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| 1 | Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer显示文摘Pancreatic cancer continues to be a leading cause of cancer-related death worldwide and there is an urgent need to develop novel diagnostic and therapeutic strategies to reduce the mortality of patients with this disease. In pancreatic cancer, some tight junction proteins, including claudins, are abnormally regulated and therefore are promising molecular targets for diagnosis, prognosis and therapy. Claudin-4 and-18 are overexpressed in human pancreatic cancer and its precursor lesions. Claudin-4 is a high affinity receptor of Clostridium perfringens enterotoxin(CPE). The cytotoxic effects of CPE and monoclonal antibodies against claudin-4 are useful as novel therapeutic tools for pancreatic cancer. Claudin-18 could be a putative marker and therapeutic target with prognostic implications for patients with pancreatic cancer. Claudin-1,-7, tricellulin and marvelD3 are involved in epithelial to mesenchymal transition(EMT) of pancreatic cancer cells and thus might be useful as biomarkers during disease. Protein kinase C is closely related to EMT of pancreatic cancer and regulates tight junctions of normal human pancreatic duct epithelial cells and the cancer cells. This review focuses on the regulation of tight junctions via protein kinase C during EMT in human pancreatic cancer for the purpose of developing new diagnostic and therapeutic modalities for pancreatic cancer. | Daisuke Kyuno Hiroshi Yamaguchi Tatsuya Ito Tsuyoshi Kono Yasutoshi Kimura Masafumi Imamura Takumi Konno Koichi Hirata Norimasa Sawada Takashi Kojima | 2014 | World Journal of Gastroenterology2014，20，31： | 3 |
| 2 | The Mechanism of Atmospheric Rusting and the Effect of Cu and P on the Rust Formation of Low Alloy Steels 显示文摘 | Misawa T Kyuno T Suetaka W | 1971 | Corrosion Science1971，11，： | 1 |
| 3 | Permittivity increase of yttrium-doped HfO2 through structural phase transformation 显示文摘 | Kita K Kyuno K Toriumi A | 2005 | Appl Phys Lett2005，86，10： | 1 |
| 4 | Immunoreactivity of phage library-derived human single-chain antibodies to amyloid beta conformers in vitro显示文摘 | Yoshihara T Takiguchi S Kyuno A | 2005 | J Biochem2005，143，4： | 1 |
| 5 | The mechanism of atmospheric rusting and the effect of Cu and P on the rust formation of low alloy steel显示文摘 | Misawa T Kyuno T Suetaka W | 1971 | Corrosion Science1971，11，： | 1 |
| 6 | Immunoreactivity of phage library-derived human single-chain antibodies to amyloid beta conformers In vitro显示文摘 | Yoshihara T Takiguchi S Kyuno A | 2008 | J Biochem2008，143，4： | 1 |
| 7 | High-k LaYOxfilms with strong moisture resistance显示文摘 | Zhao Y Kita K Kyuno K | 2006 | Appl Phys Lett2006，89，25： | 1 |
| 8 | Band Gap Enhance- ment and Electrical Properties of La2Oa Films Doped with Y203 as High-k Gate Insulators显示文摘 | Zhao Y Kita K Kyuno K etal | 2009 | Appl Phys Lett2009，94，： | 1 |
| 9 | The Mechanism of Atmospheric Rusting and the Effect of Cu and P on the Rust Formation of Low Alloy Steel 显示文摘 | Misawa T Kyuno T Stretaka W | 1971 | Corrosion Science1971，11，： | 1 |
| 10 | Immunoreactivi- ty of phage library-derived human single-chain antibodies to amyloid beta conformers in vitro 显示文摘 | Yoshihara T Takiguchi S Kyuno A | 2008 | J Biochem2008，143，4： | 1 |
| 11 | Effect of Warious Factors, Mechanisms and Preventive Methods of Grooving Corrsion of ERW and CBW Carbon Steel Pipes 显示文摘 | Kttrisu T Kyuno T Harada S | 1979 | Kawasaki Steel Technical Report1979，11，3： | 1 |
| 12 | A new physalin from physalis alkekengi:structure of physalin L显示文摘 | KAWAI M MATSUURA T KYUNO S | 1987 | Phytochemistry1987，26，12： | 1 |
| 13 | Needle electromyography in the thoracic paraspinal muscles of motor neuron disease 显示文摘 | Kyuno K Ito H Saito T | 1996 | No To Shinkei1996，48，7： | 1 |
| 14 | A new physalin from Physalis alkekengi : structure of physalin L 显示文摘 | Kawai M Matsuura T Kyuno S | 1987 | Phytochemistry1987，26，12： | 1 |
| 15 | A new physalin fi'om Physal is alkekengi: st ructure of physalin L 显示文摘 | Kawai M Mat suura T Kyuno S | 1987 | Phy tochemisry1987，26，12： | 1 |
| 16 | A drop in gas temperature in the external part of the endotyacheal tube is problematic during neonatal respiratory support显示文摘 | Yamada Y Kyuno T Suzuki S | 2008 | Pediatr Pulmonol2008，43，7： | 1 |
| 17 | The mechanism of alrnospherie rusting and the effect of Cu and P on the rust formation of lowalloy steels 显示文摘 | Misawa T Kyuno T Suataka W | 1971 | Corrosion Science1971，11，1： | 1 |
| 18 | Treatment strategy for pancreatic head cancer with celiac axis stenosis in pancreaticoduodenectomy:A case report and review of literature显示文摘BACKGROUND During pancreaticoduodenectomy in patients with celiac axis(CA)stenosis due to compression by the median arcuate ligament(MAL),the MAL has to be divided to maintain hepatic blood flow in many cases.However,MAL division often fails,and success can only be determined intraoperatively.To overcome this problem,we performed endovascular CA stenting preoperatively,and thereafter safely performed pancreaticoduodenectomy.We present this case as a new preoperative treatment strategy that was successful.CASE SUMMARY A 77-year-old man with a diagnosis of pancreatic head cancer presented to our department for surgery.Preoperative assessment revealed CA stenosis caused by MAL.We performed endovascular stenting in the CA preoperatively because we knew that going into the operation without a strategy could lead to ischemic complications.Double-antiplatelet therapy(DAPT)–which is needed when a stent is inserted–was then administered in parallel with neoadjuvant chemotherapy(NAC).This allowed us to administer DAPT for a sufficient period before the main pancreaticoduodenectomy procedure while obtaining therapeutic effects from NAC.Subtotal stomach-preserving pancreaticoduodenectomy was thenperformed.The operation did not require any unusual techniques and was performed safely.Postoperatively,the patient progressed well,without any ischemic complications.Histopathologically,curative resection was confirmed,and the patient had no recurrence or complications due to ischemia up to six months postoperatively.CONCLUSION Preoperative endovascular stenting,with NAC and DAPT,is effective and safe prior to pancreaticoduodenectomy in potentially resectable pancreatic cancer. | Eiji Yoshida Yasutoshi Kimura Takuro Kyuno Ryoko Kawagishi Kei Sato Tsuyoshi Kono Takehiro Chiba Toshimoto Kimura Hitoshi Yonezawa Osamu Funato Makoto Kobayashi Kenji Murakami Akinori Takagane Ichiro Takemasa | 2022 | World Journal of Gastroenterology2022，28，8： | 1 |
| 19 | Diffusion and dissociation of platinum clusters on Pt ( 111 ) 显示文摘 | Kyuno K Ehrlich G | 1999 | Surf Sci1999，437，12： | 1 |
| 20 | Structural and electrical properties of HfLaOx films for an amorphous high-kgate insulator显示文摘 | Yamamoto Y Kita K Kyuno K Toriumi A | | 0，，： | 1 |
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