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| 1 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 2 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 3 | Study on catalytic oxidation of planar binuclear copper phthalocyanine on 2-mercaptoethanol显示文摘Mononuclear copper phthalocyanine (CuPc) and binuclear copper phthalocyanine (Cu2Pc2) were synthesized by the phenylanhydride-urea route, and their catalytic oxidation activity on 2-mercaptoethanol was studied. Based on the experimental results, a catalytic mechanism of Cu2Pc2 on 2-mercaptoethanol has been proposed. Furthermore, the effects of pH, Cu2Pc2 concentration, and temperature on the catalytic oxidation activity were evaluated. The results showed that CuPc has no catalytic activity, while Cu2Pc2 has high catalytic oxidation activity towards 2-mercaptoethanol with the optimal activity at pH 11. The reaction can further be enhanced by increasing Cu2Pc2 concentration and temperature, due to its endothermic characteristics. | CHEN Wenxing, WEI Lili, WANG Jinqian, YAO Yuyuan, Lü Shenshui & CHEN Shiliang Key Laboratory of Advanced Textile Materials and Manufacturing Technology, Ministry of Education, Zhejiang Sci-Tech Univer- sity, Hangzhou 310018, China | 2006 | Science China Chemistry2006，49，6： | 2 |
| 4 | Monitoring activities from multiple video streams: establishing a common coordinate frame显示文摘 | LILY L RAQUEL R | 2000 | IEEE Transactions on Pattern Analysis and Machine Intelligence2000，8，： | 1 |
| 5 | Membrane-bound Fas ligand only is es- sential for Fas-induced apoptosis 显示文摘 | Lorraine A Lin T Lily L | 2009 | Nature2009，461，7264： | 1 |
| 6 | Intercultural Communication Competence: Identifying Key Components from Multicultural Perspecfives显示文摘 | Arasaratnam Lily A and Marya L Doerfel | 2005 | Internafional Journal of Intercultural Relations2005，29，2： | 1 |
| 7 | Activation of the redoxregulated molecular chaperone Hsp33-A two-step mechanism 显示文摘 | Graumann J Lilie H Tang X L | 2001 | Structure2001，9，5： | 1 |
| 8 | Competitive Fuzzy Edge Detection显示文摘 | Lily R L Carl G L | 2003 | Applied Soft Computing2003，3，： | 1 |
| 9 | Synthesis and electrochemical properties of LiFePO4/C by a novel carbothermal reduction technology显示文摘 | Tan F X Lili Meng L L Wang F | | 0，，： | 1 |
| 10 | Bicylindrical Coordinate Formulation for the Leakage Flow through the Minimal Clearance in a Rolling piston Compressor显示文摘 | Ferreira R T S Lilie D E B Gasche J L | 1992 | Proceeding of Purdue Compressor Technology Conference1992，，： | 1 |
| 11 | Vacuum and ultrasonic co-assisted electroless copper plating on carbon foams显示文摘 | Lili Z Xiujun L Tongqi L | 2015 | Vacuum2015，114，： | 1 |
| 12 | Cognitive Situation and Threat Assessments of Ground Battle Spaces显示文摘 | Carl G L Lily R L | 2003 | Information Fusion2003，4，4： | 1 |
| 13 | Volatiles and Harvest Maturity of Peaches and Nectarines显示文摘 | LILY L I M ROMANI R J | 1963 | J Food Sci1963，29，： | 1 |
| 14 | Serum uric acid is a marker of inflammation and a marker of predicting the risk of developing CVD,stroke,renal failure and cancer显示文摘 | Lily L Wu James T | 2008 | Biomed Lab Sci2008，20，1： | 1 |
| 15 | The activation of p53 mediated by Epstein-Barr virus latent membrane protein 1 in SV40 large T-antigen transformed cells显示文摘 | Lili L Shang Z Xue C | | 0，，05： | 1 |
| 16 | Competitive adsorption, release and speciation of heavy metals in the Yellow River sediments, China显示文摘 | Qingyun Fan Jiang He Hongxi Xue Changwei Lü Ying Liang Saruli Ying Sun Lili Shen | 2007 | Environmental Geology2007，，2： | 1 |
| 17 | Cognitive Situation and Threat Assessments of Ground Battle Spaces显示文摘 | Carl G L Lily R L | 2003 | Information Fusion2003，4，4： | 1 |
| 18 | Advance in preclinical investigation of prostate cancer gene therapy显示文摘 | Marxa L Figueiredo Chinghai Kao Lily Wu | 2007 | Mol Ther2007，15，6： | 1 |
| 19 | Voriconazole 显示文摘 | LILY A J FRANK J P ALEKSANDR G L | 2003 | Clin Ther2003，25，5： | 1 |
| 20 | Hyperhomocysteinemia is a risk factor for cancer and a new potential tumor marker显示文摘 | Lily L Wu James T Wu | 2002 | Clinica Chimica Acta2002，，1： | 1 |
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