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| 1 | Novel role of phosphodiesterase inhibitors in the management of end-stage heart failure显示文摘In advanced heart failure(HF), chronic inotropic therapy with intravenous milrinone, a phosphodiesterase Ⅲ inhibitor, is used as a bridge to advanced management that includes transplantation, ventricular assist device implantation, or palliation. This is especially true when repeated attempts to wean off inotropic support result in symptomatic hypotension, worsened symptoms, and/or progressive organ dysfunction. Unfortunately, patients in this clinical predicament are considered hemodynamically labile and may escape the benefits of guidelinedirected HF therapy. In this scenario, chronic milrinone infusion may be beneficial as a bridge to introduction of evidence based HF therapy. However, this strategy is not well studied, and in general, chronic inotropic infusion is discouraged due to potential cardiotoxicity that accelerates disease progression and proarrhythmic effects that increase sudden death. Alternatively, chronic inotropic support with milrinone infusion is a unique opportunity in advanced HF. This review discusses evidence that long-term intravenous milrinone support may allow introduction of beta blocker(BB) therapy. When used together, milrinone does not attenuate the clinical benefits of BB therapy while BB mitigates cardiotoxic effects of milrinone. In addition, BB therapy decreases the risk of adverse arrhythmias associated with milrinone. We propose that advanced HF patients who are intolerant to BB therapy may benefit from a trial of intravenous milrinone as a bridge to BB initiation. The discussed clinical scenarios demonstrate that concomitant treatment with milrinone infusion and BB therapy does not adversely impact standard HF therapy and may improve left ventricular function and morbidity associated with advanced HF. | Abhishek Jaiswal Vinh Q Nguyen Thierry H Le Jemtel Keith C Ferdinand | 2016 | World Journal of Cardiology2016，8，7： | 4 |
| 2 | Development of thermo- stable Candidaantarctica lipase B through novel in silico design of disulfidebridge显示文摘 | LE Q A T JOO J C YOO Y J | 2012 | Biotechnology and Bioengineering2012，109，4： | 1 |
| 3 | Modeling and analysis of coupling performance between passive magnetic bearing and hybrid magnetic radial bearing for magnetically suspended flywheel显示文摘 | Han B C Zheng S Q Le Y | 2013 | IEEE Transactions on Magnetics2013，49，10： | 1 |
| 4 | Volatile components of dry-cured ham 显示文摘 | BERDAGUAE J L DENOYER C LE Q J L | 1991 | Journal of Agricultural and Food Chemistry1991，39，7： | 1 |
| 5 | Liquids semi-continuous casting, reheating and thixoforming of a wrought aluminum alloy 7075 显示文摘 | J Dong J Z Cui Q C Le | 2003 | Materials Science and Engineering (A)2003，345，： | 1 |
| 6 | Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1显示文摘 | Carlson J M Brumme C J Martin E Listgarten J Brockman M A Le A Q Chui C K Cotton L A Knapp D J Riddler S A Haubrich R Nelson G Pfeifer N Deziel C E Heckerman D Apps R Carrington M Mallal S Harrigan P R John M Brumme Z L International HIV Adaptation Collaborative | 2012 | J Virol2012，86，13： | 1 |
| 7 | L-arginine enhances aerobic exercise capacity in association with augmented nitric oxide production 显示文摘 | MAXWELL A J HO H V LE C Q | 2001 | Journal Applied Physiology2001，90，3： | 1 |
| 8 | Single-frequency precise point positioning with optimal filtering显示文摘 | Le A Q Tiberius C | 2007 | GPS Solution2007，11，1： | 1 |
| 9 | Thixotropic Mg alloys through Liquidus and Sub-liquidus Casting显示文摘 | LE Q C CUI JZ XIAK | 2005 | Material Science Forum2005，488，： | 1 |
| 10 | Single-frequency Precise Point Positioning With Optimal Filtering显示文摘 | Le A Q Tiberius C | 2007 | GPSSolution2007，，： | 1 |
| 11 | Volatile components of dry-cured ham 显示文摘 | Denoyer C Le Q J Semon E | 1991 | Journal of Agriculture and Food Chemistry1991，39，： | 1 |
| 12 | Amylolytically-resistant tapioca starch modified by combined treatment of branching enzyme and maltogenic amylase显示文摘 | Le Q T Lee C K Kim W Y Lee S J Zhang R | 2009 | Carbohydrate Polymers2009，75，1： | 1 |
| 13 | Capillary dectrophoretic immunoassays for digoxin and gentamicin with laser- induced fluorescene polarization detection 显示文摘 | Wan Q H Le C X | 1999 | Journal of Chromatography B1999，734，： | 1 |
| 14 | CD4 ( + ) CD25 ( + ) FoxP3 ( + ) regulatory T cells suppress Mycobac- terium tuberculosis immunity in patients with active disease显示文摘 | Chen X Zhou B Li M Deng Q Wu X Le X Wu C Lar monier N Zhang W Zhang H Wang H Katsanis E | 2007 | Clin Immunol2007，123，1： | 1 |
| 15 | Effect of a low frequency electromagnetic field on the direct-chill (DC) casting of AZ80 magnesium alloy ingots显示文摘 | Guo S J Le Q C Zhao Z H | 2006 | International Journal of Materials Research2006，97，11： | 1 |
| 16 | Novel techniques forthe diagnosis of Meniere's disease显示文摘 | Le C H Truong A Q Diaz R C | 2013 | Curr Opin Otolar-yngol Head Neck Surg2013，21，5： | 1 |
| 17 | Global carbon budget 2014 显示文摘 | Le Q C Moriaty R Andrew R M | 2014 | Earth System Data Discussions2014，7，7： | 1 |
| 18 | The effect of alternating magnetic field on the process of semi-continuous casting for AZ91 billets显示文摘 | Guo S J Cui J Z Le Q C | 2005 | Materials Letters2005，59，18： | 1 |
| 19 | Genetic transformation of theactinorhizal tree Allocasuarina verticillata by Agrobacteriumtumefaciens 显示文摘 | Franche C Diouf D Le Q V | 1997 | Plant J1997，11，89： | 1 |
| 20 | Effect of a low frequency electromagnetic field on the direct-chill (DC) casting of AZ80 magnesium alloy ingots 显示文摘 | Guo S J Le Q C Zhao Z H | 2006 | International Journal of Materials Research2006，97，11： | 1 |
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