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| 1 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 2 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 3 | The application of dexmedetomidine in children undergoing vitreoretinal surgery显示文摘 | Lili X Jianjun S Haiyan Z | | 0，，4： | 1 |
| 4 | Selection of reference genes for gene expression studies in human neutrophils by real-time PCR 显示文摘 | Zhang X Z Lily D Andrew J S | 2005 | BMC Mol Biol2005，6，1： | 1 |
| 5 | The temperature fuzzycontrol system of barley malt drying based on microcon-troller显示文摘 | Xiaoyang G Yang B Lili Z | 1977 | Automatica1977，12，3： | 1 |
| 6 | High-dimensional random apollonian networks显示文摘 | Zhang Z Z Lili Ronga Francesc Comellas | 2006 | Physica A2006，364，： | 1 |
| 7 | Generalization of split Hopkinson bar technique to use viscoelastic bars显示文摘 | Wang Lili Labibes K Azari Z Pluvinage G | 1994 | International Journal of Impact Engineering1994，15，： | 1 |
| 8 | Vacuum and ultrasonic co-assisted electroless copper plating on carbon foams显示文摘 | Lili Z Xiujun L Tongqi L | 2015 | Vacuum2015，114，： | 1 |
| 9 | The application of dexmedetomidine in children undergoing vitreoretinal surgery显示文摘 | Lili X Jianjun S Haiyan Z | | 0，，04： | 1 |
| 10 | The activation of p53 mediated by Epstein-Barr virus latent membrane protein 1 in SV40 large T-antigen transformed cells显示文摘 | Lili L Shang Z Xue C | | 0，，05： | 1 |
| 11 | Detection of winter-wheat diseases显示文摘 | LILI Z DUCHESNE J NICOLAS H | 1991 | Bull Organ Eur Mediterr Prot Plant1991，21，： | 1 |
| 12 | Application of an improved biuret method to the determination of total protein in urine and cerebrospi- nal fluid without concentration step by use of Hitachi 7170 auto -an- alyzer显示文摘 | Guobing X Lili J Lihua Z | 2001 | J Clin Lab Anal2001，15，4： | 1 |
| 13 | Selection of reference genes for gene expression studies in human neutrophils by real-time PCR显示文摘 | Zhang X Z Lily D Andrew J S | 2005 | BMC Mol Biol2005，6，1： | 1 |
| 14 | Design and application of a body - language machine in mechanically ventilated patients显示文摘 | Xiaoling D Lili Z | 2010 | Journal of Nurs- ing Science2010，3，： | 1 |
| 15 | Effects of high-temperature treatment (≥100 ℃) on Alaska Pollock (Theragra cha!cogramma) surimi gels显示文摘 | Lili Z Yong X Jie X | 2012 | Journal of Food Engineering2012，115，1： | 1 |
| 16 | Isolation and characterisation of moderately halophilic bacterium Halomonas ventosae DL7 synthesizing Ectoine as compatible solute显示文摘 | Daochen Z Lili N Chenxiang W | 2007 | Annals of Microbiology2007，57，3： | 1 |
| 17 | Chromium-induced physiochemical and ultrastructural changes in four cultivars of Brassica napus L显示文摘 | Rafaqat A G Lili Z Basharat A | 2015 | Chemosphere2015，120，2： | 1 |
| 18 | Antibody conjugated magnetic iron oxide nanoparticles for cancer cell separation in fresh whole blood显示文摘 | XU H Y AGUILAR Z P LILY Y | 2011 | Biomaterials2011，32，36： | 1 |
| 19 | The application of dexmedetomidine in children undergoing vitreoretinal surgery显示文摘 | Lili X Jianjun S Haiyan Z | 2012 | J Anesth2012，26，4： | 1 |
| 20 | Selection of reference genes for gene expression studies in human neut rophils by real-time PCR 显示文摘 | Zhang X Z Lily D Andrew J S | 2005 | BMC Mol Biol2005，6，1： | 1 |
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