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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Energetic-protein supplementation in the last 60 days of gestation improves performance of beef cows grazing tropical pastures显示文摘Background: Nutrition is one of the most important factors that affect animal performance, and it therefore also impacts on financial results in beef systems. In this way, finding the best strategy for feeding supplements is of paramount importance. Aiming to evaluate the effect of supplement feeding strategies for beef cows in the last third of gestation, two experiments were conducted. In Experiment 1, 35 pregnant Nellore cows were assigned to a completely randomized design with four treatments: control, which received no supplement; supplementation for the last 30 d of gestation(30-d; 3.0 kg/d); supplementation for the last 60 d of gestation(60-d; 1.5 kg/d); or supplementation for the last 90 d of gestation(90-d; 1.0 kg/d). All supplemented treatments received the same total amount of supplement throughout the experiment: 90 kg(20% of crude protein). A second experiment(Experiment 2) was delineated to evaluate the effects of the amounts offered in Experiment 1 on intake and metabolism. Four multiparous pregnant Nellore cows were assigned to a 4 × 4 Latin square design, with periods of15 d each.Results: There was a linear effect of the number of days of supplementation on calving body weight(BW; P < 0.05)and a quadratic effect on BW change from parturition to d 31 post-calving(P < 0.05), with cows on the 60-d strategy losing less BW post-calving. No difference was found in offspring birth BW(P > 0.10). A significant linear effect on interval from parturition to conception(P < 0.05) was observed, with the highest calving to conception interval being observed in the 90-d strategy. The level of supplementation did not affect forage intake or neutral detergent fiber digestibility(P > 0.10). Nitrogen excreted through urine tended to increase linearly with the level of supplementation(P < 0.10).Conclusion: Providing 1.5 kg of supplement during the last 60 d of gestation improves cow performance after calving, reducing the magnitude of BW lost, and reduces the number of days from calving to re-conception in the following breeding season compared to the usually recommended period of supplementation of 90 d pre-partum. | Aline Gomes da Silva Mário Fonseca Paulino Edenio Detmann Henrique Jorge Fernandes Lincoln da Silva Amorim Román Enrique Maza Ortega Victor Valério de Carvalho Josilaine Aparecida da Costa Lima Felipe Henrique de Moura Mariana Benevides Monteiro Jéssika Almeida Bitencourt | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 2 |
| 3 | Parkinson's disease : a rethink of rodent models 显示文摘 | Melrose H L Lincoln S J Tyndall G M Farrer M J | 2006 | Exp Brain Res2006，173，： | 1 |
| 4 | Complex relationship between Parkin mutations and Parkinson' s disease 显示文摘 | West A Periquet M Lincoln S | 2002 | Med Genet2002，114，5： | 1 |
| 5 | A mechanism for Pglycoprotein-mediated apoptosis as by Verapamil hypersensitivity 显示文摘 | Karwatsky J Lincoln M C Georges E | 2003 | Biochemistry2003，42，12： | 1 |
| 6 | Characterisation of Wnt gene expression during the differentiation of murine embryonic stem cells in vitro:role of Wnt3a in enhancing haematopoietic differentiation显示文摘 | Lako M Lindsay S Lincoln J | | 0，，02： | 1 |
| 7 | Ancestral TSH mechanism signals summer in a photoperiodic mammal 显示文摘 | Hanon E A Lincoln G A Fustin J M | 2008 | Curt Biol2008，18，15： | 1 |
| 8 | Cyclic water floodingthe spraberry utilizes 'End Effects' to increase oil pro-duction rate (SPE545)显示文摘 | Lincoln F Elkins Arlie M Skov | 1963 | Journal of Petroleum Tech-nology1963，1963，： | 1 |
| 9 | Complex toxin pro-files in phytoplankton and green shell mussels(Perna canalicu-lus),revealed by LC-MS/M Sanalysis显示文摘 | LINCOLN M PATRICK H PAUL M | 2002 | Toxicon2002，40，9： | 1 |
| 10 | Inversion of magnetoresistance in organic semicon-ductor显示文摘 | Bergeson J D Prigodin V N Lincoln D M | 2008 | Phys Rev Lett2008，100，6： | 1 |
| 11 | MAPMAKER: an interactive computer package for constructing primary genetic maps of experimental and natural populations显示文摘 | Lander E S Green P Abrahamson J Barlow A Day M J Lincoln S E Newbury L | 1987 | Genetics1987，1，： | 1 |
| 12 | Psychometric of the Nottingham Assessment of Functional Footcare (NAFF)显示文摘 | Senussi M Lincoln N Jeffcoate W | 2011 | Int J Ther Rehabil2011，18，： | 1 |
| 13 | Complex Relationship between Parkin Mutations and Parkinson Disease显示文摘 | West A Periquet M Lincoln S | 2002 | Am J Med Genet(S0148-7299)2002，114，5： | 1 |
| 14 | Natriuretic Peptides,Their Receptors and cGMP-dependent Signa-ling Functions显示文摘 | Lincoln R P Sarah A H Deborah M D | 2005 | Endocrine Reviews2005，16，： | 1 |
| 15 | Secondary Structure and Elevated Temperature Crystallite Morphology of Nylon-6/Layered Silicate Nano-composites显示文摘 | Lincoln D M Vaia R A Wang Z G | 2001 | Polymer2001，42，： | 1 |
| 16 | The thioredoxin-thioredoxin reductase system:over expression in human cancer显示文摘 | LINCOLN D T ALIEMADI E M TONISSEN K F | 2003 | Anticancer Res2003，23，： | 1 |
| 17 | FGF23 induces left ventricular hypertrophy显示文摘 | Faul Christian Amaral Ansel P Oskouei Behzad Hu Ming-Chang Sloan Alexis Isakova Tamara Gutiérrez Orlando M Aguillon-Prada Robier Lincoln Joy Hare Joshua M Mundel Peter Morales Azorides Scialla Julia Fischer Michael Soliman Elsayed Z Chen J | 2011 | Journal of Clinical Investigation2011，，11： | 1 |
| 18 | Comparison of planned dose distributions calculated by Monte Carlo and Ray-Trace algorithms for the treatment of lung tumors with cyberknife:a preliminary study in 33 patients显示文摘 | WILCOX E E DASKALOV G M LINCOLN H | 2010 | Int J Radiat Oncol Biol Phys2010，77，1： | 1 |
| 19 | Anomalous room temperature magnetoresistance inorganic semiconductor显示文摘 | Prigodin V N Bergeson J D Lincoln D M | 2006 | Synth Met2006，156，910： | 1 |
| 20 | Secondary structureand elevated temperature crystallite morphology of nylon-6/layered silicate nanocomposites显示文摘 | D M Lincoln R A Vaia Z G Wang | 2001 | Polymer2001，42，4： | 1 |
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