|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of asymmetric dimethylarginine on renal arteries in portal hypertension and cirrhosis显示文摘AIM To evaluate the effects of asymmetric dimethylarginine(ADMA) in renal arteries from portal hypertensive and cirrhotic rats.METHODS Rat renal arteries from Sham(n = 15), pre-hepatic portal hypertension(PPVL; n = 15) and bile duct ligation and excision-induced cirrhosis(BDL; n = 15) were precontracted with norepinephrine, and additional contractions were induced with ADMA(10-6-10-3 mol/L), an endogenous inhibitor of nitric oxide(NO) synthase. Concentration-response curves to acetylcholine(1 × 10-9^(-3) × 10^(-6) mol/L) were determined in precontractedrenal artery segments with norepinephrine in the absence and in the presence of ADMA. Kidneys were collected to determine the protein expression and activity of dimethylarginine dimethylaminohydrolase(DDAH), an enzyme that catabolizes ADMA. RESULTS In renal arteries precontracted with norepinephrine, ADMA caused endothelium-dependent contractions. The pD 2 values to ADMA were similar in the Sham and PPVL groups(4.20 ± 0.08 and 4.11 ± 0.09, P > 0.05, respectively), but were lower than those of the BDL group(4.79 ± 0.16, P < 0.05). Acetylcholine-induced endothelium-dependent relaxation that did not differ, in terms of p D2 and maximal relaxation, among the 3 groups studied. Treatment with ADMA(3 × 10^(-4) mol/L) inhibited acetylcholine-induced relaxation in the 3 groups, but the inhibition was higher(P < 0.05) in the BDL group compared with that for the Sham and PPVL groups. The m RNA and protein expression of DDAH-1 were similar in kidneys from the three groups. Conversely, DDAH-2 expression was increased(P < 0.05) in PPVL and further enhanced(P < 0.05) in the BDL group. However, renal DDAH activity was significantly decreased in the BDL group. CONCLUSION Cirrhosis increased the inhibitory effect of ADMA on basal- and induced-release of NO in renal arteries, and decreased DDAH activity in the kidney. | Gloria Segarra Belén Cortina María Dolores Mauricio Susana Novella Paloma Lluch Javier Navarrete-Navarro Inmaculada Noguera Pascual Medina | 2016 | World Journal of Gastroenterology2016，22，48： | 3 |
| 2 | Circulating HER2 extracellular domain and resistance to chemotherapy in advanced breast cancer 显示文摘 | Colomer R Montero S Lluch A | 2000 | Clin Cancer Res2000，6，6： | 1 |
| 3 | Adsorption of Phosphorus on Sediments of the Balearic Islands (Spain) Related to Their Composition 显示文摘 | Lopez P X Lluch M Vidal J A Morgui | 1996 | Estuarine Coastal and Shelf Science1996，42，： | 1 |
| 4 | Molecular clo- ning and expression analysis of the mevalonate kinase gene from Arabidopsis thaliana 显示文摘 | Lluch M A Masferrer A Arr6 M | 2000 | Plant Mol Biol2000，42，2： | 1 |
| 5 | Effect of a high-protein breakfast on the postprandial ghrelin response显示文摘 | Blom WA Lluch A Stafleu A | 2006 | Am J Clin Nutr2006，83，2： | 1 |
| 6 | An integrative genomic and proteomic analysis of PIK3CA,PTEN,and AKT mutations in breast cancer显示文摘 | STEMKE-HALE K GONZALEZ-ANGULO A M LLUCH A | 2008 | Cancer Res2008，68，15： | 1 |
| 7 | Adsorption of phosphoruson sediments of the balearic islands related to their composition 显示文摘 | Lopez P Lluch X MorgufJ A | 1996 | Esmarine Coastal and Shelf Science1996，42，： | 1 |
| 8 | Gemcitabine in combination with doxorubicin in advanced breast cancer:final results of a phase II pharmacokinetic trial显示文摘 | Perez-Manga G Lluch A Alba E | 2000 | J Clin Oncol2000，18，13： | 1 |
| 9 | Gemcitabine in combination with doxorubicin in advanced breast cancer: final results of a phase Ⅱ pharmacokinetic trial 显示文摘 | PEREZ-MANGA G LLUCH A ALBA E | 2000 | J Clin Oncol2000，18，13： | 1 |
| 10 | Adsorption of phosphoruson sediments of the balearic islands related to their composition 显示文摘 | Lopez P Lluch X MorgufJ A | 1996 | Esmarine Coastal and Shelf Science1996，42，： | 1 |
| 11 | Neoadjuvant therapy for operable breast-cancer显示文摘 | Insa A ChiriveUa I Lluch A | 2006 | Med Clin (Bare)2006，126，8： | 1 |
| 12 | Sodium chloride-ABA interaction in two common bean cultivars differing in salinity tolerance显示文摘 | Khadri M Tejera N A Lluch C | 2007 | Plant Sci2007，，： | 1 |
| 13 | A phase II study of sequentialdocetaxel followed by doxorubicin/cyclophosphamide as first-linechemotherapy for metastatic breast cancer显示文摘 | Anton A Hornedo J Lluch A | 2003 | Clin Breast Cancer2003，4，4： | 1 |
| 14 | Effect of Addition of Gelatin on Microstructure of Acidic Milk Gels and Yoghurt and on Their Rheological Properties 显示文摘 | FISZMAN S M LLUCH M A SALVADOR A | 1999 | International Dairy Journal1999，9，： | 1 |
| 15 | Universal total wrist arthroplas- ty: midterm follow-up study 显示文摘 | Ferreres A Lluch A Del Valle M | 2011 | J Hand Surg Am2011，36，6： | 1 |
| 16 | Gemcitabine in combination with doxorubicin in advanced breast cancer: final results of a Phase Ⅱ pharmacokinetic trial显示文摘 | Perez Manga G Lluch A Alba A | 2000 | J Clin Oncol2000，18，13： | 1 |
| 17 | Effect of addition of gelatin on microstructure of acidic milk gels and yoghurt and on their theological properties 显示文摘 | Fiszman S M Lluch M A Salvador A | 1999 | International Dairy Journal1999，9，： | 1 |
| 18 | Adsorption of phosphoruson sediments of the balearic islands related to their composition显示文摘 | Lopez P Lluch X Morgui J A | 1996 | Estuarine Coastal and Shelf Science1996，42，： | 1 |
| 19 | Canonical variational transition-state theo- ry study of the CF3CH2CH3-FOH reaction显示文摘 | GONZ/kLEZ-LAFONT i LLUCH J M VARELA-ALVAREZ A | 2008 | J Phys Chem B2008，112，2： | 1 |
| 20 | Gemcitabine in combination with doxorubicin in advanced breast cancer: final results of a phase II pharmacokinetie trial显示文摘 | Perez-Manga G Lluch A Alba E | 2000 | J Clin Oncol2000，18，13： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员