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| 1 | A Streptococcus suis serotype 2 caused streptococcal toxic shock syndrome(STSS) in a patient显示文摘Streptococcus suis(S.suis)is a Gram-positive,facultatively anaerobic coccus that has been implicated as the cause of a wide range of clinical disease syndromes in swine and other domestic animals.S.suis has also been implicated in disease in humans,especially among abattoir workers,swine and pork handlers.Here we report a case of streptococcal toxic shock syndrome(STSS)caused by S.suis in a 59-year-old man.Despite of intensive treatment,the patient died of shock with multiple organ failure 14 h after admission.One bacterial isolate obtained from blood culture was identified to the species level by biochemical tests and serological tests as S.suis serotype 2.Identification was confirmed by PCR amplification of genes encoding 16sRNA of S.suis and the capsule of S.suis serotype 2(cps 2J).Genes encoding virulence factors were also detected.An investigation to identify the source of S.suis revealed that several days before admission the affected man had been handling sick pigs or their meat.Transmission may occur through breaks in the skin of feet with tinea due to that no measures for personal protection was taken.This case should highten awareness of the potential for occupational exposure and human infection with S.suis. | Yefei Zhu Zhongmin Tan Lingyang Zhu Hongxing Pan Xuejun Zhang Lei Xu Huimin Qian Ling Gu Xun Ye Chen Dong Changjun Bao Rongqiang Zhu Fengcai Zhu Hua Wang | 2008 | Journal of Nanjing Medical University2008，22，5： | 3 |
| 2 | Removal of toxic metal ions using chitosan coated carbon nanotube composites for supercapacitors显示文摘Environmental pollution and energy crisis are two major global challenges to human beings.Recovering energy from wastewater is considered to be one of the effective approaches to address these two issues synchronously.As the main pollutants in wastewater,toxic heavy metal ions are the potential candidates for energy storage devices with pseudocapacitive behaviors.In this study,toxic metal ions of Cr(VI)and Cu(II)are removed efficiently by chitosan coated oxygen-containing functional carbon nanotubes,and the corresponding equilibrium adsorption capacity is 142.1 and 123.7 mg g^(-1).Followed by carbonization of metal ions-adsorbed adsorbents,Cu-and Cr N-loaded carbon composites can be obtained.Electrochemical measurements show that the supercapacitor electrodes based on Cu-and Cr N-loaded carbon composites have specific capacitance of 144.9 and 114.9 F g^(-1)at2 m V s^(-1),with superior electrochemical properties to pure chitosan coated carbon nanotubes after carbonization.This work demonstrates a new strategy for the resource-utilization of other heavy metal ions for energy devices,and also provides a new way to turn environmental pollutants into clean energy. | Pin Hao Xiaoye Ma Junfeng Xie Fengcai Lei Liyi Li Wenqian Zhu Xin Cheng Guanwei Cui Bo Tang | 2018 | Science China Chemistry2018，61，7： | 2 |
| 3 | Ultra- thin two-dimensional inorganic materials:new opportu- nities for solid state nanochemistry显示文摘 | SUN Yongfu GAO Shan LEI Fengcai | 2015 | Accounts Chem Res2015，48，1： | 1 |
| 4 | Oxygen vacancies confined in uhrathin Indium Oxide porous sheets for promoted visible-light water splitting 显示文摘 | Lei Fengcai Sun Yongfu Liu Katong Gao Shah Liang Liang Pan Bicai and Xie Yi | 2014 | Journal of the American Chemical Society2014，136，： | 1 |
| 5 | The Infection of Healthcare Workers and the Reinfection of Patients by Omicron Variant—Jiangsu Province,China,December 2022 to January 2023显示文摘Summary What is already known about this topic?Healthcare workers(HCWs)and previously infected patients(PIPs)may experience a wave of epidemic following the modification of the country’s coronavirus disease(COVID)-zero policy in China.What is added by this report?As of early January 2023,the initial wave of the COVID-19 pandemic among HCWs had effectively subsided,with no statistically significant differences observed in infection rates compared to those of their co-occupants.The proportion of reinfections among PIPs was relatively low,particularly in those with recent infections.What are the implications for public health practice?Medical and health services have resumed normal operations.For patients who have recently experienced severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infections,appropriate relaxation of policies may be considered. | Chuanmeng Zhang Ting Guo Lei Zhang Aiqin Gu Jun Ye Mei Lin Ming Chu Fengcai Zhu Li Zhu | 2023 | China CDC weekly2023，5，18： | 0 |
| 6 | An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19显示文摘The global spread of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)requires an urgent need to find effective therapeutics for the treatment of coronavirus disease 2019(COVID-19).In this study,we developed an integrative drug repositioning framework,which fully takes advantage of machine learning and statistical analysis approaches to systematically integrate and mine large-scale knowledge graph,literature and transcriptome data to discover the potential drug candidates against SARS-CoV-2.Our in silico screening followed by wet-lab validation indicated that a poly-ADP-ribose polymerase 1(PARP1)inhibitor,CVL218,currently in Phase I clinical trial,may be repurposed to treat COVID-19.Our in vitro assays revealed that CVL218 can exhibit effective inhibitory activity against SARS-CoV-2 replication without obvious cytopathic effect.In addition,we showed that CVL218 can interact with the nucleocapsid(N)protein of SARS-CoV-2 and is able to suppress the LPS-induced production of several inflammatory cytokines that are highly relevant to the prevention of immunopathology induced by SARS-CoV-2 infection. | Yiyue Ge Tingzhong Tian Suling Huang Fangping Wan Jingxin Li Shuya Li Xiaoting Wang Hui Yang Lixiang Hong Nian Wu Enming Yuan Yunan Luo Lili Cheng Chengliang Hu Yipin Lei Hantao Shu Xiaolong Feng Ziyuan Jiang Yunfu Wu Ying Chi Xiling Guo Lunbiao Cui Liang Xiao Zeng Li Chunhao Yang Zehong Miao Ligong Chen Haitao Li Hainian Zeng Dan Zhao Fengcai Zhu Xiaokun Shen Jianyang Zeng | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 0 |
| 7 | Novel(Ni, Fe)S2/(Ni, Fe)3S4 solid solution hybrid: an efficient electrocatalyst with robust oxygen-evolving performance显示文摘Fabrication of high-activity electrocatalysts with operational stability is desperately needed to achieve efficient energy conversion.Herein,for the first time,we highlight a novel electrocatalyst based on binary nickel iron sulfide solid solution hybrids on carbon cloth for oxygen evolution reaction.Benefitting from the synergistic effect of varied phases and the interfacial connection between(Ni,Fe)S2 and(Ni,Fe)3S4 to accelerate the charge transport,the Ni incorporation to optimize the electronic structure of the hybrids and the downshift of the d-band center to facilitate the desorption of oxygen intermediates,the partial charge-transfer between Fe and Ni to boost the generation of catalytically active Ni3+as well as the unique nanosphere structure to offer enough buffer area for the volume changes during constant redox reactions,the obtained binary nickel iron sulfide hybrids((Ni,Fe)S2/(Ni,Fe)3S4)display high catalytic reactivity with a low overpotential of 210 mV to reach the current density of 10 mA cm-2,and excellent stability with negligible activity deterioration,making the hybrid a promising candidate for electrocatalytic alkaline water oxidation. | Pin Hao Ying Xin Jian Tian Liyi Li Junfeng Xie Fengcai Lei Lili Tong Hong Liu Bo Tang | 2020 | Science China Chemistry2020，63，8： | 0 |
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