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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Effect of a retrograde-viewing device on adenoma detection rate during colonoscopy: the TERRACE study显示文摘 | Anke M. Leufkens Daniel C. DeMarco Amit Rastogi Paul A. Akerman Kassem Azzouzi Richard I. Rothstein Frank P. Vleggaar Alessandro Repici Giacomo Rando Patrick I. Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H. Deprez Brian P. Sau | 2011 | Gastrointestinal Endoscopy2011，，3： | 5 |
| 3 | Factors influencing the miss rate of polyps in a back-to-back colonoscopy study显示文摘 | A. Leufkens M. van Oijen F. Vleggaar P. Siersema | 2012 | Endoscopy2012，，05： | 3 |
| 4 | QTc prolonging drugs and hospitalizations for cardiac arrhythmias显示文摘 | Hoes AW Leufkens HGM | 2003 | Am J Cardiol2003，91，1： | 1 |
| 5 | The epidemiology of corticosteroid-induced osteoporosis : a meta-analysis 显示文摘 | Van Staa TP Leufkens HGM Cooper C | 2002 | Oteoporos Int2002，13，： | 1 |
| 6 | Usage patterns of benzodiazepines in a dutch community: a 10-year follow-up显示文摘 | Van Hulten R Leufkens HG Bakker A | 1998 | Pharm World Sci1998，20，： | 1 |
| 7 | Use of oral corticosteroids and risk of fractures 显示文摘 | VANSTAA TP LEUFKENS HG ABENHAIM L | 2000 | J Bone Miner Res2000，15，6： | 1 |
| 8 | A cornparison of measures of disproportionality for signal detection in spontaneous reporting systems for adverse drug reactions 显示文摘 | van Puijenbroek E P Bate A Leufkens H G | 2002 | Pharmacoepidemiol Drug Saf2002，11，1： | 1 |
| 9 | The epidemiology of corticosteroid-induced osteoporosis:Ameta-analysis显示文摘 | VanStaa TP Leufkens HG Cooper C | 2002 | Osteoporos Int2002，13，： | 1 |
| 10 | Risk of hip/fe-mur fracture after stroke:a population-based case-control study显示文摘 | POUWELS S LALMOHAMED A LEUFKENS B | 2009 | Stroke2009，40，10： | 1 |
| 11 | Use of oral corticosteroids and risk of fractures显示文摘 | Van Staa TP Leufkens HG Abenhaim L | 2000 | J Bone Miner Res2000，15，6： | 1 |
| 12 | An experimental comparison of sequential first-and second-price auctions with synergies显示文摘 | Leufkens K Peeters R Vorsatz M | 2012 | The BE Journal of Theoretical Economics2012，12，1： | 1 |
| 13 | Epidemiology of fractures in England and Wales显示文摘 | van Staa TP Dennison EM Leufkens HG | 2001 | Bone2001，29，6： | 1 |
| 14 | From human menopausal gonadotropins (hMG) through purified urinary follicle stimulating hormone (FSH) preparations to recombinant FSH, a substitution study 显示文摘 | Zwart-van Rijkom JE Broekmans FJ Leufkens HG | 2002 | Hum Reprod2002，17，4： | 1 |
| 15 | The epidemiology of corticosteroid-induced osteoporosis: a meta-analysis 显示文摘 | Van Staa TP Leufkens HGM Cooper C | 2002 | Osteoporos Int2002，13，10： | 1 |
| 16 | Synergies are a reason to prefer first-price auctions显示文摘 | Leufkens K Peeters R | 2007 | Economics Letters2007，97，1： | 1 |
| 17 | The patterns of anticoagulation control and the risk of stroke, bleeding and mortality in patients with non-valvular atrial fibrillation显示文摘 | Van Den Ham HA Klungel OH Leufkens HG | 2013 | J Thromb Haemost2013，11，1： | 1 |
| 18 | Epidemiology of fractures in England and Wales显示文摘 | van Staa T Dennison E Leufkens H | 2001 | Bone2001，29，6： | 1 |
| 19 | Sequential auctions with synergies:The paradox of positive synergies显示文摘 | Leufkens K Peeters R Vermeulen D | 2010 | Economics Letters2010，109，3： | 1 |
| 20 | Use of oral corti- costeroids and risk of fractures 显示文摘 | van Staa TP Cooper C Leufkens HG | 2003 | J Bone Miner Res2003，18，5： | 1 |
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