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| 1 | Internet addiction and problematic Internet use: A systematic review of clinical research显示文摘AIM: To provide a comprehensive overview of clinical studies on the clinical picture of Internet-use related addictions from a holistic perspective. A literature search was conducted using the database Web of Science.METHODS: Over the last 15 years, the number of Internet users has increased by 1000%, and at the same time, research on addictive Internet use has proliferated. Internet addiction has not yet been understood very well, and research on its etiology and natural history is still in its infancy. In 2013, the American Psychiatric Association included Internet Gaming Disorder in the appendix of the updated version of the Diagnostic and Statistical Manual for Mental Disorders(DSM-5) as condition that requires further research prior to official inclusion in the main manual, with important repercussions for research and treatment. To date, reviews have focused on clinical and treatment studies of Internet addiction and Internet Gaming Disorder. This arguably limits the analysis to a specific diagnosis of a potential disorder that has not yet been officially recognised in the Western world, rather than a comprehensive and inclusive investigation of Internet-use related addictions(including problematic Internet use) more generally. RESULTS: The systematic literature review identified a total of 46 relevant studies. The included studies used clinical samples, and focused on characteristics of treatment seekers and online addiction treatment. Four main types of clinical research studies were identified, namely research involving(1) treatment seeker characteristics;(2) psychopharmacotherapy;(3) psychological therapy; and(4) combined treatment. CONCLUSION: A consensus regarding diagnostic criteria and measures is needed to improve reliability across studies and to develop effective and efficient treatment approaches for treatment seekers. | Daria J Kuss Olatz Lopez-Fernandez | 2016 | World Journal of Psychiatry2016，6，1： | 14 |
| 2 | 3D printing of multilayered scaffolds for rotator cuff tendon regeneration显示文摘Repairing massive rotator cuff tendon defects remains a challenge due to the high retear rate after surgical intervention.3D printing has emerged as a promising technique that enables the fabrication of engineered tissues with heterogeneous structures and mechanical properties,as well as controllable microenvironments for tendon regeneration.In this study,we developed a new strategy for rotator cuff tendon repair by combining a 3D printed scaffold of polylactic-co-glycolic acid(PLGA)with cell-laden collagen-fibrin hydrogels.We designed and fabricated two types of scaffolds:one featuring a separate layer-by-layer structure and another with a tri-layered structure as a whole.Uniaxial tensile tests showed that both types of scaffolds had improved mechanical properties compared to single-layered PLGA scaffolds.The printed scaffold with collagen-fibrin hydrogels effectively supported the growth,proliferation,and tenogenic differentiation of human adipose-derived mesenchymal stem cells.Subcutaneous implantation of the multilayered scaffolds demonstrated their excellent in vivo biocompatibility.This study demonstrates the feasibility of 3D printing multilayered scaffolds for application in rotator cuff tendon regeneration. | Xiping Jiang Shaohua Wu Mitchell Kuss Yunfan Kong Wen Shi Philipp N.Streubel Tieshi Li Bin Duan | 2020 | Bioactive Materials2020，5，3： | 7 |
| 3 | 3D printing of silk fibroin-based hybrid scaffold treated with platelet rich plasma for bone tissue engineering显示文摘3D printing/bioprinting are promising techniques to fabricate scaffolds with well controlled and patient-specific structures and architectures for bone tissue engineering.In this study,we developed a composite bioink consisting of silk fibroin(SF),gelatin(GEL),hyaluronic acid(HA),and tricalcium phosphate(TCP)and 3D bioprinted the silk fibroin-based hybrid scaffolds.The 3D bioprinted scaffolds with dual crosslinking were further treated with human platelet-rich plasma(PRP)to generate PRP coated scaffolds.Live/Dead and MTT assays demonstrated that PRP treatment could obviously promote the cell growth and proliferation of human adipose derived mesenchymal stem cells(HADMSC).In addition,the treatment of PRP did not significantly affect alkaline phosphatase(ALP)activity and expression,but significantly upregulated the gene expression levels of late osteogenic markers.This study demonstrated that the 3D printing of silk fibroin-based hybrid scaffolds,in combination with PRP post-treatment,might be a more efficient strategy to promote osteogenic differentiation of adult stem cells and has significant potential to be used for bone tissue engineering. | Liang Wei Shaohua Wu Mitchell Kuss Xiping Jiang Runjun Sun Reid Patrick Xiaohong Qin Duan Bin | 2019 | Bioactive Materials2019，4，1： | 6 |
| 4 | Exosomes derived from differentiated human ADMSC with the Schwann cell phenotype modulate peripheral nerve-related cellular functions显示文摘Peripheral nerve regeneration remains a significant clinical challenge due to the unsatisfactory functional recovery and public health burden.Exosomes,especially those derived from mesenchymal stem cells(MSCs),are promising as potential cell-free therapeutics and gene therapy vehicles for promoting neural regeneration.In this study,we reported the differentiation of human adipose derived MSCs(hADMSCs)towards the Schwann cell(SC)phenotype(hADMSC-SCs)and then isolated exosomes from hADMSCs with and without differentiation(i.e.,dExo vs uExo).We assessed and compared the effects of uExo and dExo on antioxidative,angiogenic,anti-inflammatory,and axon growth promoting properties by using various peripheral nerve-related cells.Our results demonstrated that hADMSC-SCs secreted more neurotrophic factors and other growth factors,compared to hADMSCs without differentiation.The dExo isolated from hADMSC-SCs protected rat SCs from oxidative stress and enhanced HUVEC migration and angiogenesis.Compared to uExo,dExo also had improved performances in downregulating pro-inflammatory gene expressions and cytokine secretions and promoting axonal growth of sensory neurons differentiated from human induced pluripotent stem cells.Furthermore,microRNA(miRNA)sequencing analysis revealed that exosomes and their parent cells shared some similarities in their miRNA profiles and exosomes displayed a distinct miRNA signature.Many more miRNAs were identified in dExo than in uExo.Several upregulated miRNAs,like miRNA-132-3p and miRNA-199b-5p,were highly related to neuroprotection,anti-inflammation,and angiogenesis.The dExo can effectively modulate various peripheral nerve-related cellular functions and is promising for cell-free biological therapeutics to enhance neural regeneration. | Bo Liu Yunfan Kong Wen Shi Mitchell Kuss Ke Liao Guoku Hu Peng Xiao Jagadesan Sankarasubramanian Chittibabu Guda Xinglong Wang Yuguo Lei Bin Duan | 2022 | Bioactive Materials2022，7，8： | 3 |
| 5 | 【原创论文】德国东西部睾丸癌后发生第二原发癌的风险关注对侧睾丸癌显示文摘上世纪70年代起以顺铂为基础的化疗使睾丸癌的存活率显著提高。然而,化疗和放疗具有潜在的致癌性。本研究的目的是评估德国睾丸癌存活者患第二原发癌(包括原发组织学类型精原细胞瘤和非精原细胞瘤)的风险。我们确认了德国东部地区(1961-1989年和1996-2008年)癌症登记的16990例睾丸癌和德国西部地区萨尔州(1970.2008年)癌症登记的1401例睾丸癌。我们用标准化发病率(SIRs)和95%N信区间(95%CI)估计第二原发癌的风险。我们将估计的年标准化发病率绘制成图以显示趋势。德国东部1961.1989年观察到301例第二原发癌(SIR:1.9;95%CI:1.7-2.1),1996—2008年观察到159例第二原发癌(SIR:1.7:95%CI:1.4~2.0)。两地癌症登记的对侧睾丸癌增加(SIR:萨尔6.0,德国东部13.9)。与其它地区相比,德国东部精原细胞瘤的SIR增加更为显著。数据分析显示对侧睾丸癌的SIR有稳定的趋势。大多数其它癌症(包括组织学特异性肿瘤)的SIRs的估计精度低,可能与样本量较小有关。睾丸癌患者患第二原发癌尤其是对侧睾丸癌的风险增加,因此应进行严密随访。 | Carsten Rusner Brigitte Streller Christa Stegmaier Pietro Trocchi Oliver Kuss Katherine A McGlynn Britton Traberts Andreas Stang | 2014 | Asian Journal of Andrology2014，16，2： | 2 |
| 6 | Adouble-blind,randomized comparison of intramuscularly and intravenously administered parecoxib sodium versus ketorolac in a post-oral surgery pain model显示文摘 | Daniels SE Grossman EH Kuss ME et al | 2001 | Clin Ther2001，23，7： | 1 |
| 7 | Deceased absolute counts of T lymphocy to subsects and their relation to disease in squamous cell carcinoma of the head and neck显示文摘 | Kuss I Hathaway B Ferris RL | 2004 | Clin Cancer Res2004，10，11： | 1 |
| 8 | Decreased absolute counts of T lymphocyte subsets and their relation to disease in squamous cell carcinoma of the head and neck显示文摘 | Kuss I Hathway B Ferris RL | 2004 | Clin Cancer Res2004，10，11： | 1 |
| 9 | Assessing Approximate Inference for Bi- nary Gaussian Process Classification显示文摘 | Kuss M Rasmussen C E | 2005 | Journal of Machine Lear ning Research2005，6，： | 1 |
| 10 | Decreased absolute counts of T lymphocyte subsets and their relation to disease in squamous cell carcinoma of the head and neck 显示文摘 | Kuss I Hathaway B Ferris RL | 2004 | Clin Cancer Res2004，10，11： | 1 |
| 11 | Empirical studies assessing the quality of health information for consumers on the world wide web: a systematic review显示文摘 | Eysenbach G Powell J Kuss O Sa ER | 2002 | Jour- nalofthe American Medical Association2002，287，20： | 1 |
| 12 | The COX - 2 specific inhibitor, parecoxib sodium is effective in treating postoperative pain in total hip arthroplasty patients 显示文摘 | Stulberg B Torri S Kuss M | 2001 | Anesthesiology2001，95，4： | 1 |
| 13 | The novel COX-2 specific inhibitor valdecoxib,does not affect platelet function in healthy adults显示文摘 | Leese PT Recker D Kuss Me | 2000 | Anesthesiology2000，93，： | 1 |
| 14 | Empirical studies assess- ing thequality of health information for consumers on the world wide web: asystematic review显示文摘 | Eysenbach G Powell J Kuss O | 2002 | JAMA2002，287，20： | 1 |
| 15 | Applications of microwave digestion technique for elemental analyses显示文摘 | H. -M. Kuss | 1992 | Fresenius’ Journal of Analytical Chemistry (-)1992，，9： | 1 |
| 16 | OLA-DRBI mierosatellite variants are associated with ovine growth and reproduction traits 显示文摘 | Geldermann H Mir M R Kuss A W | 2006 | Genetics Selection Evolution2006，38，4： | 1 |
| 17 | Decreased absolute counts of T lymphocyte subsets and their relation to disease in squamous cell carcinoma of the head and neck显示文摘 | Kuss I Hathway B Ferris RL | 2004 | Clin Cancer Res2004，10，11： | 1 |
| 18 | Upper GI mucosal effects of parecoxib sodium in healthy elderly subjects显示文摘 | Randall R Stoltz Stuart I Harris Michael E Kuss Diane LeComte Sheela Talwalker Shobha Dhadda Richard C Hubbard | 2002 | The American Journal of Gastroenterology2002，，1： | 1 |
| 19 | Binding of human IgG and F(ab) 2 and Fc fragments to cultured trophoblast cells from humanterm placenta 显示文摘 | Ugele B Hecht J Kuss E | 1998 | Exp Cell Res1998，244，1： | 1 |
| 20 | Decreased absolut counts of T lymphocyte subsets and their relation to disease in squamous cell carcinoma of the head and neck 显示文摘 | KUSS I HATHWAY BoFERRIS RL | 2004 | Clin Cancer Res2004，10，11： | 1 |
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