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| 1 | Security and privacy issues of physical objects in the IoT:Challenges and opportunities显示文摘In the Internet of Things(IoT),security and privacy issues of physical objects are crucial to the related applications.In order to clarify the complicated security and privacy issues,the life cycle of a physical object is divided into three stages of pre-working,in-working,and post-working.On this basis,a physical object-based security architecture for the IoT is put forward.According to the security architecture,security and privacy requirements and related protecting technologies for physical objects in different working stages are analyzed in detail.Considering the development of IoT technologies,potential security and privacy challenges that IoT objects may face in the pervasive computing environment are summarized.At the same time,possible directions for dealing with these challenges are also pointed out. | Xuanxia Yao Fadi Farha Rongyang Li Ismini Psychoul Liming Chen Huansheng Ning | 2021 | Digital Communications and Networks2021，7，3： | 3 |
| 2 | The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages显示文摘Lipid metabolic reprogramming plays an essential role in regulating the progression of colorectal cancer(CRC).However,the effect of lysophosphatidic acid(LPA)metabolism on CRC development is incompletely characterized.Here,we compared the mRNA levels of human CRC tissues to those of paracarcinoma tissues and focused on the notably enriched LPA metabolic pathways.We identified and verified that 1-acylglycerol-3-phosphate O-acyltransferase 4(Agpat4)was aberrantly expressed in CRC tissues and predicted poor survival in CRC patients.Manipulating Agpat4 expression in CRC cells did not affect the growth or migration of CRC cells in vitro,whereas Agpat4 silencing suppressed CRC cell growth in subcutaneous and peritoneal xenograft models.Mechanistically,Agpat4 silencing-induced LPA release from CRC cells and polarized macrophages to an M1-like phenotype through LPA receptors 1 and 3.This M1 activation,characterized by elevated p38/p65 signaling and increased proinflammatory cytokines,promoted the infiltration and activation of CD4+and CD8+T cells in the tumor microenvironment.Modulation of the Agpat4/LPA/p38/p65 axis regulated macrophage polarization,T-cell activity and CRC progression.Notably,combined therapy with LPA and regular chemotherapy drugs synergistically suppressed CRC development.Taken together,our results showed that the Agpat4/LPA axis in CRC cells regulated p38/p65 signaling-dependent macrophage polarization,T-cell activation,and CRC progression.The Agpat4/LPA/p38/p65 axis might represent a potential target for therapy in the clinic. | Dapeng Zhang Rongchen Shi Wei Xiang Xia Kang Bo Tang Chuan Li Linfeng Gao Xuan Zhang Lili Zhang Rongyang Dai Hongming Miao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 3 | Analysis of plasma proteome from cases of the different traditional Chinese medicine syndromes in patients with chronic hepatitis B显示文摘 | Youping Liu Peng Liu Rongyang Dai Jing Wang Yibin Zheng Jiyang Shen Fanghong Guo Leiqiong Wang Hong Li Mei Wei | 2011 | Journal of Pharmaceutical and Biomedical Analysis2011，，： | 1 |
| 4 | Overexpression of survivin is correlated with increased invasion and metastasis of colorectal cancer显示文摘 | Xiao‐YuanChu Long‐BangChen Jing‐HuaWang Quan‐ShengSu Ji‐RongYang YongLin Li‐JunXue Xiao‐BeiLiu Xiao‐BeiMo | 2012 | J. Surg. Oncol2012，，6： | 1 |
| 5 | Effectiveness Evaluation Study of Self-made Zinc Alloy Sacrificial Anode under Chloride Salt Erosion Environment显示文摘To investigate the effectiveness of self-made zinc alloy sacrificial anode material for the protection of reinforcement in concrete under chlorine salt erosion environment,salt solution immersion corrosion and electromigration accelerated corrosion tests were used to evaluate the effectiveness of self-made zinc alloy anode with the help of relevant cathodic protection guidelines and evaluation criteria for the corrosion of reinforcement in concrete.The results showed that the protection was effective because the potential of the zinc alloy anode protection steel bar in the salt solution satis?ed the“-780 mV(SCE)”validity criterion.The self-corrosion potential(E_(corr))of the sacri?cial anode protection steel in concrete was greater than-276 mV,and the protective current density of the zinc alloy anode was 1-3μA·cm^(-2),which met the standards of EN12696-2000,further indicating that the self-made zinc alloy sacri?cial anode had a good protection combining with the polarization resistance and the appearance of the corroded surface of the steel in concrete.The microscopic morphology of the corroded surface and the composition of the corrosion products indicates that the mortar of the self-made zinc alloy anode has a lower pH than the imported anodes,so the long-term protection of the selfmade zinc alloy sacri?cial anode needs to be further improved. | 南雪丽 JI Jianrui LI Rongyang CHEN Hao WANG Yi TANG Weibin | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，1： | 0 |
| 6 | Static Yield Stress of Cement-based Grouting Material under Different Rheological Modes显示文摘To quantitatively estimate the workability of cement-based grouting material,from the perspective of rheology,the result of the static yield stress evaluated using the rate-controlled and stress-controlled modes,respectively,was compared using the Rheowin rheometer.Also,the correlation of workability and solid concentration of slurry with static yield stress was studied.Results show that the static yield stress of cement-based grouting slurry relates to the established slurry structure,and is the shear stress corresponding to the transformation of elastics to plastics;In rate-controlled mode,the static yield stress of the slurry is related to the shear rate.The higher the shear rate,the greater the yield stress of the slurry.For the stress-controlled mode,the result is more accurate and suitable for testing static yield stress under different water-cement ratios.Since the water-cement ratio has a good correspondence with the static yield stress and the static yield stress has a good correspondence with the slump flow of the slurry,the static yield stress is the minimum stress to be overcome when the slurry begins to flow and it reflects the yield behavior and structural stability of the cement. | 南雪丽 CHEN Hao LI Rongyang JI Jianrui WANG Yi TANG Weibin | 2022 | Journal of Wuhan University of Technology(Materials Science)2022，37，5： | 0 |
| 7 | Targeting the ferroptosis crosstalk:novel alternative strategies for the treatment of major depressive disorder显示文摘Depression is a major contributor to poor global health and disability,with a recently increasing incidence.Although drug therapy is commonly used to treat depression,conventional antidepressant drugs have several disadvantages,including slow onset,low response rates and severe adverse effects.Therefore,developing effective therapies for depression remains challenging.Although various aetiological theories of depression exist,the underlying mechanisms of depression are complex,and further research is crucial.Moreover,oxidative stress(OS)-induced lipid peroxidation has been demonstrated to trigger ferroptosis.Both OS and ferroptosis are pivotal mechanisms implicated in the pathogenesis of neurological disorders,and investigation of the mediators involved in these processes has emerged as a prominent and active research direction.One previous study revealed that regulatory proteins involved in ferroptosis are implicated in the pathogenesis of depression,and antidepressant drugs could reverse depressive symptoms by inhibiting ferroptosis in vivo,suggesting an important role of ferroptosis in the pathogenesis of depression.Hence,our current comprehensive review offers an up-to-date perspective on the intricate mechanisms involved,specifically concerning ferroptosis and OS in the context of depression,along with promising prospects for using molecular mediators to target ferroptosis.We delineate the key targets of molecular mediators involved in OS and ferroptosis implicated in depression,most notably reactive oxygen species and iron overload.Considering the pivotal role of OS-induced ferroptosis in the pathogenesis of neurological disorders,delving deeper into the underlying subsequent mechanisms will contribute significantly to the identification of novel therapeutic targets for depression. | Luyao Wang Rongyang Xu Chengying Huang Guozhong Yi Zhiyong Li Huayang Zhang Rongxu Ye Songtao Qi Guanglong Huang Shanqiang Qu | 2023 | General Psychiatry2023，36，5： | 0 |
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