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| 1 | Helicobacter pylori infection and other bacteria in pancreatic cancer and autoimmune pancreatitis显示文摘Helicobacter pylori(H.pylori)is an infectious agent influencing as much as 50%of the world’s population.It is the causative agent for several diseases,most especially gastric and duodenal peptic ulcer,gastric adenocarcinoma and mucosaassociated lymphoid tissue lymphoma of the stomach.A number of other,extragastric manifestations also are associated with H.pylori infection.These include neurological disorders,such as Alzheimer’s disease,demyelinating multiple sclerosis and Parkinson’s disease.There is also evidence for a relationship between H.pylori infection and such dermatological diseases as psoriasis and rosacea as well as a connection with infection and open-angle glaucoma.Generally little is known about the relationship between H.pylori infection and diseases of the pancreas.Most evidence about H.pylori and its potential role in the development of pancreatic diseases concerns pancreatic adenocarcinoma and autoimmune forms of chronic pancreatitis.There is data(albeit not fully consistent)indicating modestly increased pancreatic cancer risk in H.pylori-positive patients.The pathogenetic mechanism of this increase is not yet fully elucidated,but several theories have been proposed.Reduction of antral Dcells in H.pylori-positive patients causes a suppression of somatostatin secretion that,in turn,stimulates increased secretin secretion.That stimulates pancreatic growth and thus increases the risk of carcinogenesis.Alternatively,H.pylori,as a part of microbiome dysbiosis and the so-called oncobiome,is proven to be associated with pancreatic adenocarcinoma development via the promotion of cellular proliferation.The role of H.pylori in the inflammation characteristic of autoimmune pancreatitis seems to be explained by a mechanism of molecular mimicry among several proteins(mostly enzymes)of H.pylori and pancreatic tissue.Patients with autoimmune pancreatitis often show positivity for antibodies against H.pylori proteins.H.pylori,as a part of microbiome dysbiosis,also is viewed as a potential trigger of autoimmune inflammation of the pancreas.It is precisely these relationships(and associated equivocal conclusions)that constitute a center of attention among pancreatologists,immunologists and pathologists.In order to obtain clear and valid results,more studies on sufficiently large cohorts of patients are needed.The topic is itself sufficiently significant to draw the interest of clinicians and inspire further systematic research.Next-generation sequencing could play an important role in investigating the microbiome as a potential diagnostic and prognostic biomarker for pancreatic cancer. | Lumir Kunovsky Petr Dite Petr Jabandziev Jiri Dolina Jitka Vaculova Martin Blaho Martina Bojkova Jana Dvorackova Magdalena Uvirova Zdenek Kala Jan Trna | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 5 |
| 2 | Surgical management of hallux valgus by techniques preserving the first metatarsophalangeal joint:longterm results显示文摘 | Havl fcek V Kovanda M Kunovsky R | 2007 | Acta Chit Orthop Traumatol Cech2007，74，2： | 1 |
| 3 | Surgical management of hallux valgus by techniques preserving the first metatarsophalangeal joint 显示文摘 | Havllcek V Kovanda M Kunovsky R | 2007 | Acta Chir Orthop Traumatol Cech2007，74，2： | 1 |
| 4 | Surgical management of hallux valgus by techniques preserving the first metatarsophalangeal joint:long-term results显示文摘 | HAVLICEK V KOVANDA M KUNOVSKY R | 2007 | Acta Chir Orthop Traumatol Cech2007，74，2： | 1 |
| 5 | Thyroid function and ioduria in infants after cardiac surgery: comparison of patients ,with primary, and delayed sternal closure显示文摘 | Kovacikova L Kunovsky P Lakomy M | 2005 | Pediatr Crit Care Med2005，6，2： | 1 |
| 6 | Thyroid hormone status after cardiac surgery in infants with delayedsternal closure and continued use of cutaneous povidone- iodine显示文摘 | Kovacikova L Kunovsky P Lakomy M | 2003 | Endocr Regul2003，37，1： | 1 |
| 7 | Viewpoints of the target population regarding barriers and facilitators of colorectal cancer screening in the Czech Republic显示文摘BACKGROUND Public awareness of colorectal cancer(CRC) and uptake of CRC screening remain challenges. The viewpoints of the target population(asymptomatic individuals older than 50) regarding CRC screening information sources and the reasons for and against participation in CRC screening are not well known in the Czech Republic. This study aimed to acquire independent opinions from the target population independently on the health system.AIM To investigate the viewpoints of the target population regarding the source of information for and barriers and facilitators of CRC screening.METHODS A survey among relatives(aged 50 and older) of university students was conducted. Participants answered a questionnaire about sources of awareness regarding CRC screening, reasons for and against participation, and suggestions for improvements in CRC screening. The effect of certain variables on participation in CRC screening was analyzed.RESULTS Of 498 participants, 478(96%) respondents had some information about CRC screening and 375(75.3%) had participated in a CRC screening test. General practitioners(GPs)(n = 319, 64.1%) and traditional media(n = 166, 33.3%) were the most common information sources regarding CRC screening. A lack of interest or time and a fear of colonoscopy or positive results were reported as reasons for non-participation. Individuals aged > 60 years [adjusted odds ratio(aOR) = 2.30, 95% confidence interval(CI)(1.42-3.71), P = 0.001], females(aOR =1.95, 95%CI(1.26-3.01) P = 0.003), and relatives of CRC patients(aOR = 4.17,95%CI(1.82-9.58) P = 0.001) were more likely to participate in screening.Information regarding screening provided by physicians-GPs:(aOR = 8.11,95%CI(4.90-13.41), P < 0.001) and other specialists(aOR = 4.19, 95%CI(1.87-9.38),P = 0.001) increased participation in screening. Respondents suggested that providing better explanations regarding screening procedures and equipment for stool capturing could improve CRC screening uptake.CONCLUSION GPs and other specialists play crucial roles in the successful uptake of CRC screening. Reduction of the fear of colonoscopy and simple equipment for stool sampling might assist in improving the uptake of CRC screening. | Radek Kroupa Monika Ondrackova Petra Kovalcikova Milan Dastych Tomas Pavlik Lumir Kunovsky Jiri Dolina | 2019 | World Journal of Gastroenterology2019，25，9： | 1 |
| 8 | Thyroid hormone status after cardiac surgery in infants with delayed sternal closure and continued use of cutaneous povidone-iodine 显示文摘 | Kovacikova L Kunovsky P Lakomy M | 2003 | Endocr Regul2003，37，1： | 1 |
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