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| 1 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 2 | Further studies of the fire resistance of reinforced concrete columns显示文摘 | Allen D E Lie T T | 1974 | National research Council of Canada1974，416，： | 1 |
| 3 | In vitro uptake and interaction between arginine and lysine in the intestine of Atlantic salmon ( Salmo salar) 显示文摘 | BERGE G E BAKKE-MCKELLEP A M LIED E | 1999 | Aquaculture1999，179，14： | 1 |
| 4 | Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck显示文摘 | Mork J Lie A K Glattre E | | 0，，15： | 1 |
| 5 | On the timing of CEO stock option awards显示文摘 | Lie E | 2005 | Management Science2005，51，5： | 1 |
| 6 | Financial Flexibility, Performance and the Corporate Payout Choice显示文摘 | Lie E | 2005 | Journal of business2005，78，06： | 1 |
| 7 | Transgenic human fetal fibroblasts as feeder layer for human embryonic stem cell lineage selection显示文摘 | Sidhu K S Lie K H Tuch B E | 2006 | Stem Cells Dev2006，15，5： | 1 |
| 8 | Modal analysis of measurements from a large-scale VIV model test of a riser in linearly sheared flow 显示文摘 | Lie H Kaasen K E | 2006 | Journal of Fluids and Structures2006，22，4： | 1 |
| 9 | Metabolism of T-2 toxin by rat liver carboxylesterase 显示文摘 | JOHNSEN H ODDEN E LIE O | 1986 | Biochem Phannacol1986，35，9： | 1 |
| 10 | Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae显示文摘 | Chassaing Benoit Rolhion Nathalie de Vallée Amélie Salim Sa’ad Y Prorok-Hamon Maelle Neut Christel Campbell Batty J S?derholm Johan D Hugot Jean-Pierre Colombel Jean-Frédéric Darfeuille-Michaud Arlette | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 11 | Nutrition of Atlantic salmon (Salmo salar); the requirement and metabolic effect of Arginine 显示文摘 | Berge G E Lied E Sveier H | 1997 | Comparative Biochemistry and Physiology PartA : Physiology1997，117，： | 1 |
| 12 | Effects of different levels of vitamin K in diets for cod(Gadus morhua)显示文摘 | Grahl-Madsen E Lie O | 1997 | Aquaculture1997，151，14： | 1 |
| 13 | Structural and magnetic properties of FePt film grown on Cr1-xMox underlayers 显示文摘 | DINGY F CHEN J S LIE E | 2005 | Appl Phys2005，81，7： | 1 |
| 14 | Nutrition of Atlantic salmon (Salmo salar) ;the requirement and metabolic effect of lysine 显示文摘 | Berge G E Sveier H Lied E | 1998 | Comparative Biochemistry and Physiology - Part A: Molectflar & Integrative Physiology1998，120，： | 1 |
| 15 | Nutrition of Atlantic salmon (Salmo salar) :the requirement and metabolism of arginine 显示文摘 | BERGE G E LIED E SVEIER H | 1997 | Comparative Biochemistry and Physiology Part A Physiology1997，117，4： | 1 |
| 16 | Molecular Dynamics Simulation of Liquid Water with an ab Initio Flexible Water-water Interaction Potential显示文摘 | Lie G C Clementi E | 1986 | Phys Rev A1986，33，： | 1 |
| 17 | Enzymatic hydrolysis of by-product from the fish-filleting industry; chemical characterization and nutritional evaluation显示文摘 | LIASET B LIED E ESPE M | 2000 | J Sci Food Agfic2000，80，5： | 1 |
| 18 | In vitro uptake and interaction between arginine and lysine in the intestine of Atlantic salmon (Salmo salar)显示文摘 | Berge G E Bakke-Mckellep A M Lied E | 1999 | Aquaculture1999，179，： | 1 |
| 19 | Effectiveness of sulfasalazine and methotrexate in 1102 DMARD-naive patients with early RA显示文摘 | Lie E Uhlig T Heijde D | | 0，，： | 1 |
| 20 | The effect of comedication with conventional synthetic disease modifying antirheumatie drugs on TNF inhibitor drug survival in patients with ankylosing spondylitis and undifferentiated spondyloarthritis: results from a nationwide prospective study 显示文摘 | Lie E Kristensen LE Forsblad-d'Elia H | 2015 | Ann Rheum Dis2015，74，6： | 1 |
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