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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Current management显示文摘 | A. Dignass G. Van Assche J.O. Lindsay M. Lémann J. S?derholm J.F. Colombel S. Danese A. D’Hoore M. Gassull F. Gomollón D.W. Hommes P. Michetti C. O’Morain T. ?resland A. Windsor E.F. Stange S.P.L. Travis | 2010 | Journal of Crohn’s and Colitis2010，，1： | 2 |
| 3 | Occurrence and properties of flavor-related bromophenols found in the marine environment: a review 显示文摘 | Boyle J L Lindsay R C Stuiber D A | 1993 | J Aquat Food Prod Technol1993，2，： | 2 |
| 4 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 5 | Development of Isospora suis from pigs in primary porcine and bovine cell cultures显示文摘 | Lindsay D S Blagburn B L | 1987 | Vet Perasitol1987，24，34： | 1 |
| 6 | Ultrastructure of developing Isospora suis in cultured cells显示文摘 | Lindsay D S Blagburn B L Toivio-Kinnucan M | 1991 | Am J Vet Res1991，52，3： | 1 |
| 7 | Graphite-tin composites as anode materials for lithium-ion batteries显示文摘 | WANG G X AHN J H LINDSAY M J SUN L BRADHURST D H DOU S X LIU H K | 2001 | Journal of Power Sources2001，9798，： | 1 |
| 8 | Small intestinal cryptosporidiosis in cockatiels associated with Cryptosporidium baileyi-like oocysts 显示文摘 | Lindsay D S Blagburn B L Hoerr F J | 1990 | Avian Dis1990，34，： | 1 |
| 9 | Infection dynamics of Cryptosporidium parvum ( Apicomplexa: Cryptosporiidae) in neonatal mice (Mus musculus) 显示文摘 | ERNEST J A BLAGBURN B L LINDSAY D S | 1986 | J Parasitol1986，72，5： | 1 |
| 10 | Neonatal Neospora caninum infection in dogs:isolation of the causative agent and experimental transmission显示文摘 | Dubey J P Hattel A L Lindsay D S | 1988 | J Am Vet Med Assoc1988，193，： | 1 |
| 11 | Neonatal Neospora caninum infection in dogs: isolation of the causative agent and experimental transmission 显示文摘 | Dubey J P Hattel A L Lindsay D S etal | 1988 | J Am Vet Med Assoc1988，193，10： | 1 |
| 12 | Contributions of bromophenol to marine-ssociated flavors of fish and seafood显示文摘 | Lindsay R C Stuiber D A | 1992 | J Aquat Food Prod Technol1992，1，： | 1 |
| 13 | First-principle determination of ultrahigh thermal conductivity of boron arsenide: a competitor for diamond? 显示文摘 | LINDSAY L BOIDO D A Reinecke T L | 2013 | Phys Rev Lett2013，111，02： | 1 |
| 14 | Occurrence and properties of flavor related bromophenols found in the marine environment:a review显示文摘 | Lindsay R C Stuiber D A | 1993 | J Aquat Food Prod Technol1993，2，： | 1 |
| 15 | Localization of agonist- sensitive PtdIns(3, 4, 5 )P3 reveals a nuclear pool that is insensi- tive to PTEN expression显示文摘 | Lindsay Y McCoull D Davidson L | 2006 | J Cell Sci2006，9，24： | 1 |
| 16 | Biology of mammalian Isospora 显示文摘 | Lindsay D S Blagurn B L | 1994 | Parasitol Taday1994，6，： | 1 |
| 17 | Cultivation ofCryptosporidium baileyi:studies with cell cultures,avian em-bryos,and pathogenicity of chicken embryo-passaged oocysts显示文摘 | Lindsay D S Sundermann C A Blagburn B L | 1988 | Parasitol1988，74，2： | 1 |
| 18 | Physical ac- tivity and risk of cognitive impairment and dementia in elderly persons显示文摘 | LAURIN D VERREAULT R LINDSAY J et a l | 2001 | Archiv Neurol-Chicago2001，58，3： | 1 |
| 19 | Continuous-wave pumo-enhanced singly resonant optical parametric oscillator pumped by an extend-cavity diode laser显示文摘 | LINDSAY L D PETRIDIS C | 2001 | Appl Phys Lett2001，78，7： | 1 |
| 20 | Biology of mammalian Isospora显示文摘 | Lindsay D S Blagblurn B L | | 0，，： | 1 |
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