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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study显示文摘 | Shamir R Mehta Salim Yusuf Ron JG Peters Michel E Bertrand Basil S Lewis Madhu K Natarajan Klas Malmberg Hans-Jürgen Rupprecht Feng Zhao Susan Chrolavicius Ingrid Copland Keith AA Fox | 2001 | The Lancet . 2001 (9281)2001，，9281： | 4 |
| 3 | Prevalence of anxiety and depression in patients with severe COPD: similar high levels with and without LTOT 显示文摘 | LEWIS K E ANNANDALE J A SYKES R N | 2007 | COPD2007，4，4： | 1 |
| 4 | Toxicity comparison of biosurfactants and synthetic surfactants used in oil spill remediation to two estuarine species显示文摘 | Edwards K R Lepo J E Lewis M A | 2003 | Marine Pollution Bulletin2003，46，10： | 1 |
| 5 | Practical considerations and capabili- ties for laser assisted direct metal deposition 显示文摘 | Lewis G K Schlienger E | 2002 | Materials and Design2002，，1： | 1 |
| 6 | Naturally occurring hy-pothermia is more advantageous than fever in severe forms oflipopolysaccharide-and Escherichia coli-induced systemic in-flammation 显示文摘 | Liu E Lewis K Al-Saffar H | 2012 | Am J Physiol Regul Integr Comp Physiol2012，302，12： | 1 |
| 7 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 8 | Detection of Lewis antigen structural change by FTIR spectroscopy显示文摘 | LEWIS A T JONES K LEWIS K E | 2013 | Carbohydrate Polymers2013，92，2： | 1 |
| 9 | A Bayesian method for analysis of genetic population structure with dominant marker data 显示文摘 | HOLSINGER K E LEWIS P O DEY D K | 2002 | Molecular Ecology2002，11，： | 1 |
| 10 | Planar cell polarity acts through septins to control collective cell movement and ciliogenesis显示文摘 | Kim S K Shindo A Park T J Oh E C Ghosh S Gray R S Lewis R A Johnson C A | | 0，，5997： | 1 |
| 11 | Assess- ment of rich-burn, quick-mix, lean-burn (RQL) trapped vortex combustor for stationary gas turbines 显示文摘 | Straub D L Casleton K H Lewis R E | 2005 | Transactions of the ASME2005，，127： | 1 |
| 12 | The impact of recipient list size and priority signs on electronic helping behavior显示文摘 | Lewis C E Thompson L F Wuensch K L | 2004 | Computers in Human Behavior2004，20，5： | 1 |
| 13 | Carcinoma expleomorphic adenoma: a clinicopathologic review显示文摘 | Olsen K D Lewis J E | 2001 | Head Neck2001，23，9： | 1 |
| 14 | Flexible polymer-embedded Si wire arrays 显示文摘 | Plass K E Filler M A Spurgeon J M Kayes B M Maldo- nado S Brunschwig B S Atwater H A Lewis N S | 2009 | Advanced Materials2009，21，32： | 1 |
| 15 | Combined RAPD and RFLP molecular linkage map of asparagus显示文摘 | Jiang C Lewis M E Sink K C | 1997 | Genome1997，40，： | 1 |
| 16 | Carcinoma ex pleomorphic adenoma: pathologic analysis of 73 cases 显示文摘 | Lewis J E Olsen K D Sebo T J | 2001 | Hum Pathol2001，32，6： | 1 |
| 17 | Effect of direct-fed fibrolytic enzymes on the digestive characteristic of a forage-based diet fed to beef steers显示文摘 | LEWIS G E SANCHAZ W K | 1996 | Journal of Animal Science1996，74，： | 1 |
| 18 | Sequence ontologyannotationguide显示文摘 | Eilbeck K Lewis S E | 2004 | Comparativeand FunctionalGenomics2004，5，8： | 1 |
| 19 | Control of muscle cell-type specification in the zebrafish embryo by Hedgehog signaling显示文摘 | LEWIS K E CURRIE P D ROY S | 1999 | Developmental Biology1999，216，2： | 1 |
| 20 | A high-throughput, high-resolution strategy for the study of site-selec- tive DNA binding agents: analysis of a 'highly twisted' benzimi-dazole-diamidine显示文摘 | GOODWIN K D LEWIS M A LONG E C | 2006 | J Am Chem Soe2006，128，： | 1 |
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