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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Breast and lung metastasis from pancreatic neuroendocrine carcinoma显示文摘Pancreatic neuroendocrine tumors(PNETs) are an uncommon malignancy,accounting for a small percentage of all pancreatic malignancies.Due to their insidious course,most PNETs present with metastatic disease.Although reports in the literature describe PNET metastasis to the liver,lung and brain,to date there are no reports of stage Ⅳ disease involving the breast.Moreover,the lack of consensus regarding classification and treatment of this entity leaves practitioners without standards of practice or a firm base from which to formulate prognosis.In this report,the case of a previously healthy 51-year-old woman with stage Ⅳ PNET is examined.After combined neoadjuvant therapy with 5-fluorouracil,carboplatin,etoposide and radiation,surgical resection revealed metastatic PNET to the breast and lung,with no microscopic evidence of residual disease within the pancreas.An extensive analysis of the presentation,diagnosis,imaging modalities,treatment options,and prognosis is included in the discussion.As demonstrated by our review,there is a need for further studies to delineate inconclusive evidence with respect to subtype classification,treatment and prognosis of PNETs. | Shevonne Satahoo-Dawes Joshua Palmer Eddie W Manning Ⅲ Joe Levi | 2011 | World Journal of Radiology2011，3，1： | 2 |
| 3 | Ischemic brain injury and the therapeutic window 显示文摘 | Pulsinelli W A Jacewiez M Levy D E | 1997 | Ann N Y Acade Sci1997，12，835： | 1 |
| 4 | Nitrogen fixation : Anthropogenic enhancement environmental response显示文摘 | Galloway J N W H Schlesinger H Levy Ⅱ | 1995 | Global Biogeochem Cycles1995，9，： | 1 |
| 5 | Stage specific guidelines for surveillance after radical nephrectomy for local renal cell carcinoma 显示文摘 | LEVY D A SLATON J W SWANSON D A | 1998 | J Urol1998，159，4： | 1 |
| 6 | HIV viral protein R causes atrial cardiomyocyte mitosis,mesenchymal tumor,dysrhythmia,and heart failure显示文摘 | Levis W Miller YK Haase CP Ludaway T | | 0，，： | 1 |
| 7 | C4ISR Architectures I:Developing a Process for C4ISR Architecture Design 显示文摘 | Levis Alexander H Wagenhals Lee W | 2000 | Systems Engineering2000，3，4： | 1 |
| 8 | Psychosocial aspects of the functional gastrointestinal disorders 显示文摘 | Levy R L Olden K W Naliboff B D | 2006 | Gastroenterology2006，130，5： | 1 |
| 9 | Automatic phase correction o{ common-midpoint stacked data显示文摘 | Levy S Oldenburg D W | 1987 | Geophysics1987，52，1： | 1 |
| 10 | Carotenoid composition of marigold (Tagetes erecta) flower extract used as nutritional supplement显示文摘 | Haddcn W L Watldns R H Levy L W | 1999 | Journal of Agricultural & Food Chemistry1999，47，10： | 1 |
| 11 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 12 | Use of methylpre dni- solone as an adjunct in the management of patients with pen- etrating spinal cord injury outcome analysis显示文摘 | Levy ML Gans W Wijesinghe HS | 1996 | Neurosurg1996，39，6： | 1 |
| 13 | A global threedimensional time-dependent lightning source of tropospheric NO, 显示文摘 | Levy H II Moxim W J Kasibhatla R S | 1996 | J Geophys Res1996，101，22： | 1 |
| 14 | Statin therapy is associated with lower mortality among patients with severe heart failure显示文摘 | Mozaffrian D Nye R Levy W | 2004 | Am Cardid2004，93，9： | 1 |
| 15 | Mechanism of efficacy of 2-amino oleic acid for inhibition of calcification of glutaraldehydepretreated porcine bioprosthetic valves显示文摘 | Chen W Schoen FJ Levy RJ | 1994 | Circulation1994，90，： | 1 |
| 16 | Hypothalamic dysfunction in overtrained athletes显示文摘 | Barron J L Noakes T D Levy W | 1985 | J of Clinical Endocrinology and Metabolism1985，60，4： | 1 |
| 17 | Dietary n · 3 polyunsaturated tatty acids decrease hepatic triglycefides in Fischer 344 rates 显示文摘 | Levy JR Clare JN Stevens W | 2004 | Hepatology2004，39，3： | 1 |
| 18 | Nitrogen fixation: anthropogenic enhancement - evironmental response 显示文摘 | GALLOWAY J Y SCHLESINGER W H LEVY Ⅱ H | 1995 | Global Biological Cycles1995，9，： | 1 |
| 19 | Molecular and functional analysis of the human prothrombinases gene (HF GL2) and its role in viral hepatitis显示文摘 | LEVY G A LIU M F DING J W | 2000 | Am J Pathology2000，156，12： | 1 |
| 20 | Anemia in heart failure:marker or mediator of adverse prognosis显示文摘 | Levy W C | | 0，，05： | 1 |
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