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| 1 | Inhibition of angiogenesis and HCT-116 xenograft tumor growth in mice by kallistatin显示文摘AIM: To investigate the inhibitory effect of kallistatin (KAL) on angiogenesis and HCT-116 xenograft tumor growth. METHODS: Heterotopic tumors were induced by subcutaneous injection of 2 × 106 HCT-11 cells in mice. Seven days later, 2 × 1011 rAAV-GFP or rAAV-KAL was injected intratumorally (n = 5 for each group). The mice were sacrificed at d 28, by which time the tumors in the rAAV-GFP group had grown to beyond 5% of the total body weight. Tumor growth was measured by calipers in two dimensions. Tumor angiogenesis was determined with tumor microvessel density (MVD) by immunohistology. Tumor cell proliferation was assessed by Ki-67 staining. RESULTS: Intratumor injection of rAAV-KAL inhibited tumor growth in the treatment group by 78% (171 ± 52 mm3) at d 21 after virus infection compared to the control group (776 ± 241 mm3). Microvessel density was significantly inhibited in tumor tissues treated with rAAV-KAL. rAAV-KAL also decreased the proportion of proliferating cells (Ki-67 positive cells) in tumors compared with the control group.CONCLUSION: rAAV-mediated expression of KAL inhibits the growth of colon cancer by reducing angiogenesis and proliferation of tumor cells, and may provide a promising anti-angiogenesis-based approach to the treatment of metastatic colorectal cancer. | Yong Diao Jian Ma Wei-Dong Xiao Jia Luo Xin-Yan Li Kin-Wah Chu Peter WC Fung Nagy Habib Farzin Farzaneh Rui-An Xu | 2007 | World Journal of Gastroenterology2007，13，34： | 15 |
| 2 | 6 儿童血管瘤的流行病学、影像学特征及治疗效果显示文摘对1998—2007年间收治的58例血管瘤患者进行回顾性研究,分析患者人口学资料、影像学特点、治疗方法及其结果。结果:男19例,女39例,64%的患者病变位于头颈部.3例合并卡-梅综合征.21例无影像学资料.37例行B超和(或)MRI检查,85%的患者B超为混合性回声。 | Rasalkar DD Chu WC Cheng FW | 2010 | 中国口腔颌面外科杂志2010，8，6： | 2 |
| 3 | Home mechanical ventilation in Hong Kong显示文摘 | Chu CM Yu WC Tam CM | | European Respiratory Journal0，，： | 1 |
| 4 | Biaxial flexural strength and indentation fracture toughness of three new dental core ceramics显示文摘 | Chu TM | 1996 | J Prosthet Dent1996，76，2： | 1 |
| 5 | Reliability and validity ofa Chinese version of the multidimensional fatigue symptominventory-short form (MFSI-SF-C) 显示文摘 | Pien LC Chu H Chen WC | 2011 | J Clin Nurs2011，20，16： | 1 |
| 6 | Prevalence of non -alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese : a pop- ulation study using proton - magnetic resonance spectroscopy and tran- sient elastography显示文摘 | Wong VW Chu WC Wong GL | 2012 | Gut2012，61，3： | 1 |
| 7 | Renal screening in children after exposure to low dose melamine in Hong Kong: cross sectional study显示文摘 | Lam HS Ng PC Chu WC | 2008 | BMJ2008，337，： | 1 |
| 8 | Feasibility of morphologic assessment of vascular and biliary anatomy in pediatric liver transplantation:all-in-one protocol with breath-hold magnetic resonance显示文摘 | Chu WC Yeung DT Lee KH | 2005 | J Pediatr Surg2005，40，10： | 1 |
| 9 | Prevalence of nonalcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese:a population study using proton-magnetic resonance spectroscopy and transient elastography显示文摘 | Wong VW Chu WC Wong GL | 2012 | Gut2012，61，： | 1 |
| 10 | Dynamic magnetic resonance imaging in assessing lung volumes,chest wall,and diaphragm motions in adolescent idiopathic scoliosis versus normal controls显示文摘 | Chu WC Li AM Ng BK | 2006 | Spine2006，31，19： | 1 |
| 11 | Cerebral nicrobleeds and symptom severity of post-stroke depression: a magnetic resonance imaging study显示文摘 | Tang WK Chen YK Chu WC | 2011 | J Affecrr Disord2011，129，13： | 1 |
| 12 | Hypoxia and metabolic phe- notypes during breast carcinogenesis : expression of HIF - 1 c:, GLUT1, and CAIX显示文摘 | Chen CL Chu JS Su WC | 2010 | Virchows Arch2010，457，1： | 1 |
| 13 | Hepatic steatosis in obese Chinese children显示文摘 | Chan DF Li AM Chu WC | 2004 | Int J Obes Relat Metab Disord2004，28，10： | 1 |
| 14 | Phosphorus-31 MR spectroscopy in pediatric liver transplant recipients: a noninvasive assessment of graft status with correlation with liver function tests and liver biopsy 显示文摘 | Chu WC Lam WW Lee KH | 2005 | AJR Am J Roentgenol2005，184，5： | 1 |
| 15 | Home mechanical ventilation in Hong Kong显示文摘 | Chu CM Yu WC Tam CM | 2004 | Eur ResDir ]2004，23，1： | 1 |
| 16 | Sonographic appearance of mucinous carcinoma of the breast显示文摘 | Lam WW Chu WC Tse GM | 2004 | AJR2004，182，： | 1 |
| 17 | Neutrophil CD64 is a sensitive diagnostic marker for early-onset neonatal infection 显示文摘 | Ng PC Li G Chui KM Chu WC Li K Wong RP | 2004 | Pediatr Res2004，56，5： | 1 |
| 18 | Wilson's disease with chronic active hepatitis: monitoring by in vivo 31-phosphorus MR spectroscopy before and after medical treatment 显示文摘 | Chu WC Leung TF Chan KF | 2004 | AJR Am J Roentgenol2004，183，5： | 1 |
| 19 | Intravenous leiomyomatosis:computed tomography diagnosis显示文摘 | Wong YY Chu WC Lam WW | 2006 | Hong Kong Med J2006，12，3： | 1 |
| 20 | Dynamic magnetic resonance ima- ging in assessing lung volumes,chest wall,and diaphragm motions in adolescent idiopathic seoliosis versus normal eontrols显示文摘 | Chu WC Li AM Ng BK | 2006 | Spine (Phila Pa 1976)2006，31，19： | 1 |
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