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| 1 | Report on Childhood Obesity in China (9): Sugar-sweetened Beverages Consumption and Obesity显示文摘Objective To explore the associations between sugar-sweetened beverage (SSB) consumption and obesity as well as obesity-related cardiometabolic disorders among children in China. Methods A total of 6974 (boys 3558, girls 3412) children aged 6-13 years participated in the study. Each participant's height, weight, waist circumference, fasting glucose, triglycerides, total cholesterol, high- density lipoprotein cholesterol, and low-density lipoprotein cholesterol were measured. The type of beverage consumption was determined using a self-administered questionnaire. Results SSBs were consumed regularly by 46.1% of the children. The prevalence [adjusted odds ratio (95% confidence internal (CI)] of obesity was 7.6% [as the reference group (ref.)], 10.1% [1.36(1.07, 1.74)], and 11.6% [1.46(1.21, 1.75)], among children who regularly drank milk, other beverages and SSBs, respectively. Regularly drinking SSBs elevated the likelihood of abdominal obesity [adjusted odds ratio (95% CI): 1.36 (1.17, 1.59)]. The prevalence [adjusted odds ratio (95% CI)] of obesity among children who regularly drank sports/caloric beverages, carbonated beverages, sweet tea, and plant protein beverages was 16.8% [2.00(1.31, 3.07)], 12.7% [1.52(1.23, 1.88)], 11.5% [1.52(1.18, 1.95)], and 10.4% [1.41(1.03, 1.94)], respectively, which was higher than that of regular milk drinkers [7.6 % (ref.)]. The prevalence [adjusted odds ratio (95% CI)] of abdominal obesity among children who regularly drank sweet tea, fruit/vegetable juices, and carbonated beverages was 17.7% [1.55(1.26, 1.90)], 16.2% [1.36(1.09, 1.70)], and 15.3% [1.24(1.03, 1.50)], respectively, which was much higher than that of regular milk drinkers [12.8% (ref.)]. Conclusions Regular SSB consumption was positively related to obesity and abdominal obesity. This relationship should be investigated further using a longitudinal study design. | SHANG Xian Wen LIU Ai Ling ZHANG Qian HU Xiao Qi DU Song Ming MA Jun XU Gui Fa LI Ying GUO Hong Wei DU Lin LI Ting Yu MA Guan Sheng | 2012 | Biomedical and Environmental Sciences2012，25，2： | 23 |
| 2 | Expression of regulating apoptosis gene and apoptosis index in primary liver cancer显示文摘INTRODUCTIONProgramed cell death plays an important role in thegenesis of cancer.Certain cancer genes canregulate apoptosis.Recently,several proteins thatare structurally related to Bcl-2,an inhibitor ofapoptosis,have been identified.Therefore,novel strategies and agents that target specificmolecular pathways,as well as triggering a | Hong Yu Xu You Lin Yang Xi Li Guan Guang Song Ai Min Jiang Li Jun Shi | 2000 | World Journal of Gastroenterology2000，6，5： | 21 |
| 3 | Reduction of polyethylenimine-coated iron oxide nanoparticles induced autophagy and cytotoxicity by lactosylation显示文摘Superparamagnetic iron oxide(SPIO)nanoparticles are excellent magnetic resonance contrast agents and surface engineering can expand their applications.When covered with amphiphilic alkyl-polyethyleneimine(PEI),the modified SPIO nanoparticles can be used as MRI visible gene/drug delivery carriers and cell tracking probes.However,the positively charged amines of PEI can also cause cytotoxicity and restricts their further applications.In this study,we used lactose to modify amphiphilic low molecular weight polyethylenimine(C_(12-)PEI_(2K))at different lactosylation degree.It was found that the N-alkyl-PEI-lactobionic acid wrapped SPIO nanocomposites show better cell viability without compromising their labelling efficacy as well as MR imaging capability in RAW 264.7 cells,comparing to the unsubstituted ones.Besides,we found the PEI induced cell autophagy can be reduced via lactose modification,indicating the increased cell viability might rely on down-regulating autophagy.Thus,our findings provide a new approach to overcome the toxicity of PEI wrapped SPIO nanocomposites by lactose modification. | Jiuju Du Wencheng Zhu Li Yang Changqiang Wu Bingbing Lin Jun Wu Rongrong Jin Taipeng Shen Hua Ai | 2016 | Regenerative Biomaterials2016，3，4： | 5 |
| 4 | Thermal performance analysis of non-uniform height rectangular fin based on constructal theory and entransy theory显示文摘A model of non-uniform height rectangular fin, in which the variation of base's thickness and width are taken into account, is established in this paper. The dimensionless maximum thermal resistance(DMTR) and the dimensionless equivalent thermal resistance(DETR) defined based on the entransy dissipation rate(EDR) are taken as performance evaluation indexes. According to constructal theory, the variations of the two indexes with the geometric parameters of the fin are analyzed by using a finite-volume computational fluid dynamics code, the effects of the fin-material fraction on the two indexes are analyzed. It is found that the two indexes decrease monotonically as the ratio between the front height and the back height of the fin increases subjected to the non-uniform height rectangular fin. When the model is reduced to the uniform height fin, the two indexes increase first and then decrease with increase in the ratio between the height of the fin and the fin space. The fin-material fraction has no effect on the change rule of the two indexes with the ratio between the height of the fin and the fin space. The sensitivity of the DETR to the geometric parameters of the fin is higher than that of the DMTR to the geometric parameters. The results obtained herein can provide some theoretical support for the thermal design of rectangular fins. | YANG Ai Bo CHEN Lin Gen XIE Zhi Hui FENG Hui Jun SUN Feng Rui | 2016 | Science China(Technological Sciences)2016，59，12： | 4 |
| 5 | Biodegradation of n-hexadecane by bacterial strains B1 and B2 isolated from petroleum-contaminated soil显示文摘Two hydrocarbon-biodegrading bacterial strains,B1 and B2,were isolated from petroleum-contaminated soil collected from Tianjin,China.The strains were identified as Pseudomonas aeruginosa(B1) and Acinetobacter junii(B2).The degradation rate of n-hexadecane by B1 and B2 reached 96% and 78% respectively after 7 days,though the strains employed different mechanisms of degradation.The results showed that B2 was not able to use glucose as carbon source.B1 could produce glycolipid surfactants using glucose as the carbon source,according to the results of blue agar plate analysis and thin layer chromatography(TLC),and the bacterial culture of B1 had a high oil discharge and emulsification activity.Both B1 and B2 could produce biosurfactants with hexadecane as the sole carbon source,but their modes of action were different.The carbon source was found to affect the cell surface hydrophobicity.Cell surface hydrophobicity was poor with glucose as the carbon source,but enhanced when hexadecane was used as the carbon source. | LIU Tao WANG FengHua GUO LanPing LI XiaoLiang YANG XiaoJin LIN Ai Jun | 2012 | Science China Chemistry2012，55，9： | 4 |
| 6 | Optimal Waist Circumference Cut-off values for Identifying Metabolic Risk Factors in Middle-aged and Elderly Subjects in Shandong Province of China显示文摘Objective To study the optimal waist circumference(WC) cut-off values for identifying metabolic risk factors in middle-aged and elderly subjects in Shandong Province of China. Methods A total of 2 873 men and 5 559 women were included in this cross-sectional study. Metabolic syndrome(MetS) was diagnosed according to the definition of Chinese Diabetes Society in 2004. The relation between WC and MetS was analyzed by multivariate logistic regression analysis. The optimal WC cut-off values were identified using the area under the ROC curve and the different diagnostic criteria for central obesity were compared. Results The WC was the risk factor for MetS independent of BMI, blood glucose, blood lipid, and blood pressure. The optimal WC cut-off value was 83.8 cm and 91.1 cm for identifying MetS in women and men, respectively. Compared with 80 cm and 85 cm for women and men, 85 cm and 90 cm had a higher Youden index for identifying all metabolic risk factors and MetS in women and men. Conclusion The appropriate WC cut-off value is 85 cm and 90 cm for identifying central obesity and MetS in women and men in Shandong Province of China. | HOU Xin Guo WANG Chuan MA Ze Qiang YANG Wei Fang WANG Ji Xiang LI Cheng Qiao WANG Yu Lian LIU Shu Min Hu Xiu Ping ZHANG Xiu Ping JIANG Mei WANG Wei Qing NING Guang ZHENG Hui Zhen MA Ai Xia SUN Yu SONG Jun LIN Peng LIANG Kai LIU Fu Qiang LI Wen Juan XIAO Juan GONG Lei WANG Mei Jian LIU Ji Dong YAN Fei YANG Jun Peng WANG Ling Shu TIAN Meng ZHAO Ru Xing JIANG Ling CHEN Li | 2014 | Biomedical and Environmental Sciences2014，27，5： | 3 |
| 7 | NLRP3 Deficiency Attenuates Secondary Degeneration of Visual Cortical Neurons Following Optic Nerve Injury显示文摘In the visual pathway, optic nerve(ON) injury may cause secondary degeneration of neurons in distal regions, such as the visual cortex. However, the role of the neuroinflammatory response in regulating secondary impairment in the visual cortex after ON injury remains unclear. The NOD-like receptor family pyrin domain containing 3(NLRP3) is an important regulator of neuroinflammation. In this study, we established a mouse model of unilateral ON crush(ONC) and showed that the expression of NLRP3 was significantly increased in the primary visual cortex(V1) as a response to ONC and that the NLRP3 inflammasome was activated in the contralateral V1 1 days–14 days after ONC. Ablation of the NLRP3 gene significantly decreased the trans-neuronal degeneration within 14 days. Visual electrophysiological function was improved in NLRP3-/- mice. Taken together, these findings suggest that NLRP3 is a potential therapeutic target for protecting visual cortical neurons against degeneration after ON injury. | Zhou Zhang Wenyi Liu Yubin Huang Linlin Luo Xiaofeng Cai Yunjia Liu Liqianyu Ai Jun Yan Sen Lin Jian Ye | 2020 | Neuroscience Bulletin2020，36，3： | 3 |
| 8 | The Retrospective Diagnostic Potential of Gene Xpert MTB/RIF for the Analysis of Formalin-Fixed Paraffin-Embedded Tissue from Extrapulmonary Tuberculosis Patients显示文摘Tuberculosis(TB)is a chronic disease caused by infection with Mycobacterium tuberculosis.Laboratory confirmation of this infection is challenging due to the paucibacillary nature of extrapulmonary tuberculosis(EPTB). | JIA Qing Jun ZENG Mei Chun CHENG Qing Lin HUANG Yin Yan WU Yi Fei LI Qing Chun WANG Le AI Li Yun FANG Zi Jian CHENG Shi SHU Li Ping | 2023 | Biomedical and Environmental Sciences2023，36，3： | 1 |
| 9 | Clinical epidemiology and disease burden of bronchiolitis in hospitalized children in China:a national cross-sectional study显示文摘Background Bronchiolitis is a common acute lower respiratory tract infection(ALRTI)and the most frequent cause of hospitalization of infants and young children with ALRTI.Respiratory syncytial virus is the main pathogen that leads to severe bronchiolitis.The disease burden is relatively high.To date,few descriptions of the clinical epidemiology and disease burden of children hospitalized for bronchiolitis are available.This study reports the general clinical epidemiological characteristics and disease burden of bronchiolitis in hospitalized children in China.Methods This study included the face sheet of discharge medical records collected from 27 tertiary children’s hospitals from January 2016 to December 2020 that were aggregated into the FUTang Update medical REcords(FUTURE)database.The sociodemographic variables,length of stay(LOS)and disease burden of children with bronchiolitis were analyzed and compared using appropriate statistical tests.Results In total,42,928 children aged 0–3 years were hospitalized due to bronchiolitis from January 2016 to December 2020,accounting for 1.5%of the total number of hospitalized children of the same age in the database during the period and 5.31%of the hospitalizations for ALRTI.The male to female ratio was 2.01:1.Meanwhile,more boys than girls were observed in different regions,age groups,years,and residences.The 1–2 year age group had the greatest number of hospitalizations for bronchiolitis,while the 29 days–6 months group had the largest proportion of the total inpatients and inpatients with ALRTI in the same age group.In terms of region,the hospitalization rate of bronchiolitis was the highest in East China.Overall,the number of hospitalizations from 2017 to 2020 showed a decreasing trend from that in 2016.Seasonally,the peak hospitalizations for bronchiolitis occurred in winter.Hospitalization rates in North China in autumn and winter were higher than those in South China,while hospitalization rates in South China were higher in spring and summer.Approximately,half of the patients with bronchiolitis had no complications.Among the complications,myocardial injury,abnormal liver function and diarrhea were more common.The median LOS was 6 days[interquartile range(IQR)=5–8],and the median hospitalization cost was 758 United States dollars(IQR=601.96–1029.53).Conclusions Bronchiolitis is a common respiratory disease in infants and young children in China,and it accounts for a higher proportion of both total hospitalizations and hospitalizations due to ALRTI in children.Among them,children aged 29 days–2 years are the main hospitalized population,and the hospitalization rate of boys is significantly higher than that of girls.The peak season for bronchiolitis is winter.Bronchiolitis causes few complications and has a low mortality rate,but the burden of this disease is heavy. | Jiao Tian Xin‑Yu Wang Lin‑Lin Zhang Meng‑Jia Liu Jun‑Hong Ai Guo‑Shuang Feng Yue‑Ping Zeng Ran Wang Zheng‑De Xie | 2023 | World Journal of Pediatrics2023，19，9： | 1 |
| 10 | Innewly-dIagnosedtype2d Iabetespathogenes IsandsyndromecharacterIstIcsoftrad It Ional ChInese med IcIne显示文摘 | Zou LI bo Wei Jun ping LIu Fang Wang XIu zhi Cao AI mei LIu Yajun Wang JIa Chen LIang LIu Dong Zhao Yu Tong XIao lIn | | 0，，11： | 1 |
| 11 | The effect of neighbor distance of magnetic nanoparticle clusters on magnetic resonance relaxation properties显示文摘Superparamagnetic iron oxide(SPIO) nanoparticle clusters are one unique form which can enhance magnetic relaxivity and improve the magnetic resonance imaging contrast at the same iron concentration, comparing to single SPIO nanoparticles. Controlling of cluster size and other structural parameters have drawn great interests in this field to further improve their magnetic properties. In this study, we investigated how the interparticle distance(also known as neighbor distance) of SPIO nanocrystals within clusters affect their magnetic relaxation behaviors.To adjust the neighbor distance, different amount of cholesterol(CHO) was chosen as model spacers embedded into SPIO nanocluster systems with the help of amphiphilic diblock copolymer poly(ethylene glyco)-polyester. Smallangle X-ray scattering was applied to quantify the neighbor distance of SPIO clusters. The results demonstrated that the averaged SPIO nanocrystal neighbor distance of nanoclusters increased with higher amount of added CHO.Moreover, these SPIO nanocrystal clusters had the prominent magnetic relaxation properties. Simultaneously, controlling of SPIO nanocrystal neighbor distance can regulate the saturation magnetization(Ms) and magnetic resonance(MR) T2 relaxation of the aggregation, and ultimately obtain better MR contrast effects with decreased neighbor distance. | Dan Wang Bingbing Lin Taipeng Shen Jun Wu Chunchao Xia Bin Song Hua Ai | 2016 | Science Bulletin2016，61，13： | 1 |
| 12 | Identification and Characterisation of Phenolics in Polygonum capitatum by Ultrahigh‐Performance Liquid Chromatography with Photodiode Array Detection and Tandem Mass Spectrometry显示文摘 | Shang‐Gao Liao Li‐Juan Zhang Fa Sun Zhen Wang Xun He Ai‐Min Wang Yong‐Jun Li Yong Huang Yan‐Yu Lan Bo‐Li Zhang Yong‐Lin Wang | 2013 | Phytochem. Anal2013，，6： | 1 |
| 13 | Nanoformulation of metal complexes: Intelligent stimuli- responsive platforms for precision therapeutics显示文摘 | Ming Hu Xiangzhao Ai Zhimin Wang Zhijun Zhang Haolun Cheong Wenmin Zhang Jun Lin Juan Li Huanghao Yang Bengang Xing | 2018 | Nano Research2018，11，10： | 1 |
| 14 | MT1 - MMP mediates nitric oxide - induced activation of matrix metalloproteinase - 13 显示文摘 | Ai G Lin Y Jun CG | 2009 | Orthopedics2009，1，： | 1 |
| 15 | Raltitrexed induces mitochondrial?mediated apoptosis in SGC7901 humangastric cancer cells显示文摘 | Song Xue Ying?Xia Chen Shu?Kui Qin Ai?Zhen Yang Lin Wang Hai?Jun Xu Hai?Yun Geng | 2014 | Molecular Medicine Reports2014，，4： | 1 |
| 16 | Two New Gallotannins from Pistacia weinmannifolia显示文摘Two new gallotannins, pistafolins A (l) and B (2), were isolated from the leaf extract of Pistacia weinmannifolia. Their structures were determined by spectral methods. | Ai Jun HOU Li Yan PENG Yan Ze LIU Zhong Wen LIN Han Dong SUN | 2000 | Chinese Chemical Letters2000，11，1： | 0 |
| 17 | Exposure to Radon and Kidney Cancer:A Systematic Review and Meta-analysis of Observational Epidemiological Studies显示文摘Objective To evaluate the possible association between radon exposure and kidney cancer. Methods We performed a systematic review and a meta-analysis based on random effect models to provide a pooled association measure. Results We subjected 8 studies(overall relative risks and 95% confidence intervals: 1.01, 0.72 to 1.43, I^2 = 64.4%) to meta-analysis. Subgroup analysis revealed a marginally significant association between radon exposure and kidney cancer in studies conducted in Europe. Two population-based studies provided no evidence for the increased risk of kidney cancer in the general population. Conclusion The association between radon and kidney cancer remains unclear but cannot be excluded because of its biological plausibility and the limited number and quality of existing studies. Additional data from the general population and well-designed miner cohort studies are needed to reveal the real relationship between radon exposure and kidney cancer. | CHEN Bin YUAN Tan Wei WANG Ai Qing ZHANG Hong FANG Li Jun WU Qian Qian ZHANG Hong Bo TAO Sha Sha TIAN Hai Lin | 2018 | Biomedical and Environmental Sciences2018，31，11： | 0 |
| 18 | Expert consensus on prevention and cardiopulmonary resuscitation for cardiac arrest in COVID-19显示文摘Background:Cardiopulmonary resuscitation(CPR)strategies in COVID-19 patients differ from those in patients suffering from cardiogenic cardiac arrest.During CPR,both healthcare and non-healthcare workers who provide resuscitation are at risk of infection.The Working Group for Expert Consensus on Prevention and Cardiopulmonary Resuscitation for Cardiac Arrest in COVID-19 has developed this Chinese Expert Consensus to guide clinical practice of CPR in COVID-19 patients.Main recommendations:1)A medical team should be assigned to evaluate severe and critical COVID-19 for early monitoring of cardiac-arrest warning signs.2)Psychological counseling and treatment are highly recommended,since sympathetic and vagal abnormalities induced by psychological stress from the COVID-19 pandemic can induce cardiac arrest.3)Healthcare workers should wear personal protective equipment(PPE).4)Mouth-to-mouth ventilation should be avoided on patients suspected of having or diagnosed with COVID-19.5)Hands-only chest compression and mechanical chest compression are recommended.6)Tracheal-intubation procedures should be optimized and tracheal-intubation strategies should be implemented early.7)CPR should be provided for 20-30 min.8)Various factors should be taken into consideration such as the interests of patients and family members,ethics,transmission risks,and laws and regulations governing infectious disease control.Changes in management:The following changes or modifications to CPR strategy in COVID-19 patients are proposed:1)Healthcare workers should wear PPE.2)Hands-only chest compression and mechanical chest compression can be implemented to reduce or avoid the spread of viruses by aerosols.3)Both the benefits to patients and the risk of infection should be considered.4)Hhealthcare workers should be fully aware of and trained in CPR strategies and procedures specifically for patients with COVID-19. | Wei Song Jie Wei Xiangdong Jian Deren Wang Yanhong Ouyang Yuanshui Liu Xianjin Du Ying Chen Yingqi Zhang Heping Xu Shuming Xianyu Qiong Ning Xiang Li Xiaotong Han Feng Zhan Tao Yu Wenteng Chen Jun Zhang Wenwei Cai Sheng’ang Zhou Shengyang Yi Yu Cao Xiaobei Chen Shunjiang Xu Zong’an Liang Duohu Wu Fen Ai Zhong Wang Qingyi Meng Yuhong Mi Sisen Zhang Rongjia Yang Shouchun Yan Wenbin Han Yong Lin Chuanyun Qian Wenwu Zhang Yan Xiong Jun Lv Baochi Liu Yan Cao Xiaojun He Xuelian Sun Yufang Cao Tian’en Zhou | 2021 | Asian Pacific Journal of Tropical Medicine2021，14，6： | 0 |
| 19 | Characterization of Mutations in Genes Related to Rifampicin and Isoniazid Resistance in Multidrug-resistant Mycobacterium tuberculosis Strains from Hangzhou,China显示文摘Tuberculosis(TB),caused by the Mycobacterium tuberculosis complex(MTBC),is the 13^(th)leading cause of death and the second leading cause of infectious killer after COVID-19(above HIV and AIDS),according to the World Health Organization's 2022 Global TB Report.In 2021,10.6 million people were diagnosed with a new episode of TB and 1.6 million people died as a result. | HUANG Yin Yan XIE Li WU Yi Fei JIA Qing Jun CHENG Qing Lin LI Qing Chun AI Li Yun BAI Xue Xin | 2023 | Biomedical and Environmental Sciences2023，36，9： | 0 |
| 20 | Two New ent-Kaurane Diterpenoids from Isodon xerophilus显示文摘Two new ent-kaurane diterpenoids, xerophilusin E (1) and xerophilusin F (2), were isolated from the leaves of Isodon xerophilus. Their structures were determined as 3, 20: 7, 20diepoxy-ent-kaur- 16-en- 15-one and 70, 146, 20 (R)-trihydroxy- 11-acetoxy-7, 20-cyclo-ent- kaurl 6-en-6, 15-dione, respectively, by spectral methods and X-ray crystallographic analysis. | Ai Jun HOU Hui YANG Bei JIANG Qin Shi ZHAO Yan Ze LIU Zhong Wen LIN Han Dong SUN | 2000 | Chinese Chemical Letters2000，11，9： | 0 |
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