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283篇 您的检索式：作者名="LANGEVELD"

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	题名	作者	年代	出处	被引量
1	Juvenile polyposis syndrome显示文摘Juvenile polyposis syndrome is a rare autosomal dominant syndrome characterized by multiple distinct juvenile polyps in the gastrointestinal tract and an increased risk of colorectal cancer.The cumulative life-time risk of colorectal cancer is 39% and the relative risk is 34.Juvenile polyps have a distinctive histology characterized by an abundance of edematous lamina propria with inflammatory cells and cystically dilated glands lined by cuboidal to columnar epithelium with reactive changes.Clinically,juvenile polyposis syndrome is defined by the presence of 5 or more juvenile polyps in the colorectum,juvenile polyps throughout the gastrointestinal tract or any number of juvenile polyps and a positive family history of juvenile polyposis.In about 50%-60% of patients diagnosed with juvenile polyposis syndrome a germline mutation in the SMAD4 or BMPR1A gene is found.Both genes play a role in the BMP/TGF-beta signalling pathway.It has been suggested that cancer in juvenile polyposis may develop through the socalled 'landscaper mechanism' where an abnormal stromal environment leads to neoplastic transformation of the adjacent epithelium and in the end invasive carcinoma.Recognition of this rare disorder is important for patients and their families with regard to treatment,follow-up and screening of at risk individuals.Each clinician confronted with the diagnosis of a juvenile polyp should therefore consider the possibility of juvenile polyposis syndrome.In addition,juvenile polyposis syndrome provides a unique model to study colorectal cancer pathogenesis in general and gives insight in the molecular genetic basis of cancer.This review discusses clinical manifestations,genetics,pathogenesis and management of juvenile polyposis syndrome.	Lodewijk AA Brosens Danielle Langeveld W Arnout van Hattem Francis M Giardiello G Johan A Offerhaus	2011	World Journal of Gastroenterology2011，17，44：	7
2	Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo显示文摘	Cor H. J. Lamers Sabine C. L. Langeveld Corrien M. Groot-van Ruijven Reno Debets Stefan Sleijfer Jan Willem Gratama		Cancer Immunology Immunotherapy0，，：	2
3	Synthetic peptidevactines: unexpected fulfillment of discarded hope? 显示文摘	Meloen R H Langeveld J P Schaaper W M	2001	Biological2001，29，：	1
4	Identification of the goodpasture antigen as the alpha 3 (Ⅳ) chain of collagen Ⅳ显示文摘	Saus J Wieslander J Langeveld JP	1988	J Biol Chem1988，263，13：	1
5	Implication of glucocorticoid receptors in the stimulation of human glioma cell proliferation by dexamethasone 显示文摘	Langeveld CH van Waas MP Stoof JC	1992	J Neurosci Res1992，31，3：	1
6	Gentamicinresistant menadione and hemin auxotrophic Staphylococcus aureus persist within cultured endothelial cells显示文摘	Balwit J M van Langevelde P Vann J M	1994	The Journal of Infectious Diseases1994，170，4：	1
7	Synthetic peptide viccines : unexpected fullfillment of discarded Hope 显示文摘	Rob H M Langeveld P M Wim M M	2001	Biologicals2001，29，34：	1
8	Open or endoscopic total extraperitoneal inguinal hernia repair ? A systematic review显示文摘	Kuhry E van Veen RN Langeveld HR	2007	Surg Endosc2007，21，2：	1
9	The role of the active phase of Raney-type Ni catalysts in the selective hydrogenation of d -glucose to d -sorbitol显示文摘	B.W Hoffer E Crezee F Devred P.R.M Mooijman W.G Sloof P.J Kooyman A.D van Langeveld F Kapteijn J.A Moulijn	2003	Applied Catalysis A General2003，，2：	1
10	An advanced explicit surface potential model physically accounting for the quantization effects in deep-submi- cron MOSFETs显示文摘	Pregaldiny F Lallement C Van Langevelde R	2004	Solid-State Electronics2004，48，3：	1
11	Trace Element Determinations Using a 15 keV Synchrotron X-ray Microprobe 显示文摘	Langevelde F Vis R D	1991	AnalChem1991，63，：	1
12	Transformation of lily by Agrobacterium显示文摘	Langeveld S A Gerrits M M Derked F L M	1995	Euphytica1995，85，：	1
13	Molecular characterization of carla-and potyviruses from Narcissus in China显示文摘	Chen J Chen J P Langeveld	2003	Phytopathology2003，151，：	1
14	An explicit surface- potential-based MOSFET model for circuit simulation 显示文摘	Van Langevelde R Klaassen F M	2000	Solid-State Electronics2000，44，3：	1
15	Transformation of lily by grobacterium显示文摘	LANGEVELD S A GERRITS M M DERKS F L M etal	1995	Euphytica1995，85，1：	1
16	Angiotensin-(1-7) attenuates neointimal formation after stent implantation in the rat 显示文摘	Langeveld B van Gilst WH Tio RA	2005	Hypertension2005，45，：	1
17	Analog circuits in ultra-deep-submicron CMOS 显示文摘	ANNEMA A J NAUTA B VAN LANGEVELDE R	2005	IEEE J Sol Sta Circ2005，40，1：	1
18	Characterization of sulfided Mo/Al2O3 catalysts by temperature-programmed reduction and low temperature Fourier transform infrared spectroscopy of adsorbed carbon monoxide显示文摘	MUELLER B VAN LANGEVELD A D MOULUN J A	1993	J Phys Chem1993，97，35：	1
19	Endotoxin, cytokines, and procalcitonin in febrile patients admitted to the hospital: identification of subjects at high risk of mortality显示文摘	Langevelde P Joop K Loon J	2000	Clin Infect Dis2000，31，6：	1
20	Transformation of Lily by agrobacterium显示文摘	Langeveld S A Gerrits M M Anton F L M	1995	Euphytica1995，85，：	1

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