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| 1 | Pattern and timing of late Cenozoic rapid exhumation and uplift of the Helan Mountain,China显示文摘The Helan Mountain, an intraplate deformation belt in the North China Craton, is located in the northern portion of the China North-South seismic belt, and at the northwestern margin of the Ordos Block. The Cenozoic deformation history of the Helan Mountain is characterized by extension along the eastern Helan Mountain fault (EHSF), resulting in the exhumation and uplift of the Helan Mountain, relative to the rifting of the adjacent Yinchuan Basin. Here we present new apatite fission track (AFT) data from several transects adjacent to the EHSF in the central and northern Helan Mountain. AFT ages from the northern Helan Mountain (Dawukou and Zhengyiguan transects) range from 10 Ma to 89 Ma, whereas AFT ages from the southern Helan Mountain (Suyukou transect) are greater than 71 Ma. The AFT data analysis reveals initiation of rapid uplift and exhumation of the Helan Mountain at 10–12 Ma. Additionally, a plot of the AFT ages versus their mean track length shows a distinctive 'boomerang' pattern indicating that the Helan Mountain experienced a discrete phase of accelerated exhumation beginning at 10-12 Ma. Spatially, AFT samples systematically increase in age away from the EHSF and are consistent with late Cenozoic exhumation that was slow in the southwestern Helan Mountain and rapid in the northeastern Helan Mountain, as well more rapid adjacent to the EHSF and slower away from the EHSF. Obviously, the spatial distribution of late Cenozoic exhumation indicates that normal faulting of the EHSF is related to southwestward tilting and rapid exhumation of the Helan Mountain beginning at 10–12 Ma. The uplift and exhumation of the Helan Mountain was a response to the intensive extension of the northwestern margin of the Ordos Block in the late Cenozoic; this occurred under a regional extensional stress field oriented NW-SE along the Yinchuan-Jilantai-Hetao and the Weihe-Shanxi graben systems adjacent to the Ordos Block. | LIU JianHui ZHANG PeiZhen ZHENG DeWen WAN JinLin WANG WeiTao DU Peng LEI QiYun | 2010 | Science China Earth Sciences2010，53，3： | 23 |
| 2 | Dextral strike-slip of Sanguankou-Niushoushan fault zone and extension of arc tectonic belt in the northeastern margin of the Tibet Plateau显示文摘Sanguankou-Niushoushan 差错(SGK-NSSF ) 的运动学的特征具有到弧的延期的理解的大意义在西藏高原的东北边缘的构造的带。用地调查和各种各样的数据收集方法,包括大规模地质的印射,典型地形学的测量,并且沉积阶层标明日期, SGK-NSSF 展出明显的右罢工滑倒特征并且因此不是一个左首的罢工滑倒差错,由以前的研究人员相信了,这被决定。这研究的结果证明地质的边界为古生代,中生代,和新生代时代都被差错右地打乱,与是类似的指责的排水量。在地志的效果的消除以后,差错的最大的罢工滑倒排水量被发现是 | LEI QiYun ZHANG PeiZhen ZHENG WenJun CHAI ChiZhang WANG WeiTao DU Peng YU JingXing | 2016 | Science China Earth Sciences2016，59，5： | 17 |
| 3 | USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA显示文摘圈套(也作为 MITA 知道) 调停天生的抗病毒的发信号和圈套的 ubiquitination 对它的功能关键。然而,圈套的 deubiquitination 过程是不清楚的。这里,我们报导那 USP18 成员 USP20 到连接 K48 的 ubiquitination 从圈套锁住并且支持的 deconjugate 圈套和类型的表示的稳定性我在 DNA 病毒感染以后的 IFN 和 proinflammatory cytokines。USP18 缺乏或 USP20 击倒导致了提高的连接 K48 的 ubiquitination 并且加速了圈套的降级,并且与 DNA 病毒 HSV-1 或各种各样的 DNA ligands 的 transfection 在感染以后损害了下游的基因的 IRF3 和 NF-B 以及正式就职的激活。另外, Usp18 / 老鼠与野类型的同窝出生的人相比更产生 HSV-1 感染。USP18 deubiquitinate 没在 vitro 叮,但是便于 USP20 在 USP18 的酶的活动的一个方式独立人士催化圈套的 deubiquitination。另外,进 Usp18 / MEF 的圈套的宪法恢复了下游的基因和细胞的抗病毒的回答的 HSV-1-induced 表示。我们的调查结果因此以前揭开在调停的 USP18 和 USP20 的 uncharacterized 角色被触发病毒的发信号并且贡献天生的抗病毒的回答的复杂规章的系统的理解。 | Man Zhang Meng-Xin Zhang Qiang Zhang Gao-Feng Zhu Lei Yuan Dong-Er Zhang Qiyun Zhu Jing Yao Hong-Bing Shu Bo Zhong | 2016 | Cell Research2016，26，12： | 12 |
| 4 | Characteristics of Late Quaternary Activity of the Luhuatai Buried Fault Revealed by Drilling显示文摘The Luhuatai fault is one of the important buried tectonics in the Yinchuan basin. Based on the results of shallow seismic exploration, we conducted composite drilling section exploration and dating of the samples from boreholes. Some useful data was obtained, such as the depth of the upper breaking point, the latest activity age, displacement in the late Quaternary, and slip rates, etc. This study shows that the activity is different between the north and south segment along the Luhuatai fault. The north segment is a Holocene fault, while the south segment is a late mid-Pleistocene fault. From north to south along the north segment of Luhuatai fault, the activity has been enhanced, and the faulting is stronger in late Pleistocene than Holocene. | Lei Qiyun Chai Chizhang Du Peng Wang Yin Meng Guangkui | 2012 | Earthquake Research in China2012，26，2： | 1 |
| 5 | A low-power Bluetooth-based wireless sensor network and its global confliction-solving impact localization method显示文摘During the whole service lifetime of aircraft structures with composite materials,impacts are inevitable and can usually cause severe but barely visible damages.Since the occurrences of impact are random and unpredictable,it is a hotspot direction to develop an online impact monitoring system that can meet strict limitations of aerospace applications including small size,light weight,and low power consumption.Piezoelectric(PZT)sensor,being able to generate impact response signals with no external power and cover a large-scale structure with only a small amount of them,is a promising choice.Meanwhile,for real systems,networks with multiple nodes are normally required to monitor large-scale structures in a global way to identify any impact localization confliction,yet the existing studies are mostly evaluated with single nodes instead of networks.Therefore,in this paper,based on a new low-power node designed,a Bluetooth-based digital impact monitoring PZT sensor network is proposed for the first time with its global confliction-solving impact localization method.Evaluations of the system as a network are researched and analyzed on a complex real aircraft wing box for a global confliction-solving impact localization,showing a satisfying high accuracy. | Yuanjia WANG Lei QIU Qiyun XU Liming SHI | 2024 | Chinese Journal of Aeronautics2024，37，1： | 0 |
| 6 | Engineered extracellular vesicles efficiently deliver CRISPR-Cas9 ribonucleoprotein(RNP)to inhibit herpes simplex virus1 infection in vitro and in vivo显示文摘Extracellular vesicles(EVs)have recently emerged as a promising delivery platform for CRISPR/Cas9 ribonucleoproteins(RNPs),owing to their ability to minimize off-target effects and immune responses.However,enhancements are required to boost the efficiency and safety of Cas9 RNP enrichment within EVs.In response,we employed the Fc/Spa interaction system,in which the human Fc domain was fused to the intracellular domain of PTGFRN-Δ687 and anchored to the EV membrane.Simultaneously,the B domain of the Spa protein was fused to the C domain of cargos such as Cre or spCas9.Due to the robust interaction between Fc and Spa,this method enriched nearly twice the amount of cargo within the EVs.EVs loaded with spCas9 RNP targeting the HSV1 genome exhibited significant inhibition of viral replication in vitro and in vivo.Moreover,following neuron-targeting peptide RVG modification,the in vivo dosage in neural tissues substantially increased,contributing to the clearance of the HSV1 virus in neural tissues and exhibiting a lower off-target efficiency.These findings establish a robust platform for efficient EV-based SpCas9 delivery,offering potential therapeutic advantages for HSV1 infections and other neurological disorders. | Yuanda Wan Liren Li Ruilin Chen Jiajia Han Qiyun Lei Zhipeng Chen Xiaodong Tang Wenyu Wu Shuwen Liu Xingang Yao | 2024 | Acta Pharmaceutica Sinica B2024，14，3： | 0 |
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