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	题名	作者	年代	出处	被引量
1	Genome survey uncovers the secrets of sex and lifestyle in caterpillar fungus显示文摘The caterpillar fungus Ophiocordyceps sinensis (best known as Cordyceps sinensis) mummifies ghost moth larvae exclusively in Tibetan Plateau alpine ecosystems. Touted as 'Himalayan Viagra', the fungus is highly prized due to its medical benefits and dwindling supplies. Attempts to culture the sexual fruiting-body have failed and the huge market demand has led to severe devastation of local ecosystems and to the fungus heading towards extinction. By genome sequencing, we establish that unlike related insect pathogens O. sinensis contains two compatible mating-type genes in its genome and is self-fertile, i.e. homothallic. However, sexual processes are only initiated under native environmental conditions. O. sinensis resembles biotrophic plant pathogens in having a genome shaped by retrotransposon-driven expansions. The resulting changes in gene content suggest that O. sinensis has a biphasic pathogenic mechanism beginning with stealth pathogenesis in early host instars. O. sinensis is the first psychrophilic fungus sequenced and is adapted to extreme cold with putative antifreeze proteins and mechanisms for increasing lipid accumulation and fatty acid unsaturation. We hypothesize that for the inbreeding O. sinensis the massive proliferation of retrotransposons provides a tradeoff between the advantages of increased genetic variation independent of sexual recombination and deletion of genes dispensable for its specialized pathogenic lifestyle.	HU Xiao ZHANG YongJie XIAO GuoHua ZHENG Peng XIA YongLiang ZHANG XingYu ST LEGER Raymond J LIU XingZhong WANG ChengShu	2013	Chinese Science Bulletin2013，58，23：	26
2	A thyroxine dosage of 8 μg/kg per day is appropriate for theinitial theatment of the majority of infants with long enital pothyroidism显示文摘	TOUATI G LEGER J TOUBLANC JE	1997	Eur J Pe diatr1997，156，：	1
3	Differential gene expression by Metarhizium anisopliae growing in root exudate and host(Manduca sexta)cuticle or hemolymph reveals mechanisms of physiological adaptation显示文摘	Wang C S Hu G St Leger R J	2005	Fungal Genetics and Biology2005，42，：	1
4	Thickened pituitary stalk on magnetic resonance imaging in children with central diabetes insipidus显示文摘	Leger J Velasquez A Garel C	1999	J Clin Endocrinol Metab1999，84，6：	1
5	Assessmentof body protein: energy status in chronic kidneydisease 显示文摘	Cano NJ Miolane-Debouit M Leger J	2009	Seminars in Nephrology2009，29，1：	1
6	Selected materials issues associated with space station显示文摘	Leger L Visentine J Santos-Mason B	1987	SAMPE Quarterly1987，18，2：	1
7	Electrocatalytic oxidation of 1,2-propanediol-Ⅲa kinetic analysis of its oxidation on platinum in acid medium显示文摘	Leger J M Lamy C	1988	Electrochemical Acta1988，33，10：	1
8	Engineering improved mycoinsecticides显示文摘	St Leger R J Roberts D W	1997	Trends in Biotechnology1997，15，：	1
9	Mode shaping of a graded-reflectivitymirror unstable resonator with an intra-cavity phase element显示文摘	MAKKI S LEGER J	2001	IEEE Journal of Quantum Electronics2001，37，1：	1
10	Influence of severity of congenital hypothyroidism and adequacy of treatment on school achievement in young adolescents : a populati0n-based cohort study显示文摘	Leger J Larroque B Norton J	2001	Acta Paediatr2001，90，11：	1
11	The Metarbizium anisopliae Perilipin homolog MPL1 regulates lipid metabolism, appressorial turgor pressure, and vintlence显示文摘	Wang Chengshu St Leger R J	2007	J Biol Chem2007，282，21：	1
12	Ontogeny of leptin in human fetuses and newborns: Effect of intrauterine growth retardation on serum leptin concentrations 显示文摘	aquet D Leger J Levy-marchal C	1998	J Clin Endocrinol Metab1998，83，：	1
13	Synthesis and design of superhard materials 显示文摘	Haines J Leger J M Bocquillon G	2001	Annu Rev Mater Res2001，31，：	1
14	Synergistic effect in the electrocatalytic oxidation of methanol on platinum palladium alloy electrodes 显示文摘	Kadirgan F Beden B Leger J M	1981	J Electroanal Chem1981，125，：	1
15	Graves' disease in childhood: advances in management with antithyroid drug therapy 显示文摘	Kaguelidou F Carel JC Leger J	2009	Horm Res2009，71，6：	1
16	Relative Stability of ZrO2 and HfO2 Structural Phase 显示文摘	Lowther J E Dewhurst J K Leger J M	1999	Phys Rev B1999，60，14：	1
17	Modulation transfer function estimation from nonspecific images显示文摘	J M Delvit D Leger		0，，06：	1
18	Growth hormone deficiency with ectopic neurohypophysis: anatomical variations and relationship between the visibility of the pituitary stalk asserted by magnetic resonance imaging and anterior pituitary function显示文摘	Chen S Leger J Garel C	1999	J Clin Endocrinol Metab1999，84，7：	1
19	Growth factors and intrauterine growth retardation显示文摘	Leger J Noel M Limal JM ct al	1996	Pediatrics Research1996，40，1：	1
20	Bone reconstruction with in- duced membrances and cancellous autogfaft:resuhs in 18 cases of os- teitis显示文摘	Rezzouk J Leclere J Leger OP	2005	J Bone Joint Surg Br2005，2，：	1

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