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| 1 | IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice显示文摘The gut microbiota plays a key role in obesity and related metabolic disorders, and multiple factors including diet, host genotype, and age regulate it. Many studies have examined the contribution of extrinsic factors to the regulation of the gut microbiota, but the importance of the host genetic constitution cannot be ignored. Interleukin 17A(IL-17A), a pro-inflammatory cytokine, is important in the defense against infection and diseases. Here, we investigated the association among IL-17, a high-fat diet(HFD), and the gut microbiota. Mice deficient in IL-17A were resistant to diet-induced obesity and related diseases. Compared with the Ⅱ-17^(-/-)mice, wild-type(WT) mice challenged with HFD showed obvious weight fluctuations, such as those seen in type 2 diabetes, and hematological changes similar to those associated with metabolic syndrome. However, housing WT mice and Ⅱ-17a^(-/-)mice together significantly alleviated these symptoms in the WT mice. A metagenomic analysis of the mouse feces indicated that the microbial community compositions of these two groups differed before HFD feeding. The HFD mediated shifts in the gut microbial compositions, which were associated with the mouse phenotypes.We also identified potentially beneficial and harmful species present during this period, and drew networks of the most abundant species. A functional analysis indicated pathway changes in the WT and Ⅱ-17a^(-/-)mice when fed the HFD. Collectively, these data underscore the importance of the host factor IL-17 A in shaping and regulating the gut microbiota, which conversely, influences the host health. | Yujing Bi Chunxiao Li Lin Liu Jiyuan Zhou Zhengchao Li Huimin Deng Chunyan Wu Yanping Han Yajun Song Yafang Tan Xiaoyi Wang Zongmin Du Yujun Cui Yanfeng Yan Fachao Zhi Guangwei Liu Nan Qin Heping Zhang Ruifu Yang | 2017 | Science Bulletin2017，62，15： | 5 |
| 2 | Research on the 3PL Supplier Selection Based on Set-Val- ued Satisfaction显示文摘 | Fachao Li Ling Li Chenxia Jin Ruijiang Wang Hong Wang | 2012 | Computers and Operations Research2012，39，8： | 1 |
| 3 | Fuzzy metric and convergences based on the symmetric difference 显示文摘 | Wu Congxin Li Fachao | 1999 | Fuzzy Sets ana Systems1999，108，3： | 1 |
| 4 | The completeness for p-mean symmetric difference metric 显示文摘 | Li Fachao Qiu Jiqing Zhai Jianren | 2000 | Fuzzy Sets and Systems2000，116，3： | 1 |
| 5 | Fuzzy metric and convergences based on the symmetric difference 显示文摘 | Wu Congxin LI Fachao | 1999 | Fuzzy Sets ana Systems1999，108，3： | 1 |
| 6 | Intelligent Bionic Genetic Algorithm (IB-GA) and its convergence显示文摘 | Li Fachao Xu Lida Jin Chenxia | 2011 | Expert Systems with Applications2011，38，7： | 1 |
| 7 | A few measures for ensuring supply chain quality显示文摘 | Li Zhang Wang Song Li Fachao | | 0，，01： | 1 |
| 8 | A generalized fuzzy ID3 algorithm using generalized information entropy显示文摘 | JIN CHENXIA LI FACHAO LI YAN | 2014 | Knowledgebased Systems2014，64，7： | 1 |
| 9 | Structure of Multi-Stage Composite Genetic Algorithm (MSC-GA) and its performance 显示文摘 | Li Fachao Xu Li Da Jin Chenxia | 2011 | Expert Systems with Applications2011，38，7： | 1 |
| 10 | The application of generating fuzzy ID3 algorithm in performance evaluation显示文摘 | LI Yan JIANG Dandan LI Fachao | | 0，，29： | 1 |
| 11 | Genetic and Functional Differences of Escherichia coli Strains from Colorectal Cancer Mucosal Tissues显示文摘Colorectal cancer(CRC)is the third leading cancer globally.Metagenomics has been widely used to analyze the association between the gut microbiota and CRC based on bacterial genus-or species-level comparisons,providing evidence of dysbiosis in CRC development.However,this kind of analysis is unable to provide strain-level information for understanding the individual role of a species in CRC.Here,we used culturomics to isolate CRC mucosal samples and selected 158 Escherichia coli strains to reveal their differences in both genomics and functions by means of phylogenetic analysis and inflammatory induction based on cell and animal experiments.Through genomic comparison,these strains were divided into five phylogroups.The representative strains of each phylogroup significantly induced different levels of cytokine secretion by human leukemic monocyte(THP-1 cell)-based Transwell and animal experiments.Further bioinformatic analysis revealed different profiles of single-nucleotide polymorphisms,genes,and metabolic pathways in the different phylogroups,which can improve the current understanding of the phenotypic differences between these strains.The strain differences revealed in both genomics and functions indicate that the microbiota’s function at the strain level should be investigated in order to understand the interacting mechanisms between hosts and gut bacteria. | Yuxiao Chang Xiang Li Lei Ding Chao Yang Zhiyuan Pan Ni Han Yujun Cui Fachao Zhi Ruifu Yang Hong Gao Yujing Bi | 2022 | Engineering2022，，9： | 0 |
| 12 | Recent developments in electrosynthesis of nitriles and electrocatalytic cyanations显示文摘Nitrile compounds are a class of high-value chemicals and versatile intermediates which can easily be transformed into a variety of useful products bearing functional groups such as carboxyl, carbamoyl, aminomethyl, ketyl and heterocyclic derivatives. Various thermal catalytic cyanation procedures have been devised and scaled up industrially while developing alternative methods are actively pursued. The access to these classes of molecules electrochemically offers greener alternatives to their preparation. The development of electrochemical synthesis of cyano-containing compounds under mild conditions with low energy consumption will imminently become indispensable approaches for industrial production of nitriles. The electrochemical cyanation presents many challenges from the toxicity of cyanide to the development of catalysts and the design of electrochemical cells. Electrochemical cyanation reaction offers promise to conveniently accessing nitriles but still requires efficient electro-catalysts, safe protocols and scale up considerations. This review discusses recent progress in the field of electrochemical synthesis of nitrile compounds placing emphasis on electro-synthetic and electro-catalytic mechanism aspects while making reference to original works to highlight the progress in this area. | Haiyan Hu Shanxuan Wu Fachao Yan Mohamed Makha Yuxia Sun Chen-Xia Du Yuehui Li | 2022 | Journal of Energy Chemistry2022，31，7： | 0 |
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