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| 1 | Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 expression in fibrotic rat liver显示文摘INTRODUCTIONLiver fibrosis is an excessive deposition ofextracellular matrix(ECM)resulted from bothincreased synthesis and decreased degradation.Matrix metalloproteinases(MMPs)represent agroup of neutral proteinases with variable | Liu HL Li XH Wang DY Yang SP | 2000 | World Journal of Gastroenterology2000，6，6： | 31 |
| 2 | Effects of endogenous beta-amyloid overproduction on tau phosphorylation in cell culture.显示文摘 | Wang ZF Li HL Li XC Zhang Q Tian Q Wang Q Xu H Wang JZ | 2006 | 中国生物学文摘2006，20，9： | 15 |
| 3 | Production of soybean isoflavone genistein in non-legume plants via genetically modified secondary metabolism pathway显示文摘 | Liu, RR Hu, YL Li, HL Lin, ZP | 2007 | 中国生物学文摘2007，21，10： | 15 |
| 4 | Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms.显示文摘 | Zhang YJ Xu YF Liu YIH Yin J Li HL Wang Q Wang JZ. | 2006 | 中国生物学文摘2006，20，9： | 10 |
| 5 | Novel functional proteins interact with midkine in hepatic cancer cells显示文摘BACKGROUND: Midkine is a heparin-binding growth factor that promotes the proliferation, survival, migration and differentiation of various target cells. Midkine plays an important role in tumorigenesis and tumor progression, and is overexpressed in many human malignant tumors. Patients with high tumor midkine expression frequently have a worse prognosis than those with low expression. The present study was designed to investigate the interaction network of midkine in hepatic cancer cells, and to elucidate its role in hepatocellular carcinoma. METHODS: DNA encoding full-length midkine was cloned into pDBLeu vector to serve as bait in yeast two-hybrid screening to identify interacting proteins. Candidate proteins were examined on SC-Leu-Trp-His+3-AT (20 mmol/L) plates and assayed for X-gal activity, then sequenced and classified according to the GenBank. Finally, identified proteins were expressed by the in vitro expression system pCMVTnT, and protein interactions were confirmed by co-immunoprecipitation. RESULTS: Using the yeast two-hybrid system, we found 6 proteins that interacted with midkine: NK-kappa-B inhibitor alpha (I-κ-B-α), Dvl-binding protein naked cuticle 2, granulin, latent active TGF-β binding protein 3, latent active TGF-β binding protein 4, and phospholipid scramblase 1. In vitro co-immunoprecipitation demonstrated that all identified proteins directly interacted with midkine.CONCLUSION: The identification of midkine-interacting proteins in hepatic cancer cells indicates that midkine is a multifunctional factor that may participate in cell migration, differentiation, and proliferation, and is also associated with the multicellular response feedback during the development of hepatocellular carcinoma. | Qiang Yan, Hui-Lian Huang, Xing Yao, Jing Li, Li-Qin Li, Jing Zhong, Li-Shan Min, Li-Cheng Dai and Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery, Huzhou Central Hospital (Yan Q and Yao X) Huzhou Key Laboratory of Molecular Medicine, Affiliated Central Hospital of Huzhou Teachers College (Huang HL, Li J, Li LQ, Zhong J, Min LS and Dai LC), Huzhou 313000, China Division of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Yan Q and Zheng SS) | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，3： | 7 |
| 6 | A transitory activation of protein kinase-A induces a sustained tau hyperphosphorylation at multiple sites in N2a cells-imply a new mechanism in Alzheimer pathology.显示文摘 | Zhang Y Li HL Wang DL Liu S J Wang JZ | 2006 | 中国生物学文摘2006，20，9： | 4 |
| 7 | 3D-QSAR STUDY ON HUPERZINE A ANALOGS WITH MOLECULAR MODELING AND COMPARATIVE MOLECULAR FIELD ANALYSIS(COMFA) METHODS显示文摘3D-QSARSTUDYONHUPERZINEAANALOGSWITHMOLECULARMODELINGANDCOMPARATIVEMOLECULARFIELDANALYSIS(COMFA)METHODS￥HuaLiangJIANG;KaiXianC... | Jiang, HL Chen, KX Chen, JZ Tang, Y Wang, QM Li, Q Shen, X Ji, RY | 1996 | Chinese Chemical Letters1996，7，3： | 2 |
| 8 | CYCLIC VOLTAMMETRY STUDY ON ANTIMALARIAL MECHANISM OF ARTEMISININ(QINGHAOSU)DERIVATIVES显示文摘CYCLICVOLTAMMETRYSTUDYONANTIMALARIALMECHANISMOFARTEMISININ(QINGHAOSU)DERIVATIVES￥HuaLiangJIANG;KaiXianCHEN;YunTANG;JianZhongC... | Jiang, HL Chen, KX Tang, Y Chen, JZ Li, Y Wang, QM Li, Q Ji, RY Zhuang, QK | 1996 | Chinese Chemical Letters1996，7，7： | 2 |
| 9 | The gain-of-function 17: a double-edged sword between thrombosis and bleeding in clopidogrel-treated patients 显示文摘 | Li Y Tang HL Hu YF variant allele CYP2C19 * | 2012 | J Thromb Haemost2012，10，2： | 1 |
| 10 | Supine lithotomy venus prone position in minimally invasive percutaneous nephrolithotomy for upper urinary tract calculi显示文摘 | Zhan HL Li ZC Zhou XF | 2013 | Urol Int2013，91，3： | 1 |
| 11 | Expression of E2F3, miR-17-5p, miR-20a and their interplay in bladder cancer显示文摘 | Ren HL SunY Li XN | 2011 | AFR J Biotecbn- ol2011，10，11： | 1 |
| 12 | Mechanism of protective ac- tion of bicycle against CC14 induced liver injury in mice显示文摘 | Liu GT Li Y Wei HL | 2005 | Liver Int2005，25，3： | 1 |
| 13 | Tyrosine nitrationof prostacyclin synthase is associated with enhancedretinal cell apoptosis in diabetes显示文摘 | Zou MH Li HL He CY | 2011 | Ame J Pathol2011，179，： | 1 |
| 14 | Severe fever with thrombocytopenia virus glycoproteins are targeted by neutralizing antibodies and can use DC-SIGN as a receptor for pH-dependent entry into human and animal cell lines显示文摘 | Hofmann H Li X X Zhang X A Liu W Kühl A Kaup F Soldan S S González-Scarano F Weber F He Y X Phlmann S | 2013 | J Virol2013，87，8： | 1 |
| 15 | protective effect of Ast- agaloside on focal cerebral ischemia/reperfusion injury in rats显示文摘 | Yin YY Li WP Gong HL | 2010 | Am J Chin Med2010，38，3： | 1 |
| 16 | Haloperidol prophylaxis decreases delirium incidence in elderly patients after noncardiac surgery: a randomized controlled trial 显示文摘 | Wang W Li HL Wang DX | 2012 | Crit Care Med2012，40，3： | 1 |
| 17 | Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C heads to hyperphosphorylation of Tau and impairment of spatial memory显示文摘 | Liu SJ Zhang AH Li HL | 2003 | Neurochem2003，87，6： | 1 |
| 18 | IVF results in de novo DNA methylation and histonc metylation at an Igf2-H19 imprinting epigenetic switch 显示文摘 | Li T Vu TH Ulaner GA Littman E Ling JQ Chen HL | 2005 | Mol Hum Reprod2005，11，9： | 1 |
| 19 | Phosphorylation of tau antagonizes apoptosis by stabilizing beta-catenin,a mechanism involved in Alzheimer's neurodegeneration显示文摘 | Li HL Wang HH Liu SJ | 2007 | Proc Natl Acad Sci USA2007，104，： | 1 |
| 20 | Analysis of overall survival from a phase Ⅲ study of ixabepilone plus capecitabine versus capecitabine in patients with MBC resistant to anthracyclines and taxanes显示文摘 | Hortobagyi GN Gomez HL Li RK | 2010 | Breast Cancer Res Treat2010，122，2： | 1 |
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