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| 1 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 2 | 无针喷注器注射博来霉素治疗瘢痕疙瘩和肥厚性瘢痕的一项初步研究显示文摘Background: Numerous treatment modalities have been used to treat keloids and hypertrophic scars, but the optimal treatment has not been established. Objectiv e: The aim of this study was to determine the efficacy and safety of intralesion al jet injection of bleomycin as therapy for keloids and hypertrophic scars that are unresponsive to intralesional steroid injection. Methods: The study include d 14 patients with 15 keloids or hypertrophic scars that had not responded to a minimum of three intralesional injections of triamcinolone acetonide. Multiple j et injections of 0.1 ml of bleomycin (1.5 IU/ml) were administered to each lesio n, with injection sites spaced 0.5 mm apart. Injections were repeated each month . Scar height was measured, and scar pliability and erythema were scored at base line and then monthly during the treatment and followup periods. Patients’self -assessments of subjective symptoms (pruritus and pain)were also scored. Clinic al improvementwas defined primarily on the basis of scar height reduction (perce ntage reduction from baseline), and was classified using the following scale: co mplete flattening (100%), highly significant flattening (> 90%), significant f lattening (75-90%), moderate flattening (50-75%), and minimal flattening (< 50%). Preand post-treatment mean values for scar height, scar pliability, eryt hema, pruritus and pain were statistically compared. Results: The number of sess ions required to successfully treat the lesions ranged from two to six. Eleven l esions (73.3%) showed complete flattening, one (6.7%) showed highly significan t flattening, two (13.3%) showed significant flattening, and one scar (6.7%) s howed moderate flattening. The mean scar height was significantly lower, and the mean scores for scar pliability and erythema were significantly better at the e nd of treatment (P < 0.001, P < 0.001 and P < 0.001, respectively). The mean sco res for pruritus and pain also improved significantly (P < 0.001 and P=0.01, res pectively). The observed side-effects were hyperpigmentation (four lesions) and skin atrophy (three lesions). No recurrences were noted during follow up (mean duration of 19 months). Conclusions: Intralesional jet injection of bleo mycin is an effective and safe method of treating keloids and hypertrophic scars that are unresponsive to intralesional steroid therapy. | Saray Y GüleT 冯义国 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，0，1： | 2 |
| 3 | Acute-on-chronic liver failure: Controversies and consensus显示文摘Acute-on-chronic liver failure(ACLF)is a poorly defined syndrome characterised by rapid clinical deterioration in patients with chronic liver disease.Consequences include high short-term morbidity,mortality,and healthcare resource utilisation.ACLF encompasses a dysregulated,systemic inflammatory response,which can precipitate extra hepatic organ failures.Common precipitants include infection,alcoholic hepatitis,and reactivation of viral hepatitis although frequently no cause is identified.Heterogenous definitions,diagnostic criteria,and treatment guidelines,have been proposed by international hepatology societies.This can result in delayed or missed diagnoses of ACLF,significant variability in clinical management,and under-estimation of disease burden.Liver transplantation may be considered but the mainstay of treatment is organ support,often in the intensive care unit.This review will provide clarity around where are the controversies and consensus in ACLF including:Epidemiology and resource utilisation,key clinical and diagnostic features,strategies for management,and research gaps. | Natalie L Y Ngu Eliza Flanagan Sally Bell Suong T Le | 2023 | World Journal of Gastroenterology2023，29，2： | 2 |
| 4 | Optical absorption and electron paramagnetic resonance of Fe ions in KDP crystals 显示文摘 | GARCES N Y STEVENS K T HALLIBURTON LE | 2001 | J Cryst Growth2001，225，24： | 1 |
| 5 | Subjective reactions to intervention with artificial interferences in subjects with and without a history of temporomandibular disorders显示文摘 | Le Bell Y Niemi PM J(a)ms(a) T | 2006 | Acta Odontol Scand2006，64，1： | 1 |
| 6 | Development of thermo- stable Candidaantarctica lipase B through novel in silico design of disulfidebridge显示文摘 | LE Q A T JOO J C YOO Y J | 2012 | Biotechnology and Bioengineering2012，109，4： | 1 |
| 7 | Pre- dicting effects of cations on copper toxicity to lettuce (Lactuca sativa) by the biotic ligand model 显示文摘 | Le T T Y Peijnenburg W J G M Hendriks A J | 2012 | Environ- mental Toxicology and Chemistry2012，31，2： | 1 |
| 8 | Residues of selected antibiotics in water and mud from shrimp ponds in mangrove are?as in Viet Nam显示文摘 | Le T X Munekage Y | 2004 | Marine Pollution Bulletin2004，49，1112： | 1 |
| 9 | Effect of dronedarone on renal function in healthy subjects显示文摘 | Tschuppert Y Buclin T Rothuizen LE | 2007 | Br J Clin Pharmacol2007，64，： | 1 |
| 10 | Therapeutic drug monitoring of mycophenolate mofetil in transplantation显示文摘 | van Gelder T Le Meur Y Shaw LM etal | 2006 | T- her Drug Monit2006，28，2： | 1 |
| 11 | Wet industrial flue gas desulfurization unit: model development and validation on industrial data 显示文摘 | Neveux T Le Moullec Y | 2011 | Ind Eng Chem Res2011，50，12： | 1 |
| 12 | A more versatile route to block copolymers and other polymers of complex architecture by living radical polymerization : the RAFT process 显示文摘 | Chong Y K le P T Moad G | 1999 | Macromolecules1999，32，6： | 1 |
| 13 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 14 | Towards self-organizing mobile ad-hoc networks: the Terminodes project显示文摘 | HUBAUX P GROSS T LE Y | 2001 | IEEE Communication Magazine2001，39，1： | 1 |
| 15 | Taste preference for fatty acids is mediated by GPR40 and GPR120显示文摘 | Cartoni C Yasumatsu K Ohkuri T Shigemura N Yoshida R Godinot N le Coutre J Ninomiya Y Damak S | | 0，，25： | 1 |
| 16 | In vivo accuracy of two intra-parenchymal intracranial pressure monitors显示文摘 | Lescot T Reina V Le Manach Y | | 0，，05： | 1 |
| 17 | The influ- ence of greening the suppliers and green innovation on environ- mental performance and competitive advantage in Taiwan 显示文摘 | CHIOU T Y CHAN H K LE'ITICE F | 2011 | Transportation Research Part E2011，47，6： | 1 |
| 18 | Modeling tox- icity of binary metal mixtures (Cu2-Ag+, Cu2+-Zn2) to lettuce, Lactuca sativa, with the biotic ligand model 显示文摘 | Le T T Y Vijver M G Hendriks A J | 2013 | Environmental Toxicology and Chemistry2013，32，1： | 1 |
| 19 | Effect of dronedarone on renal function in healthy subjects 显示文摘 | Tschuppert Y Buclin T Rothuizen LE | 2007 | Br J Clin Pharmacol2007，64，6： | 1 |
| 20 | Role of androgens in sex differences in cardiac damage during myocardial infarction显示文摘 | LE T Y ASHTON A W MARDINI M | 2014 | Endocrinology2014，155，2： | 1 |
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