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| 1 | Exploring the N-terminus region: Synthesis, bioactivity and 3D-QSAR of allatostatin analogs as novel insect growth regulators显示文摘Allatostatins(ASTs), a family of insect neuropeptide, can inhibit juvenile hormone(JH) biosynthesis by the corpora allata(CA) in Diploptera punctata, and therefore be regarded as potential leads for the discovery of new insect growth regulators(IGRs). But several shortcomings, such as their sensitivity to peptidases and high cost, impeded their practical application in pest management. In order to discover new IGRs, one AST analog B1 possessing non-peptide group was discovered with high ability to inhibit JH biosynthesis in vitro(IC_(50): 0.09 mmol/L) in our previous studies. In the present work, two series of B1 analogs with different substituents on the N-terminus region were designed and synthesized. The result suggested that benzene showed better activity than other heterocycles, and the para-substitution on the benzene was beneficial for activity. Moreover, analogs with log P value over 2.0 exhibited good activity,which indicated the hydrophobicity is important to the bioactivity. Three dimension quantitative structure-activity relationship(3D-QSAR) studies were performed to highlight the structural requirements of AST analogs, which demonstrated introduction of bulkier substituents on the N-terminus would increase the activity. Analog Ⅱ12(IC_(50): 0.08 mmol/L) exhibited similar inhibitory activity to the lead B1,but its synthetic route was simpler than B1. Therefore, Ⅱ12 could be used as a new lead compound for the discovery eco-friendly IGRs. | Meizi Wang Li Zhang Xianwei Wang Yun Ling Xiaoqing Wu Xinlu Li Yiduo Mi Xinling Yang | 2018 | Chinese Chemical Letters2018，29，9： | 2 |
| 2 | YB-1 stabilizes HIV-1 genomic RNA and enhances viral production显示文摘HIV-1 utilizes cellular factors for effi cient replication.The viral RNA is different from cellular mRNAs in many aspects,and is prone to attacks by cellular RNA quality control systems.To establish effective infection,the virus has evolved multiple mechanisms to protect its RNA.Here,we show that expression of the Y-box binding protein 1(YB-1)enhanced the production of HIV-1.Downregulation of endogenous YB-1 in producer cells decreased viral production.YB-1 increased viral protein expression by stabilizing HIV-1 RNAs.The stem loop 2 in the HIV-1 RNA packaging signal was mapped to be the YB-1-responsive element.Taken together,these results indicate that YB-1 stabilizes HIV-1 genomic RNA and thereby enhances HIV-1 gene expression and viral production. | Xin Mu Wei Li Xinlu Wang Guangxia Gao | 2013 | Protein & Cell2013，4，8： | 2 |
| 3 | Prediction Model of Coal Reservoir Pressure and its Implication for the Law of Coal Reservoir Depressurization显示文摘The main methods of coalbed methane(CBM)development are drainage and depressurization,and a precise prediction of coal reservoir pressure is thus crucial for the evaluation of reservoir potentials and the formulation of reasonable development plans.This work established a new reservoir pressure prediction model based on the material balance equation(MBE)of coal reservoir,which considers the self-regulating effects of coal reservoirs and the dynamic change of equivalent drainage area(EDA).According to the proposed model,the reservoir pressure can be predicted based on reservoir condition data and the actual production data of a single well.Compared with traditional reservoir pressure prediction models which regard EDA as a fixed value,the proposed model can better predict the average pressure of reservoirs.Moreover,orthogonal experiments were designed to evaluate the sensitivity of reservoir parameters on the reservoir pressure prediction results of this proposed model.The results show that the saturation of irreducible water is the most sensitive parameter,followed by Langmuir volume and reservoir porosity,and Langmuir pressure is the least sensitive parameter.In addition,the pressure drop of reservoirs is negatively correlated with the saturation of irreducible water and the Langmuir volume,while it is positively correlated with porosity.This work analyzed the reservoir pressure drop characteristics of the CBM wells in the Shizhuangnan Block of the Qinshui Basin,and the results show that the CBM reservoir depressurization can be divided into three types,i.e.,rapidly drop type,medium-term stability type,and slowly drop type.The drainage features of wells were reasonably interpreted based on the comprehensive analysis of the reservoir depressurization type;the latter was coupled to the corresponding permeability dynamic change characteristics,eventually proving the applicability of the proposed model. | YAN Xinlu ZHANG Songhang TANG Shuheng LI Zhongcheng WANG Kaifeng YI Yongxiang DANG Feng HU Qiuping | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 2 |
| 4 | A novel network composite cathode of LiFePO4/multiwalled carbon nanotubes with high rate capability for lithium ion batteries 显示文摘 | Li Xinlu Kang Feiyu Bai Xinde | 2007 | Electrochemistry Communications2007，，9： | 1 |
| 5 | Graphene as a High-capacity Anode Material for Lithium Ion Batteries显示文摘Graphene was produced via a soft chemistry synthetic route for lithium ion battery applications. The sample was characterized by X-ray diffraction, nitrogen adsorption-desorption, field emission scanning electron microscopy and transmission electron microscopy, respectively. The electrochemical performances of graphene as anode material were measured by cyclic voltammetry and galvanostatic charge/discharge cycling. The experimental results showed that the graphene possessed a thin wrinkled paper-like morphology and large specific surface area (342 m2g1). The first reversible specific capacity of the graphene was as high as 905 mAhg1 at a current density of 100 mAg1. Even at a high current density of 1000 or 2000 mAg1, the graphene maintained good cycling stability, indicating that it is a promising anode material for high-performance lithium ion batteries. | 柳红东 黄佳木 LI Xinlu LIU Jia ZHANG Yuxin | 2013 | Journal of Wuhan University of Technology(Materials Science)2013，28，2： | 1 |
| 6 | Investigations on the modified natural graphite as anode materials in lithium ion hattery 显示文摘 | Zou Lin Kang Fei' u Li Xinlu | 2008 | Journal of Physics and Chemistry' of' Solids2008，69，56： | 1 |
| 7 | An Improved Semi-Orthogonal User Selection Algorithm Based on Condition Number for Multiuser MIMO Systems显示文摘 | LU Xinlu WU Jun HUANG Xinlin LI Wenfeng LU Jianmin GONG Zhengwei | 2014 | China Communications2014，11，A01： | 1 |
| 8 | Paleoenvironment controls on organic matter accumulation in transitional shales from the eastern Ordos Basin,China显示文摘To investigate the paleoenvironmental controls on organic matter accumulation of Upper Paleozoic shales in the eastern Ordos Basin,China,26 shale samples were collected from two wells drilled into the Shanxi and Taiyuan Formations.The total organic carbon(TOC)content,mineral compositions and elemental geochemistry of the samples were analyzed.Quartz(35.42%)and clay minerals(48.34%)are the dominant minerals and trace elements(Li,Cs,Cu,V,Co,and Cr)are commonly enriched in the shale samples compared to the Upper Continental Crust.C-values(ranging from 0.2 to 4.5),chemical indices of weathering(CIW)values(48.82 to 99.11),and Sr/Cu ratios(1.00 to 11.05)suggest that the paleoclimate was humid in the study area during the Late Paleozoic.Elemental redox indices(e.g.,Al_(2)O_(3)/(Al_(2)O_(3)+Fe_(2)O_(3)),V/Cr,Ni/Co,V/(V+Ni)and U/Th)indicate a dysoxic to oxic paleoenvironment characterized by transi-tional sedimentary deposits in a continental margin setting.In addition,chemical index of alteration(CIA,ranging from 77.92%to 98.36%)and CIW(89.19%to 99.11%)values suggest that there was intense chemical weathering in the study area,while the Al_(2)O_(3)-CaO^(*)+Na_(2)O-K_(2)O(A-CN-K)ternary diagram demonstrates that the shales were not subjected to potassium metasomatism during diagen-esis.Al_(2)O_(3)/TiO_(2)and TiO_(2)/Zr ratios,as well as REE characteristics suggest a felsic source rocks and discount seawater as an REE source.Ce anomalies indicate an oxic environment with terrigenous input during black shale deposition,and LREE enrichment with negative Eu anomalies suggests that both shale formations were affected by detrital input rather than hydrothermal fluids.The correlation of TOC(ranging from 1.10%to 6.39%,with an average of 2.77%)with trace elemental redox indices(Sr/Cu,Sr/Ba,V/Cr,and U/Th)indicates that a warm-humid,dysoxic to oxic environment preserved much of the organic matter. | Jianwei LV Songhang ZHANG Ning YANG Chunbo FU Xinlu YAN Yang LI | 2021 | Frontiers of Earth Science2021，15，4： | 1 |
| 9 | In situ synthesis of SnO 2 nanosheet/graphene composite as anode materials for lithium-ion batteries显示文摘 | Hongdong Liu Jiamu Huang Chengjie Xiang Jia Liu Xinlu Li | 2013 | Journal of Materials Science: Materials in Electronics2013，，10： | 1 |
| 10 | Expression of YB-1 enhances production of murine leukemia virus vectors by stabilizing genomic viral RNA显示文摘Murine leukemia virus(MLV)-based retroviral vectors is widely used for gene transfer and basic research,and production of high-titer retroviral vectors is very important.Here we report that expression of the Y-box binding protein 1(YB-1)enhanced the production of infectious MLV vectors.YB-1 specifically increased the stability of viral genomic RNA in virus-producing cells,and thus increasing viral RNA levels in both producer cells and virion particles.The viral element responsive to YB-1 was mapped to the repeat sequence(R region)in MLV genomic RNA.These results identified YB-1 as a MLV mRNA stabilizer,which can be used for improving production of MLV vectors. | Wei Li Xinlu Wang Guangxia Gao | 2012 | Protein & Cell2012，3，12： | 1 |
| 11 | Flower- like SnO2/grapheme composite for high capacity lithium storage显示文摘 | Liu Hongdong Huang Jiamu Li Xinlu | 2012 | Applied Surface Science2012，258，： | 1 |
| 12 | Electrochimica Acta显示文摘 | Li Xinlu Kang Feiyu She Wancin | 2007 | 53: 17612007，53，： | 1 |
| 13 | Efficient de novo assembly and modification of large DNA fragments显示文摘Synthetic genomics has provided new bottom-up platforms for the functional study of viral and microbial genomes.The construction of the large,gigabase(Gb)-sized genomes of higher organisms will deepen our understanding of genetic blueprints significantly.But for the synthesis and assembly of such large-scale genomes,the development of new or expanded methods is required.In this study,we develop an efficient pipeline for the construction of large DNA fragments sized 100 kilobases(kb)or above from scratches and describe an efficient method for“scar-free”engineering of the assembled sequences.Our method,therefore,should provide a standard framework for producing long DNA molecules,which are critical materials for synthetic genomics and metabolic engineering. | Shuangying Jiang Yuanwei Tang Liang Xiang Xinlu Zhu Zelin Cai Ling Li Yingxi Chen Peishuang Chen Yuge Feng Xin Lin Guoqiang Li Jafar Sharif Junbiao Dai | 2022 | Science China(Life Sciences)2022，65，7： | 1 |
| 14 | A nano- composite of graphene/MnO2 nanoplatelets for high-ca- pacity lithium storage显示文摘 | Li Xinlu Song Hongfang Wang Hao etal | 2012 | Journal of Applied Electro- ehemistry2012，42，12： | 1 |
| 15 | Flower-like SnO2/graphene composite for highcapacity lithium storage显示文摘 | Liu Hongdong Huang Jiamu Li Xinlu | | 0，，11： | 1 |
| 16 | ANew Simplified Selection Algorithm of the Guide Star Catalogue for Star Sensor 显示文摘 | LI Xinlu YANG Jinhua ZHANG Liu | 2014 | Journal of Navigation(S0373-4633)2014，67，06： | 1 |
| 17 | Investigations on the modified natural graphite as anode materials in lithium ion battery显示文摘 | Lin Zou Feiyu Kang Xinlu Li Yong-Ping Zheng Wanci Shen Jing Zhang | 2007 | Journal of Physics and Chemistry of Solids2007，，5： | 1 |
| 18 | Analysis of influence of the length of ground heat exchangers on the operation characteristics and economy of ground source heat pumps显示文摘A three-dimensional finite element dynamic simulation platform of the ground source heat pump system(GSHPS)is established.According to the outlet temperature of ground heat exchangers(GHEs)required by the code in summer and winter,the calculated minimum buried depth of GHEs meeting the requirements is 60 m,when the number of borehole is 9.By using the established platform,the annual operation performance and cost of the GSHPS under different buried pipe depths are studied.The results show that the deeper the buried depth of GHEs is,the better the heat exchange effect of GHEs is.Compared with the GHEs with 60 m buried depth,when the buried depth of GHEs is 65 m,70 m,75 m and 80 m,the average coefficient of performance(COP)of the unit increases by 4.1%,6.3%,7.7%and 8.2%in cooling period and 1.0%,1.6%,1.8%and 1.9%in heating period,respectively.Considering the performance and initial investment of the GHSPS comprehensively,the optimal buried depth of GHEs is 60 m.However,considering the performance the system and the total cost of the system running for 20 years comprehensively,the optimal buried depth of GHEs is 70 m. | Hongzhi Zhang Zongwei Han Lingyan Yang Jiawei Yuan Xinlu Cheng Mingzhen Ji Gui Li | 2021 | Energy and Built Environment2021，2，2： | 1 |
| 19 | A novel network composite cathode of LiFePO4/multiwalled carbon nanotubes with high rate capability for lithium ion batteries 显示文摘 | Li Xinlu Kang Feiyu Bai Xinde | 2007 | Electrochem Commun2007，9，4： | 1 |
| 20 | Increasing Anthropogenic Mercury Pollution over the Last 200 Years Revealed by Lagoonal Sediments from Hainan Island,South China显示文摘The toxic heavy metal mercury(Hg)has significantly enhanced the global Hg cycle influenced by human activities over the last century.In this study,we presented a high-resolution Hg deposition history between∼1780 and 2015 AD in a sediment core from Xincun Lagoon,located in the southeastern Hainan Island,South China,and analyzed it in conjunction with geochemical elements,grain-size distribution,organic matter,and HYSPLIT backward trajectory simulation.The objective was to investigate the influencing factors affecting historical Hg deposition in relatively remote regions and assess the extent of the effects of natural background and human activities.The results showed that the Hg in the sediment was deposited primarily through atmospheric deposition,which was closely related to regional and even global human activities.Anthropogenic Hg contamination increased gradually from the 1830s to 1850s,possibly due to Hg emissions from Opium Wars I and II occurring in southeastern China.High broad peaks of anthropogenic Hg were observed during the 1910s to 1950s and in the 1980s,likely associated with the two world wars and modern Chinese wars.In addition,a further sharp increase in anthropogenic Hg from the mid-1970s to the present occurred,likely originating from the intense industrial activities in China triggered by the reform and opening-up policy of China in 1978 and some countries in Southeast Asia. | LI Yanting XUE Jibin CHEN Jingqiang LU Yi MA Xinlu | 2023 | Chinese Geographical Science2023，33，6： | 0 |
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