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| 1 | 应用Rho激酶抑制剂对大鼠阴茎勃起的作用显示文摘目的 :探讨将RhoA/Rho激酶抑制剂Y 2 76 32涂抹于阴茎白膜表面以及阴茎龟头皮肤表面有无促进阴茎勃起的作用及其对体循环的影响。 方法 :2 0只成年雄性SD大鼠 ,体重为 2 5 0~ 30 0g ,随机分为实验组和对照组。全身麻醉后颈动脉和海绵体插管连续监测平均动脉压 (MAP)和阴茎海绵体内压 (CCP)的变化。寻找盆腔星状神经节(MPG)并以系列电刺激诱发勃起。向海绵体白膜表面及阴茎龟头皮肤表面涂抹Y 2 76 32 ,观察用药前后阴茎勃起的改变及MAP的改变。 结果 :将Rho激酶抑制剂Y 2 76 32涂抹于大鼠阴茎白膜表面和阴茎龟头皮肤表面均可促进在无阴茎支配神经电刺激下发生勃起 (ICP/MAP明显升高 ) ,在系列电刺激MPG时用药后发生的勃起反应较用药前亦明显增强。表面用药后还发现大鼠体循环血压有不同程度的降低。 结论 :阴茎皮肤表面应用Rho激酶抑制剂是一种安全有效的ED治疗方法 。 | 戴玉田 孙则禹 Chitaley K Webb RC Mills TM Lewis RW | 2004 | 中华男科学杂志2004，10，8： | 5 |
| 2 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 3 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study显示文摘 | Shamir R Mehta Salim Yusuf Ron JG Peters Michel E Bertrand Basil S Lewis Madhu K Natarajan Klas Malmberg Hans-Jürgen Rupprecht Feng Zhao Susan Chrolavicius Ingrid Copland Keith AA Fox | 2001 | The Lancet . 2001 (9281)2001，，9281： | 4 |
| 4 | Recommendations to quantify villous atrophy in video capsule endoscopy images of celiac disease patients显示文摘AIM To quantify the presence of villous atrophy in endoscopic images for improved automation.METHODS There are two main categories of quantitative descriptors helpful to detect villous atrophy:(1) Statistical and(2) Syntactic. Statistical descriptors measure the small intestinal substrate in endoscope-acquired images based on mathematical methods. Texture is the most commonly used statistical descriptor to quantify villous atrophy. Syntactic descriptors comprise a syntax, or set of rules, for analyzing and parsing the substrate into a set of objects with boundaries. The syntax is designed to identify and distinguish three-dimensional structures based on their shape.RESULTS The variance texture statistical descriptor is useful to describe the average variability in image gray level representing villous atrophy, but does not determine the range in variability and the spatial relationships between regions. Improved textural descriptors will incorporate these factors, so that areas with variability gradients and regions that are orientation dependent can be distinguished. The protrusion syntactic descriptor is useful to detect three-dimensional architectural components, but is limited to identifying objects of a certain shape. Improvement in this descriptor will require incorporating flexibility to the prototypical template, so that protrusions of any shape can be detected, measured, and distinguished.CONCLUSION Improved quantitative descriptors of villous atrophy are being developed, which will be useful in detecting subtle, varying patterns of villous atrophy in the small intestinal mucosa of suspected and known celiac disease patients. | Edward J Ciaccio Govind Bhagat Suzanne K Lewis Peter H Green | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，18： | 3 |
| 5 | Implementation of a polling protocol for predicting celiac disease in videocapsule analysis显示文摘AIM: To investigate the presence of small intestinal villous atrophy in celiac disease patients from quantitative analysis of videocapsule image sequences.METHODS: Nine celiac patient data with biopsy-proven villous atrophy and seven control patient data lacking villous atrophy were used for analysis. Celiacs had biopsy-proven disease with scores of Marsh Ⅱ-Ⅲ C except in the case of one hemophiliac patient. At four small intestinal levels (duodenal bulb, distal duodenum, jejunum, and ileum), video clips of length 200 frames (100 s) were analyzed. Twenty-four measurements were used for image characterization. These measurements were determined by quantitatively processing the videocapsule images via techniques for texture analysis, motility estimation, volumetric reconstruction using shape-from-shading principles, and image transformation. Each automated measurement method, or automaton, was polled as to whether or not villous atrophy was present in the small intestine, indicating celiac disease. Each automaton's vote was determined based upon an optimized parameter threshold level, with the threshold levels being determined from prior data. A prediction of villous atrophy was made if it received the majority of votes (≥ 13), while no prediction was made for tie votes (12-12). Thus each set of images was classified as being from either a celiac disease patient or from a control patient. RESULTS: Separated by intestinal level, the overall sensitivity of automata polling for predicting villous atrophy and hence celiac disease was 83.9%, while the specificity was 92.9%, and the overall accuracy of automata-based polling was 88.1%. The method of image transformation yielded the highest sensitivity at 93.8%, while the method of texture analysis using subbands had the highest specificity at 76.0%. Similar results of prediction were observed at all four small intestinal locations, but there were more tie votes at location 4 (ileum). Incorrect prediction which reduced sensitivity occurred for two celiac patients with Marsh type Ⅱ pattern, which is characterized by crypt hyperplasia, but normal villous architecture. Pooled from all levels, there was a mean of 14.31 ± 3.28 automaton votes for celiac vs 9.67 ± 3.31 automaton votes for control when celiac patient data was analyzed (P<0.001). Pooled from all levels, there was a mean of 9.71 ± 2.8128 automaton votes for celiac vs 14.32 ± 2.7931 automaton votes for control when control patient data was analyzed (P<0.001). CONCLUSION: Automata-based polling may be useful to indicate presence of mucosal atrophy, indicative of celiac disease, across the entire small bowel, though this must be confirmed in a larger patient set. Since the method is quantitative and automated, it can potentially eliminate observer bias and enable the detectionof subtle abnormality in patients lacking a clear diagnosis. Our paradigm was found to be more efficacious at proximal small intestinal locations, which may suggest a greater presence and severity of villous atrophy at proximal as compared with distal locations. | Edward J Ciaccio Christina A Tennyson Govind Bhagat Suzanne K Lewis Peter H Green | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 3 |
| 6 | Fungal diversity notes 1–110:taxonomic and phylogenetic contributions to fungal species显示文摘This paper is a compilation of notes on 110 fungal taxa,including one new family,10 new genera,and 76 new species,representing a wide taxonomic and geographic range.The new family,Paradictyoarthriniaceae is introduced based on its distinct lineage in Dothideomycetes and its unique morphology.The family is sister to Biatriosporaceae and Roussoellaceae.The new genera are Allophaeosphaeria(Phaeosphaeriaceae),Amphibambusa(Amphisphaeriaceae),Brunneomycosphaerella(Capnodiales genera incertae cedis),Chaetocapnodium(Capnodiaceae),Flammeascoma(Anteagloniaceae),Multiseptospora(Pleosporales genera incertae cedis),Neogaeumannomyces(Magnaporthaceae),Palmiascoma(Bambusicolaceae),Paralecia(Squamarinaceae)and Sarimanas(Melanommataceae).The newly described species are the Ascomycota Aliquandostipite manochii,Allophaeosphaeria dactylidis,A.muriformia,Alternaria cesenica,Amphibambusa bambusicola,Amphisphaeria sorbi,Annulohypoxylon thailandicum,Atrotorquata spartii,Brunneomycosphaerella laburni,Byssosphaeria musae,Camarosporium aborescentis,C.aureum,C.frutexensis,Chaetocapnodium siamensis,Chaetothyrium agathis,Colletotrichum sedi,Conicomyces pseudotransvaalensis,Cytospora berberidis,C.sibiraeae,Diaporthe thunbergiicola,Diatrype palmicola,Dictyosporium aquaticum,D.meiosporum,D.thailandicum,Didymella cirsii,Dinemasporium nelloi,Flammeascoma bambusae,Kalmusia italica,K.spartii,Keissleriella sparticola,Lauriomyces synnematicus,Leptosphaeria ebuli,Lophiostoma pseudodictyosporium,L.ravennicum,Lophiotrema eburnoides,Montagnula graminicola,Multiseptospora thailandica,Myrothecium macrosporum,Natantispora unipolaris,Neogaeumannomyces bambusicola,Neosetophoma clematidis,N.italica,Oxydothis atypica,Palmiascoma gregariascomum,Paraconiothyrium nelloi,P.thysanolaenae,Paradictyoarthrinium tectonicola,Paralecia pratorum,Paraphaeosphaeria spartii,Pestalotiopsis digitalis,P.dracontomelon,P.italiana,Phaeoisaria pseudoclematidis,Phragmocapnias philippinensis,Pseudocamarosporium cotinae,Pseudocercospora tamarindi,Pseudotrichia rubriostiolata,P.thailandica,Psiloglonium multiseptatum,Saagaromyces mangrovei,Sarimanas pseudofluviatile,S.shirakamiense,Tothia spartii,Trichomerium siamensis,Wojnowicia dactylidicola,W.dactylidis and W.lonicerae.The Basidiomycota Agaricus flavicentrus,A.hanthanaensis,A.parvibicolor,A.sodalis,Cantharellus luteostipitatus,Lactarius atrobrunneus,L.politus,Phylloporia dependens and Russula cortinarioides are also introduced.Epitypifications or reference specimens are designated for Hapalocystis berkeleyi,Meliola tamarindi,Pallidocercospora acaciigena,Phaeosphaeria musae,Plenodomus agnitus,Psiloglonium colihuae,P.sasicola and Zasmidium musae while notes and/or new sequence data are provided for Annulohypoxylon leptascum,A.nitens,A.stygium,Biscogniauxia marginata,Fasciatispora nypae,Hypoxylon fendleri,H.monticulosum,Leptosphaeria doliolum,Microsphaeropsis olivacea,Neomicrothyrium,Paraleptosphaeria nitschkei,Phoma medicaginis and Saccotheciaceae.A full description of each species is provided with light micrographs(or drawings).Molecular data is provided for 90 taxa and used to generate phylogenetic trees to establish a natural classification for species. | Jian Kui Liu Kevin D.Hyde E.B.Gareth Jones Hiran A.Ariyawansa Darbhe J.Bhat Saranyaphat Boonmee Sajeewa S.N.Maharachchikumbura Eric H.C.McKenzie Rungtiwa Phookamsak Chayanard Phukhamsakda Belle Damodara Shenoy Mohamed A,Abdel-Wahab Bart Buyck Jie Chen K.W.Thilini Chethana Chonticha Singtripop Dong Qin Dai Yu Cheng Dai Dinushani ADaranagama Asha J.Dissanayake Mingkwan Doilom Melvina J.D’souza Xin Lei Fan Ishani DGoonasekara Kazuyuki Hirayama Sinang Hongsanan Subashini C.Jayasiri Ruvishika S.Jayawardena Samantha C.Karunarathna Wen Jing Li Ausana Mapook Chada Norphanphoun Ka Lai Pang Rekhani H.Perera Derek Peršoh Umpava Pinruan Indunil CSenanayake Sayanh Somrithipol Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Qing Tian Saowaluck Tibpromma Danushka Udayanga Nalin N.Wijayawardene Dhanuska Wanasinghe Komsit Wisitrassameewong Xiang Yu Zeng Faten AAbdel-Aziz Slavomir Adamčík Ali H.Bahkali Nattawut Boonyuen Timur Bulgakov Philippe Callac Putarak Chomnunti Katrin Greiner Akira Hashimoto Valerie Hofstetter Ji Chuan Kang David Lewis Xing Hong Li Xing Zhong Liu Zuo Yi Liu Misato Matsumura Peter E.Mortimer Gerhard Rambold Emile Randrianjohany Genki Sato Veera Sri-Indrasutdhi Cheng Ming Tian Annemieke Verbeken Wolfgang von Brackel Yong Wang Ting Chi Wen Jian Chu Xu Ji Ye Yan Rui Lin Zhao Erio Camporesi | 2015 | Fungal Diversity2015，，3： | 3 |
| 7 | 利用B细胞培养和RT-PCR技术从我国HIV-1感染者中筛选膜蛋白特异性单克隆抗体的初步研究显示文摘本研究通过采集1型人类免疫缺陷病毒(Human immunodeficiency virus-1,HIV-1)感染者抗凝全血,分离出外周血单个核细胞,然后用磁珠分选纯化记忆性B细胞和体外活化记忆性B细胞,促使其分泌抗体,用ELISA法识别阳性B细胞克隆,并提取阳性B细胞的RNA,从中扩增抗体重链和轻链基因并克隆到表达载体中,再用携带重链基因的质粒和携带轻链基因的质粒共转染293T细胞,获得HIV-1特异性人单克隆抗体,进行抗体特性的鉴定。结果从1例HIV-1感染者的记忆性B细胞中筛选出了4株HIV-1包膜糖蛋白(Envelope glycoprotein,Env)特异性人单克隆抗体,其中2株具有较好的抗体依赖细胞介导的细胞毒作用活性,另有1株对HIV-1假病毒有较弱的中和活性。说明我们成功地引进了利用B细胞培养和RT-PCR技术从人体淋巴细胞中筛选特异性抗体基因的人单克隆抗体技术平台。用该技术可以成功获得HIV-1Env特异性单克隆抗体,为将来从能产生高滴度广谱中和抗体的感染者体内筛选广谱中和抗体打下了基础。 | 汪慧敏 徐柯 余双庆 丁林林 罗海艳 Robin Flinko George K Lewis 冯霞 邵继荣 管永军 曾毅 | 2012 | 病毒学报2012，28，4： | 2 |
| 8 | Two feet- two approaches: a component - based model of ecological footprinting 显示文摘 | Simmons C Lewis K Barrett J | 2000 | Ecological Economics2000，32，3： | 1 |
| 9 | Robust Adaptive Control of Induction Motors Without Flux Measurment显示文摘 | Kwan C M Lewis F L Yeung K S | 1995 | ACC1995，32，6： | 1 |
| 10 | Prevalence of anxiety and depression in patients with severe COPD: similar high levels with and without LTOT 显示文摘 | LEWIS K E ANNANDALE J A SYKES R N | 2007 | COPD2007，4，4： | 1 |
| 11 | Stretch-induced membrane type matrix metalioprotoinase and tissue plssminogen activator in cardiac fibroblast ceils 显示文摘 | Lewis K Pikss D | 1998 | JCell Phyaiol1998，176，： | 1 |
| 12 | Toxicity comparison of biosurfactants and synthetic surfactants used in oil spill remediation to two estuarine species显示文摘 | Edwards K R Lepo J E Lewis M A | 2003 | Marine Pollution Bulletin2003，46，10： | 1 |
| 13 | New Triterpenoid Extractives from Lemaireocereus chichipe显示文摘 | Khong P W Lewis K G | 1975 | Aust J Chem1975，28，： | 1 |
| 14 | Toll-like receptor and T-helper-1/T-helper-2 responses显示文摘 | Dabbagh K Lewis DB | 2003 | Curr Opin Infect Dis2003，16，3： | 1 |
| 15 | Metformin therapy in obese adolescents with polycystic ovary syndrome and impaired glucose tolerance: Amelioration of exaggerated adenal response to adrenocorticotropin with reduction of insulinemia/insulin resistance 显示文摘 | Arslanian S Lewy V Danadian K | 2002 | J Clin Endocrinol Metab2002，87，4： | 1 |
| 16 | Unilateral interspecific incomatibility in fiowering plants显示文摘 | Lewis D Crowe L K | 1958 | Heredity1958，12，： | 1 |
| 17 | Identification of urocortin III,an additional member of the corticotrophin-releasing factor (CRF) family with high affinity for the CRF2 receptor显示文摘 | Lewis K Li C Perrin M H | 2001 | Proc Natl Acad Sci USA2001，98，13： | 1 |
| 18 | Hot-wire chemical vapor deposition (HWCVD) of fluorocarbon and organosilicon thin films显示文摘 | Lau K K S Lewis H G P Limb S J | 2001 | Thin Solid Films2001，395，12： | 1 |
| 19 | A finite element model of the squeeze casting process 显示文摘 | Lewis R W Ravindran K | 2006 | International Journal of Numerical Methods for Heat & FluidFlow2006，16，5： | 1 |
| 20 | Multidrug tolerance of biofilms and persister cells 显示文摘 | Lewis K | 2008 | Curt Top Microbiol Immunol2008，322，： | 1 |
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