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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Eggs forev- er?显示文摘 | BYSKOY A G FADDY M J LEMMEN J G | 2005 | Differentiation2005，73，910： | 1 |
| 3 | Interaction of estrogenic chemical and phytoestrogens with estrogen receptor β 显示文摘 | Kuiper G J M Lemmen G Carlsson B | 1998 | Endocrinology1998，139，： | 1 |
| 4 | Overview and consistency of migration experiments in clay显示文摘 | AERTSENS M de CANNIERE P LEMMENS K | 2008 | Physics and Chemistry on Earth2008，33，1416： | 1 |
| 5 | Estimation of water pollution sources in Lake Victoria, East Africa: Application and elaboration of the :rapid assessment methodology显示文摘 | Scheren P A G M Zanting H A Lemmens A M C | 2000 | Journal of Environmental Management2000，58，： | 1 |
| 6 | Shortcomings in Spatial Documentation of Heritage Sites,Laser Scanning Technology Challenged显示文摘 | Lemmens M | 2007 | GIM International2007，，： | 1 |
| 7 | Role of neuregu- lin-1/ErbB2 signaling in endothelium-cardiomyocyte cross- talk显示文摘 | Lemmens K Segers V F Demolder M | 2006 | J Biol Chem2006，281，19： | 1 |
| 8 | Bole of nell- regnlin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-talk显示文摘 | Lemmens K Segers VF Demolder M | 2006 | J Biol Chem2006，281，19： | 1 |
| 9 | Reducing prehospital delay in a- cute stroke显示文摘 | Bouckaert M Lemmens R Thijs V | 2009 | Nat Rev Neurol2009，5，9： | 1 |
| 10 | Matrix metalloproteinase-2 and-9 as promising benefactors in development,plasticity and repair of the nervous system显示文摘 | Verslegers M Lemmens K Van Hove I | 2013 | Prog Neurobiol2013，105，： | 1 |
| 11 | DNA double-strand break repair in Caenorhabditis elegans显示文摘 | Lemmens BB Tijsterman M | | 0，，01： | 1 |
| 12 | A combined analysis of double-blind studies with risperidone vs placebo and other antipsychotic agents:factors associated with extrapyramidal symptoms显示文摘 | Lemmens P Brecher M Van Baelen B | 1999 | Acta Psychiatr Scand1999，99，2： | 1 |
| 13 | Role of neuregu- lin-1/ErbB2 signaling in talk 显示文摘 | Lemmens K Segers VF Demolder M | 2006 | J Biol Chem2006，281，19： | 1 |
| 14 | Role of neuregulin1/ERBB2 signaling in endothelium-cardiomyocyte cross-talk显示文摘 | Lemmens K Segers VF Demolder M | 2006 | J Biol Chem2006，281，19： | 1 |
| 15 | Role of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-talk显示文摘 | Lemmens K Segers VF Demolder M | 2006 | J Biol Chem2006，281，19： | 1 |
| 16 | Flatness Based Control for Hydraulic Drives显示文摘 | WEY T LEMMEN M | 1998 | Stability and Control Theory and Applications1998，，1： | 1 |
| 17 | Integrating semantic and syntactic descriptions to chain geographic services显示文摘 | Granell C Lemmens R Gould M | 2006 | IEEE Interact Computing2006，10，5： | 1 |
| 18 | A Zener-Damping peak in Fe-4wt% Si 显示文摘 | Boesono Ir Ernst G J Lemmens M C | 1967 | Physica Status Solidi A-Applied Research1967，19，1： | 1 |
| 19 | New opportunities for drug outcomes research in cancer patients:the linkage of the eindhoven cancer registry and the PHARMO record linkage system显示文摘 | van Herk-Sukel M P van depoll-Franse L V Lemmens V E | 2010 | Eur J Cancer2010，46，2： | 1 |
| 20 | The ability to detoxify the mycotoxin deoxynivalenol colocalizes with a major quanti tative trait locus for Fusarium head blight resistance in wheat 显示文摘 | Lemmens M Scholz U Berthiller F | 2005 | Molecular Plant-microbe Interactions2005，181，： | 1 |
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