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| 1 | Wilson disease:Histopathological correlations with treatment on follow-up liver biopsies显示文摘AIM:To investigate the progression of hepatic histopathology in serial liver biopsies from Wilson disease(WD)patients.METHODS:We report a group of 12 WD patients treated with zinc and/or penicillamine who underwent multiple follow-up liver biopsies.Demographic,clinical and laboratory data were gathered and all patients underwent an initial biopsy and at least one repeat biopsy.RESULTS:Time to repeat biopsy ranged from 2 to 12 years.Six patients(non-progressors)showed stable hepatic histology or improvement.In one case,we observed improvement of fibrosis from stage 2 to 0.Six patients(progressors)had worsening of fibrosis.There was no significant correlation between the histological findings and serum aminotransferases or copper me-tabolism parameters.The hepatic copper concentration reached normal levels in only two patients:one from the non-progressors and one from the progressors group.The estimated rate of progression of hepatic fibrosis in the entire group was 0 units per year in the time frame between the first and the second liver biopsy(4 years),and 0.25 between the second and the third(3 years).In the progressors group,the rate of progression of liver fibrosis was estimated at 0.11 fibrosis units per year between the first and second biopsy and,0.6 fibrosis units between the second and third biopsy.CONCLUSION:The inability of clinical tools to detect fibrosis progression in WD suggests that a liver biopsy with hepatic copper quantification every 3 years should be considered. | Sandy Cope-Yokoyama Milton J Finegold Giacomo Carlo Sturniolo Kyoungmi Kim Claudia Mescoli Massimo Rugge Valentina Medici | 2010 | World Journal of Gastroenterology2010，16，12： | 10 |
| 2 | Site specific modification of genome with cell permeable Cre fusion protein in preimplanta tion mouse embryo 显示文摘 | Kyoungmi K Hwain K Daekee L | 2009 | Biochem Biophys Res Commun2009，388，1： | 1 |
| 3 | Effects of high pressure processing on fatty acid composition and volatile compounds in Korean native black goat meat显示文摘 | Geunho Kang Soohyun Cho Pilnam Seong Beomyoung Park Sangwoo Kim Donghun Kim Youngjun Kim Sunmun Kang Kyoungmi Park | 2013 | Meat Science2013，，4： | 1 |
| 4 | The gas barrier coating of 3-aminopropyltriethoxysilane on polypropylene film显示文摘 | Jang Kyoungmi Kim Hyunjoon | 2007 | J Sol- Gel Sci Techn2007，41，1： | 1 |
| 5 | The Influence of Cultural Thinking Style on Evaluative Processes显示文摘 | Kyoungmi L Shavitt S | 2004 | Advances in Consumer Research2004，31，1： | 1 |
| 6 | Optimal Allocation of Replicates for Measurement Evaluation Studies显示文摘Optimal experimental design is important for the efficient use of modern high- throughput technologies such as microarrays and proteomics. Multiple factors in- cluding the reliability of measurement system, which itself must be estimated from prior experimental work, could influence design decisions. In this study, we de- scribe how the optimal number of replicate measures (technical replicates) for each biological sample (biological replicate) can be determined. Different allocations of biological and technical replicates were evaluated by minimizing the variance of the ratio of technical variance (measurement error) to the total variance (sum of sampling error and measurement error). We demonstrate that if the number of biological replicates and the number of technical replicates per biological sample are variable, while the total number of available measures is fixed, then the opti- mal allocation of replicates for measurement evaluation experiments requires two technical replicates for each biological replicate. Therefore, it is recommended to use two technical replicates for each biological replicate if the goal is to evaluate the reproducibility of measurements. | Stanislav O. Zakharkin Kyoungmi Kim Alfred A. Bartolucci Grier P. Page David B. Allison | 2006 | Genomics, Proteomics & Bioinformatics2006，4，3： | 0 |
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