|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor显示文摘因为早察觉和治疗为病人的医药管理是批评的,为早前列腺癌症诊断的新奇简历标记的鉴定是高度重要的。在基础房间层和地下室膜的连续性的混乱为高级职业人员静电干扰 intraepithelial 瘤形成(HGPIN ) 的前进是必要的到在人的前列腺的侵略腺癌。涉及变换到侵略显型的分子是强烈审查的题目。我们以前报导了矩阵 metalloproteinase-26 (MMP-26 ) 经由地下室膜蛋白质并且由激活 MMP-9 的酶原形式的劈开支持人的前列腺癌症房间的侵略。而且,我们发现了 metalloproteinases-4 (TIMP-4 ) 的那个织物禁止者是大多数有势力 MMP-26 的内长的禁止者。这里,我们更高示威(p<0.0001 ) 在 HGPIN 和癌症的 MMP-26 和 TIMP-4 表示,与非肿瘤的 acini 相比。他们的表示层次在 HGPIN 是最高的,但是在一样的纸巾在侵略癌症(为各个的 p<0.001 ) 衰退。连续前列腺癌症织物节染色的 Immunohistochemical 建议 MMP-26 和 TIMP-4 的 colocalization。现在的学习显示 MMP-26 和 TIMP-4 可以在 HGPIN 的变换期间起一个不可分的作用到侵略癌症并且可以也为早前列腺癌症诊断用作标记。房间研究(2006 ) 16:750-758。做 i:10.1038/sj .cr.7310089;出版联机 2006 年 8 月 29 日。 | Seakwoo Lee Kevin K Desai Kenneth A Iczkowski Robert G Newcomer Kevin J WU Yun-Ge Zhao Winston W Tan Mark D Roycik Qing-Xiang Amy Sang | 2006 | Cell Research2006，16，9： | 18 |
| 2 | Treatment responses in Asians and Caucasians with chronic hepatitis C infection显示文摘AIM:To conduct a multicentre retrospective review of virological response rates in Asians infected with genotype 1 chronic hepatitis C(CHC) treated with combination interferon and ribavirin and then to compare their responses to that among Caucasians.METHODS:Asian patients infected with genotype 1 CHC treated at 4 Australian centres between 2001 to 2005 were identified through hospital databases.Baseline demographic characteristics,biochemical,virological and histological data and details of treatment were collected.Sustained virological responses(SVR) in this cohort were then compared to that in Caucasian subjects,matched by genotype,age,gender and the stage of hepatic fibrosis.RESULTS:A total of 108 Asians with genotype 1 CHC were identified.The end of treatment response(ETR) for the cohort was 79% while the SVR was 67%.Due to the relatively advanced age of the Asian cohort,only sixty-four subjects could be matched with Caucasians.The ETR among matched Asians and Caucasians was 81% and 56% respectively(P=0.003),while the SVR rates were 73% and 36%(P <0.001) respectively.This difference remained significant after adjusting for other predictive variables. | Kenneth K Yan Marianne Guirgis Amany Zekry Thuy Dinh Anouk Dev Jacob George Alice Lee | 2008 | World Journal of Gastroenterology2008，14，21： | 12 |
| 3 | Bone morphogenetic protein 2 improves patellar tendon healing by promoting migration and proliferation of tenocytes显示文摘The repair of injured tendons remains a great challenge because of the poor intrinsic healing capacity of tendons. In this study, we examined the spatiotemporal expression pattern of the bone morphogenetic protein 2 (bmp-2) gene in normal and experimentally injured rat patellar tendons. We also investigated the ability of exogenously applied BMP-2 to promote patellar tendon healing. In situ hybridization with bmp-2 and alk-6 (bmp-2 receptor) antisense riboprobes revealed that both genes were normally expressed at low levels in intact rat tendons. However, bmp-2 expression was significantly upregulated in tenocytes found in the wound site at 7 d and later following tendon injury. In addition, it was found that bmp-2 was expressed in cultured patellar tenocytes. Appli- cation of exogenous BMP-2 to the tendon wound site significantly enhanced tendon repair. Moreover, in vitro and in vivo studies further demonstrated that BMP-2 enhanced tenocyte proliferation and migration to the wound site. The detectable amount of BMP-2 in normal tendons suggests that a basal level of bmp-2 expression was likely present to maintain the normal functions of the patellar tendon. Injury to the tendon induced increased bmp-2 expression intrinsically, but the expression level was insufficient for proper tendon repair. Our findings indicate that it is possible to significantly improve tendon healing by applying exogenous BMP-2 to the wound site, inferring that this protein could be developed as a potential therapeutic reagent for the treatment of damaged tendons. | TANG MeiKuen LEE Kenneth K | 2011 | Chinese Science Bulletin2011，56，13： | 2 |
| 4 | Effects of in situ light reduction on the maintenance, growth and partitioning of carbon resources in Thalassia testudinum Banks ex Konig显示文摘 | LEE K KENNETH H | 1997 | J Exp Mar Biol Ecol1997，210，1： | 1 |
| 5 | The Effects of Attitudinal and Demographic Factors on Intention to Buy Pirated CDs:The Case of Chinese Consumers显示文摘 | KENNETH K KWONG OLIVER H M YAU JENNY S Y LEE etc | 2003 | Journal of Business Ethics2003，47，： | 1 |
| 6 | Addition of bevacizumab to standard chemoradiation for locoregionally advanced nasopharyngeal carcinoma (RTOG 0615): a phase 2 multi-institutional trial显示文摘 | Nancy Y Lee Qiang Zhang David G Pfister John Kim Adam S Garden James Mechalakos Kenneth Hu Quynh T Le A Dimitrios Colevas Bonnie S Glisson Anthony TC Chan K Kian Ang | 2012 | Lancet Oncology2012，，2： | 1 |
| 7 | Sortilin is essential for proNGF induced neuronal cell death显示文摘 | Nykjaer Ramee Lee Kenneth K | 2004 | Nature2004，427，6977： | 1 |
| 8 | Flexural Cracks in Fiber-Reinforced Concrete Beams with Fiber-Reinforced Polymer Reinforcing Bars显示文摘 | Lee Won K Jansen Daniel C Berlin Kenneth B Cohen Ian E | 2010 | ACI Structural Journal2010，，3： | 1 |
| 9 | Addition of bevacizumab to standard chemoradiation for locoregionally advanced nasopharyngeal carcinoma (RTOG 0615): a phase 2 multi-institutional trial显示文摘 | Nancy Y Lee Qiang Zhang David G Pfister John Kim Adam S Garden James Mechalakos Kenneth Hu Quynh T Le A Dimitrios Colevas Bonnie S Glisson Anthony TC Chan K Kian Ang | 2012 | Lancet Oncology2012，，2： | 1 |
| 10 | Sortilin isessential for proNGF induced neuronal cell death 显示文摘 | NYKJAER RAMEE LEE KENNETH K | 2004 | Na-ture2004，427，6977： | 1 |
| 11 | Three-wavelength light transmission technique to measure smoke particle size and concentration显示文摘 | Kenneth L Cashdollar Calvin K Lee Joseph M Singer | 1979 | Applied Optics1979，18，： | 1 |
| 12 | The Effects of attitudinal and demographic factors on intention to buy pirated CDs:The case of chinese consumers 显示文摘 | KWONG KENNETH K OLIVER H M YAU JENNY S Y LEE | 2003 | J Business Ethics2003，，47： | 1 |
| 13 | ACC/AHA2006年非心脏手术围手术期心血管评估指南更新:关于围手术期β-受体阻滞剂使用的专题更新--美国心脏病学会/美国心脏协会医疗指南工作组报告(非心脏手术围手术期心血管评估2002指南更新编写委员会)显示文摘美国心脏病学会/美国心脏协会(ACC/AHA)医疗指南工作组尽力避免因编写委员会成员与企业的关系或个人利益而导致的任何实际的、可能的,或者是已发现的利益冲突。编写委员会的所有成员以及本文件的同行评议人必须对可能被视为是实际上或是潜在的利益冲突进行声明。工作组对以上声明进行审查。在每次会议上,这些声明必须口头汇报给编写委员会的每位成员;当发生变动时,编写委员会对声明进行更新并再次核查。编写委员会成员和企业的关系见附表1,同行评议人与企业的关系见附表2。本指南旨在确定在大多数情形下满足大部分患者需求的方案。指南反映了对当前可获得的科学文献进行系统分析后专家们达成的共识,其目的在于提高医疗质量。如果将指南用于管理/投资决策,其终极目标应是医疗质量得到提高并服务于患者。关于具体患者的医疗问题,必须由医疗人员和患者根据具体情况共同做出最终决定。Sidney C Smith,Jr.,MD,FACC,FAHA ACC/AHA医疗指南工作组主席Elliot M.Antman,MD,FACC,FAHA | Lee A. Fleisher, MD, FACC Joshua A. Beckman, MD, FACC Kenneth A. Brown, MD, FACC, FAHA Hugh Calkins, MD, FACC, FAHA EUiott L. Chaikof, MD, PhD Kirsten E. Fleischmann, MD, MPH, FACC William K. Freeman, MD, FAC James B. Froehlich, MD, MPH, FACC Edward K. Kasper, MD, FACC Judy K Kersten, MD, FACC Barbara Riegel, DNSc, RN, FAHA John F. Robb, MD, FACC 李恒(译) 阎哲(译) 杨承祥(校) | 2008 | 麻醉与镇痛2008，4，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员