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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Screening for gastric cancer in Asia: current evidence and practice显示文摘 | Wai K Leung Ming-shiang Wu Yasuo Kakugawa Jae J Kim Khay-guan Yeoh Khean Lee Goh Kai-chun Wu Deng-chyang Wu Jose Sollano Udom Kachintorn Takuji Gotoda Jaw-town Lin Wei-cheng You Enders KW Ng Joseph JY Sung | 2008 | Lancet Oncology2008，，3： | 7 |
| 3 | Hematopoietic cell transplantation for Crohn’s disease;is it time?显示文摘AIM: To review all studies in the literature that have assessed Hematopoietic cell transplantation (HCT) and Crohn’s disease (CD) with the ultimate aims of determining if this is a viable treatment option for those with CD. A secondary aim was to review the above literature and determine if the studies shed further light on the mechanisms involved in the pathogenesis of CD. METHODS: An extensive Medline search was performed on all articles from 1970 to 2005 using the ; bone marrow transplant, stem cell, hematopoietic cell, Crohn’s disease and inflammatory bowel disease. RESULTS: We identified one case in which a patient developed CD following an allogeneic HCT from a sibling suffering with CD. Evidence for transfer of the genetic predisposition to develop CD was also identified with report of a patient that developed severe CD following an allogeneic HCT. Following HCT it was found that the donor (that had no signs or symptoms of CD) and the recipient had several haplotype mismatches in HLA class Ⅲ genes in the IBD3 locus including a polymorphism of NOD2/CARD15 that has been associated with CD. Thirty three published cases of patients with CD who underwent either autologous or allogeneic HCT were identified. At the time of publication 29 of these 33 patients were considered to be in remission. The median follow-up time was seven years, and twenty months for allogeneic and autologous HCT respectively.For patients who underwent HCT primarily for treatment of their CD there have been no mortalities related to transplant complications. CONCLUSION: Overall these preliminary data suggest that both allogeneic and autologous HCT may be effective in inducing remission in refractory CD. Thissupports the hypothesis that the hematolymphatic cells play a key role in CD and that resetting of the immune system may be a critical approach in the management or cure of CD. | Y Leung M Geddes J Storek R Panaccione PL Beck | 2006 | World Journal of Gastroenterology2006，12，41： | 5 |
| 4 | Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring显示文摘现在有充分证据,对在使肥沃的后代显型的父亲的贡献多于公平 DNA。然而,这 nongenetic 继承的身份和机制糟糕被理解。在这个研究区域的更重要的问题之一是:在精子 DNA methylation 的变化为后代有 phenotypic 后果吗?我们以前报导了肥胖的雄的老鼠的后代与控制相比改变了葡萄糖新陈代谢并且这效果通过 nongenetic 工具被继承。这里,我们用一样的协议在一个新队描述调查进精子 DNA methylation。在高脂肪的节食的雄的老鼠是 30% 比喂控制的男性重在交配的时候(16-19 星期旧, n = 14/14 ) 。一小(0.25%) 在全部的 5-methyl-2 ’ 增加; -deoxycytidine 被液体层析双人脚踏车团 spectrometry 在肥胖的老鼠精子检测。那 retrotransposon DNA methylation 在精子说的有定序的充实蛋白质的染色体(MBD-Seq ) 和 pyrosequencing 揭示了的 methyl-CpG 绑定领域的染色体的重复部分的检查没被肥胖,而是 methylation 在整个染色体在卫星重复影响被增加。然而,从男 27-week-old 后代从的肌肉,肝,和精子的检查肥胖并且控制父亲(从 8 生的 n = 的两个组) 表明正常 DNA methylation 层次在后代开发期间被恢复。而且,没有变化在肥胖的老鼠精子在三个 genomic 印记被发现。我们的调查结果为 transgenerational epigenetic reprogramming 有含意。他们建议 postfertilization 机制为使导致 environmentally 的 DNA methylation 在精子房间改变的一些正常化存在。 | Neil A Youngson Virginie Lecomte Christopher A Maloney Preston Leung Jia Liu Luke B Hesson Fabio Luciani Lutz Krause Margaret J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 3 |
| 5 | Screening for gastric cancer in Asia: current evidence and practice显示文摘 | Wai K Leung Ming-shiang Wu Yasuo Kakugawa Jae J Kim Khay-guan Yeoh Khean Lee Goh Kai-chun Wu Deng-chyang Wu Jose Sollano Udom Kachintorn Takuji Gotoda Jaw-town Lin Wei-cheng You Enders KW Ng Joseph JY Sung | 2008 | Lancet Oncology2008，，3： | 3 |
| 6 | Role of sphingosine kinase and sphingosine-1-phosphate in inflammatory arthritis显示文摘The importance of sphingosine kinase(SphK)and sphingosine-1-phosphate(S1P)in inflammation has been extensively demonstrated.As an intracellular second messenger,S1P plays an important role in calcium signaling and mobilization,and cell proliferation and survival.Activation of various plasma membrane receptors,such as the formyl methionyl leucyl phenylalanine receptor,C5a receptor,and tumor necrosis factor α receptor,leads to a rapid increase in intracellular S1P level via SphK stimulation.SphK and S1P are implicated in various chronic autoimmune conditions such as rheumatoid arthritis, primary Sjgren's syndrome,and inflammatory bowel disease.Recent studies have demonstrated the important role of SphK and S1P in the development of arthritis by regulating the pro-inflammatory responses.These novel pathways represent exciting potential therapeutic targets. | Alirio J Melendez Bernard P Leung | 2010 | World Journal of Biological Chemistry2010，1，11： | 3 |
| 7 | The conversion factor of K_(eff) to K_(3.7) in thermoluminescence dating显示文摘In the fine-grain TL dating the full o dose must be converted into the equivalent P dose. The conversion is finished by Keff-value, which is an effective or effectiveness. But the Keff can not be measured directly for each sample and only the external radiative efficiency K3.7 can be measured. In order to obtain the Keff a special study for the conversion factor of Keff to K3.t has been made using the ultrathin TLD. The results show that the conversion factor of tile TLD for archaeological samples is 0.847, which is in agreement with calculated value 0.85. | Wang Wei-Da Zhou Zhi-Xin Xia Jun-Ding (Research Laborotory for Conservation and Archaeology, Shanghai Museum, Shanghai 200951)Leung P L Stokes M J(Department of Physics and Materials Science, City University of Hong Kong) | 1998 | Nuclear Science and Techniques1998，9，4： | 3 |
| 8 | 危重患者抗菌药物持续静脉滴注或延长滴注时间:系统综述和meta分析显示文摘危重患者抗菌药物持续静脉滴注或延长滴注时间:系统综述和meta分析
摘译:本研究对入住ICU危重患者使用以药物代谢动力学为基础的方法行抗菌药物持续静脉滴注或延长静脉滴注时间,并与传统间歇性静脉滴注抗菌药物进行比较,观察包括病死率在内的各种预后变化。 | 罗勇 Chant C Leung A Frienrich J O | 2014 | 临床误诊误治2014，27，8： | 3 |
| 9 | Anaerobic bacteria and intrahepatic stones: detections of Clostridium sp. and Bacteroides fragilis显示文摘To detect anaerobic bacteria Clostridium sp . and Bacteroides fragilis in intrahepatic stones by molecular genetic method Methods DNA was extracted from 59 stone samples and subjected to polymerase chain reaction (PCR) amplification targeting the 16S rRNA gene of Clostridium sp . and the glutamine synthetase gene of Bacteroides fragilis Single-strand conformational polymorphism (SSCP) analysis was performed to identify the Clostridium sp Results 16S rRNA gene sequences for Clostridium sp. were identified in 49 stones (83%, 49/59) The two most common groups were detected in 19 (41%) and 17 (37%) of the 46 samples using SSPC analysis, and 25/59 (42%) stones were tested positive for Bacteroides fragilis Conclusions Anaerobes such as Clostridium sp and Bacteroides fragilis present in intrahepatic stones and may play a role in stone formation PCR is a useful technique to detect fastidious pathogens, which are difficult to culture SSCP of PCR products is a rapid method in differentiating bacterial | LIU Yanlei Kan Lam Yajarayma J Tang Paul H Gumerlock Dong Ki Lee Myung Hwa Kim Sum P Lee Joseph SilvaJr Joseph W Leung | 2000 | Chinese Medical Journal2000，，9： | 2 |
| 10 | Effect of closure of live poultry markets on poultry-to-person transmission of avian influenza A H7N9 virus: an ecological study显示文摘 | Hongjie Yu Joseph T Wu Benjamin J Cowling Qiaohong Liao Vicky J Fang Sheng Zhou Peng Wu Hang Zhou Eric H Y Lau Danhuai Guo Michael Y Ni Zhibin Peng Luzhao Feng Hui Jiang Huiming Luo Qun Li Zijian Feng Yu Wang Weizhong Yang Gabriel M Leung | 2013 | The Lancet2013，，： | 2 |
| 11 | Water-aided colonoscopy: a systematic review显示文摘 | Felix W. Leung Arnaldo Amato Christian Ell Shai Friedland Judith O. Harker Yu-Hsi Hsieh Joseph W. Leung Surinder K. Mann Silvia Paggi Jürgen Pohl Franco Radaelli Francisco C. Ramirez Rodelei Siao-Salera Vittorio Terruzzi | 2012 | Gastrointestinal Endoscopy2012，，3： | 2 |
| 12 | Statistical performance analysis of track initiation techiniques显示文摘 | Hu Z J Leung H | | IEEE Trans on AES0，45，2： | 1 |
| 13 | Indigenous Chinese personality constructs: Is the five factor model complete? 显示文摘 | CHEUNG F M LEUNG K ZI-IANG J X | 2001 | J Cross Cultural Psychol2001，32，40： | 1 |
| 14 | Transvaginal sonography and theconservative management of spontaneous abortion 显示文摘 | Haines C J Chung T Leung DY | 1994 | Gyneeol Obstet Invest1994，37，1： | 1 |
| 15 | Asian-Pacific consensus statement on the management of chronic hepatitis B:a 2008update显示文摘 | Liaw Y F Leung N Kao J H | 2008 | Hepatol Int2008，2，3： | 1 |
| 16 | Polysaccharide biological response modifiers 显示文摘 | Leung Y K Liu C Koon J C M | 2006 | Immunol Lett2006，105，： | 1 |
| 17 | Rapid clearance of fetal DNA from maternal plasma显示文摘 | Lo Y M Zhang J Leung T N | 1999 | Am J Hum Genet1999，64，： | 1 |
| 18 | Man portable power needs of the 21st century显示文摘 | Atwater T B Cygan P J Leung F C | 2000 | J Power Sources2000，91，1： | 1 |
| 19 | Distribution of symptomatic congenital heart disease in Hong Kong显示文摘 | Jacobs EG Leung MP Kariberg J | 2000 | Pediatr Cardial2000，21，： | 1 |
| 20 | Gene expression of the renin-angiotensin system in human kidney显示文摘 | Lai K N Leung J C Lai K B | 1998 | J Hypertens1998，16，： | 1 |
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