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| 1 | Precise orbit determination of Beidou Satellites with precise positioning显示文摘Chinese Beidou satellite navigation system constellation currently consists of eight Beidou satellites and can provide preliminary service of navigation and positioning in the Asia-Pacific Region.Based on the self-developed software Position And Navigation Data Analysis(PANDA) and Beidou Experimental Tracking Stations (BETS),which are built by Wuhan University,the study of Beidou precise orbit determination,static precise point positioning (PPP),and high precision relative positioning,and differential positioning are carried out comprehensively.Results show that the radial precision of the Beidou satellite orbit determination is better than 10 centimeters.The RMS of static PPP can reach several centimeters to even millimeters for baseline relative positioning.The precision of kinematic pseudo-range differential positioning and RTK mode positioning are 2-4 m and 5-10 cm respectively,which are close to the level of GPS precise positioning.Research in this paper verifies that,with support of ground reference station network,Beidou satellite navigation system can provide precise positioning from several decimeters to meters in the wide area and several centimeters in the regional area.These promising results would be helpful for the implementation and applications of Beidou satellite navigation system. | SHI Chuang ZHAO QiLe LI Min TANG WeiMing HU ZhiGang LOU YiDong ZHANG HongPing NIU XiaoJi LIU JingNan | 2012 | Science China Earth Sciences2012，55，7： | 61 |
| 2 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 3 | Chemical characteristics of fine particles and their impact on visibility impairment in Shanghai based on a 1-year period observation显示文摘In this work, a one-year observation focusing on high time resolution characteristics of components in fine particles was conducted at an urban site in Shanghai. Contributions of different components on visibility impairment were also studied. Our research indicates that the major components of PM_(2.5) in Shanghai are water-soluble inorganic ions and carbonaceous aerosol, accounting for about 60% and 30% respectively. Higher concentrations of sulfate(SO42-) and organic carbon(OC) in PM_(2.5) occurred in fall and summer, while higher concentrations of nitrate(NO_3^-) were observed in winter and spring. The mass concentrations of Cl^- and K^+ were higher in winter. Moreover, NO_3^- increased significantly during PM_(2.5) pollution episodes. The high values observed for the sulfate oxidizing rate(SOR), nitrate oxidizing rate(NOR) and secondary organic carbon(SOC) in OC indicate that photochemical reactions were quite active in Shanghai. The IMPROVE(Interagency Monitoring of Protected Visual Environments) formula was used in this study to investigate the contributions of individual PM_(2.5) chemical components to the light extinction efficient in Shanghai. Both NH_4NO_3 and(NH_4)_2SO_4 had close relationships with visibility impairment in Shanghai. Our results show that the reduction of anthropogenic SO_2, NO_x and NH_3 would have a significant effect on the improvement of air quality and visibility in Shanghai. | Min Zhou Liping Qiao Shuhui Zhu Li Li Shengrong Lou Hongli Wang Qian Wang Shikang Tao Cheng Huang Changhong Chen | 2016 | Journal of Environmental Sciences2016，28，10： | 22 |
| 4 | Advanced oxidation protein products decrease expression of nephrin and podocin in podocytes via ROS-dependent activation of p38 MAPK显示文摘Accumulation of plasma advanced oxidation protein products(AOPPs) promotes progression of proteinuria and glomerulo-sclerosis.To investigate the molecular basis of AOPPs-induced proteinuria,normal Sprague-Dawley rats were treated with AOPPs-modified rat serum albumin.The expression of glomerular podocyte slit diaphragm(PSD)-associated proteins,nephrin and podocin,was significantly decreased coincident with the onset of albuminuria in rats treated with AOPPs.Chronic inhibi-tion of NADPH oxidase by apocynin prevented down-regulation of nephrin and podocin and decreased albuminuria in AOPPs-challenged rats.This suggested that accumulation of AOPPs promotes proteinuria,possibly via down-regulating the expression of PSD-associated proteins. | YANG Li,LIANG Min,ZHOU QiuGen,XIE Di,LOU AiJu,ZHANG Xun & HOU FanFan Key Laboratory for Organ Failure Research,Division of Nephrology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China. | 2010 | Science China(Life Sciences)2010，53，1： | 14 |
| 5 | Chemical and optical properties of aerosols and their interrelationship in winter in the megacity Shanghai of China显示文摘A field campaign on air quality was carried out in Shanghai in winter of 2012. The concentrations of NO, NO2, NOx, SO2, CO, and PM2.5increased during haze formation. The average masses of SO42-, NO3-and NH4+were 10.3, 11.7 and 6.7 μg/m3 during the haze episodes, which exceeded the average(9.2, 7.9, and 3.4 μg/m3) of these components in the non-haze days. The mean values for the aerosol scattering coefficient(b sp), aerosol absorption coefficient(b ap) and single scattering albedo(SSA) were 288.7, 27.7 and0.91 Mm-1, respectively. A bi-peak distribution was observed for the mass concentrations of CO, NO, NO2, and NOx. More sulfate was produced during daytime than that in the evening due to photochemical reactions. The mass concentration of NH4+achieved a small peak at noontime. NO3-showed lower concentrations in the afternoon and higher concentrations in the early morning. There were obvious bi-peak diurnal patterns for b sp and b ap as well as SSA. b sp and b ap showed a positive correlation with PM2.5mass concentration.(NH4)2SO4, NH4NO3, organic mass, elemental carbon and coarse mass accounted for 21.7%, 19.3%, 31.0%, 9.3% and 12.3% of the total extinction coefficient during non-haze days, and 25.6%, 24.3%, 30.1%, 8.1% and 8.2% during hazy days. Organic matter was the largest contributor to light extinction. The contribution proportions of ammonium sulfate and ammonium nitrate to light extinction were significantly higher during the hazy time than during the non-haze days. | Tingting Han Liping Qiao Min Zhou Yu Qu Jianfei Du Xingang Liu Shengrong Lou Changhong Chen Hongli Wang Fang Zhang Qing Yu Qiong Wu | 2015 | Journal of Environmental Sciences2015，27，1： | 14 |
| 6 | Dynamic Responses of Top Tensioned Riser Under Combined Excitation of Internal Solitary Wave, Surface Wave and Vessel Motion显示文摘An investigation on the dynamic response of a top tensioned riser (TTR) under combined excitation of internal solitary wave, surface wave and vessel motion is presented in this paper. The riser is idealized as a tensioned slender beam with dynamic boundary conditions. The KdV-mKdV equation is chosen to simulate the internal solitary wave, and the vessel motion is analysed by using the method proposed by Sexton. Using finite element method, the governing equation is solved in time domain with Newmark-β method. The computation programs for solving the differential equations in time domain are compiled and numerical results are obtained, including dimensionless displacement and stress. The action of internal solitary wave on the riser is like a slow powerful impact, and is much larger than those of surface wave and vessel motion. When the riser is under combined excitation, it vibrates at frequencies of both surface wave and vessel motion, and the vibration is dominated by internal solitary wave. As the internal solitary wave crest passes by the centre of the riser, the maximum displacement and stress along the riser occur. Compared to the lower part, the displacement and stress of the riser in the upper part are much larger. | GUO Haiyan ZHANG Li LI Xiaomin LOU Min | 2013 | Journal of Ocean University of China2013，12，1： | 10 |
| 7 | Induction of actin disruption and downregulation of P-glycoprotein expression by solamargine in multidrug-resistant K562/A02 cells显示文摘 | LI Xia ZHAO Ying JI Mei LIU Shan-shan CUI Min LOU Hong-xiang | 2011 | Chinese Medical Journal2011，，13： | 9 |
| 8 | Synthesis of the novel PARP-1 inhibitor AG- 690/11026014 and its protective effects on angiotensin II-induced mouse cardiac remodeling显示文摘我们以前 poly 作为一篇小说识别了 AG-690/11026014 (6014 )( 自动数据处理核糖) 有效地阻止了血管收缩素 II (Ang II ) 的 polymerase-1 (PARP-1 ) 禁止者导致了 cardiomyocyte 肥大。在现在的学习,我们为 6014 报导了一条新合成线路,并且在 Ang 上调查了它的保护的效果在老鼠的导致 II 的心脏的改变和心脏的机能障碍和内在的机制。我们设计了一条新合成线路在 vivo 学习为这获得 6014 的足够的数量。C57BL/6J 老鼠与 Ang II 被灌输并且与 6014 对待(10, 30, 90 mg 日吗?? | Guo-shuai FENG Cui-ge ZHU Zhuo-ming LI Pan-xia WANG Yi HUANG Min LIU Ping HE Lan-lan LOU Shao-rui CHEN Pei-qing LIU | 2017 | Acta Pharmacologica Sinica2017，38，5： | 8 |
| 9 | 胃镜联合胆道镜在腹腔镜胆总管探查术中的应用(英文)显示文摘目的:通过探讨胃镜联合胆道镜在腹腔镜胆总管探査术(LCBDE)中的应用,为胆总管结石的手术治疗提供更多的手术方式,改善患者生活质量,降低手术难度。创新点:摒弃了以往LCBDE术后需行T管引流的方式,以鼻胆管代替T管,改善患者生活质量。同时胃镜的操作难度较内镜逆行胰胆管造影(ERCP)低。因此,本手术方式可以得到更好的推广。方法:研究对象为2017年7月1日至2017年10月30日于浙江大学医学院附属邵逸夫医院就诊的胆总管结石患者。收集这些患者的年龄、性别等临床数据,排除那些不能耐受麻醉、患急性胰腺炎及急性胆管炎、并发肝内胆管结石及胆总管结石呈泥沙状或者絮状的患者。对患者行胃镜联合胆道镜的LCBDE手术,统计其手术时长、术中出血量、术后并发症、术后住院时长以及住院花费。结论:胃镜联合胆道镜放置鼻胆管在预防LCBDE术后胆漏上切实有效,且由于术后无需留置T管,对患者的生活质量有所改善。同时,本手术方式对手术操作技术的要求较低,对于初学胆总管一期缝合的医师来说,可降低其术后胆漏的概率。 | Song-mei LOU Min ZHANG Zheng-rong WU Gui-xing JIANG Hua SHEN Yi DAI Yue-long LIANG Li-ping CAO Guo-ping DING | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，11： | 8 |
| 10 | Medical expenditure for esophageal cancer in China:a 10-year multicenter retrospective survey(2002-2011)显示文摘Background: Esophageal cancer is associated with substantial disease burden in China, and data on the economic burden are fundamental for setting priorities in cancer interventions. The medical expenditure for the diagnosis and treatment of esophageal cancer in China has not been fully quantified. This study aimed to examine the medical expenditure of Chinese patients with esophageal cancer and the associated trends.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 37 hospitals in 13 provinces/municipalities across China as a part of the Cancer Screening Program of Urban China. For each esophageal cancer patient diagnosed between 2002 and 2011, clinical information and expense data were extracted by using structured questionnaires. All expense data were reported in Chinese Yuan(CNY; 1 CNY = 0.155 USD) based on the2011 value and inflated using the year-specific health care consumer price index for China.Results: A total of 14,967 esophageal cancer patients were included in the analysis. It was estimated that the overall average expenditure per patient was 38,666 CNY, and an average annual increase of 6.27% was observed from 2002(25,111 CNY) to 2011(46,124 CNY). The average expenditures were 34,460 CNY for stage Ⅰ,39,302 CNY for stage Ⅱ,40,353 CNY for stage Ⅲ, and 37,432 CNY for stage IV diseases(P < 0.01). The expenditure also differed by the therapy type, which was 38,492 CNY for surgery, 27,933 CNY for radiotherapy, and 27,805 CNY for chemotherapy(P < 0.05).Drugs contributed to 45.02% of the overall expenditure.Conclusions: These conservative estimates suggested that medical expenditures for esophageal cancer in China substantially increased in the last 10 years, treatment for early-stage esophageal cancer costs less than that for advanced cases, and spending on drugs continued to account for a considerable proportion of the overall expenditure. | Lan-Wei Guo Hui-Yao Huang Ju-Fang Shi Li-Hong Lv Ya-Na Bai A-Yan Mao Xian-Zhen Liao Guo-Xiang Liu Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Jin-Yi Zhou Ji-Yong Gong Qi Zhou Lin Zhu Yu-Qin Liu Bing-Bing Song Ling-Bin Du Xiao-Jing Xing Pei-An Lou Xiao-Hua Sun Xiao Qi Shou-Ling Wu Rong Cao Li Lan Ying Ren Kai Zhang Jie He Jian.Gong Zhang Min Dai | 2017 | Chinese Journal of Cancer2017，36，11： | 7 |
| 11 | Cryotherapy for cirrhosis-based hepatocellular carcinoma: a single center experience from 1595 treated cases显示文摘Cryoablation 是为 hepatocellular 癌(HCC ) 的不太流行的经皮的夺格的治疗,并且关于它的实用性的当前的证据是有限的。我们在与经皮的 cryoablation 对待 1595 个 HCC 案例关于有效性,安全和这治疗的长期的结果给全面侧面报导我们的经验。从 2003 年 1 月到 2013 年 12 月,有 2313 个 HCC 小瘤的 1595 个病人在我们的中心与 2958 个 cryoablation 会议被切除。完全的脱离与 3.4 朠湥浯捩椠獮慴楢楬祴 ? 畢 ? 的一条吝啬的直径为 1893 个小瘤在 1294 个病人被完成 ?? 潣扭湩摥眠瑩 ??? 瑡整畮瑡摥琠敨攠瑸湥 ? 景朠湥浯捩椠獮慴楢楬祴椠 ? 牰浩牡 ? 塖′畴潭 ? 楴獳敵瑡吗?? | Guanghua Rong Wenlin Bai Zheng Dong Chunping Wang Yinying Lu Zhen Zeng Jianhui Qu Min Lou Hong Wang Xudong Gao Xiujuan Chang Linjing An Yan Chen Yongping Yang | 2015 | Frontiers of Medicine2015，9，1： | 7 |
| 12 | Chinese Stroke Association guidelines for clinical management of cerebrovascular disorders:executive summary and 2019 update on organizational stroke management显示文摘Aim Stroke is characterised by high morbidity,mortality and disability,which seriously affects the health and safety of the people.Stroke has become a serious public health problem in China.Organisational stroke management can significantly reduce the mortality and disability rates of patients with stroke.We provide this evidence-based guideline to present current and comprehensive recommendations for organisational stroke management.Methods A formal literature search of MEDLINE(1 January 1997 through 30 September 2019)was performed.Data were synthesised with the use of evidence tables.Writing group members met by teleconference to discuss data-derived recommendations.The Chinese Stroke Association’s Levels of Evidence grading algorithm was used to grade each recommendation.results Evidence-based guidelines are presented for the organisational management of patients presenting with stroke.The focus of the guideline was subdivided into prehospital first aid system of stroke,rapid diagnosis and treatment of emergency in stroke centre,organisational management of stroke unit and stroke clinic,construction of regional collaborative network among stroke centres and evaluation and continuous improvement of stroke medical quality.Conclusions The guidelines offer an organisational stroke management model for patients with stroke which might help dramatically. | Min Lou Jing Ding Bo Hu Yusheng Zhang Hao Li ZeFeng Tan Yan Wan An-Ding Xu Chinese Stroke Association Stroke Council Guideline Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 7 |
| 13 | Machine Learning−based Weather Support for the 2022 Winter Olympics显示文摘1.A key support for the 2022 Winter Olympics The XXIV Olympic Winter Games are scheduled to take place from 4 to 22 February 2022,followed by the Paralympic Games from 4 to 13 March,in Beijing and towns in the neighboring Hebei Province,China.Weather plays an extremely important role in the outcome of the games(Chen et al.,2018).It can not only cause a difference between a medal or not,but affect the safety of athletes.Success of the Winter Olympics will greatly depend on weather conditions at the outdoor competition venues,dealing with many weather elements including the snow surface temperature,apparent temperature,gust wind speed,snow,visibility,etc.To ensure that the scheduled games go smoothly,it is imperative to have hourly or even every 10-minutely forecasts as well as updated weather-related risk assessments at the venues for the next 240 hours.So far,the Beijing/Hebei Meteorological Observatory has already started intelligent weather forecasting at 3-km resolution based on the results of numerical weather prediction(NWP)models.However,these experiments have suggested that the current forecasting techniques are incapable of capturing the complex mountain weather variations around some venues.The forecasting capability of NWP is constrained partly by limited knowledge of the local weather mechanisms. | Jiangjiang XIA Haochen LI Yanyan KANG Chen YU Lei JI Lve WU Xiao LOU Guangxiang ZHU Zaiwen Wang Zhongwei YAN Lizhi WANG Jiang ZHU Pingwen ZHANG Min CHEN Yingxin ZHANG Lihao GAO Jiarui HAN | 2020 | Advances in Atmospheric Sciences2020，37，9： | 6 |
| 14 | Salvage therapy with lenalidomide containing regimen for relapsed/refractory Castleman disease: a report of three cases显示文摘Castleman 疾病(CD ) 是有未知病原学的不平常的非同种细胞的 lymphoproliferative 混乱。没有标准治疗为 relapsed/refractory CD 病人被推荐,因此要求新奇试验性的途径的开发。我们有 multicentric CD (MCD ) 的三个成年病人的队被对待与对传统的化疗包含 lenalidomide 政体倔强(1025 mg lenalidomide perorally 在天管理了 121 在 28 天的周期) 作为第二 -- 到第四线的治疗。部分宽恕在第一个血浆房间 CD 病人被完成, relapsed 在自体同源的造血的干细胞移植以后的七个月然后没能对化疗的四个周期作出回应。organomegaly,部分宽恕与 CD 和 polyneuropathy 在第二个病人被获得 endocrinopathy, monoclonal gammopathy,和皮肤变化症候群。第三个案例与血小板计数的肋膜的流出和腹水和正规化的完全的消失显示出完全的宽恕。得出结论,令人鼓舞的临床的回答与基于 lenalidomide 的政体在三个病人的队被完成,不过,长期的功效尚待被遵守。我们在对待 MCD 建议这药的治疗学的潜力的进一步的调查。 | Xinping Zhou Juying Wei Yinjun Lou Gaixiang Xu Min Yang Hui Liu Liping Mao Hongyan Tong Jie Jin | 2017 | Frontiers of Medicine2017，11，2： | 6 |
| 15 | Overexpression of metastasis-associated in colon cancer 1 predicts a poor outcome of hepatitis B virus-related hepatocellular carcinoma显示文摘AIM: To investigate the intratumoral expression of metastasis-associated in colon cancer 1 (MACC1) and c-Met and determine their clinical values associated with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). METHODS: A retrospective study admitted three hundred fifty-four patients with HBV-related HCC. The expression and distribution of MACC1 and c-Met were assessed by quantitative real-time polymerase chain reaction and immunohistochemistry staining. Prognostic factors influencing survival, metastasis and recurrence were assessed. RESULTS: Intratumoral MACC1 level was found to be associated with HCC disease progression. Both median tumor-free survival (TFS) and overall survival (OS) were significantly shorter in the postoperative HCC patients with high intratumoral MACC1 expression, as compared to those with low intratumoral MACC1 levels (TFS: 34 mo vs 48.0 mo, P < 0.001; OS: 40 mo vs 48 mo, P < 0.01). Multivariable analysis indicated that high MACC1 expression or co-expression with c-Met were independent predictors for HCC clinic outcome (P < 0.001). CONCLUSION: High intratumoral MACC1 expression can be associated with enhanced tumor progression and poor outcome of HBV-related HCC. MACC1 may serve as a prognostic biomarker for postoperative HCC. | Jian-Hui Qu Xiu-Juan Chang Yin-Ying Lu Wen-Lin Bai Yan Chen Lin Zhou Zhen Zeng Chun-Ping Wang Lin-Jing An Li-Yan Hao Gui-Lin Xu Xu-Dong Gao Min Lou Ji-Yun Lv Yong-Ping Yang | 2012 | World Journal of Gastroenterology2012，18，23： | 6 |
| 16 | An AIEgens and exonuclease Ⅲ aided quadratic amplification assay for detecting and cellular imaging of telomerase activity显示文摘Monitoring telomerase activity with high sensitive and reliable is of great importance to cancer analysis.In this paper, we report a sensitive and facile method to detect telomerase activity using AIEgens modified probe(TPE-Py-DNA) as a fluorescence reporter and exonuclease Ⅲ(Exo Ⅲ) as a signal amplifier.With the aid of telomerase, repeat units(TTAGGG)n are extended from the end of template substrate oligonucleotides(TS primer) that form duplex DNAs with TPE-Py-DNA. Then, Exo Ⅲ catalyzes the digestion of duplex DNAs, liberating elongation product and releasing hydrophobic TPE-Py. The released hydrophobic TPE-Py aggregate together and produce a telomerase-activity-related fluorescence signal.The liberated product hybridizes with another TPE-Py-DNA probe, starting the second cycle. Finally,we obtain the target-to-signal amplification ratio of 1:N^2. This strategy exhibits good performance for detecting clinical urine samples(distinguishing 15 cancer patients' samples from 8 healthy ones) and checking intracellular telomerase activity(differentiating cell lines including He La, MDA-MB-231,MCF-7, A375, HLF and MRC-5 from the cells pretreated with telomerase-related drug), which shows its potential in clinical diagnosis as well as therapeutic monitoring of cancer. | Xuehong Min Lei Xia Yuan Zhuang Xudong Wang Jie Du Xiaojin Zhang Xiaoding Lou Fan Xia | 2017 | Science Bulletin2017，62，14： | 5 |
| 17 | The nucleoprotein of severe fever with thrombocytopenia syndrome virus processes a stable hexameric ring to facilitate RNA encapsidation显示文摘Severe fever with thrombocytopenia syndrome virus(SFTSV),a member of the Phlebovirus genus from the Bunyaviridae family endemic to China,is the causative agent of life-threatening severe fever with thrombocyto-penia syndrome(SFTS),which features high fever and hemorrhage.Similar to other negative-sense RNA viruses,SFTSV encodes a nucleocapsid protein(NP)that is essen-tial for viral replication.NP facilitates viral RNA encapsida-tion and is responsible for the formation of ribonucleopro-tein complex.However,recent studies have indicated that NP from Phlebovirus members behaves in inhomogene-ous oligomerization states.In the present study,we report the crystal structure of SFTSV NP at 2.8Åresolution and demonstrate the mechanism by which it processes a ring-shaped hexameric form to accomplish RNA encapsida-tion.Key residues essential for oligomerization are identi-fi ed through mutational analysis and identifi ed to have a signifi cant impact on RNA binding,which suggests that correct formation of highly ordered oligomers is a criti-cal step in RNA encapsidation.The fi ndings of this work provide new insights into the discovery of new antiviral reagents for Phlebovirus infection. | Honggang Zhou Yuna Sun Ying Wang Min Liu Chao Liu Wenming Wang Xiang Liu Le Li Fei Deng Hualin Wang Yu Guo Zhiyong Lou | 2013 | Protein & Cell2013，4，6： | 4 |
| 18 | The pointwise dimensions of Moran measures显示文摘In this paper,we get the formulas of upper(lower) pointwise dimensions of some Moran measures on Moran sets in Rd under the strong separation condition.We also obtain formulas for the dimension of the Moran measures.Our results extend the known results of some self-similar measures and Moran measures studied by Cawley and Mauldin. | Lou ManLi Wu Min | 2010 | Science China Mathematics2010，53，5： | 3 |
| 19 | Liquid-liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA显示文摘Dear Editor,The COVID-19 pandemic worldwide is caused by a novel coronavirus SARS-CoV-2(the severe acute respiratory syndrome coronavirus 2).1 After viral invasion into the host cells,the〜30 kb viral genome RNA injected is translated into structural and nonstructural proteins to replicate viral genome and assemble more viral particles.Many copies of nucleocapsid(N)protein can bind to viral genome RNA and pack it into^100 nm particles,assisting membrane(M)and envelope(E)proteins to efficiently assemble the viral envelope.2 The exact molecular mechanism by which N protein packs up the viral genome still remains elusive. | Hui Chen Yang Cui Xuling Han Wei Hu Min Sun Yong Zhang Pei-Hui Wang Guangtao Song Wei Chen Jizhong Lou | 2020 | Cell Research2020，30，12： | 3 |
| 20 | Multimodal imaging findings in normal-appearing white matter of leucoaraiosis: a review显示文摘Leucoaraiosis(LA),also referred to as white matter hyperintensities(WMHs),are usually seen as patchy or confluent hyperintense areas on T2-weighted or fluid-attenuated inversion recovery MRI in the elderly.It is often asymptomatic in its early stages,yet its persistent evolution to more advanced stages may lead to substantial neurological dysfunction including dementia,stroke and death.Despite its clinical significance,the pathogenic mechanisms underlying LA development are uncertain.In patients with LA,the pathophysiological changes in white matter(WM)are suggested to be continuous from WMHs to its neighbourhood‘normal-appearing white matter(NAWM)’on conventional MRI sequences.Multimodal imaging studies revealed that the so-called‘NAWM’was actually abnormal with regard to underlying haemodynamic and microstructural changes.On the basis of positron emission tomography CT,xenon-CT,perfusion MRI,etc,the cerebral blood flow of NAWM was found to be significantly reduced in patients with LA,compared with healthy controls.Meanwhile,the integrity of microstructures and blood–brain barrier in NAWM was also demonstrated to be impaired with diffusion tensor imaging and dynamic contrastenhanced MRI studies,respectively.In addition,the integrity of NAWM correlated much stronger with cognitive performance than did WMHs load.It is reasonable to assume that the subtle injury of NAWM would be more reversible than WMHs themselves.Therefore,multimodal imaging modalities could be appropriately applied to future interventional studies targeting at early pathophysiological changes of NAWM.In this paper,we summarise current knowledge about NAWM of LA mainly acquired from multimodal imaging studies in vivo,and attempt to give options for future work. | Genlong Zhong Min Lou | 2016 | Stroke & Vascular Neurology2016，1，2： | 3 |
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