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| 1 | Critical function of DNA methyltransferase 1 in tomato development and regulation of the DNA methylome and transcriptome显示文摘DNA methylation confers epigenetic regulation on gene expression and thereby on various biological processes.Tomato has emerged as an excellent system to study the function of DNA methylation in plant development.To date,regulation and function of DNA methylation maintenance remains unclear in tomato plants.Here,we report the critical function of tomato(Solanum lycopersicum)Methyltransferase 1(Sl MET1)in plant development and DNA methylome and transcriptome regulation.Using CRISPR-Cas9 gene editing,we generated slmet1 mutants and observed severe developmental defects with a frame-shift mutation,including small and curly leaves,defective inflorescence,and parthenocarpy.In leaf tissues,mutations in Sl MET1 caused CG hypomethylation and CHH hypermethylationon a whole-genome scale,leading to a disturbed transcriptome including ectopic expression of many RIN target genes such as ACC2 in leaf tissues,which are normally expressed in fruits.Neither the CG hypomethylation nor CHH hypermethylation in the slmet1 mutants is related to tissue culture.Meanwhile,tissue culture induces non-CG hypomethylation,which occurs more frequently at gene regions than at TE regions.Our results depict Sl MET1-and tissue culture-dependent tomato DNA methylomes,and that Sl MET1 is required for maintaining a normal transcriptome and normal development of tomato. | Yu Yang Kai Tang Tatsiana U Datsenka Wenshan Liu Suhui Lv Zhaobo Lang Xingang Wang Jinghui Gao Wei Wang Wenfeng Nie Zhaoqing Chu Heng Zhang Avtar K HANDa Jian-Kang Zhu Huiming Zhang | 2019 | Journal of Integrative Plant Biology2019，61，12： | 3 |
| 2 | Surface NMR within a Geophysical Study of an Aqui{er at Halden- sleben (Germany) 显示文摘 | Yaramanci U Lange G Knodel K | 1999 | Geophysical Prospecting1999，47，： | 1 |
| 3 | Combined overexpression of genes of the er- gosterol biosynthetic pathway leads to accumulation of sterols in Saccharo- myces cerevisiae 显示文摘 | Veen M Stahl U Lang C | 2003 | Fems Yeast Research2003，4，： | 1 |
| 4 | Complications in surgical treatment of thoracolumbar injuries显示文摘 | Knop C Bastian L Lange U | 2002 | Eur Spine J2002，11，3： | 1 |
| 5 | Synthesis and activity of novel and selective 1 (Ks) -channel blockers 显示文摘 | Gerlach U Brendel J Lang HJ | 2001 | J Med Chem2001，44，23： | 1 |
| 6 | Enhancement of radiosensitivity of wild-type p53 human glioma cells by adenovirus-mediated delivery of the p53 gene显示文摘 | LANG F F YUNG W K RAJU U | 1998 | J Neurosurg1998，89，1： | 1 |
| 7 | Aquifer characterisation using surface NMR jointly with other geophysical techniques at the Nauen/Berlin test site显示文摘 | Yaramanci U Lange G Hertrich M | 2002 | Journal of Applied Geophysics2002，50，2： | 1 |
| 8 | Evaluation of the mobi- lity of adjacent segment after posterior thoracolumbar fixation : a bi- omechanical study显示文摘 | BASTIAN L LANGE U KNOP C | 2001 | Eur Spine J2001，10，4： | 1 |
| 9 | Complications in surgical treatment of thoracolumbar injuries显示文摘 | Knop C Bastian L Lange U | 2002 | Eur Spine J2002，11，： | 1 |
| 10 | Marginal fit of ce- mented and screw-retained crowns incorporated on the Straumann(ITI)Dental Implant System: an in vitro study 显示文摘 | Tosches NA Br/i gger U Lang NP | 2009 | Clin Oral Implants Res2009，20，1： | 1 |
| 11 | Effects of acute and chronic treatment with the sodium hydrogen exchanger 1 (NHE-1) inhibitor cariporide on myocardial infarct mass in rabbits with hypercholesterolaemia显示文摘 | Jung O Albus U Lang HJ | 2004 | Basic Clin Pharmacol Toxicol2004，95，： | 1 |
| 12 | Ankylosing spondylitis and bone mineral density - what is the ideal tool for measurement?显示文摘 | Lange U Kluge A Strunk J | 2005 | Rheumatol Int2005，26，： | 1 |
| 13 | Complications in surgical treatment of thoracolumbar injuries显示文摘 | Knop C Bastian L Lange U | 2002 | Spine2002，11，3： | 1 |
| 14 | Motor learning in man a review of functional and clinical studies显示文摘 | Halsband U Lange RK | 2006 | J Physiol Paris2006，99，4： | 1 |
| 15 | Nebivolol decreases endothelial cell stiffness via the estrogen receptor beta: a nano-imaging study 显示文摘 | HILLEBRAND U LANG D TELGMANN R G | 2009 | J Hypertens2009，27，3： | 1 |
| 16 | Scanning probe microscopy of carbon nanotubes显示文摘 | HUBLER U JESS P LANG H P | 1998 | Carbon1998，36，56： | 1 |
| 17 | Enhancement of radiosensitivity of wild-type p53 human glioma cells by adenovims-mediated delivery of the p53 gene 显示文摘 | Lang FF Yung WK Raju U | 1998 | J Neurosurg1998，89，1： | 1 |
| 18 | Anterior vertebral body replacement with a titanium implant of adjustable height:a prospective clinical study显示文摘 | Lange U Edeling S Knop C | 2007 | Eur Spine J2007，16，2： | 1 |
| 19 | Systematic review of the efficacy and safety of colorectal stents 显示文摘 | KHOT U P LANG A W MURALI K | 2002 | Br J Surg2002，89，： | 1 |
| 20 | High-dose chemotherapy with peripheral blood progenitor cell support for patients with non-small cell lung cancer: the experience of the European Group for Bone Marrow Transplantation (EBMT) Solid Tumours Work- ing Party显示文摘 | De Giorgi U Blaise D Lange A | 2007 | Bone Marrow Transplant2007，40，11： | 1 |
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