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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Bevacizumab as a second- or later-line of treatment for metastatic colorectal cancer显示文摘AIM: To determine the efficacy of bevacizumab in patients with metastatic colorectal cancer (MCRC) who have failed prior chemotherapy without bevacizumab. METHODS: Between March 2002 and June 2010, 40 patients in South Korea with MCRC who were treated with bevacizumab plus chemotherapy as a second or later-line treatment were analyzed retrospectively for their overall response rate (ORR), overall survival (OS), and progression-free survival (PFS). The tumor responses were assessed using the RECIST (Response Evaluation Criteria in Solid Tumors) guidelines. RESULTS: All of the patients had progressed under prior chemotherapy without bevacizumab. Three patients (7.5%) exhibited an ORR, twenty one patients (52.5%) exhibited stable disease (SD), and fifteen patients (37.5%) exhibited disease progression. The median duration of the OS and PFS were 14.0 and 6.13 mo respectively. The median OSs were 16.60, 14.07 and 13.00 mo for second-line, third-line and fourth- or later-line treatments, respectively. The median PFSs were 7.23, 7.30 and 3.87 mo for the second-line, third-line and fourth- or later-line treatments, respectively. CONCLUSION: In patients with MCRC, bevacizumab combined chemotherapy may be beneficial during second- or later-line treatment. | Lee Chun Park Ho Sup Lee Seong Hoon Shin Seun Ja Park Moo In Park Sung Yong Oh Hyuk Chan Kwon Jin ho Baek Young Jin Choi Myoung Joo Kang Yang Soo Kim | 2012 | World Journal of Gastroenterology2012，18，10： | 3 |
| 3 | 利用杀菌剂防治松萎蔫病(英文)显示文摘松萎蔫病是一种非常复杂的病害。据报道,松材线虫(Bursaphelenchus xylophilus)及其携带的细菌诱导了该病,但是对于细菌的的作用尚存争议。笔者筛选出杀细菌剂进行了温室和林间防治松萎蔫病的实验。利用每株3年生赤松(Pinus densiflora)注射3mg的恶喹酸,松萎蔫病防效达到71%。利用恶喹酸或阿维菌素及两者混合物对大约20年生赤松的试验表明,3种处理均显示了很高的防效。以上结果证明伴生细菌是诱导松萎蔫病的必要因素,对松萎蔫病可利用杀细菌剂或杀细菌剂与杀线剂混合物进行防控。 | Jin-Cheol Kim Hyeok Ran Kwon Gyung Ja Choi Yong Ho Choi Kyoung Soo Jang Myung Soo Park Nack-Do Sung Mun Seong Kang Yilseong Moon Seung Kyu Lee | 2010 | 南京林业大学学报(自然科学版)2010，34，5： | 2 |
| 4 | Synergistic Memory Impairment Through the Interaction of Chronic Cerebral Hypoperfusion and Amlyloid Toxicity in a Rat Model显示文摘 | Bo-Ryoung Choi Sang Rim Lee Jung-Soo Han Sang-Keun Woo Kyeong Min Kim Dong-Hee Choi Kyoung Ja Kwon Seol-Heui Han Chan Young Shin Jongmin Lee Chin-Sang Chung Seong-Ryong Lee Hahn Young Kim | 2011 | Stroke2011，，9： | 2 |
| 5 | Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma显示文摘 | Ho Lee Kyung Ryoul Kim Sang Jae Noh Ho Sung Park Keun Sang Kwon Byung-Hyun Park Sung Hoo Jung Hyun Jo Youn Byoung Kil Lee Myoung Ja Chung Dai Ha Koh Woo Sung Moon Kyu Yun Jang | 2011 | Human Pathology2011，，2： | 2 |
| 6 | Assessment of colon polyp morphology: Is education effective?显示文摘AIM To determine the inter-observer variability for colon polyp morphology and to identify whether education can improve agreement among observers.METHODS For purposes of the tests, we recorded colonoscopy video clips that included scenes visualizing the polyps. A total of 15 endoscopists and 15 nurses participated in the study. Participants watched 60 video clips of the polyp morphology scenes and then estimated polyp morphology(pre-test). After education for 20 min, participants performed a second test in which the order of 60 video clips was changed(post-test). To determine if the effectiveness of education was sustained, four months later, a third, follow-up test was performed with the same participants.RESULTS The overall Fleiss' kappa value of the inter-observer agreement was 0.510 in the pre-test, 0.618 in the post-test, and 0.580 in the follow-up test. The overall diagnostic accuracy of the estimation for polyp morphology in the pre-, post-, and follow-up tests was 0.662, 0.797, and 0.761, respectively. After education, the inter-observer agreement and diagnostic accuracy of all participants improved. However, after four months, the inter-observer agreement and diagnostic accuracy of expert groups were markedly decreased, and those of beginner and nurse groups remained similar to pre-test levels. CONCLUSION The education program used in this study can improve inter-observer agreement and diagnostic accuracy in assessing the morphology of colon polyps; it is especially effective when first learning endoscopy. | Jae Hyun Kim Kyoung Sik Nam Hye Jung Kwon Youn Jung Choi Kyoungwon Jung Sung Eun Kim Won Moon Moo In Park Seun Ja Park | 2017 | World Journal of Gastroenterology2017，23，34： | 2 |
| 7 | Characterization of the interaction between DARPP-32 and protein phosphatase 1 (PP-1):DARPP-32 peptides antagonize the interaction of PP-1 with binding proteins显示文摘 | Kwon YG Huang HB Desdouits F Girault JA Greengard P Nairn AC | 1997 | Proc Natl Acad Sci USA1997，94，8： | 1 |
| 8 | Transcriptional repression of the human p53 gene by hepatitis B viral core protein (HBc) in human liver cells显示文摘 | Kwon JA Rho HM | 2003 | Biol Chem2003，384，2： | 1 |
| 9 | Tailored eradication vs empirical bismuth-containing quadruple therapy for first-line Helicobacter pylori eradication: A comparative,open trial显示文摘BACKGROUND Few studies have compared the efficacy and safety profile of a tailored eradication(TR)strategy based on the presence of a 23S ribosomal RNA point mutation with those of empirical bismuth-based quadruple therapy(EBQT)for first-line eradication of Helicobacter pylori(H.pylori)in Korean patients.AIM To compare the efficacy and safety of a TR strategy and those of EBQT regimen as first-line eradication therapy for H.pylori.METHODS This is an open-label,comparative study in which we prospectively enrolled patients over 18 years of age with H.pylori infection and retrospectively reviewed their data.H.pylori-positive patients diagnosed by rapid urease test,Giemsa staining,or dual priming oligonucleotide polymerase chain reaction(DPO-PCR)were enrolled from May 2016 to September 2018 at Gil Medical Center.Patients with H.pylori infection received either a TR regimen or the EBQT regimen.In the tailored therapy group that underwent DPO-PCR testing,patients with A2142G and/or A2143G point mutations were treated with a bismuth-containing quadruple regimen.The eradication rate,patient-reported side effect rate,and H.pylori eradication success rate were evaluated and compared between the groups.RESULTS A total of 150 patients were assigned to the TR(n=50)or EBQT group(n=100).The first-line eradication rate of H.pylori did not differ between the groups(96.0%vs 95.7%,P=0.9).The rate of eradication-related side effects for TR was 12.0%,which differed significantly from that of EBQT(43.0%)for first-line treatment(P<0.001).CONCLUSION DPO-PCR-based TR for H.pylori eradication may be equally efficacious,with less treatment-related complications,compared to EBQT in Korea,where clarithromycin resistance is high. | Youn I Choi Jun Won Chung Dong Kyun Park Kyoung Oh Kim Kwang An Kwon Yoon Jae Kim Ja Young Seo | 2019 | World Journal of Gastroenterology2019，25，46： | 1 |
| 10 | Prevalence of resistance tomacrolide,lincosamide and streptogramin antibiotics in Grain-positive cocci isolated in a Korean hospital显示文摘 | Lim JA Kwon AR Kim SK | 2002 | J Antimicmb Chemother2002，49，： | 1 |
| 11 | A case of Spitz nevus with multiple satlite lesions显示文摘 | Song JY Kwon JA Park CJ | 2005 | J Am Acad Dermatol2005，52，2： | 1 |
| 12 | Effects of aspirin on nitric oxide formation and de novo protein synthesis by RINn5F cell and islets显示文摘 | Kwon G Hill JR Corbett JA | 1997 | Mol Pharmacol1997，52，1： | 1 |
| 13 | Effects of aspirin on nitric oxide formation and de novo protein synthesis by RINm5F cellls and islets显示文摘 | Kwon G Hil JR Corbett JA | 1997 | Mol Pharmacol1997，52，3： | 1 |
| 14 | Prevalence of resistance to macrolide,lincosamide and streptogramin antibiotics in Grampositive cocci isolated in a Korean hospital显示文摘 | Lim JA Kwon AR Kim SK | 2002 | J Antimicrob chemother2002，49，3： | 1 |
| 15 | CpG island hypermethylation and repetitive DNA hypomethylation in premalignant lesion of extrahepatic cholangiocarcinoma显示文摘 | Baek-hui Kim Nam-Yun Cho So Hyun Shin Hyeong-Ju Kwon Ja June Jang Gyeong Hoon Kang | 2009 | Virchows Archiv2009，，4： | 1 |
| 16 | Evidence for involvement of the proteasome complex (26S) and NFkappaB in IL -1beta-induced nitric oxide and prostaglandin production by rat islets and RINmSF cells 显示文摘 | Kwon G Corbett JA Hauser S | 1998 | Diabetes1998，47，4： | 1 |
| 17 | Nitric oxide regulates interleukin 1 bioactivity released from murine macrophages显示文摘 | Hill JR Corbett JA Kwon G | 1996 | J Biol Chem1996，271，22： | 1 |
| 18 | Prevalence of resistance to macrolide, lincosamide and streptogramin antibiotics in Gram-positive cocci isolated in a Korean hospital 显示文摘 | Lim JA Kwon AR Kim SK | 2002 | J Antimicrob Chemother2002，49，3： | 1 |
| 19 | Effects of aspirin on nitric oxide formation and de novo protein synthesis by RINm5F cells and rat islets 显示文摘 | Kwon G Hill JR Corbett JA | 1997 | Mol Pharmacol1997，52，3： | 1 |
| 20 | Activation of ErbB2during wallerian degeneration of sciatic nerve 显示文摘 | Kwon YK Bhattacharyya A Alberta JA | 1997 | J Neurosci1997，17，21： | 1 |
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