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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | The role of cysteines in polyketide synthases 显示文摘 | Lanz T Tropf S Mamer F J | 1991 | J Biol Chem1991，266，15： | 1 |
| 3 | Differentiation of cytotoxic and vasogenic edema in a patient with reversible posterior leukoencephalopathy syndrome using diffusion-weighted MRI显示文摘 | Doelken M Lanz S Rennert J | 2007 | Diagn Interv Radiol2007，13，3： | 1 |
| 4 | Evidence that stilbene synthases have developed from ehaleone synthases several times in the course of evolution 显示文摘 | Tropf S Lanz T Rensing S A | 1994 | Journal of Molecular Evolution1994，38，6： | 1 |
| 5 | Rac-3 is a NF-kappa B coactivator显示文摘 | WERBAJH S NOJEK I LANZ R | 2000 | FEBS Lett2000，485，23： | 1 |
| 6 | Mechanisms of neuropathic pain显示文摘 | Nickel F T Seifert F Lanz S | 2012 | Eur Neuropsychopharmacol2012，22，2： | 1 |
| 7 | The γ-secretase inhibitor N--S-pbenylglycine t-butyl ester reduces Aβ levels in vivo in plasma and cerebrospinal fluid in young ( plaque-free ) and aged ( plaque-bearing ) Tg2576 mice 显示文摘 | LANZ T A HIMES C S PALLANTE G | 2003 | J Pharmacol Exp Ther2003，305，3： | 1 |
| 8 | Bilateral paramedian'pontine base infarction显示文摘 | Lanz S Dutseh M Raneh C | 2006 | Stroke2006，15，： | 1 |
| 9 | RAC-3 is a NF-B coactivator 显示文摘 | Werbajh S Nojek I Lanz R | 2000 | FEBS Lett2000，485，24： | 1 |
| 10 | Bulk acoustic wave resonator operating at 8 GHz for gravi- metric sensing of organic films显示文摘 | Rey-Mermet S Lanz R Muralt P | 2005 | Sensors and Actuators B2005，114，2： | 1 |
| 11 | Relation between platelet response to exercise and coronary angiographic findings in patients with effort angina显示文摘 | Lanze GA Sestito A Iacovella S | 2003 | Circulation2003，107，10： | 1 |
| 12 | Protein ki- nase Cβ as a therapeutic target stabilizing blood- brain barrier disruption in experimental autoimmune encephalomyelitis显示文摘 | Lanz TV Becker S Osswald M | 2013 | Proc Natl Acad Sci U S A2013，110，14： | 1 |
| 13 | Cellular-mediated reactions to foreign organisms inoculated into the hemocoel of Anopheles albimanus (Diptera: Culicidae)显示文摘 | Hernandez-Martinez S Lanz H Rodriguez MH | 2002 | Med Entomol2002，39，1： | 1 |
| 14 | Cooperative interaction of hypoxia inducible factor-2ct (hif-2alpha) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 ( Flk-1 )显示文摘 | Elvert G Kappel A Heidenreieh R Englmeier U Lanz S Acker T | 2003 | J Biol Chem2003，278，9： | 1 |
| 15 | The role of cysteines in polyketides synthases, site-directed mutagenesis of resveratrol and chalcone synthase, two key en zymes in different plant specific pathways 显示文摘 | Lanz T Tropf S Marner F J | 1991 | Biol Chem1991，266，： | 1 |
| 16 | Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo显示文摘 | Lanz R B Chua S S Barron N | 2003 | Mol Cell Biol2003，23，20： | 1 |
| 17 | On-line SPE LC-MS/MS for the quan- tification of Delta9- tetrahydrocannabinol (THC) and its two major metabolites in human peripheral blood by liquid chromatography tan- dem mass spectrometry显示文摘 | Konig S Aebi B Lanz S | 2011 | Anal Bioanal Chem2011，400，1： | 1 |
| 18 | RAC-3 is a NF-kappa B coactivator显示文摘 | Werbajh S Nojek I Lanz R | | 0，，2： | 1 |
| 19 | Swine Interferon-Inducible Transmembrane Proteins Potently Inhibit Influenza A Virus Replication显示文摘 | Lanz C Yángüez E Andenmatten D Stertz S | 2015 | J Virol2015，89，1： | 1 |
| 20 | Mechanisms of neuropathicpain显示文摘 | NICKEL F T SEIFERT F LANZ S | 2012 | Eur Neuropsychopharmacol2012，22，2： | 1 |
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