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| 1 | C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses显示文摘C 类型 lectin 受体(CLR ) 属于在他们的细胞外的域上包含糖类识别域(CRD ) 和钙绑定地点的蛋白质的一个大家庭。最近的研究显示许多 CLR 例如 Dectin-1, Dectin-2 和 Mincle,作为从感染的微生物认出糖类 ligands 的模式识别受体(PRR ) 工作。在 ligand 绑定之上,这些 CLR 通过他们的自己的 immunoreceptor 导致多重信号 transduction 串联基于酷氨酸的激活主题(ITAM ) 或与象 FcRγ 那样的包含 ITAM 适配器蛋白质交往;。新兴的证据显示导致 CLR 的发信号串联导致原子因素 kappaB 的激活(NF-κ B ) 通过一条 Syk 依赖、 CARD9 依赖的小径的 transcriptional 因素的家庭。NF-κ 的激活; B 在跟随微生物引起的感染和织物损坏的天生的有免疫力、煽动性的回答的正式就职起一个关键作用。在这评论,我们将在 CLR 导致的信号 transduction 小径上总结最近的进步,并且这些 CLR 怎么激活 NF-κ B 并且贡献天生的有免疫力、煽动性的回答。 | Lara M Kingeter Xin Lin | 2012 | Cellular & Molecular Immunology2012，9，2： | 14 |
| 2 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 3 | Renin-angiotensin system in the kidney: What is new?显示文摘The renin-angiotensin system(RAS)has been known for more than a century as a cascade that regulates body fluid balance and blood pressure.AngiotensinⅡ(AngⅡ)has many functions in different tissues;however it is on the kidney that this peptide exerts its main functions.New enzymes,alternative routes for AngⅡformation or even active AngⅡ-derived peptides have now been described acting on AngⅡAT1or AT2receptors,or in receptors which have recently been cloned,such as Mas and AT4.Another interesting observation was that old members of the RAS,such as angiotensin converting enzyme(ACE),renin and prorenin,well known by its enzymatic activity,can also activate intracellular signaling pathways,acting as an outside-in signal transduction molecule or on the renin/(Pro)renin receptor.Moreover,the endocrine RAS,now is also known to have paracrine,autocrine and intracrine action ondifferent tissues,expressing necessary components for local AngⅡformation.This in situ formation,especially in the kidney,increases AngⅡlevels to regulate blood pressure and renal functions.These discoveries,such as the ACE2/Ang-(1-7)/Mas axis and its antangonistic effect rather than classical deleterious AngⅡeffects,improves the development of new drugs for treating hypertension and cardiovascular diseases. | Fernanda M Ferr?o Lucienne S Lara Jennifer Lowe | 2014 | World Journal of Nephrology2014，3，3： | 5 |
| 4 | Reninoma: case report and literature review显示文摘 | Lara Wong Thomas HS Hsu Mark G Perlroth Lawrence V Hofmann Claudia M Haynes Laurence Katznelson | 2008 | Journal of Hypertension2008，，2： | 2 |
| 5 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 6 | The role of squamous cell carcinoma antigen in the management of laryngeal and hypopharyngeal cancer显示文摘 | Lara P C Cuyas J M | 1995 | Cancer1995，76，5： | 1 |
| 7 | Channel estintation using implicit training 显示文摘 | Orozvo- Lugo A G Lara M M M McLernon D C | 2004 | IEEE Transactions on Signal Processing2004，52，1： | 1 |
| 8 | Relationships between ethylene, abscisic acid and quality during postharvest storage of'Granny Smith' apples显示文摘 | LARA I VENDRELL M | 1998 | Postharvest Biology and Technology1998，13，1： | 1 |
| 9 | Black liquor lignin biodegradation by Trametes elegans 显示文摘 | Lara M A R M Antonio J R Orlando J | 2003 | Intemation Biodeterioration & Biodegradation2003，52，3： | 1 |
| 10 | High ALTlevel predict viremia in anti-HCV-positive HD patients if a modi-fied normal range of ALT is applied显示文摘 | Espinosa M Martin-Malo A Alvarez de Lara MA | 2000 | Clin Nephrol2000，54，2： | 1 |
| 11 | Passivation of the calcite surface with malonate ion 显示文摘 | Salinas-Nolasco M F Mendez-Vivar J Lara V H | 2004 | Journal of Colloid and Interface Science2004，274，1： | 1 |
| 12 | Aroma volatile compounds of Fuji apples in relation to harvest date and cold storage technology: A comparison of two seasons显示文摘 | ECHEVERRIA G FUENTES T GRAELL J LARA I LOPEZ M L | 2004 | Postharvest Biology and Technology2004，32，： | 1 |
| 13 | Beetle pollination and floral thermogenicity in Magnolia tamaulipana ( Magnoli- aceae) 显示文摘 | DIERINGER G LARA M LOYA L | 1999 | International Journal of Plant Sciences1999，160，1： | 1 |
| 14 | Numerical analysis of wave overtopping of rubble mound breakwaters显示文摘 | Losada I J Lara J L Guanchea R Gonzalez-Ondina J M | 2008 | Coastal Engineering2008，55，1： | 1 |
| 15 | Analogies and differences between w-Conotoxins MVIIC and MVIID: binding sites and functions in bovine chromaffin cells 显示文摘 | Gandia LB Lara JS Imperial M et gl | 1997 | Pflugers Arch1997，435，： | 1 |
| 16 | Two-level evolution of foraging agent communities显示文摘 | ALFONSECA M LARA J | 2002 | BioSystems2002，66，： | 1 |
| 17 | Periodic solutions in electrodynamic tethers on inclined orbits显示文摘 | Pelfiez J Lara M | | 0，，： | 1 |
| 18 | Effect of treatment with Ginkgo biloba extract EGb 761 (oral) on unilateral idiopathic sudden hearing loss in a prospective randomized double-blind study of 106 outpatients显示文摘 | Martin A. Burschka Hassan Abdel-Hady Hassan Thorsten Reineke Lara van Bebber David M. Caird R. M?sges | 2001 | European Archives of Oto - Rhino - Laryngology2001，，5： | 1 |
| 19 | Yes-associated protein(YAP)functions as a tumor suppressor in breast显示文摘 | Yuan M Tomlinson V Lara R | 2008 | Cell Death Differ2008，15，11： | 1 |
| 20 | Effects of exercise modalities on arterial stiffness and wave refleetiom a systematic review and meta-analysis of randomized controlled trials显示文摘 | Ashor AW Lara J Siervo M | 2014 | PLoS 0ne2014，9，11： | 1 |
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