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| 1 | Sphingosine Kinase-1/sphingosine 1-phosphate pathway in diabetic nephropathy显示文摘 | Deng Yanhui Lan Tian Huang Juan Huang Heqing | 2014 | Chinese Medical Journal2014，，16： | 6 |
| 2 | Cell sheet formation enhances the therapeutic effects of human umbilical cord mesenchymal stem cells on myocardial infarction as a bioactive material显示文摘Stem cell-based therapy has been used to treat ischaemic heart diseases for two decades.However,optimal cell types and transplantation methods remain unclear.This study evaluated the therapeutic effects of human umbilical cord mesenchymal stem cell(hUCMSC)sheet on myocardial infarction(MI).Methods:hUCMSCs expressing luciferase were generated by lentiviral transduction for in vivo bio-luminescent imaging tracking of cells.We applied a temperature-responsive cell culture surface-based method to form the hUCMSC sheet.Cell retention was evaluated using an in vivo bio-luminescent imaging tracking system.Unbiased transcriptional profiling of infarcted hearts and further immunohistochemical assessment of monocyte and macrophage subtypes were used to determine the mechanisms underlying the therapeutic effects of the hUCMSC sheet.Echocardiography and pathological analyses of heart sections were performed to evaluate cardiac function,angiogenesis and left ventricular remodelling.Results:When transplanted to the infarcted mouse hearts,hUCMSC sheet significantly improved the retention and survival compared with cell suspension.At the early stage of MI,hUCMSC sheet modulated inflammation by decreasing Mcp1-positive monocytes and CD68-positive macrophages and increasing Cx3cr1-positive non-classical macrophages,preserving the cardiomyocytes from acute injury.Moreover,the extracellular matrix produced by hUCMSC sheet then served as bioactive scaffold for the host cells to graft and generate new epicardial tissue,providing mechanical support and routes for revascularsation.These effects of hUCMSC sheet treatment significantly improved the cardiac function at days 7 and 28 post-MI.Conclusions:hUCMSC sheet formation dramatically improved the biological functions of hUCMSCs,mitigating adverse post-MI remodelling by modulating the inflammatory response and providing bioactive scaffold upon transplantation into the heart.Translational perspective:Due to its excellent availability as well as superior local cellular retention and survival,allogenic transplantation of hUCMSC sheets can more effectively acquire the biological functions of hUCMSCs,such as modulating inflammation and enhancing angiogenesis.Moreover,the hUCMSC sheet method allows the transfer of an intact extracellular matrix without introducing exogenous or synthetic biomaterial,further improving its clinical applicability. | Rui Guo Feng Wan Masatoshi Morimatsu Qing Xu Tian Feng Hang Yang Yichen Gong Shuhong Ma Yun Chang Siyao Zhang Youxu Jiang Heqing Wang Dehua Chang Hongjia Zhang Yunpeng Ling Feng Lan | 2021 | Bioactive Materials2021，6，9： | 6 |
| 3 | Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK–S1P signaling pathway显示文摘 | Tian Lan Xiaoyan Shen Peiqing Liu Weihua Liu Suowen Xu Xi Xie Qin Jiang Wenyuan Li Heqing Huang | 2010 | Archives of Biochemistry and Biophysics2010，，2： | 1 |
| 4 | Berberine attenuates lipopolysaccharide-induced extracelluar matrix accumulation and inflammation in rat mesangial cells: Involvement of NF-κB signaling pathway显示文摘 | Qin Jiang Peiqing Liu Xiaoqian Wu Weihua Liu Xiaoyan Shen Tian Lan Suowen Xu Jing Peng Xi Xie Heqing Huang | 2010 | Molecular and Cellular Endocrinology2010，，1： | 1 |
| 5 | Emodin suppresses cell proliferation and fibronectin expression via p38MAPK pathway in rat mesangial cells cultured under high glucose显示文摘 | Xuejuan Li Weihua Liu Qin Wang Peiqing Liu Yanhui Deng Tian Lan Xiaoyan Zhang Baoming Qiu Hairong Ning Heqing Huang | 2009 | Molecular and Cellular Endocrinology2009，，1： | 1 |
| 6 | Corrosion Resistance of Fused Cr_2O_3-Al_2O_3 Grains with Different Compositions显示文摘Six kinds of Cr2O3 Al2O3 fused grains ( the mass percent of Cr2O3 was 15% ,40% ,50% ,60% ,85% and 99% ,respectively) were prepared using chrome green and Al2O3 powder as starting materials by electrofusion,named as CR15,CR40,CR50,CR60,CR85, and CR99,respectively. The corrosion resistance of the six kinds of Cr2O3 Al2O3 fused grains ( 4 1 mm) was studied using rotary slag corrosion method. The results show that: ( 1) the corrosion resistance of the fused grains increases with the Cr2O3 content and the grain size increasing; ( 2) the grains of CR99 and CR85 with higher Cr2O3 content are corroded at the slag surface layer,because FeO and Al2O3 in the slag corrode the grains; FeO reacts with Cr2O3 in the aggregates forming ( Fe,Cr) 3O4 spinel firstly,and the spinel reacts with other phases forming composite spinel; when FeO is fully consumed,Al2O3 penetrated into the grains reacts with Cr2O3 forming Al2O3 Cr2O3 solid solution on the grains surface; ( 3) for CR60,the corrosion exists both in the slag surface layer and in the penetration layer; in the penetration layer,CaO and SiO2 react with Al2O3 in Al2O3 Cr2O3 solid solution forming anorthite, gehlenite, and glass phase; the grains of CR50,CR40 and CR15 have the same corrosion mechanism with CR60 in the penetration layer. | WANG Han LAN Heqing GENG Keming LV Shiping FANG Xu | 2012 | China's Refractories2012，21，2： | 0 |
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