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| 1 | Understanding host-microbial interactions in rumen:searching the best opportunity for microbiota manipulation显示文摘Ruminants utilize a wide variety of dietary substrates that are not digestible by the mammals, through microbial fermentation taking place in the rumen. Recent advanced molecular based approaches have allowed the characterization of rumen microbiota and its compositional changes under various treatment conditions.However, the knowledge is still limited on the impacts of variations in the rumen microbiota on host biology and function. This review summarizes the information to date on host-microbial interactions in the rumen and how we can apply such information to seek the opportunities to enhance the animal performance through manipulating the rumen function. | Nilusha Malmuthuge Le Luo Guan | 2017 | Journal of Animal Science and Biotechnology2017，8，2： | 23 |
| 2 | Salvianolic Acid B Down-regulates Matrix Metalloproteinase-9 Activity and Expression in Tumor Necrosis Factor-α-induced Human Coronary Artery Endothelial Cells显示文摘 | Le Ma Yun-Qian Guan Zhong-Dong Du | 2015 | Chinese Medical Journal2015，，19： | 11 |
| 3 | Accuracy of ^18F-FDG PET/CT for lymph node staging in non-small-cell lung cancers显示文摘这回顾的研究评估了的背景2-( F18 )的诊断精确性在在有 non-small-cell 肺癌症( NSCLC )的病人的变形 mediastinal 和 hilar 淋巴节点的外科手术前的诊断的 -fluoro-2-deoxy-D-glucose-positron 排放断层摄影术( 18F-FDG-PET ) /COmputed 断层摄影术( PET/CT ) 39 个病人全部的 .Methods A 收到了外科手术前的 18F-FDG PET/CT 并且手术后的 biopsy.We 在 39 N 把外科手术前的 PET/CT 扫描结果与相应 intraoperative histopathalogic | LIU Bao-jun DONG Jing-cheng XU Chang-qing ZUO Chuan-tao LE Jing-jing GUAN Yi-hui ZHAO Jun WU Jin-feng DUAN Xiao-hong CAO Yu-xue | 2009 | Chinese Medical Journal2009，，15： | 11 |
| 4 | SM ALL项目数字化地磁资料可靠性分析显示文摘在对中美合作 SMALL (中国低纬地磁台阵 )项目安装在北京地磁台 (白家疃 )和云南通海地磁台的磁通门磁力仪记录资料与磁变仪模拟记录资料进行了详细的对比分析后 ,得出的结果表明 ,两者的日变形态、日变幅有较好的一致性 ,所选特定事件的变化幅度非常一致 ,说明磁通门磁力仪记录到的变化磁场的资料是真实可靠的。尽管目前磁通门磁力仪的基线值存在温度影响和离散度较大的问题 ,但随温度变化有明显的规律性 ,若能采取改进观测条件和观测方法以及缩短观测时间等措施 ,并对基线值进温度校正 ,磁通门磁力仪完全可以提供长期连续可靠的资料。而其为地震预报 ,空间环境预报 ,为日地物理 ,空间物理和地磁学的研究提供的高精度、高分辨率、连续可靠的数字化变化磁场资料是磁变仪模拟记录无法比拟的。 | 韩德胜 张福 高玉芬 周锦屏 Guan Le | 2000 | 地震地磁观测与研究2000，21，5： | 9 |
| 5 | A Novel Recognition Method for Low SNR DSSS Signals Based on Four-Order Cumulant and Eigenvalue Analysis显示文摘At present it is very difficult to estimate the carrier frequency, spread spectrum code period and spread spectrum code pattern of Direct sequence spread spectrum(DSSS) signals with low Signal-to-noise ratio(SNR) accurately and simultaneously in the condition of Gaussian white noise. A novel method of estimation for carrier frequency and spread spectrum code period of DSSS signals based on four-order cumulant and eigenvalue analysis is presented. Compared with the correlative detection in time domain, square filtering detection and Hebbian rule, the proposal method in this study can realize the estimation for the carrier frequency and period of spread spectrum code of low SNR DSSS signals with a high accuracy simultaneously. In a priori condition of the spread spectrum code period the proposal method can calculate synchronization loss time between spread spectrum code and information symbol. The proposal method this paper has a strong ability to suppress Gaussian noise. | GUAN Mingxiang WANG Le | 2015 | Chinese Journal of Electronics2015，24，3： | 7 |
| 6 | Deformation mechanism and microstructures on polycrystalline aluminum induced by high-current pulsed electron beam显示文摘In this paper, we present an experimental investigation of deformation twinning in polycrystalline aluminum exposed to high-current pulsed electron beam (HCPEB) irradiation. The residual tensile stress with about 10 2 MPa was introduced in the irradiated surface layer. The feature characteristic irradiated with various numbers of pulses was investigated. The formation of a large number of twin bands on the surface irradiated with multiple pulses was determined. The experimental observations indicated that the deformation twinning was indeed triggered during HCPEB irradiation. It is suggested that high value of stress and strain rate induced by rapid heating and cooling due to HCPEB irradiation may cause the shifting of whole atomic planes simultaneously. Additionally, some slipping systems may be suppressed due to the geometric confinement by thinned size of surface layer, which can promote the initiation of deformation twinning. | CAI Jie JI Le YANG ShengZhi WANG XiaoTong LI Yan HOU XiuLi GUAN QingFeng | 2013 | Chinese Science Bulletin2013，58，20： | 7 |
| 7 | A Dominant Locus, qBSC-1, Controls β Subunit Content of Seed Storage Protein in Soybean(Glycine max(L.) Merri.)显示文摘Soybean seed storage protein is one of the most important plant vegetable proteins, and β subunit is of great significance to enhance soybean protein quality and processing property. F2 segregated population and residual heterozygous lines(RHL) derived from the cross between Yangyandou(low level of β subunit) and Zhonghuang 13(normal level of β subunit) were used for mapping of β subunit content. Our results showed that β subunit content was controlled by a single dominant locus, qBSC-1(β subunit content), which was mapped to a region of 11.9 cM on chromosome 20 in F2 population of 85 individuals. This region was narrowed down to 2.5 cM between BARCSOYSSR_20_0997 and BARCSOYSSR_20_0910 in RHL with a larger population size of 246 individuals. There were 48 predicted genes within qBSC-1 region based on the reference genome(Glyma 1.0, Williams 82), including the two copies of β subunit coding gene CG4. An InDel marker developed from a thymine(TT) insertion in one copy of CG4 promoter region in Yangyandou cosegregrated with BARCSOYSSR_20_0975 within qBSC-1 region, suggesting that this InDel marker maybe useful for marker-assisted selection(MAS). | WANG Jun LIU Lin GUO Yong WANG Yong-hui ZHANG Le JIN Long-guo GUAN Rong-xia LIU Zhang-xiong WANG Lin-lin CHANG Ru-zhen QIU Li-juan | 2014 | Journal of Integrative Agriculture2014，13，9： | 5 |
| 8 | Implication and challenges of direct-fed microbial supplementation to improve ruminant production and health显示文摘Direct-fed microbials(DFMs)are feed additives containing live naturally existing microbes that can benefit animals’health and production performance.Due to the banned or strictly limited prophylactic and growth promoting usage of antibiotics,DFMs have been considered as one of antimicrobial alternatives in livestock industry.Microorganisms used as DFMs for ruminants usually consist of bacteria including lactic acid producing bacteria,lactic acid utilizing bacteria and other bacterial groups,and fungi containing Saccharomyces and Aspergillus.To date,the available DFMs for ruminants have been largely based on their effects on improving the feed efficiency and ruminant productivity through enhancing the rumen function such as stabilizing ruminal pH,promoting ruminal fermentation and feed digestion.Recent research has shown emerging evidence that the DFMs may improve performance and health in young ruminants,however,these positive outcomes were not consistent among studies and the modes of action have not been clearly defined.This review summarizes the DFM studies conducted in ruminants in the last decade,aiming to provide the new knowledge on DFM supplementation strategies for various ruminant production stages,and to identify what are the potential barriers and challenges for current ruminant industry to adopt the DFMs.Overall literature research indicates that DFMs have the potential to mitigate ruminal acidosis,improve immune response and gut health,increase productivity(growth and milk production),and reduce methane emissions or fecal shedding of pathogens.More research is needed to explore the mode of action of specific DFMs in the gut of ruminants,and the optimal supplementation strategies to promote the development and efficiency of DFM products for ruminants. | Yajing Ban Le Luo Guan | 2022 | Journal of Animal Science and Biotechnology2022，13，2： | 4 |
| 9 | Hot deformation behavior and microstructure evolution of a Mg–Gd–Nd–Y–Zn alloy显示文摘The hot deformation behavior of homogenized Mg–6.5Gd–1.3Nd–0.7Y–0.3Zn alloy was investigated during compression at temperatures of 250–400 ℃ and at strain rates ranging from 0.001 to 0.100 s^(-1). Microstructure analyses show that the flow behaviors are associated with the deformation mechanisms. At the lower temperatures(250–300 ℃), deformation twinning is triggered due to the difficult activation of dislocation cross-slip. Dynamic recrystallization(DRX) accompanied by dynamic precipitation occurs at the temperature of 350 ℃ and influences the softening behavior of the flow.DRX that develops extensively at original grain boundaries is the main softening mechanism at the high temperature of 400 ℃ and eventually brings a more homogeneous microstructure than that in other deformation conditions. The volume fraction of the DRXed grains increases with temperature increasing and decreases with strain rate increasing. | Xiu-Li Hou Yan Li Peng Lv Jie Cai Le Ji Qing-Feng Guan | 2016 | Rare Metals2016，35，7： | 4 |
| 10 | Comprehensive test stand for high-intensity cyclotron development显示文摘A comprehensive test stand for high-intensity cyclotron development,a 10 MeV 430 μA cyclotron,has been successfully constructed at China Institute of Atomic Energy (CIAE) for the experimental verification of the viability of a 100 MeV high-intensity cyclotron (CYCIAE-100) being constructed at CIAE.The verification includes the overall design technology,detail design and engineering technology for the crucial parts of the machine,e.g.main magnet and beam diagnostics.It will also pave the way for future enhancement of the beam intensity.The test stand consists of a H-ion source,axial injection system,central region,main magnet and coil,RF resonator,stripping extraction,and auxiliary systems,which include the RF power amplifier,high voltage and DC power supplies,electric apparatus,beam diagnostics,control,vacuum,water cooling,pneumatic system,and safety interlock.This paper presents the work regarding the design and sub-system development of the test sand,and the results of the beam commissioning of the machine. | ZHANG TianJue LI ZhenGuo CHU ChengJie XING JianSheng GUAN FengPing ZHONG JunQing JI Bin GE Tao YIN ZhiGuo HOU ShiGang PAN GaoFeng YAO HongJuan LU YinLong WANG ZhenHui WU LongCheng LIN Jun JIA XianLu WEI SuMin WEN LiPeng WANG Feng XIA Le CAI HongRu XIE HuaiDong CHEN RongFan ZHANG Yan ZHANG SuPing LIU GengShou ZOU Jian AN ShiZhong YANG JianJun BI YuanJie YANG Fang | 2011 | Chinese Science Bulletin2011，56，3： | 3 |
| 11 | A review of the resistome within the digestive tract of livestock显示文摘Antimicrobials have been widely used to prevent and treat infectious diseases and promote growth in food-production animals.However,the occurrence of antimicrobial resistance poses a huge threat to public and animal health,especial y in less developed countries where food-producing animals often intermingle with humans.To limit the spread of antimicrobial resistance from food-production animals to humans and the environment,it is essential to have a comprehensive knowledge of the role of the resistome in antimicrobial resistance(AMR),The resistome refers to the col ection of al antimicrobial resistance genes associated with microbiota in a given environment.The dense microbiota in the digestive tract is known to harbour one of the most diverse resistomes in nature.Studies of the resistome in the digestive tract of humans and animals are increasing exponential y as a result of advancements in next-generation sequencing and the expansion of bioinformatic resources/tools to identify and describe the resistome.In this review,we outline the various tools/bioinformatic pipelines currently available to characterize and understand the nature of the intestinal resistome of swine,poultry,and ruminants.We then propose future research directions including analysis of resistome using long-read sequencing,investigation in the role of mobile genetic elements in the expression,function and transmission of AMR.This review outlines the current knowledge and approaches to studying the resistome in food-producing animals and sheds light on future strategies to reduce antimicrobial usage and control the spread of AMR both within and from livestock production systems. | Tao Ma Tim A.McAllister Le Luo Guan | 2022 | Journal of Animal Science and Biotechnology2022，13，3： | 2 |
| 12 | Understanding the role of rumen epithelial host-microbe interactions in cattle feed efficiency显示文摘Feed efficiency is one of the economically important traits for the cattle industry that affects profit(feed costs)and the environment(production of manure and methane).Due to that feed efficiency is driven by multi-factors,mechanisms contributing to the animal to animal variation in this trait have not been well defined,limiting the development of precision feeding strategies to improve the herd production efficiency.Rumen microbial fermentation and volatile fatty acids(VFA)production have been recently reported to be associated with cattle feed efficiency,however the roles of rumen epithelial function in feed efficiency are less studied although the rumen epithelium has an important function in VFA absorption and metabolism which can affect host feed efficiency.Rumen epithelium is colonized with a diverse microbial population,termed epimural microbiota,which has proposed functions in tissue development,barrier and inflammation,urea transport,and oxygen scavenging,suggesting that they can affect rumen epithelial functions and subsequently cattle feed efficiency.Especially,prospective functions of epimural microbiota,enhanced rumen immunity and increased rumen epithelial thickness,might contribute to less nutritional requirement for tissue recuperation.Thus,the understanding of the functions of rumen epithelium,epimural microbiota,and rumen epithelial host-microbe interactions is essential to identify their roles in contributing to feed efficiency.In this review,we will focus on to date research findings on the structure of rumen epithelium,epimural microbiota,and epithelial host-microbe interactions together with their functions and how these are associated with feed efficiency,aiming to provide insights on future directions to study rumen epithelial host-microbe interactions and improve the rumen functions in cattle. | Sang Weon Na Le Luo Guan | 2022 | Animal Nutrition2022，，3： | 2 |
| 13 | Contribution of Temperature Increase to Restrain the Transmission of COVID-19显示文摘The COVID-19 outbreak has already become a global pandemic and containing this rapid worldwide transmission is of great challenge.The impacts of temperature and humidity on the COVID-19 transmission rate are still under discussion.Here,we elucidated these relationships by utilizing two unique scenarios,repeated measurement and natural experiment,using the COVID-19 cases reported from January 23–February 21,2020,in China.The modeling results revealed that higher temperature was most strongly associated with decreased COVID-19 transmission at a lag time of 8 days.Relative humidity(RH)appeared to have only a slight effect.These findings were verified by assessing SARSCoV-2 infectivity under the relevant conditions of temperature(4C–37C)and RH(>40%).We concluded that temperature increase made an important,but not determined,contribution to restrain the COVID19 outbreak in China.It suggests that the emphasis of other effective controlling polices should be strictly implemented to restrain COVID19 transmission in cold seasons. | Mengyuan Ren Rongjuan Pei Bahabaike Jiangtulu Junxi Chen Tao Xue Guofeng Shen Xiaoru Yuan Kexin Li Changxin Lan Zhen Chen Xinwen Chen Yun Wang Xiaoqian Jia Zewu Li Audil Rashid Tippawan Prapamontol Xiuge Zhao Zhaomin Dong Yali Zhang Le Zhang Rongwei Ye Zhiwen Li Wuxiang Guan Bin Wang | 2021 | The Innovation2021，2，1： | 2 |
| 14 | Association between a rare novel TP53 variant (rs78378222) and melanoma, squamous cell carcinoma of head and neck and lung cancer susceptibility in non-Hispanic Whites显示文摘 | Guan X Wang LE Liu Z | 2013 | J Cell Mol Med2013，17，7： | 1 |
| 15 | Effect of contact area and depth between cell cathode and interconnect on stack performance for planar solid oxide fuel cells显示文摘 | Le Jin Wanbing Guan Jinqi Niu Xiao Ma Wei Guo Wang | 2013 | Journal of Power Sources2013，，： | 1 |
| 16 | Detection and identification of Lactobacillus species in crops of broilers of different ages by using PCR-denaturing gradient gel Electrophoresis and amplified ribosomal DNA restriction analysis显示文摘 | Le Luo Guan Karen E Hagen Gerald W Tannock | 2003 | Appl Environ Microbiol2003，69，11： | 1 |
| 17 | Simultaneous qualitative assessment and quantitative analysis of flavonoids in various tissues of lotus ( Nelumbo nucifera ) using high performance liquid chromatography coupled with triple quad mass spectrometry显示文摘 | Sha Chen Linchuan Fang Huifen Xi Le Guan Jinbao Fang Yanling Liu Benhong Wu Shaohua Li | 2012 | Analytica Chimica Acta2012，，： | 1 |
| 18 | Magnetic storms in Mercury's magnetosphere显示文摘We present evidence of geomagnetic storms in Mercury’s magnetosphere based on MESSENGER magnetic field observations made just before the probe impacted the planet.Our findings answer the question of whether geomagnetic storms can occur in other planetary magnetospheres.The interaction of the solar wind with Mercury’s magnetosphere is known to involve flux transfer events in the dayside magnetosphere,plasmoids and flux ropes in the magnetotail,and substorm-like processes,all of which occur morphologically similar to Earth but with significant differences.The significantly weaker magnetic field,smaller magnetosphere,and much faster timescale of processes around Mercury,when compared with Earth,enable charged particles to escape its magnetosphere more efficiently through magnetopause shadowing and direct bombard of the surface.Our analysis of MESSENGER’s data during a coronal mass ejection(CME)proves that,despite these substantial differences,a bifurcated ring current can form in Mercury’s magnetosphere that initiates magnetic storms under strong solar wind driving. | ZONG QiuGang ZHAO JiuTong LIU JianJun FU SuiYan SUN WeiJie ZHANG Hui LE Guan RANKIN Robert WEI Yong | 2022 | Science China(Technological Sciences)2022，65，6： | 1 |
| 19 | Analysis of flavonoids from lotus ( Nelumbo nucifera ) leaves using high performance liquid chromatography/photodiode array detector tandem electrospray ionization mass spectrometry and an extraction method optimized by orthogonal design显示文摘 | Sha Chen Ben-Hong Wu Jin-Bao Fang Yan-Ling Liu Hao-Hao Zhang Lin-Chuan Fang Le Guan Shao-Hua Li | 2012 | Journal of Chromatography A2012，，： | 1 |
| 20 | Selection of aptamers against live bacterial cells显示文摘 | Hamula C L Zhang H Guan L L Li X F Le X C | | 0，，20： | 1 |
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