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| 1 | 糖尿病视网膜病变患者玻璃体样本中白细胞介素-8和肿瘤坏死因子-α水平(英文)显示文摘目的:测量糖尿病性视网膜病变(DR)行玻璃体切除术(PPV)患者玻璃体样品中白细胞介素-8(IL-8),肿瘤坏死因子-α(TNF-α)的水平,与对照组比较结果并探讨其对DR的影响。方法:将伊斯坦布尔Bilim大学眼科系的57例(57眼)DR患者和22例黄斑裂孔未伴有增生性玻璃体视网膜病变患者分为研究组和对照组。对所有79例患者行3切口,20G PPV。PPV手术眼内灌注前,用Vitrector抽吸0.5mL玻璃体样品并稀释。样品转至冷藏室,存放在-70℃。IL-8和TNF-α的测量结果用酶联免疫吸附法以pg/mL为单位计算。结果:DR患者玻璃体样本中IL-8水平[82.7891±74.08700(0.08-307.09)pg/mL]明显高于对照组患者[2.9805±3.77546(0.08-18.53)pg/mL](P<0.001)。同样,DR患者TNF-α水平[18.0007±13.90015(2.32-51.11)pg/mL]也显着高于对照组[1.7005±1.26949(0.1-5.17)pg/mL](P<0.001)。结论:在视网膜新生血管形成中起重要作用的TNF-α和作为炎症和血管生成介体的IL-8水平在DR患者玻璃体样本中明显高。 | Rifat Rasier Ozgur Artunay Uzay Gormus Erdal Yuzbasioglu Alper Sengul Amber Senel Kukner Murat Oncel Halil Bahcecioglu | 2013 | 国际眼科杂志2013，13，12： | 8 |
| 2 | Inhibitory effects of regorafenib, a multiple tyrosine kinase inhibitor, on corneal neovascularization显示文摘AIM:To evaluate the inhibitory effects of regorafenib(BAY 73-4506),a multikinase inhibitor,on corneal neovascularization(NV).METHODS:Thirty adult male Sprague-Dawley rats weighing 250-300 g,were used.Corneal NV was induced by NaOH in the left eyes of each rat.Following the establishment of alkali burn,the animals were randomized into five groups according to topical treatment.Group 1(n=6)received 0.9%NaCl,Group 2(n=6)received dimethyl sulfoxide,Group 3(n=6)received regorafenib 1 mg/mL,Group 4(n=6)received bevacizumab 5 mg/mL and Group 5(n=6)received 0.1%dexamethasone phosphate.On the 7d,the corneal surface covered with neovascular vessels was measured on photographs as the percentage of the cornea's total area using computer-imaging analysis.The corneas obtained from rats were semiquantitatively evaluated for caspase-3 and vascular endothelial growth factor by immunostaining.RESULTS:A statistically significant difference in the percent area of corneal NV was found among the groups(P<0.001).Although the Group 5 had the smallest percent area of corneal NV,there was no difference among Groups 3,4 and 5(P>0.005).There was a statistically significant difference among the groups in apoptotic cell density(P=0.002).The staining intensity of vascular endothelial growth factor in the epithelial and endothelial layers of cornea was significantly different among the groups(P<0.05).The staining intensity of epithelial and endothelial vascular endothelial growth factor was significantly weaker in Groups 3,4 and 5 thanin Groups 1 and 2.CONCLUSION:Topical administration of regorafenib 1mg/mL is partly effective for preventing alkali-induced corneal NV in rats. | Halil Ibrahim Onder Mesut Erdurmus Yasin Yücel Bucak Hüseyin Simavli Murat Oktay Ahmet Sahap Kukner | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 3 | Protective effects of CAPE on liver inj ury induced by CC14 : an electron micros?copy study显示文摘 | Colakoglu N Kus I Kukner A et a1 | 2011 | Ultrastruct Pathol2011，35，1： | 1 |
| 4 | Effect of Octreotide on experimental corneal neovascularization显示文摘 | Demir T Celiker UO Kukner A | 1999 | Acta Ophthalmol Scand1999，77，4： | 1 |
| 5 | The effect of beta receptor blockadethrough propranolol on corneal neovascularization 显示文摘 | SIMAVU H ERDURMUS M TERZI EH BUCAK YY ONDERHI KUKNER AS | 2014 | J Oc-ul Pharmacol Therapeut2014，30，： | 1 |
| 6 | Protective effects of intraperitoneal vitamin C, aprotinin and melatonin administration on retinal edema during experimental uveitis in the guinea pig显示文摘 | Kukner A S Kukner A Naziroglu M | 2004 | Cell Biochem Funct2004，22，5： | 1 |
| 7 | Choroidal and retinal blood flow changes in degenerative myopia 显示文摘 | Akyol N Kukner AS Ozdemir T | 1996 | Can J Ophthalmol1996，31，3： | 1 |
| 8 | Effects of systemic octreotide,local mytomycine -C and local corticosteroids on wound -healing reaction after glaucoma surgery 显示文摘 | AKYOL N DEMIR T KUKNER A | 2001 | Int Ophthalmol2001，24，5： | 1 |
| 9 | Protective effects of CAPE on liver injury induced by CC14: an electron microscopy study 显示文摘 | Colakoglu N Kus I Kukner A | 2011 | Ultrastructural Pathology2011，35，1： | 1 |
| 10 | Large bilateral lateral rectus reces- sion in large angle divergence excess exotropia 显示文摘 | CELEBI S KUKNER AS | 2001 | Eur J Ophthalmol2001，11，1： | 1 |
| 11 | Demographic and epi- demiologic features of female adolescents in Turkeg显示文摘 | Vicdan K KuKner S Daba KogluT | 1996 | Jadolese Health1996，18，1： | 1 |
| 12 | Pain relief carbamazepine in mercary poisoning显示文摘 | Karagol U Deda G Kukner S | 1998 | Eur J Pediatr1998，157，3： | 1 |
| 13 | The preventive effect of low molecular weight heparin on CC14-induced necrosis and apoptosis in rat liver 显示文摘 | Kukner A Tore F Firat T | 2010 | Ann Hepatol2010，9，4： | 1 |
| 14 | Aprotinin reduces ischemia - reperfusion injury in the retina of guinea pigs显示文摘 | Yilmaz T Kukner AS Aydemir O | 2003 | Eur J Ophthalmol2003，13，7： | 1 |
| 15 | Effects of systemic octreotide,local mytomycine - C and local corticosteroids on wound -healing reaction after glaucoma surgery 显示文摘 | AKYOL N DERMIR T KUKNER A | 2001 | Int ophthalmol2001，24，5： | 1 |
| 16 | Effects of melatonin,vitamin E and octreotide on lipid peroxidation during ischemia-reperfusion in the guinea pig retina显示文摘 | Celebi S Dilsiz N Yilmaz T Kukner AS | 2002 | Eur J Ophthalmol2002，12，2： | 1 |
| 17 | Choroidal and retinal blood flow changes in degenerative myopia显示文摘 | Akyol N Kukner AS Ozdemir T | 1996 | Can J Ophthalmol1996，31，3： | 1 |
| 18 | Choroidal and retinal blood flow changes in degenerative myopia显示文摘 | Akyol N Kukner AS Ozdemir T | 1996 | Can J Ophthalmol1996，31，3： | 1 |
| 19 | Antioxidant effects of alpha-gamma and succinate-tocopherols in guinea pig retina during lschemia reperfusion injury显示文摘 | Aydemir O NazirogIu M Celebi S Yilmaz T Kukner AS | | 0，，： | 1 |
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