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| 1 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 2 | Out of southern East Asia: the natural history of domestic dogs across the world显示文摘 | Guo-Dong Wang Weiwei Zhai He-Chuan Yang Lu Wang LioZhong Yan-Hu Liu Ruo-Xi Fan Ting-Ting Yin Chun-Ling Zhu Andrei D Poyarkov David M Irwin Marjo K Hytonen Hannes Lohi Chung-I Wu Peter Savolainen Ya-Ping Zhang | 2016 | Cell Research2016，26，1： | 16 |
| 3 | Management of granulomatous lobular mastitis: an international multidisciplinary consensus(2021 edition)显示文摘Granulomatous lobular mastitis(GLM) is a rare and chronic benign inflammatory disease of the breast. Difficulties exist in the management of GLM for many front-line surgeons and medical specialists who care for patients with inflammatory disorders of the breast. This consensus is summarized to establish evidence-based recommendations for the management of GLM. Literature was reviewed using PubMed from January 1, 1971 to July 31, 2020. Sixty-six international experienced multidisciplinary experts from 11 countries or regions were invited to review the evidence.Levels of evidence were determined using the American College of Physicians grading system, and recommendations were discussed until consensus. Experts discussed and concluded 30 recommendations on historical definitions,etiology and predisposing factors, diagnosis criteria, treatment, clinical stages, relapse and recurrence of GLM. GLM was recommended as a widely accepted definition. In addition, this consensus introduced a new clinical stages and management algorithm for GLM to provide individual treatment strategies. In conclusion, diagnosis of GLM depends on a combination of history, clinical manifestations, imaging examinations, laboratory examinations and pathology.The approach to treatment of GLM should be applied according to the different clinical stage of GLM. This evidencebased consensus would be valuable to assist front-line surgeons and medical specialists in the optimal management of GLM. | Qian-Qian Yuan Shu-Yuan Xiao Omar Farouk Yu-Tang Du Fereshte Sheybani Qing Ting Tan Sami Akbulut Kenan Cetin Afsaneh Alikhassi Rami Jalal Yaghan Irmak Durur-Subasi Fatih Altintoprak Tae Ik Eom Fatih Alper Mustafa Hasbahceci David Martínez-Ramos Pelin Seher Oztekin Ava Kwong Cedric W.Pluguez-Turul Kirstyn EBrownson Shirish Chandanwale Mehran Habib Liu-Yi Lan Rui Zhou Xian-Tao Zeng Jiao Bai Jun-Wen Bai Qiong-Rong Chen Xing Chen Xiao-Ming Zha Wen-Jie Dai Zhi-Jun Dai Qin-Yu Feng Qing-Jun Gao Run-Fang Gao Bao-San Han Jin-Xuan Hou Wei Hou Hai-Ying Liao Hong Luo Zheng-Ren Liu Jing-Hua Lu Bin Luo Xiao-Peng Ma Jun Qian Jian-Yong Qin Wei Wei Gang Wei Li-Ying Xu Hui-Chao Xue Hua-Wei Yang Wei-Ge Yang Chao-Jie Zhang Fan Zhang Guan-Xin Zhang Shao-Kun Zhang Shu-Qun Zhang Ye-Qiang Zhang Yue-Peng Zhang Sheng-Chu Zhang Dai-Wei Zhao Xiang-Min Zheng Le-Wei Zheng Gao-Ran Xu Wen-Bo Zhou Gao-Song Wu | 2022 | Military Medical Research2022，9，4： | 13 |
| 4 | A large outbreak of acute gastroenteritis caused by the human norovirus GII.17 strain at a university in Henan Province,China显示文摘Background:Human noroviruses are a major cause of viral gastroenteritis and are the main etiological agents of acute gastroenteritis outbreaks.An increasing number of outbreaks and sporadic cases of norovirus have been reported in China in recent years.There was a large acute gastroenteritis outbreak at a university in Henan Province,China in the past five years.We want to identify the source,transmission routes of the outbreak by epidemiological investigation and laboratory testing in order to provide the effective control measures.Methods:The clinical cases were investigated,and analysed by descriptive epidemiological methods according to factors such as time,department,grade and so on.Samples were collected from clinical cases,healthy persons,the environment,water,and food at the university.These samples were tested for potential bacteria and viruses.The samples that tested positive for norovirus were selected for whole genome sequencing and the sequences were then analysed.Results:From 4 March to 3 April 2015,a total of 753 acute diarrhoea cases were reported at the university;the attack rate was 3.29%.The epidemic curve showed two peaks,with the main peak occurring between 10 and 20 March,accounting for 85.26%of reported cases.The rates of norovirus detection in samples from confirmed cases,people without symptoms,and environmental samples were 32.72%,17.39%,and 9.17%,respectively.The phylogenetic analysis showed that the norovirus belonged to the genotype GII.17.Conclusions:This is the largest and most severe outbreak caused by genotype GII.17 norovirus in recent years in China.The GII.17 viruses displayed high epidemic activity and have become a dominant strain in China since the winter of 2014,having replaced the previously dominant GII.4 Sydney 2012 strain. | Xue-Yong Huang Jia Su Qian-Chao Lu Shi-Zheng Li Jia-Yong Zhao Meng-Lei Li Yi Li Xiao-Jing Shen Bai-Fan Zhang Hai-Feng Wang Yu-Jiao Mu Shu-Yu Wu Yan-Hua Du Li-Cheng Liu Wei-Jun Chen John David Klena Bian-Li Xu | 2017 | Infectious Diseases of Poverty2017，6，1： | 10 |
| 5 | Endovascular treatment with or without intravenous alteplase for acute ischaemic stroke due to basilar artery occlusion显示文摘Background and purpose It remains controversial if endovascular treatment(EVT)can improve the outcome of patients with acute basilar artery occlusion(BAO).This study aims to compare the functional outcomes between EVT with and without intravenous thrombolysis(IVT)first in patients who had acute ischaemic stroke(AIS)due to BAO.Methods Patients who had AIS with BAO who underwent EVT within 24 hours of onset were enrolled in this multicentre cohort study,and the efficacy and safety were compared between IVT+EVT and direct EVT.The primary outcome was 90-day functional independence.All outcomes were assessed with adjusted OR(aOR)from the multivariable logistic regression.In addition,a meta-analysis was performed on all recently published pivotal studies on functional independence after EVT in patients with BAO.Results Of 310 enrolled patients with BAO,241(78%)were treated with direct EVT and 69(22%)with IVT+EVT.Direct EVT was associated with a worse functional outcome(aOR,0.46(95%CI 0.24 to 0.85),p=0.01).IVT+EVT was associated with a lower percentage of patients who needed≥3 passes of stent retriever(10.14%vs 20.75%).The meta-analysis regression revealed a potential positive correlation between bridging with IVT first and functional independence(r=0.14(95%CI 0.05 to 0.24),p<0.01).Conclusions This study showed that compared with direct EVT,EVT with IVT first was associated with better functional outcomes in patients with BAO treated within 24 hours of onset.The meta-analysis demonstrated similar favourable efficacy of IVT first followed by EVT in patients with BAO. | Ximing Nie David Wang Yuehua Pu Yufei Wei Qixuan Lu Hongyi Yan Xin Liu Lina Zheng Jingyi Liu Xinxuan Yang Yarong Ding Dacheng Liu Wanying Duan Zhe Zhang Zhonghua Yang Miao Wen Weibin Gu Xinyi Hou Xinyi Leng Yuesong Pan Zhongrong Miao Liping Liu | 2022 | Stroke & Vascular Neurology2022，7，3： | 10 |
| 6 | The policy-driven peak and reduction of China's carbon emissions显示文摘Pursuant to the Paris Agreement,China committed itself to peak its carbon emissions by around 2030 and to increase the non-fossil share ofprimary energy to 20%at the same time.The government has supported the international agreement by setting and strengthening the domesticpolicy targets for an earlier peak and faster reduction,aiming to contain the average global temperature increase to well below 2℃.We developa Kaya Inequality method to assess the time of peak and pace of reduction of China's energy-related CO2emissions based on the national energypolicy targets for 2030.We find that,despite the minor fluctuations,the current plateau essentially represents the peak emissions and should entera phase of steady decline by around 2025,given current trends in energy consumption and decarbonization.Such developments would beconsistent with the strengthened national policy target to achieve 50%of renewable power generation by 2030.However,the basic policy targetsea 20%share of non-fossil energy and 6 Gtce in total energy consumption by 2030ewould be insufficient to peak carbon emissions by around 2030.The synergy and interplay between domestic policy target setting and international climate commitments shed light on the need to elevatenational climate ambitions under the Paris Agreement and beyond. | QI Ye Nicholas STERN HE Jian-Kun LU Jia-Qi LIU Tian-Le David KING WU Tong | 2020 | Advances in Climate Change Research2020，11，2： | 10 |
| 7 | Clinical practice of transarterial chemoembolization for hepatocellular carcinoma:consensus statement from an international expert panel of International Society of Multidisciplinary Interventional Oncology(ISMIO)显示文摘Importance:Transarterial chemoembolization(TACE)has been associated with a wide range of practice variations for hepatocellular carcinoma(HCC)between the East and the West.This considerable ambiguity may lead to the heterogeneous quality in treatment and have a negative impact on the role of TACE in the overall multidisciplinary HCC treatment system.Objective:It may be a good start to establish a guideline worldwide to have this consensus from experts who represent east and west,although it does not cover all aspects of TACE.Evidence Review:An international expert panel on TACE is convened to cluster the expert’s opinions and summary a standard consensus.This panel committee consist of leading physicians in TACE on HCC from USA,France,Japan,Singapore,Korea,China,and so on.The first-round face-to-face consensus meeting was held during in Nanjing,China in October 2019.The second-round conference for revision of the consensus was held during the Annual Meeting of Chinese College of Interventionalists in August 2020 by a hybrid format of a Webinar and roundtable meeting.After several on-line revisions,the final manuscript was approved by all members of the panel in June 2021.Findings:The consensus statements were organized into the following categories:patients’selection,performing the procedure,TACE outcomes,repeat TACE,TACE failure/refractory,and TACE-based combination treatments.Conclusions and Relevance for Reviews:More and more evidences have showed the better outcomes with strategy of combined TACE with other local therapies such as ablations.The most-recently developing strategy of combined TACE with PD-1/PD-L1 plus tyrosine kinase inhibitor(TKI)agents has shined a light to the HCC patients,especially to those with high risk of tumor recurrence after treatment or TACE failure/refractory. | Jian Lu Ming Zhao Yasuaki Arai Bin-Yan Zhong Hai-Dong Zhu Xiao-Long Qi Thierry de Baere Uei Pua Hyun Ki Yoon David C.Madoff Gao-Jun Teng International Society of Multidisciplinary Interventional Oncology(ISMIO) | 2021 | Hepatobiliary Surgery and Nutrition2021，10，5： | 9 |
| 8 | 共聚物在超声介导基因转染中的新功能显示文摘目的探讨超声和共聚物在促进基因转染中是否有协同作用.方法应用3种水溶性不同的共聚物F127,L61和P85.超声参数设定为1 MHz,1~3 W/cm2,脉冲作功周期为20%.选用C2C12,3T3-MDEI,和CHO 3种细胞系为研究对象.质粒DNA为可产生绿色荧光蛋白的GFP.应用荧光显微镜和流式细胞仪(FACS)评价转染率,台盼蓝染色评价细胞的成活率.每一实验结果至少重复3次以上.结果与以前的研究结果相同,超声可介导基因转染,但随着超声能量的增加,细胞的破坏也增加;单独应用3种共聚物未观察到基因转染.但当与超声同时应用,在较低浓度时共聚物可使超声介导的基因转染率提高2~4倍.结论在较低浓度时,共聚物可显著提高超声介导的基因转染作用. | 陈云超 张青萍 LIANG Hai-Dong David O. Cosgrove Martin JK Blomley Qi-Long Lu | 2005 | 中华超声影像学杂志2005，14，11： | 7 |
| 9 | Hierarchical highly ordered SnO_(2) nanobowl branched ZnO nanowires for ultrasensitive and selective hydrogen sulfide gas sensing显示文摘Highly sensitive and selective hydrogen sulfide(H_(2)S)sensors based on hierarchical highly ordered SnO_(2) nanobowl branched ZnO nanowires(NWs)were synthesized via a sequential process combining hard template processing,atomic-layer deposition,and hydrothermal processing.The hierarchical sensing materials were prepared in situ on microelectromechanical systems,which are expected to achieve high-performance gas sensors with superior sensitivity,long-term stability and repeatability,as well as low power consumption.Specifically,the hierarchical nanobowl SnO_(2)@ZnO NW sensor displayed a high sensitivity of 6.24,a fast response and recovery speed(i.e.,14 s and 39 s,respectively),and an excellent selectivity when detecting 1 ppm H_(2)S at 250°C,whose rate of resistance change(i.e.,5.24)is 2.6 times higher than that of the pristine SnO_(2) nanobowl sensor.The improved sensing performance could be attributed to the increased specific surface area,the formation of heterojunctions and homojunctions,as well as the additional reaction between ZnO and H_(2)S,which were confirmed by electrochemical characterization and band alignment analysis.Moreover,the well-structured hierarchical sensors maintained stable performance after a month,suggesting excellent stability and repeatability.In summary,such well-designed hierarchical highly ordered nanobowl SnO_(2)@ZnO NW gas sensors demonstrate favorable potential for enhanced sensitive and selective H_(2)S detection with long-term stability and repeatability. | Li-Yuan Zhu Kai-Ping Yuan Jia-He Yang Cheng-Zhou Hang Hong-Ping Ma Xin-Ming Ji Anjana Devi Hong-Liang Lu David Wei Zhang | 2020 | Microsystems & Nanoengineering2020，6，1： | 7 |
| 10 | 土壤硝酸盐试纸条-反射仪测定法存在问题及其解决方案显示文摘针对浸提方法影响硝酸盐试纸条-反射仪法结果的问题,选择陕西关中的土娄土和渭南的黑垆土为供试材料,通过室内对比试验,对土壤硝酸盐浸提剂、振荡与沉淀时间及水土质量比等因素进行优化。结果表明,浸提剂类型、振荡与静置时间均对试纸条-反射仪法的土壤硝酸盐测试结果产生较大影响,而水土质量比对测定结果无显著影响,最终确定利用饱和硫酸钙作为浸提剂、振荡10 min、静置5 min为最佳前处理方法,在此条件下,硝酸盐试纸条-反射仪法测试结果准确,测试效率高。 | 王芳 高鹏程 同延安 张树兰 张恒 LU Yuelai David Powlson | 2011 | 西北农业学报2011，20，3： | 6 |
| 11 | Two centuries of April-July temperature change in southeastern China and its influence on grain productivity显示文摘China is a traditional agriculture based country and one main region for crop production is southeastern China where temperature is a dominant climate variable affecting agriculture. Temperature and social disturbances both influence crop production, yet distinguishing their relative impacts is difficult due to a lack of reliable, high-resolution historical climatic records before the very recent period. Here we present the first tree-ring based warm-season temperature reconstruction for southeastern China, a core region of the East Asian monsoon, for the past 227 years. The reconstruction target was April-July mean temperature, and our model explained 60.6% of the observed temperature variance during 1953–2012.Spatial correlation analysis showed that the reconstruction is representative of April-July temperature change over most of eastern China. The reconstructed temperature series agrees well with China-scale(heavily weighted in eastern China) agricultural production index values quite well at decadal timescales.The impacts of social upheavals on food production, such as those in the period 1920–1949, were confirmed after climatic influences were excluded. Our study should help distinguish the influence of social disturbance and warm-season temperature on grain productivity in the core agricultural region of China during the past two centuries. | Jiangfeng Shi Jinbao Li David D.Zhang Jingyun Zheng Shiyuan Shi Quansheng Ge Harry F.Lee Yesi Zhao Jie Zhang Huayu Lu | 2017 | Science Bulletin2017，62，1： | 6 |
| 12 | Neuroprotectants attenuate hypobaric hypoxia-induced brain injuries in cynomolgus monkeys显示文摘Hypobaric hypoxia (HH) exposure can cause serious brain injury as well as life-threatening cerebral edema in severe cases. Previous studies on the mechanisms of HH-induced brain injury have been conducted primarily using non-primate animal models that are genetically distant to humans, thus hindering the development of disease treatment. Here, we report that cynomolgus monkeys (Macaca fascicularis) exposed to acute HH developed human-like HH syndrome involving severe brain injury and abnormal behavior. Transcriptome profiling of white blood cells and brain tissue from monkeys exposed to increasing altitude revealed the central role of the HIF-1 and other novel signaling pathways, such as the vitamin D receptor (VDR) signaling pathway, in co-regulating HH-induced inflammation processes. We also observed profound transcriptomic alterations in brains after exposure to acute HH, including the activation of angiogenesis and impairment of aerobic respiration and protein folding processes, which likely underlie the pathological effects of HH-induced brain injury. Administration of progesterone (PROG) and steroid neuroprotectant 5α-androst-3β,5,6β-triol (TRIOL) significantly attenuated brain injuries and rescued the transcriptomic changes induced by acute HH. Functional investigation of the affected genes suggested that these two neuroprotectants protect the brain by targeting different pathways, with PROG enhancing erythropoiesis and TRIOL suppressing glutamate-induced excitotoxicity. Thus, this study advances our understanding of the pathology induced by acute HH and provides potential compounds for the development of neuroprotectant drugs for therapeutic treatment. | Pei Zhang Jie-Si Chen Qi-Ye Li Long-Xiang Sheng Yi-Xing Gao Bing-Zheng Lu Wen-Bo Zhu Xiao-Yu Zhan Yuan Li Zhi-Bing Yuan Gang Xu Bi-Tao Qiu Min Yan Chun-Xue Guo You-Qiong Wang Yi-Jun Huang Jing-Xia Zhang Fu-Yu Liu Zhong-Wei Tang Sui-Zhen Lin David NCooper Huan-Ming Yang Jian Wang Yu-Qi Gao Wei Yin Guo-Jie Zhang Guang-Mei Yan | 2020 | Zoological Research2020，41，1： | 6 |
| 13 | Advancement toward Polymer Electrolyte Membrane Fuel Cells at Elevated Temperatures显示文摘Elevation of operational temperatures of polymer electrolyte membrane fuel cells(PEMFCs)has been demonstrated with phosphoric acid-doped polybenzimidazole(PA/PBI)membranes.The technical perspective of the technology is simplified construction and operation with possible integration with,e.g.,methanol reformers.Toward this target,significant efforts have been made to develop acid-base polymer membranes,inorganic proton conductors,and organic-inorganic composite materials.This report is devoted to updating the recent progress of the development particularly of acid-doped PBI,phosphate-based solid inorganic proton conductors,and their composite electrolytes.Long-term stability of PBI membranes has been well documented,however,at typical temperatures of 160℃.Inorganic proton-conducting materials,e.g.,alkali metal dihydrogen phosphates,heteropolyacids,tetravalent metal pyrophosphates,and phosphosilicates,exhibit significant proton conductivity at temperatures of up to 300℃ but have so far found limited applications in the form of thin films.Composite membranes of PBI and phosphates,particularly in situ formed phosphosilicates in the polymer matrix,showed exceptionally stable conductivity at temperatures well above 200℃.Fuel cell tests at up to 260℃ are reported operational with good tolerance of up to 16%CO in hydrogen,fast kinetics for direct methanol oxidation,and feasibility of nonprecious metal catalysts.The prospect and future exploration of new proton conductors based on phosphate immobilization and fuel cell technologies at temperatures above 200℃ are discussed. | Jin Zhang David Aili Shanfu Lu Qingfeng Li and San Ping Jiang | 2020 | Research2020，，1： | 6 |
| 14 | Agriculture Green Development in China and the UK: common objectives and converging policy pathways显示文摘This paper has three aims.First,to examine how the negative environmental consequences of intensive agriculture have driven China and the UK to shift away from narrowly focused farm output policies and adopt more holistic green development pathways.Second,to explore the policy objectives they have in common.Third,to assess the numerous opportunities for joint research and knowledge sharing through the Sustainable Agriculture Innovation Network and other existing institutional mechanisms.The intensification of agricultural production in the UK started several decades earlier than in China as did the negative environmental consequences of the farm practices.However,their strategies and policies for sustainable intensification and green development have much in common.These are set out in two main documents:the Chinese State Council guidelines for green agriculture and the UK Department for Environment,Food and Rural Affairs 25 Year Environment Plan.There are substantial mutual advantages from greater collaboration on problem identification and monitoring;the development of appropriate technological and management responses and the formulation of sound policies.To achieve this potential,it is recommended that further thought be given to how best to bring together all of the key stakeholders along the whole food chain. | Yuelai LU David NORSE David POWLSON | 2020 | Frontiers of Agricultural Science and Engineering2020，7，1： | 5 |
| 15 | Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation显示文摘BACKGROUND Arachidyl amido cholanoic acid(Aramchol)is a potent downregulator of hepatic stearoyl-CoA desaturase 1(SCD1)protein expression that reduces liver triglycerides and fibrosis in animal models of steatohepatitis.In a phase IIb clinical trial in patients with nonalcoholic steatohepatitis(NASH),52 wk of treatment with Aramchol reduced blood levels of glycated hemoglobin A1c,an indicator of glycemic control.AIM To assess lipid and glucose metabolism in mouse hepatocytes and in a NASH mouse model[induced with a 0.1%methionine and choline deficient diet(0.1MCD)]after treatment with Aramchol.METHODS Isolated primary mouse hepatocytes were incubated with 20μmol/L Aramchol or vehicle for 48 h.Subsequently,analyses were performed including Western blot,proteomics by mass spectrometry,and fluxomic analysis with 13C-uniformly labeled glucose.For the in vivo part of the study,male C57BL/6J mice were randomly fed a control or 0.1MCD for 4 wk and received 1 or 5 mg/kg/d Aramchol or vehicle by intragastric gavage for the last 2 wk.Liver metabolomics were assessed using ultra-high-performance liquid chromatography-time of flight-MS for the determination of glucose metabolism-related metabolites.RESULTS Combination of proteomics and Western blot analyses showed increased AMPK activity while the activity of nutrient sensor mTORC1 was decreased by Aramchol in hepatocytes.This translated into changes in the content of their downstream targets including proteins involved in fatty acid(FA)synthesis and oxidation[PACCα/β(S79),SCD1,CPT1A/B,HADHA,and HADHB],oxidative phosphorylation(NDUFA9,NDUFB11,NDUFS1,NDUFV1,ETFDH,and UQCRC2),tricarboxylic acid(TCA)cycle(MDH2,SUCLA2,and SUCLG2),and ribosome(P-p70S6K[T389]and P-S6[S235/S236]).Flux experiments with 13Cuniformely labeled glucose showed that TCA cycle cataplerosis was reduced by Aramchol in hepatocytes,as indicated by the increase in the number of rounds that malate remained in the TCA cycle.Finally,liver metabolomic analysis showed that glucose homeostasis was improved by Aramchol in 0.1MCD fed mice in a dose-dependent manner,showing normalization of glucose,G6P,F6P,UDP-glucose,and Rbl5P/Xyl5P.CONCLUSION Aramchol exerts its effect on glucose and lipid metabolism in NASH through activation of AMPK and inhibition of mTORC1,which in turn activate FAβ-oxidation and oxidative phosphorylation. | David Fernández-Ramos Fernando Lopitz-Otsoa Laura Delacruz-Villar Jon Bilbao Martina Pagano Laura Mosca Maider Bizkarguenaga Marina Serrano-Macia Mikel Azkargorta Marta Iruarrizaga-Lejarreta Jesús Sot Darya Tsvirkun Sebastiaan Martijn van Liempd Felix M Goni Cristina Alonso María Luz Martínez-Chantar Felix Elortza Liat Hayardeny Shelly C Lu JoséM Mato | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 16 | In-Situ Differentiation of Acidic and Non-Acidic Tundra via Portable X-ray Fluorescence (PXRF) Spectrometry显示文摘Frozen soils or those with permafrost cover large areas of the earth's surface and support unique vegetative ecosystems. Plants growing in such harsh conditions have adapted to small niches, which allow them to survive. In northern Alaska, USA, both moist acidic and non-acidic tundra occur, yet determination of frozen soil p Hs currently requires thawing of the soil so that electrometric pH methods can be utilized. Contrariwise, a portable X-ray fluorescence(PXRF) spectrometer was used in this study to assess elemental abundances and relate those characteristics to soil pH through predictive multiple linear regressions. Two operational modes, Soil Mode and Geochem Mode, were utilized to scan frozen soils in-situ and under laboratory conditions, respectively, after soil samples were dried and ground. Results showed that lab scanning produced optimal results with adjusted coefficient of determination(R^2) of 0.88 and 0.33 and root mean squared errors(RMSEs) of 0.87 and 0.34 between elemental data and lab-determined pH for Soil Mode and Geochem Mode, respectively. Even though the presence of ice attenuated fluoresced radiation under field conditions, adjusted R^2 and RMSEs between the datasets still provided reasonable model generalization(e.g., 0.73 and 0.49 for field Geochem Mode). Principal component analysis qualitatively separated multiple sampling sites based on elemental data provided by PXRF, reflecting differences in the chemical composition of the soils studied. Summarily, PXRF can be used for in-situ determination of soil pH in arctic environments without the need for sample modification and thawing. Furthermore, use of PXRF for determination of soil pH may provide higher sample throughput than traditional eletrometric-based methods, while generating elemental data useful for the prediction of multiple soil parameters. | Somsubhra CHAKRABORTY David C. WEINDORF GARY J. MICHAELSON Chien Lu PING Ashok CHOUDHURY Tarek KANDAKJI Autumn ACREE Akriti SHARMA WANG Dandan | 2016 | Pedosphere2016，26，4： | 4 |
| 17 | p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。 | Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen | 2015 | Cell Research2015，25，3： | 4 |
| 18 | Strategies to reduce nutrient pollution from manure management in China显示文摘As the demand for livestock products continues to increase in China,so too does the challenge of managing increasing quantities of manure.Urgent action is needed to control point source(housing,storage and processing)and diffuse(field application)pollution and improve the utilization of manure nutrients and organic matter.Here,we review strategies to improve management at each stage of the manure management chain and at different scales.Many strategies require infrastructure investment,e.g.,for containment of all manure fractions.Engineering solutions are needed to develop advanced composting systems with lower environmental footprints and design more efficient nutrient stripping technologies.At the field-scale,there is an urgent need to develop a manure nutrient recommendation system that accounts for the range of manure types,cropping systems,soils and climates throughout China.At the regional scale,coordinated planning is necessary to promote recoupling of livestock and cropping systems,and reduce nutrient accumulation in regions with little available landbank,while minimizing the risk of pollution swapping from one region to another.A range of stakeholders are needed to support the step change and innovation required to improve manure management,reduce reliance on inorganic fertilizers,and generate new business opportunities. | David R.CHADWICK John R.WILLIAMS Yuelai LU Lin MA Zhaohai BAI Yong HOU Xinping CHEN Thomas H.MISSELBROOK | 2020 | Frontiers of Agricultural Science and Engineering2020，7，1： | 4 |
| 19 | 减氮施肥推广技术在陕西的实践显示文摘氮素面源污染是中国最为严重的环境问题之一,过量使用氮肥是土壤氮素面源污染的主要原因。作为一项利于资源和环境的农业生产技术,减氮施肥的效果虽然在试验和示范中不断被验证,然而由于常规推广方法的局限性,这一技术并没有为广大农户所采用。通过调查分析农民过量施肥发生的原因,有针对性地为农民提供多样化的培训活动,使得农民充分了解氮肥相关知识以及过量使用氮肥对环境的负面影响,同时开展由农民主导的减氮施肥试验示范,结合氮素速测仪测定播前土壤氮素含量,帮助农民制定出合理氮肥用量,此外,利用村内能人的带动作用以及农民专业协会的网络功能,推动减氮施肥技术在农民群众间的扩散,使其成为农民生产中的自觉行为。 | 高鹏程 同延安 张树兰 张恒 Lu Yuelai David Powlson | 2010 | 陕西农业科学2010，56，1： | 3 |
| 20 | Liver Transplantation Criteria For Hepatocellular Carcinoma Should Be Expanded: A 22-Year Experience With 467 Patients at UCLA显示文摘 | John P. Duffy Andrew Vardanian Elizabeth Benjamin Melissa Watson Douglas G. Farmer Rafik M. Ghobrial Gerald Lipshutz Hasan Yersiz David S. K. Lu Charles Lassman Myron J. Tong Jonathan R. Hiatt Ronald W. Busuttil | 2007 | Annals of Surgery2007，，3： | 3 |
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