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| 1 | Mapping wetland changes in China between 1978 and 2008显示文摘Four wetland maps for all China have been produced,based on Landsat and CBERS-02B remote sensing data between 1978 and 2008 (1978,1990,2000 and 2008).These maps were mainly developed by manual interpretation and validated by substantial field investigation in 2009.Based on these maps,we analyzed the 2008 wetland distribution in China and discussed wetland changes and their drivers over the past 30 years.(i) There were about 324097 km 2 of wetlands in 2008,for which inland marshes or swamps were the most common wetland type (35%),with lakes (26%) second.Most of the wetlands were in Heilongjiang,Inner Mongolia,Qinghai and Tibet,occupying about 55% of the national wetland area.(ii) From 1978 to 2008,China's wetland area continually and significantly decreased,by about 33% based on changes in the wetland map.This was in sharp contrast to the increase in artificial wetlands,which increased by about 122%.Inland marshes accounted for the main loss of total wetlands from 1978 to 2000.From 2000 through 2008,riverine and lacustrine wetlands constituted the main wetland loss.Fortunately however,the rate of wetland loss decreased from 5523 to 831 km 2 /a.(iii) The change ratio of lost natural wetlands (including inland and coastal wetlands) to non-wetlands has decreased slightly over the past 30 years.From 1978 to 1990,nearly all natural wetlands (98%) lost were transformed into non-wetlands.However,the ratio declined to 86% from 1990 to 2000,and to 77% from 2000 to 2008.(iv) All Chinese provinces were divided into three groups according to patterns of wetland changes,which could relate to the driving forces of such changes.Tibet was completely different from other provinces,as it was one representative example in which there was a net wetland increase,because of global warming and decreased human activity since 1990.Increased economic development caused considerable wetland loss in most eastern provinces,and artificial wetlands increased. | NIU ZhenGuo ZHANG HaiYing WANG XianWei YAO WenBo ZHOU DeMin ZHAO KuiYi ZHAO Hui LI NaNa HUANG HuaBing LI CongCong YANG Jun LIU CaiXia LIU Shuang WANG Lin LI Zhan YANG ZhenZhong QIAO Fei ZHENG YaoMin CHEN YanLei SHENG YongWei GAO XiaoHong ZHU WeiHong WANG WenQing WANG Hong WENG YongLing ZHUANG DaFang LIU JiYuan LUO ZhiCai CHENG Xiao GUO ZiQi GONG Peng | 2012 | Chinese Science Bulletin2012，57，22： | 51 |
| 2 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 3 | PandaX: a liquid xenon dark matter experiment at CJPL显示文摘PandaX is a large liquid-xenon detector experiment usable for direct dark-matter detection and 136Xe double-beta decay search.The central vessel was designed to accommodate a staged target volume increase from initially 120 kg(stage I)to 0.5 t(stage II)and eventually to a multi-ton scale.The experiment is located in the Jinping Deep-Underground Laboratory in Sichuan,China.The detector operates in dual-phase mode,allowing detection of both prompt scintillation,and ionization charge through proportional scintillation.In this paper a detailed description of the stage I detector design and performance as well as results established during the commissioning phase are presented. | CAO XiGuang CHEN Xun CHEN YunHua CUI XiangYi FANG DeQing FU ChangBo GIBONI Karl L. GONG HaoWei GUO GuoDong HE Ming HU Jie HUANG XingTao JI XiangDong JU YongLin LI ShaoLi LIN Qing LIU HuaXuan LIU JiangLai LIU Xiang LORENZON Wolfgang MA YuGang MAO YaJun NI KaiXuan PUSHKIN Kirill REN XiangXiang SCHUBNELL Michael SHEN ManBing SHI YuJie STEPHENSON Scott TAN AnDi TARLé Greg WANG HongWei WANG JiMing WANG Meng WANG XuMing WANG Zhou WEI YueHuan WU ShiYong XIAO MengJiao XIAO Xiang XIE PengWei YE Tao YOU YingHui ZEN XiongHui ZHANG Hua ZHANG Tao ZHAO HaiYing ZHAO Li ZHOU XiaoPeng ZHU ZhongHua | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，8： | 9 |
| 4 | Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells显示文摘有各种各样的长度的 telomeres 的返老还童在导致的 pluripotent 干细胞(iPSCs ) 被发现了。telomere 长度规定的机制在 iPSCs 的正式就职和增长期间留下逃犯。我们证明 telomere 动力学在 reprogramming 和经过期间在鼠标 iPSCs 是可变的,并且建议这些差别多半源于多重潜在的因素,包括包括外长的 reprogramming 因素的表示的 telomerase 机械, telomerase 独立的机制和同种细胞的影响。用一个基因模型 telomerase 缺乏(为 iPSCs 的推导和段落的 Terc −/− 和 Terc +/−) 房间,我们发现 telomerase 在 iPSCs 的 reprogramming 和自强起一个关键作用。进一步,当由再结合的延伸和维护的其他的小径也被要求时, telomeres 的 telomerase 维护为真 pluripotency 的正式就职是必要的,然而并非足够。一起, telomere 生物学的几个方面可以在 iPSCs 说明可变 telomere 动力学。尤其是,采用在 iPSC reprogramming 期间维持 telomeres 的机制很类似于胚胎的干细胞的那些。这些调查结果可以也联系到这些机制能为在由体的房间的原子 reprogramming 以后的 telomere 异质负责的克隆的地原子转移。 | Fang Wang Yu Yin Xiaoying Ye Kai Liu Haiying Zhu Lingling Wang Maria Chiourea Maja Okuka Guangzhen Ji Jiameng Dan Bingfeng Zuo Minshu Li Qian Zhang Na Liu Lingyi Chen Xinghua Pan Sarantis Gagos David L Keefe Lin Liu | 2012 | Cell Research2012，22，4： | 7 |
| 5 | Seasonal changes in the water-use strategies of three herbaceous species in a native desert steppe of Ningxia,China显示文摘Frequent periods of drought conditions are known to limit plant performance,primary production,and ecosystem stability in arid and semi-arid desert steppe environments.Plants often avoid competition by shifting their water use seasonally,which affects the water-use patterns of dominant species as well as the composition and structure of plant communities.However,the water-use strategies of dominant herbaceous species,which grow under natural field conditions in the desert steppe region of Ningxia Hui Autonomous Region,China,are poorly known.Here,we explored the possible sources of water uptake and water-use efficiency(WUE)of three dominant herbaceous plant species(Stipa breviflora,Agropyron mongolicum,and Glycyrrhiza uralensis)in a native desert steppe in the semi-arid area of Ningxia through an analysis of multiple parameters,including(1)the stable isotopic oxygen and hydrogen(δ18O andδ2H)compositions of precipitation,soil water,and stem water,(2)the carbon isotope(13C)composition of leaves,and(3)the soil water contents,based on field sampling across varying water conditions from June to September,2017.Frequent small precipitation events replenished shallow soil water,whereas large events only percolated down to the deep soil layers.Changes in soil water availability affected the water-use patterns of plants.Generally,during light precipitation periods,the deep root system of G.uralensis accessed deeper(>80 cm)soil water,whereas S.breviflora and A.mongolicum,which only have shallow roots,primarily absorbed water from the shallow and middle soil layers.As precipitation increased,all three plant species primarily obtained water from the shallow soil layers.Variation in soil water uptake between the dry and wet seasons enabled plants to make better use of existing satoil water.In addition,theδ13C values of G.uralensis and S.breviflora were higher than those of A.mongolicum.Theδ13C values of the three plant species were significantly negatively correlated with soil water content.Therefore,G.uralensis and S.breviflora maintained a higher WUE through their conservative and water-saving strategies across the entire growing season.In contrast,A.mongolicum,with a relatively low WUE in the wet season but a high WUE in the dry season,exhibited a more flexible water-use strategy.The different water-use strategies of these dominant plant species demonstrated the mechanisms by which plant communities can respond to drought. | HU Haiying ZHU Lin LI Huixia XU Dongmei XIE Yingzhong | 2021 | Journal of Arid Land2021，13，2： | 4 |
| 6 | Protective effects of silybin and analogues against X-ray radiation-induced damage显示文摘Silybin (SLB ) 和类似的类似物,也就是 hesperetin (HESP ) , naringenin (NAN ) 和 naringin (NAR ) ,被相信是为某些癌症作为 chemopreventive 代理人被报导了的自然 flavonoids 的活跃成分。而且, SLB 和类似物被决定了快由脉搏 radiolysis 技术从氧化损坏修理 DNA 底。现在的学习被设计评估 SLB 的保护的效果,软 X-ray-induced 上的类似物在 vitro 损坏 DNA 到 plasmid。DNA 损坏被 agarose 胶化电气泳动决定。SLB 和类似物被发现在 micromolar 集中保护 DNA 免受放射损坏的伤害。在测试的混合物之中, HESP 和 SLB 在阻止 DNA 单个海滨的裂缝(SSB ) 的 X-ray-induced 形成是最有效的。有另外的实验的这些结果的比较证明 SLB 和类似物的能力与混合物的能力相关在 vitro 禁止 DNA 损坏清除自由激进分子。我们的工作表明自然 flavonoids, SLB 和类似物可以对放射损坏被用作有势力辐射防护药物。 | Haiying Fu Mingzhang Lin Yosuke Katsumura Akinari Yokoya Kuniki Hata Yusa Muroya Kentaro Fujii Naoya Shikazono | 2010 | Acta Biochimica et Biophysica Sinica2010，42，7： | 4 |
| 7 | Therapy-Related Acute Myeloid Leukemia in A Primary Pulmonary Leiomyosarcoma Patient with Skin Metastasis显示文摘Primary pulmonary leiomyosarcoma (LMS) is a very unusual tumor.Although LMS has well-known metastatic potential,cutaneous metastasis is a remarkably uncommon.Exposure to cytotoxic agents could lead to 'therapy-related myeloid neoplasm' (t-MN).Starting from 2008,the World Health Organization (WHO) has adopted the term to cover the spectrum of malignant diseases previously known as therapy-related acute myeloid leukemia (t-AML),therapy-related myelodysplastic syndrome (t-MDS) and therapy-related myelodysplastic/myelo-proliferative neoplasm (t-MDS/MPN).We described the onset of t-MDS and progression to t-AML in one case diagnosed as primary pulmonary LMS with cutaneous metastasis.This patient achieved complete remission (CR) after three courses of IA regimen chemotherapy (idarubicin 5 mg/d,d 1-3;cytarabine 100 mg/d,d 1-5) and 1 course of HA chemotherapy regimen (homoharringtonine 3 mg/d,d 1-3;cytarabine 100 mg/d,d 1-7).This case presents the natural course of therapy-related neoplasm and provides therapeutic experience for t-AML. | Yan Ma Bo-bin Chen Xiao-ping Xu Guo-wei Lin Yuan Ji Sujie Akesu Haiying Zen | 2011 | Chinese Journal of Cancer Research2011，23，3： | 2 |
| 8 | Effect of oxymatrine on interferon-gamma and tumor necrosis factor-alpha serum levels in an experimental rat model of autoimmune encephalomyelitis显示文摘BACKGROUND:Studies have demonstrated that experimental autoimmune encephalomyelitis(EAE) onset correlates with increased interferon-γ(IFN-γ) and tumor necrosis factor-α(TNF-α) expression.Oxymatrine(OM) has been shown to inhibit autoimmune responses,but there are no reports showing that it could prevent the development of EAE.OBJECTIVE:To observe the effect of OM on serum levels of IFN-γ and TNF-α in a rat model of EAE.DESIGN,TIME AND SETTING:A randomized,controlled,animal study was performed at the Experimental Animal Center of Henan Academy of Chinese Medicine and at the Key Disciplines Laboratory Clinical Medicine of Henan Province between July and December 2008.MATERIALS:OM was purchased from Chia-tai Tianqing Pharmaceutical,China;complete Freund's adjuvant was purchased from Sigma,USA.METHODS:Forty female Wistar rats were randomly assigned to four groups:EAE model(M),low-dose OM treatment(OM-L),high-dose OM treatment(OM-H),and normal control(N,no immunization),with 10 rats in each group.EAE was established in the M,OM-L,and OM-H groups following immunization with Guinea pig spinal cord homogenate and complete Freund's adjuvant.The M and N groups were intraperitoneally injected with normal saline(6.7 mL/kg per day),the OM-L group received an intraperitoneal injection of OM(100 mg/kg per day),and the OM-H group received OM(150 mg/kg per day).MAIN OUTCOME MEASURES:At 16 days after immunization,the degree of histopathological changes in the spinal cord was assessed by hematoxylin-eosin stanining.Enzyme-linked immunosorbent assay was used to detect serum levels of IFN-γ,and radioimmunoassay was utilized to determine serum TNF-α level.Neurological scores were measured on a daily basis according to a 0-5 scale.RESULTS:Daily injections of OM,both high and low doses,resulted in decreased neurological scores in EAE rats(P < 0.01),as well as reduced cellular infiltration in the spinal cord and decreased levels of serum IFN-γ and TNF-α(P < 0.01).CONCLUSION:OM reduced the onset and severity of EAE,which correlated with decreased IFN-γ and TNF-α expression. | Xiaobin Guo Quancheng Kan Yifan Song Lin Zhu Xiang Li Haiying Hua GuangxianZhang | 2010 | Neural Regeneration Research2010，5，10： | 2 |
| 9 | A new IQ detection method for LLRF显示文摘 | Qiu Feng Gao Jie Lin Haiying | 2012 | Nuclear Instruments and Methods in Physics Research A2012，675，5： | 1 |
| 10 | 显示文摘 | Lin Hong Wang Haiying Xue Changhu | 2002 | Enzyme and Microbial Technology2002，31，5： | 1 |
| 11 | Automatic geo-registration for port surveillance显示文摘 | CAO Xiaochun WU Lin RASHEED Z LIU Haiying CHOI T E GUo Feng HAERING N LI Xiaohong CAO Zuoliang | 2010 | International Journal of Pattern Recognition and Artificial Intelligence2010，24，4： | 1 |
| 12 | Overexpression of Hdac6 extends reproductive lifespan in mice显示文摘 | Xiaoxi Zhang Jiao Yang Haiying Wang Renpeng Guo Yu Yin Dongdong Zhang Qian Zhang Hua Wang Zhongcheng Zhou Lingyi Chen Jun Zhou Lin Liu | 2017 | Protein & Cell2017，8，5： | 1 |
| 13 | Strategic alliance forma- tion and structural configuration 显示文摘 | LIN Haiying DARNAL N | 2014 | Journal of Bus- iness Ethics2014，，2： | 1 |
| 14 | Preparation of chitosan oligomers by immobilized Papain 显示文摘 | Hong lin Haiying Wang Changhu Xue | 2002 | Enzyme and Microbial Technology2002，31，： | 1 |
| 15 | Effect of ultrasonic treatment on the morphology of casein particles显示文摘 | LIN Lin CUI Haiying HE Ronghai | 2014 | Ultrasonics Sonochemistry2014，21，2： | 1 |
| 16 | Crystalline metallic Au nanoparticle-loadedα-Bi2O3microrods for improved photocatalysis显示文摘 | JIANG Haiying CHENG Kun LIN Jun | 2012 | Physical Chemistry Chemical Physics2012，35，12： | 1 |
| 17 | Nanoliposomes containing Eucalyptus citriodora as antibiotic with specific antimicrobial activity显示文摘 | Lin Lin Haiying Cui Hui Zhou Xuejing Zhang Christian Bortolini Menglin Chert Lei Liu and Mingdong Dong | 2015 | Chemical Communications2015，51，： | 1 |
| 18 | The specific antibacterial activity of liposome-encapsulated Clove oil and its application in tofu显示文摘 | Haiying Cui Chengting Zhao Lin Lin | 2015 | Food Control2015，，56： | 1 |
| 19 | Status of the IHEP 1.3 GHz superconducting RF program显示文摘The 1.3 GHz superconducting radio-frequency (SRF) technology is one of the key technologies for the ILC and future XFEL and ERL projects in China. With the aim to develop 1.3 GHz SRF technology, IHEP has started a program to build an SRF Accelerating Unit. This unit contains a 9-cell 1.3 GHz superconducting cavity, a short cryomodule, a high power input coupler, a tuner and a low level RF system. This program also includes the SRF laboratory upgrade, which will permit the unit to be built and tested at IHEP. The unit will be used for the 1.3 GHz SRF system integration study, high power horizontal test and possible beam test in the future. In this paper, we report the recent R&D status of this program. The first large grain low-loss shape 9-cell superconducting RF cavity made by IHEP reached 20 MV/m in the first vertical test in July, 2010. The prototype tuner and low level RF (LLRF) system are under test. The high power input coupler and cryomodule are under fabrication. Several key SRF facilities for 9-cell cavity surface treatment and pre-tuning were successfully commissioned and are in operation. | GAO Jie ZHAI JiYuan PAN WeiMing LI ShaoPeng SUN Yi DAI JianPing CHI YunLong LI ZhongQuan ZHAO TongXian HUANG TongMing MA Qiang GE Rui LI ChunHua GUO HaiSheng WANG GuangWei QIU Feng LIN HaiYing HOU Mi WANG QunYao | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 1 |
| 20 | Radio-frequency system of the high energy photon source显示文摘Purpose High energy photon source is a 6 GeV diffraction-limited storage ring light source currently under construction in Beijing.A low-frequency fundamental radio-frequency(rf)system of 166.6 MHz was proposed to accommodate the accelerator physics design.Superconducting rf(srf)technologies were chosen for the storage ring rf accompanied by solid-state power amplifiers and digital low-level rf controls.The design of the rf system was completed,and the parameters are frozen.Elucidation of the rf design with key parameters is desired.Methods The requirements from the accelerator physics design will be presented followed by the detailed rf design.The logic behind the choice of key rf parameters is elaborated.The configuration of the entire rf system is presented.Results and conclusions The fundamental srf cavity of 166.6 MHz was designed to accelerate the ultrarelativistic electron beam.Heavy damping of higher-order modes in these cavities is required to avoid the coupled bunch instabilities.An active third harmonic srf of 499.8 MHz was adopted to realize the required rf gymnastics.Normal-conducting 5-cell cavities will be used for the booster rf.Solid-state amplifiers of 2.4 MW in total will be installed at HEPS to drive these cavities in the booster and the storage ring.A digital low-level rf system will be used to regulate rf field inside each cavity with high stabilities.The rf configuration during the commissioning and the operation scenarios are also presented. | Pei Zhang Jin Dai Ziwei Deng Lin Guo Tongming Huang Dongbing Li Jian Li Zhongquan Li Haiying Lin Yuanli Luo Qiang Ma Fanbo Meng Zhenghui Mi Qunyao Wang Haisheng Xu Xinying Zhang Facheng Zhao Hongjuan Zheng | 2023 | Radiation Detection Technology and Methods2023，7，1： | 1 |
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