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| 1 | Ideal cardiovascular health and incidence of atherosclerotic cardiovascular disease among Chinese adults:the China-PAR project显示文摘Existing evidence on the relationship between cardiovascular health(CVH) metrics and cardiovascular disease(CVD) was primarily derived from western populations. We aimed to evaluate the benefits of ideal CVH metrics on preventing incident atherosclerotic CVD(ASCVD) in Chinese population. This study was conducted among 93,987 adults from the China-PAR project(Prediction for ASCVD Risk in China) who were followed up until 2015. Cox proportional hazard regression models were used to estimate the hazard ratios(HRs) and their corresponding 95% confidence intervals(CIs) of CVH metrics for the risk of ASCVD, including coronary heart disease(CHD), stroke and ASCVD death. We further estimated the population-attributable risk percentage(PAR%) of these metrics in relation to each outcome. We observed gradient inverse associations between the number of ideal CVH metrics and ASCVD incidence. Compared with participants having ≤2 ideal CVH metrics, the multivariable-adjusted HRs(95% CIs) of ASCVD for those with 3, 4, 5, 6 and 7 ideal CVH metrics were 0.83(0.74–0.93), 0.66(0.59–0.74), 0.55(0.48–0.61), 0.44(0.38–0.50) and 0.24(0.18–0.31), respectively(P for trend <0.0001). Approximately 62.1% of total ASCVD, 38.7% of CHD, 66.4% of stroke, and 60.5% of ASCVD death were attributable to not achieving all the seven ideal CVH metrics. After adjusting effects of ideal health factors, having four ideal health behaviors could independently bring adults health benefits in preventing 17.4% of ASCVD, 18.0% of CHD, 16.7% of stroke, and 10.1% of ASCVD death. Among all the seven CVH metrics, to keep with ideal blood pressure(BP) implied the largest public health gains against various ASCVD events(PAR% between 33.0% and 47.2%), while ideal diet was the metric most difficult to be achieved in the long term. Our study indicates that the more ideal CVH metrics adults have, the less ASCVD burden there is in China. Special efforts of health education and behavior modification should be made on keeping ideal BP and dietary habits in general Chinese population to prevent the epidemic of ASCVD. | Chao Han Fangchao Liu Xueli Yang Jichun Chen Jianxin Li Jie Cao Ying Li Chong Shen Ling Yu Zhendong Liu Xianping Wu Liancheng Zhao Dongshen Hu Xiangfeng Lu Xigui Wu Dongfeng Gu | 2018 | Science China(Life Sciences)2018，61，5： | 60 |
| 2 | Changes in intestinal mucosal immune barrier in rats with endotoxemia显示文摘AIM:To investigate the dysfunction of the immunological barrier of the intestinal mucosa during endotox-emia and to elucidate the potential mechanism of this dysfunction.METHODS:Male Wistar rats were randomly distributed into two groups:control group and lipopolysaccharide(LPS)group.Endotoxemia was induced by a single caudal venous injection of LPS.Animals were sacrifi ced in batches 2,6,12 and 24 h after LPS infusion.The number of microfold(M)-cells,dendritic cells(DCs),CD4+ T cells,CD8+ T cells,regulatory T(Tr)cells and IgA+ B cells in the intestinal mucosa were counted after immunohistochemical staining.Apoptotic lympho-cytes were counted after TUNEL staining.The levels of interleukin(IL)-4,interferon(IFN)-γ and forkhead box P3(Foxp3)in mucosal homogenates were measured by ELISA.The secretory IgA(sIgA)content in the total protein of one milligram of small intestinal mucus was detected using a radioimmunological assay.RESULTS:This research demonstrated that LPS-induced endotoxemia results in small intestinal mucosa injury.The number of M-cells,DCs,CD8+ T cells,and IgA+ B cells were decreased while Tr cell and apoptotic lymphocyte numbers were increased signifi cantly.The number of CD4+ T cells increased in the early stages and then slightly decreased by 24 h.The level of IL-4 significantly increased in the early stages and then reversed by the end of the study period.The level of IFN-γ increased slightly in the early stages and then decreased markedly by the 24 h time point.Level of Foxp3 increased whereas sIgA level decreased.CONCLUSION:Mucosal immune dysfunction forms part of the intestinal barrier injury during endotoxemia.The increased number and function of Tr cells as well as lymphocyte apoptosis result in mucosal immunodefi ciency. | Chong Liu Ang Li Yi-Bing Weng Mei-Li Duan Bao-En Wang Shu-Wen Zhang | 2009 | World Journal of Gastroenterology2009，15，46： | 35 |
| 3 | Treatment outcomes for different subgroups of nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy显示文摘Although many studies have investigated intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC),sample sizes in the reported studies are usually small and different in outcomes in different T and N subgroups are seldom analyzed.Herein,we evaluated the outcomes of NPC patients treated with IMRT and further explored treatment strategy to improve such outcome.We collected clinical data of 865 NPC patients treated with IMRT alone or in combination with chemotherapy,and classified all cases into the following prognostic categories according to different TNM stages:early stage group (T1-2N0-1M0),advanced local disease group (T3-4N0-1M0),advanced nodal disease group (T1-2N2-3M0),and advanced locoregional disease group (T3-4N2-3M0).The 5-year overall survival (OS),local relapse-free survival (LRFS),and distant metastases-free survival (DMFS) were 83.0%,90.4%,and 84.0%,respectively.The early disease group had the lowest treatment failure rate,with a 5-year OS of 95.6%.The advanced local disease group and advanced nodal disease group had similar failure pattern and treatment outcomes as well as similar hazard ratios for death (4.230 and 4.625,respectively).The advanced locoregional disease group had the highest incidence of relapse and death,with a 5-year DMFS and OS of 62.3% and 62.2%,respectively,and a hazard ratio for death of 10.402.Comparing with IMRT alone,IMRT in combination with chemotherapy provided no significant benefit to locoregionally advanced NPC.Our results suggest that the decision of treatment strategy for NPC patients should consider combinations of T and N stages,and that IMRT alone for early stage NPC patients can produce satisfactory results.However,for advanced local,nodal,and locoregional disease groups,a combination of chemotherapy and radiotherapy is recommended. | Sheng-Fa Su 1,2,3,Fei Han 1,2,Chong Zhao 1,2,Ying Huang 1,2,Chun-Yan Chen 1,2,Wei-Wei Xiao 1,2,Jia-Xin Li 1,2 and Tai-Xiang Lu 1,2 1 State Key Laboratory of Oncology in South China,Guangzhou,Guangdong 510060,P.R.China 2 Department of Radiation Oncology,Sun Yat-sen University Cancer Center,Guangzhou,Guangdong 510060,P.R.China 3 Department of Oncology,Guiyang Medical College Hospital,Tumor Hospital of Guizhou,Guiyang,Guizhou 550003,P.R.China. | 2011 | Chinese Journal of Cancer2011，30，8： | 40 |
| 4 | Lushan M_S7.0 earthquake:A blind reserve-fault event显示文摘In the epicenter of the Lushan MS7.0 earthquake there are several imbricate active reverse faults lying from northwest to southeast,namely the Gengda-Longdong,Yanjing-Wulong,Shuangshi-Dachuan and Dayi faults.Emergency field investigations have indicated that no apparent earthquake surface rupture zones were located along these active faults or their adjacent areas.Only brittle compressive ruptures in the cement-covered pavements can be seen in Shuangshi,Taiping,Longxing and Longmen Townships,and these ruptures show that a local crustal shortening occurred in the region during the earthquake.Combining spatial distribution of the relocated aftershocks and focal mechanism solutions,it is inferred that the Lushan earthquake is classified as a typical blind reverse-fault earthquake,and it is advised that the relevant departments should pay great attention to other historically un-ruptured segments along the Longmenshan thrust belt and throughout its adjacent areas. | XU XiWei WEN XueZe HAN ZhuJun CHEN GuiHua LI ChuanYou ZHENG WenJun ZHNAG ShiMin REN ZhiQun XU Chong TAN XiBin WEI ZhanYu WANG MingMing REN JunJie HE ZhongTai LIANG MingJian | 2013 | Chinese Science Bulletin2013，58，28： | 35 |
| 5 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 6 | Heterotrimeric G protein α subunit is involved in rice brassinosteroid response显示文摘Heterotrimeric G proteins are known to function as messengers in numerous signal transduction pathways.The nullmutation of RGA(rice heterotrimeric G protein α subunit),which encodes the α subunit of heterotrimeric G proteinin rice,causes severe dwarfism and reduced responsiveness to gibberellic acid in rice.However,less is known aboutheterotrimeric G protein in brassinosteroid(BR)signaling,one of the well-understood phytohormone pathways.In thepresent study,we used root elongation inhibition assay,lamina inclination assay and coleoptile elongation analysis todemonstrated reduced sensitivity of dl mutant plants(caused by the null mutation of RGA)to 24-epibrassinolide(24-epiBL),which belongs to brassinosteroids and plays a wide variety of roles in plant growth and development.Moreover,RGA transcript level was decreased in 24-epiBL-treated seedlings in a dose-dependent manner.Our results show thatRGA is involved in rice brassinosteroid response,which may be beneficial to elucidate the molecular mechanisms of Gprotein signaling and provide a novel perspective to understand BR signaling in higher plants. | Lei Wang Yun-Yuan Xu Qi-Bin Ma Dan Li Zhi-Hong Xu Kang Chong | 2006 | Cell Research2006，16，12： | 29 |
| 7 | Overexpression of PGA37/MYB118 and MYB115 promotes vegetative-to-embryonic transition in Arabidopsis显示文摘从 non-germline 房间的体的胚胎的形成对更高的植物唯一并且能被操作在许多种类。以前的研究表明包括 WUSCHEL (WUS )/PLANT 生长 ACTIVATOR6 (PGA6 ) ,几 Arabidopsis 基因的 overexpression 纵容繁荣,叶状的 COTYLEDON1 (LEC1 ) ,和 LEC2,能引起 vegetative-to-embryonic 转变或体的胚胎的形成。这里,我们报导那在 Arabidopsis PGA37 基因的一个 gain-of-function 变化,编码 MYB118 抄写因素,导致的 vegetative-to-embryonic 转变,从根将生物的活组织移植于培养基中培养的体的胚胎的形成,和提高的 LEC1 表示水平。两倍变异的分析证明 WUS 没被 PGA37/MYB118 为体的胚胎的正式就职要求。另外, MYB115 的 overexpression, PGA37/MYB118 的一个相当或相同的事物,引起了象 pga37 一样显型。两倍异种没显示出的 myb118 myb115 明显的发展畸形。一起,这些结果建议 PGA37/MYB118 和 MYB115 支持 vegetative-to-embryonic 转变,通过 WUS 的一个发信号的小径独立人士。 | Xingchun wang Qi-Wen Niu Chong Teng Chao Li Jinye Mu Nam-Hai Chua Jianru Zuo | 2009 | Cell Research2009，19，2： | 30 |
| 8 | Predicting lifetime risk for developing atherosclerotic cardiovascular disease in Chinese population:the China-PAR project显示文摘Evidence on the lifetime risk for atherosclerotic cardiovascular disease(ASCVD) is insufficient;yet,estimating an individual's lifetime risk allows for a comprehensive assessment of ASCVD burden.We developed and validated lifetime risk prediction equations for ASCVD using four large and ongoing prospective cohorts of Chinese,the China-PAR project(Prediction for ASCVD Risk in China).Sexspecific equations were developed using two cohorts(as the derivation cohort) of 21,320 participants.Two other independent cohorts with 14,123 and 70,838 participants were used for their external validation,respectively.We evaluated both calibration and discrimination measures for model performance.Furthermore,we estimated ASCVD-free years lost or excess absolute risk attributable to high 10-year risk(!10.0%) and/or high lifetime risk(!32.8%).After 12.3 years' follow-up of the derivation cohort,1048 ASCVD events and 1304 non-ASCVD deaths were identified.Our sex-specific equations had good internal validation,with discriminant C statistics of 0.776(95% confidence interval [CI]:0.757–0.794) and 0.801(95% CI:0.778–0.825),and calibration χ~2 of 9.2(P = 0.418) and 5.6(P = 0.777) for men and women,respectively.Good external validation was also demonstrated with predicted rates closely matched to the observed ones.Compared with men having both low 10-year and low lifetime risk,men would develop ASCVD 3.0,4.6 and 8.6 years earlier if they had high 10-year risk alone,high lifetime risk alone,or both high 10-year and high lifetime risk at the index age of 35 years,respectively.We developed wellperformed lifetime risk prediction equations that will help to identify those with the greatest potential to avert ASCVD burden after implementation of innovative clinical and public health interventions in China. | Fangchao Liu Jianxin Li Jichun Chen Dongsheng Hu Ying Li Jianfeng Huang Xiaoqing Liu Xueli Yang Jie Cao Chong Shen Ling Yu Zhendong Liu Xianping Wu Liancheng Zhao Xigui Wu Dongfeng Gu Xiangfeng Lu | 2018 | Science Bulletin2018，63，12： | 30 |
| 9 | Effect of specimen size on energy dissipation characteristics of red sandstone under high strain rate显示文摘In this experiment, red sandstone specimens, having slenderness ratios of 0.5, 0.7, 0.9 and 1.1 respectively, were subjected to blow tests using a Split Hopkinson Pressure Bar(SHPB) system at a pressure of 0.4 atmospheres. In this paper, we have analyzed the effect of slenderness ratio on the mechanical properties and energy dissipation characteristics of red sandstone under high strain rates. The processes of compaction, elastic deformation and stress softening deformation of specimens contract with an increase in slenderness ratio, whilst the nonlinear deformation process extends correspondingly. In addition, degrees of damage of specimens reduced gradually and the type of destruction showed a transformation trend from stretching failure towards shear failure when the slenderness ratio increased. A model of dynamic damage evolution in red sandstone was established and the parameters of the constitutive model at different ratios of length to diameter were determined. By comparison with the experimental curve, the accuracy of the model, which could reflect the stress–strain dynamic characteristics of red sandstone, was verified. From the view of energy dissipation, an increase in slenderness ratio of a specimen decreased the proportion of energy dissipation and caused a gradual fall in the capability of energy dissipation during the specimen failure process. To some extent, the study indicated the effects of slenderness ratios on the mechanical properties and energy dissipation characteristics of red sandstone under the high strain rate, which provides valuable references to related engineering designs and academic researches. | Li Ming Mao Xianbiao Lu Aihong Tao Jing Zhang Guanghui Zhang Lianying Li Chong | 2014 | International Journal of Mining Science and Technology2014，24，2： | 24 |
| 10 | Laser cleaning of steel structure surface for paint removal and repaint adhesion显示文摘Paint removal from steel structure is executed for shipyards of marine and offshore engineering.Due to environmental unfriendliness and unhealthy drawbacks of sand blasting technique, laser ablation technique is proposed as a substituting method.By absorbing high energy of the 1064 nm pulsed laser, the paint is vaporized quickly.The ablated debris is then collected by using a suction pump.Initial metal surface of the steel is exposed when laser beam irradiates perpendicularly and scans over it.The cleaned surface fulfills the requirements of surface preparation standards ISO 8501 of SA2.The adhesion is further characterized with pull-off test after carrying out painting with Jotamastic 87 aluminum paint.The repainting can be embedded onto the laser cleaned surface to bond much more tightly.The excellent adhesion strength of 20 MPa between repainted coating and the substrate is achieved, which is higher than what is required by shipyards applications. | Xiaoguang Li Tingting Huang Ang Wei Chong Rui Zhou Yoo Sang Choo Minghui Hong | 2017 | 光电工程2017，44，3： | 24 |
| 11 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 12 | Flow Characteristics Diagnosis and Optimization for Dust Collectors Inflow Duct in Thermal Power Plants显示文摘火电厂烟风道用于输送烟气、冷风等介质,其设计优化水平不但影响火电厂烟风系统阻力的大小,而且影响与烟风道直接相连的各个设备的运行状态。某600MW机组除尘器前烟道设计不合理,存在磨损严重、进入除尘器烟气分配不均等问题,文中采用标准缸￡模型,利用Fluent求解器对该部分烟道的流场进行数值计算,诊断分析其存在的主要问题,提出的3个改造方案均可使烟道阻力大幅度下降、烟道磨损减轻、进入除尘器烟气分配均匀。同时,研究了缓转半径及烟气流速对该段烟道阻力和烟气分配的影响情况,计算结果表明该段烟道缓转半径宜选在0.875以上,烟气流速对该段烟道的性能基本没有影响。 | LIU Ming MENG Guixiang YAN Junjie CHEN Weixiong LI Weidong CHONG Daotong LIU Jiping | 2013 | 中国电机工程学报2013，33，11： | 22 |
| 13 | Parameters optimum matching of pure electric vehicle dual-mode coupling drive system显示文摘As an important development direction of pure electric vehicle drive system,the distributed drive system has the advantages of compact structure,high transmission efficiency,and flexible control,but there are some serious problems such as high performance requirements to the drive motors,complex control strategies,and poor reliability.To solve these problems,a two motors dual-mode coupling drive system has been developed at first,which not only has the capacity of two-speed gear shifting,but also can automatically switch between the distributed drive and the centralized drive by means of modes change control.So,the performance requirements to the drive motors can be reduced,the problem of abnormal running caused by the fault of unilateral distributed drive systems also can be resolved by replacing the drive mode with centralized drive.Then,the system parameters primary and the optimum matching under the principle of efficiency optimization have been carried out,which makes the drive system achieve predetermined functions and meet the actual demands of different operating statuses.At last,the economic comparison of a pure electric vehicle installation with a dual-mode coupling drive sytem,a single-motor centralized drive system or a dual-motor distributed drive system in the simulation conditions has been completed.Compared with other systems,the driving range of the electric vehicle driven by the designed system is significantly increased,which proves the better efficiency and application value of the system. | ZHANG LiPeng LI Liang QI BingNan WANG Chong ZHANG YaHui SONG Jian | 2014 | Science China(Technological Sciences)2014，57，11： | 22 |
| 14 | Lithium–matrix composite anode protected by a solid electrolyte layer for stable lithium metal batteries显示文摘Lithium (Li) metal with an ultrahigh specific theoretical capacity and the lowest reduction potential is strongly considered as a promising anode for high-energy-density batteries. However, uncontrolled lithium dendrites and infinite volume change during repeated plating/stripping cycles hinder its practical applications immensely. Herein, a house-like Li anode (housed Li) was designed to circumvent the above issues. The house matrix was composed of carbon fiber matrix and affords a stable structure to relieve the volume change. An artificial solid electrolyte layer was formed on composite Li metal, just like the roof of a house, which facilitates uniform Li ions diffusion and serves as a physical barrier against electrolyte corrosion. With the combination of solid electrolyte layer and matrix in the composite Li metal anode, both dendrite growth and volume expansion are remarkably inhibited. The housed Li|LiFePO4 batteries exhibited over 95% capacity retention after 500 cycles at 1.0 C in coin cell and 85% capacity retention after 80 cycles at 0.5 C in pouch cell. The rationally combination of solid electrolyte layer protection and housed framework in one Li metal anode sheds fresh insights on the design principle of a safe and long-lifespan Li metal anode for Li metal batteries. | Xin Shen Xinbing Cheng Peng Shi Jiaqi Huang Xueqiang Zhang Chong Yan Tao Li Qiang Zhang | 2019 | Journal of Energy Chemistry2019，28，10： | 23 |
| 15 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 16 | Therapy for acute pancreatitis with platelet-activating factor receptor antagonists显示文摘Acute pancreatitis (AP) causes release of platelet- activating factor (PAF), which induces systemic effects that contribute to circulatory disturbances and multiple organ failure. PAF is a cell surface secretion of bioactive lipid, which could produce physiological and pathological effects by binding to its cell surface receptor called platelet-activating factor receptor (PAF-R). Studies showed that PAF participates in the occurrence and development of AP and administration of platelet-activating factor receptor antagonists (PAF-RAs) could significantly reduce local and systemic events after AP. PAF has also been implicated as a key mediator in the progression of severe AP, which can lead to complications and unacceptably high mortality rates. Several classes of PAF-RA show PAF- RAs significant local and systemic effects on reducing inflammatory changes. As a preventive treatment, PAF-RA could block a series of PAF-mediated inflammatory injury and thus improve the prognosis of AP. This review introduces the important role of PAF-RA in the treatment of AP. | Chong Chen Shi-Hai Xia Hong Chen Xiao-Hong Li | 2008 | World Journal of Gastroenterology2008，14，30： | 21 |
| 17 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 18 | Gastric Lgr5+ stem cells are the cellular origin of invasive intestinal-type gastric cancer in mice显示文摘 | Xiu-Bin Li Guan Yang Liang Zhu Yu-Ling Tang Chong Zhang Zhenyu Ju Xiao Yang Yan Teng | 2016 | Cell Research2016，26，7： | 20 |
| 19 | Applications of HPLC/MS in the analysis of traditional Chinese medicines显示文摘In China,traditional Chinese medicines(TCMs)have been used in clinical applications for thousands of years.The successful hyphenation of high-performance liquid chromatography(HPLC)and mass spectrometry(MS)has been applied widely in TCMs and biological samples analysis.Undoubtedly,HPLC/MS technique has facilitated the understanding of the treatment mechanism of TCMs.We reviewed more than 350 published papers within the last 5 years on HPLC/MS in the analysis of TCMs.The present review focused on the applications of HPLC/MS in the component analysis,metabolites analysis,and pharmacokinetics of TCMs etc.50% of the literature is related to the component analysis of TCMs,which show that this field is the most popular type of research.In the metabolites analysis,HPLC coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry has been demonstrated to be the powerful tool for the characterization of structural features and fragmentation behavior patterns.This paper presented a brief overview of the applications of HPLC/MS in the analysis of TCMs.HPLC/MS in the fingerprint analysis is reviewed elsewhere. | Miao Li Xiao- Fang Hou Jie Zhang Si-Cen Wang Qiang Fu Lang- Chong He | 2011 | Journal of Pharmaceutical Analysis2011，1，2： | 17 |
| 20 | A Possible Dynamic Mechanism for Rapid Production of the Extreme Hourly Rainfall in Zhengzhou City on 20 July 2021显示文摘In this study,the unprecedented extreme rainfall event during 19-20 July 2021,which caused devastating flooding in Zhengzhou City and its nearby areas,is examined based on observational data analysis and WRF model 40-h simulations on 1-km horizontal resolution.The results show that the model successfully reproduces(i)major synopticscale weather systems(i.e.,the western Pacific subtropical high,the Tibetan high,two typhoons,and the Huang-Huai cyclone),(ii)convective initiation along the east to north edge of the Songshan Mountain,where orographic lifting is obvious,and(iii)subsequent formation of the convective storm producing the extreme rainfall in Zhengzhou.In particular,the model generates the maximum rainfall rate of 233 mm h^(-1)and 40-h accumulated rainfall of 704 mm,corresponding well to the observed extreme values of 201.9 mm h^(-1)and 818 mm,at nearly observed timing and location.Importantly,the model reproduces an intense quasi-stationary,well-organized meso-γ-scale convective system,surrounded by an arc-shaped convergence zone,allowing the development of convective updrafts in a three-quarter circle around the convective system,in a way similar to“multidirectional pumping,”attracting all associated precipitation overlaid and concentrated into the same trailing region to generate the extreme hourly rainfall over Zhengzhou.Our study emphasizes the significant contribution of the unique dynamic structure of the well-organized meso-γ-scale convective system to the record-high hourly rainfall.A possible dynamic mechanism for short-time extreme rainfall production is proposed.That is,the arc-shaped convergence zone of the mesoscale convective system,acting like multidirectional lifting pumps,transports precipitation from different directions into the same region,and thus produces the extreme rainfall.The results gained herein may shed new light on better understanding and forecasting of short-time extreme rainfall. | Jinfang YIN Haodong GU Xudong LIANG Miao YU Jisong SUN Yanxin XIE Feng LI Chong WU | 2022 | Journal of Meteorological Research2022，36，1： | 17 |
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