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| 1 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 2 | Black liquor lignin biodegradation by Trametes elegans 显示文摘 | Lara M A R M Antonio J R Orlando J | 2003 | Intemation Biodeterioration & Biodegradation2003，52，3： | 1 |
| 3 | Phase Ⅱ trial of irinote-ean/cisplatin compared with etoposide/cisplatin in extersive-stage small-cen lung cancer:clinical and pharmarogenomic results from SWOG SO124 显示文摘 | Lara P N Jr Natale R Crouley J | 2009 | J Clin Onco12009，27，15： | 1 |
| 4 | Phase Ⅲ trial of irinotecan/cisplatin compared with etoposide/cisplatin in extensive-stage small-cell lung cancer:clinical and pharmacogenomic results from SWOGS0124显示文摘 | Lara PN Jr Natale R Crowley J | 2009 | J Clin Oncol2009，27，15： | 1 |
| 5 | Dynamical strength of social ties in information spreading显示文摘 | MIRITELLO G MORO E LARA R | 2011 | Physics Review E2011，83，04： | 1 |
| 6 | Prognostic signif- icane of the distribution of neck node metastasis from oral carcinoma 显示文摘 | Kowalski LP Bagitetto R Lara JR | 2000 | Head Neck2000，22，3： | 1 |
| 7 | Progress in small cell lung cancer:the lowest common denominator显示文摘 | Gandara DR Lara PN Natale R | 2008 | J Clin Oncol2008，26，： | 1 |
| 8 | Numerical analysis of wave overtopping of rubble mound breakwaters显示文摘 | Losada I J Lara J L Guanchea R Gonzalez-Ondina J M | 2008 | Coastal Engineering2008，55，1： | 1 |
| 9 | A comparison of pal iative stenting or emergent surgery for obstructing incurable colon cancer显示文摘 | Vemulapal i R Lara LF Sreenarasimhaiah J | | 0，，10： | 1 |
| 10 | Yes-associated protein(YAP)functions as a tumor suppressor in breast显示文摘 | Yuan M Tomlinson V Lara R | 2008 | Cell Death Differ2008，15，11： | 1 |
| 11 | Prognostic significance of the distribution of neck node metastasis from oral carcinoma显示文摘 | Kowalski LP Bagietto R Lara JR | 2000 | Head Neck2000，22，3： | 1 |
| 12 | Prognostic significance of the distribution of neck node metastasis from oral carcinoma 显示文摘 | Kowalski LP Bagietto R Lara JR | 2000 | Head Neck2000，22，： | 1 |
| 13 | Long-term eculizumab improves clinical outcomes in atypical hemolytic uremic syn- drome 显示文摘 | Vilalta R Lara E Madrid A | 2012 | Pediatr Nephrol2012，27，12： | 1 |
| 14 | Phase III trial of irinotecan/cisplatin compared with etoposide/cisplatin in extensive - stage small - cell lung cancer: clinical and pharmacogenomic results from SWOG S0124 显示文摘 | Lara P N Jr Natale R Crowley J | 2009 | J Clin Oncol2009，27，15： | 1 |
| 15 | Ozone oxidation and aerobic biodegradation with spent mushroom compost for detoxification and benzo(a)pyrene removal from contaminated soil显示文摘 | LARA R LUIGI R VINCENZO B | 2012 | Chemosphere2012，87，6： | 1 |
| 16 | Resorbable synthetic mesh supported with omentum flap in the treatment of giant hiatal hernia显示文摘 | Pérez Lara FJ Marín R del Rey A | 2014 | Int Surg2014，99，5： | 1 |
| 17 | Neuromyelitis optica syndrome in Cuba:a prospective clinical study of 54 cases显示文摘 | Cabrera-Gomez JA Gonzalez YR Lara R | 2005 | Neurology2005，64，： | 1 |
| 18 | Adaptive fuzzy Petri nets for dynamic knowledge representation and inference显示文摘 | Li X O Yu W Lara F R | 2000 | Expert Systems with Application2000，30，4： | 1 |
| 19 | Phase m trial of Irinotecan/Cisplatin compared with Etoposide/Cisplatin in extensive-stage small-cell lung cancer: Clinical and pharmacoge- nomic results from SWOG S0124 显示文摘 | Lara PN Jr Natale R Crowley J | 2009 | J Clin Oncol2009，27，15： | 1 |
| 20 | Oxaliplatin-related neurotoxici- ty: How and Why? 显示文摘 | Lara MP Mario RD Elena R | 2006 | Oncology Hematology2006，59，： | 1 |
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