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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Bile leakage after loop closure vs clip closure of the cystic duct during laparoscopic cholecystectomy:A retrospective analysis of a prospective cohort显示文摘BACKGROUND Laparoscopic cholecystectomy(LC)is one of the most frequently performed surgical procedures.Cystic stump leakage is an underestimated,potentially life threatening complication that occurs in 1%-6%of the patients.With a secure cystic duct occlusion technique during LC,bile leakage becomes a preventable complication.AIM To investigate the effect of polydioxanone(PDS)loop closure of the cystic duct on bile leakage rate in LC patients.METHODS In this retrospective analysis of a prospective cohort,the effect of PDS loop closure of the cystic duct on bile leakage complication was compared to patients with conventional clip closure.Logistic regression analysis was used to develop a risk score to identify bile leakage risk.Leakage rate was assessed for categories of patients with increasing levels of bile leakage risk.RESULTS Of the 4359 patients who underwent LC,136(3%)underwent cystic duct closure by a PDS loop.Preoperatively,loop closure patients had significantly more complicated biliary disease compared to the clipped closure patients.In the loop closure cohort,zero(0%)bile leakage occurred compared to 59 of 4223(1.4%)clip closure patients.For patients at increased bile leakage risk(risk score≥1)rates were 1.6%and up to 13%(4/30)for clip closure patients with a risk score≥4.This risk increase paralleled a stepwise increase of actual bile leakage complication for clip closure patients,which was not observed for loop closure patients.CONCLUSION Cystic duct closure with a PDS loop during LC may reduce bile leakage in patients at increased risk for bile leakage. | Sandra C Donkervoort Lea M Dijksman Aafke H van Dijk Emile A Clous Marja A Boermeester Bert van Ramshorst Djamila Boerma | 2020 | World Journal of Gastrointestinal Surgery2020，12，1： | 4 |
| 3 | Comparison of genomic DNA extraction techniques from whole blood samples: a time, cost and quality evaluation study 显示文摘 | Chaeon-Cortes D Haupt L M Lea R A | 2012 | Mol Biol Rep2012，39，5： | 1 |
| 4 | Two cytosolic glutamine synthetase isoforms of maize are specifically involved in the control of grain production 显示文摘 | Martin A Lee J Kichey T Gerentes D Zivy M Tatout C Dubois F Balliau T Valot B Davanture M Laforgue T T Quillere I Coque M Gallais A Moro M B G Bethencourt L Habash D Z Lea P J Charcosset A Perez P Murigneux A Sakakibara H Edwards K J Hirel B | 2006 | The Plant Cell2006，18，11： | 1 |
| 5 | Seasonal prediction of hurricane activity reaching the coast of the United States 显示文摘 | SAUNDERS M A LEA A S | 2005 | Nature2005，434，： | 1 |
| 6 | Comparison of ge- nomic DNA extraction techniques from whole blood samples: a time, cost and quality evaluation study 显示文摘 | Chacon - cortes D Haupt L M Lea R A | 2012 | Mol Biol Rep2012，39，5： | 1 |
| 7 | Self-esteem, appraisal and coping: a comparison of unemployed and reemployed people显示文摘 | Lea E W Kathleen A M | 2002 | Journal of Organizational Behavior2002，，5： | 1 |
| 8 | Inhibitory action of tea extracts and(-)-epigallocatechin gallate on cell proliferation显示文摘 | LEA M A XIAO Q SADHUKHAN A K | 1993 | Proc Annu Meet Am Assoc Cancer Res1993，34，4： | 1 |
| 9 | Untrastructure of the encapsulation of Plasmodium cynomolgi(B strain)on the midgut of a refractory strain of Anopheles gambiae显示文摘 | PASKEWITZ S M BROWN M R LEA A O | 1988 | J Parasitol1988，74，3： | 1 |
| 10 | The immunolocalization of bcl-2 at the maternal-fetal interface in healthy and failing pregnancies显示文摘 | A I-SHAREKH I V TULPPALA M | 1997 | Human Reprod1997，12，： | 1 |
| 11 | A chimeric sperm peptide induces antibodies and strain - specific reversible infertility in mice显示文摘 | LEA I A Van LIEROP M J WIDGREN E E | 1998 | Biol Reprod1998，59，3： | 1 |
| 12 | Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP显示文摘 | LEA P M 4TH FADEN A I | 2006 | CNS Drug Rev2006，12，2： | 1 |
| 13 | Effect of cadmium on antioxidant enzyme activities in sugar cane显示文摘 | FOMZIER R F FENEIRA R R VITORIA A P MOLINA S M G LEA P J | 2002 | Biology Plant2002，45，1： | 1 |
| 14 | A Role for Shoot Protein in Shoot Root Dry Matter Allocation in Higher Plants显示文摘 | Andrews M Raven J A Lea P J | 2006 | Ann Bot2006，97，： | 1 |
| 15 | Inhibition of growth and induction of differentiation of colon cancer cells by peach and plum phenolic compounds显示文摘 | Lea M A Ibeh C desBordes C | 2008 | Anticancer Research2008，28，4： | 1 |
| 16 | The effect of ovariectomy on concentrations of plasma prolactin and LH and parwntal behavior in the domestic fowl显示文摘 | Lea R W Richard Yris M A Sharp P J | 1996 | General and Comparative Endocrinology1996，101，： | 1 |
| 17 | A chimeric sperm peptide induces antibodies and strain-specific reversible infertility in mice显示文摘 | Lea I A van Lierop M J Widgren E E | 1998 | Biol Repord1998，59，3： | 1 |
| 18 | Immune response to immunization with sperm antigens in the macaque oviduct显示文摘 | Lea I A Kurth B O'Rand M G | 1998 | Biol Reprod1998，58，3： | 1 |
| 19 | Building a secreting nanomachine:a structural overview of the typeⅢsecretion system显示文摘 | ABRUSCI P MCDOWELL M A LEA S M | 2014 | Current Opinion in Structural Biology2014，25，： | 1 |
| 20 | Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella显示文摘 | Lea I A Widgren E E O' Rand M G | 2004 | Reprod Biol Endocrinol2004，2，： | 1 |
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