy flexible programming(FFP) techniques. IFNLM allows uncertainties expressed as discrete interval values and fuzzy sets to be incorporated within a general optimization framework. It can also facilitate national-scale land-use planning under various environmental, ecological, social conditions within a multi-period and multi-option context. Then, IFNLM was applied to a real case study of land-use planning in China. The satisfaction degree of environmental constraints is between 0.69 and 0.97, the system benefit will between 198.25 × 1012 USD and 229.67 × 1012 USD. The results indicated that the hybrid model can help generate desired policies for land-use allocation with a maximized economic benefit and minimized environmental violation risk. Optimized land-use allocation patterns can be generated from the proposed IFNLM. | ZHOU Min CAI Yunlong GUAN Xingliang TAN Shukui LU Shasha | 2015 | Chinese Geographical Science2015，25，1： | 7 |
| 6 | Chemical genomics reveals inhibition of breast cancer lung metastasis by Ponatinib via c-Jun显示文摘Metastasis is the leading cause of human cancer deaths.Unfortunately,no approved drugs are available for antimetastatic treatment.In our study,high-throughput sequencing-based high-throughput screening(HTS^2)and a breast cancer lung metastasis(BCLM)-associated gene signature were combined to discover anti-metastatic drugs.After screening of thousands of compounds,we identified Ponatinib as a BCLM inhibitor.Ponatinib significantly inhibited the migration and mammosphere formation of breast cancer cells in vitro and blocked BCLM in multiple mouse models.Mechanistically,Ponatinib represses the expression of BCLM-associated genes mainly through the ERK/c-Jun signaling pathway by inhibiting the transcription of JUN and accelerating the degradation of c-Jun protein.Notably,JUN expression levels were positively correlated with BCLM-associated gene expression and lung metastases in breast cancer patients.Collectively,we established a novel approach for the discovery of anti-metastatic drugs,identified Ponatinib as a new drug to inhibit BCLM and revealed c-Jun as a crucial factor and potential drug target for BCLM.Our study may facilitate the therapeutic treatment of BCLM as well as other metastases. | Wei Shao Shasha Li Lu Li Kequan Lin Xinhong Liu Haiyan Wang Huili Wang Dong Wang | 2019 | Protein & Cell2019，10，3： | 7 |
| 7 | Cross-Scale Synthesis of Organic High-k Semiconductors Based on Spiro-Gridized Nanopolymers显示文摘High dielectric constants in organic semiconductors have been identified as a central challenge for the improvement in not only piexoelectric,preolecric,and freeltric efcts but also photoclecric conversion eficiency in OPVs,carrier mobility in OFETS,and charge density in charge-trapping memories.Herein,we report an ultralong persistence length(≈41 nm)efet of spiro-fused organic nanopolymers on dielectric properties,together with excitonic and charge carrier behaviors.The state-of-the-art nanopolymers,namely,nanopolyspirogrids(NPSGs),are synthesized via the simple crossscale Friedel-Crafts polygridlization of AjB-type nanomonomers.The high dielectric constant(k=8.43)of NPSG is firstly achieved by locking spiro-polygridization efect that results in the enhancement of dipole polarization.When doping into a polystyrene-based dielectric layer,such a high-k feature of NPSG increases the feld-ffct carrier mobility from 0.20 to 0.90cm^(2)Vl s'in pentacene OFET devices.Meanwhile,amorphous NPSG film exhibits an ultralow energy disorder(<50 meV)for an exellent zero-field hole mobility of 3.94×10^(-1)cm^(2)V^(-1)s^(-1).surpassing most of the amorphousπconjugated polymers Onganic nanopolymers with high dielectric constants open a new way to break through the bottleneck of eficiency and multifunctionality in the blueprint of the fourth generation semiconductors. | Dongqing Lin Wenhua Zhang Hang Yin Haixia Hu Yang Li He Zhang Le Wang Xinmiao Xie Hongkai Hu Yongxia Yan Haifeng Ling Jin'an Liu Yue Qian Lei Tang Yongxia Wang Chaoyang Dong Linghai Xie Hao Zhang Shasha Wang Ying Wei Xuefeng Guo Dan Lu Wei Huang | 2022 | Research2022，，2： | 3 |
| 8 | Spatio-temporal change of urban–rural equalized development patterns in China and its driving factors显示文摘 | Yansui Liu Shasha Lu Yufu Chen | 2013 | Journal of Rural Studies2013，，： | 2 |
| 9 | Institutional Investors, Earnings Quality and Asset Liquidity: Evidence from China's Stock Market显示文摘 | Dongmin Kong Shasha Liu Ting Lu | 2012 | Frontiers of Business Research in China2012，6，3： | 1 |
| 10 | Effect of a new antitranspirant on the physiology and water use efficiency of soybean under different irrigation rates in an arid region显示文摘Antitranspirants are exogenous substances applied to leaves to reduce luxury transpiration by regulating stomatal conductance to increase water use efficiency(WUE). A cheap and environmentally-friendly antitranspirant, FZ, was newly developed, extracted mainly from Alhagi sparsifolia. Its effects on soybean water use were investigated in a field experiment using the locally-used irrigation rate and a low irrigation rate(The lower and upper limit of irrigation is 40%–70% of field capacity). Foliar application of FZ and measurement of leaf physiological characteristics, final biomass, seed yield and water use efficiency were carried out during the pod bearing and pod filling stages of drip-irrigated soybean with film-mulching. Under the low irrigation rate, leaf stomatal conductance(gs) and transpiration rate(Tr)decreased significantly by 7 d after spraying, but photosynthesis(Pn) and instantaneous water use efficiency(WUE_(in)) were not significantly affec ted. The stomatal frequency, stomatal aperture, gs, Tr and Pn decreased by 1 d after spraying, without significantly increasing WUE_(in).However, applying FZ during the pod bearing and pod filling stages did not significantly affect the final biomass,water consumption, seed yield and WUE of soybean.Under the locally-used irrigation rate, applying FZ increased the activities of superoxide dismutase and peroxidase in the leaves by 38% and 33%, respectively,but did not significantly affect gs, Tr, Pn, stomatal aperture and stomatal frequency. Applying FZ three times during pod bearing and pod filling stages enhanced seed yield and WUE by 24% and 21%, respectively, but did not significantly affect the final biomass and water consumption. Therefore, seed yield and WUE of soybean were significantly increased by foliar application of FZ during the pod bearing and pod filling stages under the locally-used irrigation rate in arid region, but applying FZ did not have a positive effect on water use efficiency of soybean under a low irrigation rate. | Shasha JI Ling TONG Fusheng LI Hongna LU Sien LI Taisheng DU Youjie WU | 2017 | Frontiers of Agricultural Science and Engineering2017，4，2： | 1 |
| 11 | Effects of Ultraviolet(UV)Radiation on Outdoor-and Indoor-Cultured Prorocentrum lima,a Toxic Benthic Dinoflagellate显示文摘The effects of different types of ultraviolet(UV)radiation(UVR,wavelength=280-400 nm)and light intensities on cell growth,pigment composition,UV-absorbing compounds(UVACs),and chlorophyll a(Chl a)fluorescence were studied in dinoflag-ellate Prorocentrum lima cultured outdoors for 16 days and indoors for 18 days.In the outdoor experiment,UVA radiation(320-400 nm)increased the growth rate of this dinoflagellate when solar light intensities were<12%;decreased growth rates were observed when intensities were>12%.Exposure to UVB radiation(280-320 nm)alleviated the negative effects of UVA.In the indoor ex-periment,UVA and low doses of UVB enhanced growth rates.Addition of low doses of UVB to UVA exposure resulted in higher contents of Chl a and photoprotective pigments compared with UVA exposure only.The results of both experiments showed that UVB is the primary signal of UVAC synthesis.High-dose UVB exposure accelerated growth rates when UVAC contents were maintained at high levels,suggesting that the latter plays a key role in UVR damage protection.Furthermore,the repair rate was en-hanced by UVB exposure after 16 days of culture.This study confirms the positive effects of UVA and UVB on the growth of P.lima,with the latter enhancing the photoprotective and recovery pathways of the species. | CHEN Heng HUANG Kaixuan LIU Shasha LU Songhui | 2021 | Journal of Ocean University of China2021，20，3： | 1 |
| 12 | Chain-shattering Pt(IV)-backboned polymeric nanoplatform for efficient CRISPR/Cas9 gene editing to enhance synergistic cancer therapy显示文摘CRISPR/Cas9 system has become a promising gene editing tool for cancer treatment.However,development of a simple and effective nanocarrier to incorporate CRISPR/Cas9 system and chemotherapeutic drugs to concurrently tackle the biological safety and packaging capacity of viral vectors and combine gene editing-chemo for cancer therapy still remains challenges.Herein,a chain-shattering Pt(IV)-backboned polymeric nanoplatform is developed for the delivery of EZH2-targeted CRISPR/Cas9 system(NPCSPt/pEZH2)and synergistic treatment of prostate cancer.The pEZH2/Pt(II)could be effectively triggered to unpack/release from NPCSPt/pEZH2 in a chain-shattering manner in cancer cells.The EZH2 gene disruption efficiency could be achieved up to 32.2%of PC-3 cells in vitro and 21.3%of tumor tissues in vivo,leading to effective suppression of EZH2 protein expression.Moreover,significant H3K27me3 downregulation could occur after EZH2 suppression,resulting in a more permissive chromatin structure that increases the accessibility of released Pt(II)to nuclear DNA for enhanced apoptosis.Taken together,substantial proliferation inhibition of prostate cancer cells and further 85.4%growth repression against subcutaneous xenograft tumor could be achieved.This chain-shattering Pt(IV)-backboned polymeric nanoplatform system not only provides a prospective nanocarrier for CRISPR/Cas9 system delivery,but also broadens the potential of combining gene editing-chemo synergistic cancer therapy. | Qingfei Zhang Gaizhen Kuang Shasha He Sha Liu Hongtong Lu Xiaoyuan Li Dongfang Zhou Yubin Huang | 2021 | Nano Research2021，14，3： | 1 |
| 13 | Investigation and analysis on the energy consumption of starred hotel buildings in Hainan Province, the tropical region of China 显示文摘 | Lu Shilei Wei Shasha Zhang Ke | 2013 | Energy Conversion and Management2013，75，： | 1 |
| 14 | Emission trends and source characteristics of SO 2 , NO x , PM 10 and VOCs in the Pearl River Delta region from 2000 to 2009显示文摘 | Qing Lu Junyu Zheng Siqi Ye Xingling Shen Zibing Yuan Shasha Yin | 2013 | Atmospheric Environment2013，，： | 1 |
| 15 | Emission trends and source characteristics of SO 2 , NO x , PM 10 and VOCs in the Pearl River Delta region from 2000 to 2009显示文摘 | Qing Lu Junyu Zheng Siqi Ye Xingling Shen Zibing Yuan Shasha Yin | 2013 | Atmospheric Environment2013，，： | 1 |
| 16 | Localization of elastic waves in one-dimensional detuned phononic crystals with flexoelectric effect显示文摘Although forbidden band effect in perfectly periodic phononic crystals(PC)is very attractive,random disordered(i.e.detuning)phenomenon is inevitable in engineering processing,thus explor-ing the effect of detuning on the wave characteristics of PC becomes a necessity.In this study,fundamental governing equa-tions and boundary conditions are derived from the principle of virtual work.Wave characteristics and localization factor of one-dimensional(1D)detuned nano-PC are investigated based on the transfer matrix method,with flexoelectric effect duly accounted for.Subsequently,with BaTiO_(3)��SrTiO_(3) nano-PC taken for illustration,forbidden band properties and localization factor of 1D elastic waves in harmonic and detuned states are systematically character-ized.It is demonstrated that localization factor can characterize the energy band structure of 1D PC perfectly.Flexoelectric effect tends to widen the width of forbidden band with increasing detuning,and detuning is linearly related to the bandwidth.The forbidden band is more sensitive to flexoelectric coefficient detuning than thickness detuning.The research results provide useful theoretical guidance for designing high-frequency nanoscaled devices with the function of filtering based on band gap effect of nano-PC. | Cheng Shen Yifan Kong Tian Jian Lu Shasha Yang | 2022 | International Journal of Smart and Nano Materials2022，13，2： | 1 |
| 17 | Spatial-temporal change of urban-rural equalized development patterns in China and its driving factors显示文摘 | Liu Yansui Lu Shasha Chen Yufu | 2013 | Journal of Rural Studies2013，32，： | 1 |
| 18 | A refined 2010-based VOC emission inventory and its improvement on modeling regional ozone in the Pearl River Delta Region, China 显示文摘 | YIN Shasha ZHENG Junyu LU Qing | 2015 | Science of the Total Environment2015，514，： | 1 |
| 19 | Conductive fibers for biomedical applications显示文摘Bioelectricity has been stated as a key factor in regulating cell activity and tissue function in electroactive tissues.Thus,various biomedical electronic constructs have been developed to interfere with cell behaviors to promote tissue regeneration,or to interface with cells or tissue/organ surfaces to acquire physiological status via electrical signals.Benefiting from the outstanding advantages of flexibility,structural diversity,customizable mechanical properties,and tunable distribution of conductive components,conductive fibers are able to avoid the damage-inducing mechanical mismatch between the construct and the biological environment,in return to ensure stable functioning of such constructs during physiological deformation.Herein,this review starts by presenting current fabrication technologies of conductive fibers including wet spinning,microfluidic spinning,electrospinning and 3D printing as well as surface modification on fibers and fiber assemblies.To provide an update on the biomedical applications of conductive fibers and fiber assemblies,we further elaborate conductive fibrous constructs utilized in tissue engineering and regeneration,implantable healthcare bioelectronics,and wearable healthcare bioelectronics.To conclude,current challenges and future perspectives of biomedical electronic constructs built by conductive fibers are discussed. | Leqian Wei Shasha Wang Mengqi Shan Yimeng Li Yongliang Wang Fujun Wang Lu Wang Jifu Mao | 2023 | Bioactive Materials2023，，4： | 1 |
| 20 | Spatio-temporal change of urban–rural equalized development patterns in China and its driving factors显示文摘 | Yansui Liu Shasha Lu Yufu Chen | 2013 | Journal of Rural Studies2013，，： | 1 |
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