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| 1 | Prostaglandin levels in stimulated macrophages are controlled by phospholipase A2-activating protein and by activation of phospholipase C and D显示文摘 | Crowe SE Kuhl KR | 2001 | J Biol Chem2001，276，8： | 1 |
| 2 | The prognostic inflammatory and nutitional index in traumatized patients receiving enteral nutrition support 显示文摘 | Vehe KL Brown RO Kuhl DA | 1991 | J Am Coll Nutr1991，10，4： | 1 |
| 3 | The DSM-5 : Classification and criteria changes显示文摘 | Regier DA Kuhl EA Kupfer DJ | 2013 | World Psychiatry2013，12，2： | 1 |
| 4 | Role of melittin-like region within phospholipase A (2)-activating protein in biological fumction显示文摘 | Kuhl KR Peterson JW | 2002 | Toxicon2002，40，5： | 1 |
| 5 | Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox 显示文摘 | Fu YH Kuhl DA Pizzuti A | 1991 | Cell1991，67，： | 1 |
| 6 | Experimental cryptospo ridiosis in adult and neonatal rabbits显示文摘 | Mosier DA Cimon KY Kuhls TL | 1997 | Vet Parasitol1997，69，34： | 1 |
| 7 | The HIV-1 Vpu viroporin inhibitor BIT225 does not affect Vpu-mediated tetherin antagonism显示文摘 | Kuhl BD Cheng V Donahue DA | 2011 | PLo S One2011，6，27： | 1 |
| 8 | Parkin protein expression and its impact on survival of patients with advanced colorectal cancer显示文摘Objective:Features of colorectal cancer such as natural history,molecular,chromosomal,and epigenetic alterations have been well described.However,there is still a lack of accurate prognostic markers,which is evident by the lower overall survival rates of patients with advanced cancer.Although alterations in parkin protein expression have been described in colorectal cancer,the functional significance of this protein remains unknown.The present study aimed to investigate the involvement of parkin expression in colorectal adenocarcinoma development and progression by evaluating the association between its expression,clinicopathological parameters,and expression of known proteins involved in colorectal cancer.Methods:Tissue microarrays consisting of 73 tumor and 64 normal tissue samples were generated to examine parkin expression and localization by immunohistochemistry.Results:A positive correlation of parkin and APC expression was observed in the superficial,intermediate,and profound regions of all cases(ρ=0.37;P=0.001).Parkin expression was also significantly associated with tumors in men(P=0.049),those of the mucinous subtype(P=0.028),and of advanced stage(III+IV,P=0.041).In addition,increased parkin expression was observed in the invasive front tumor region(P=0.013).More importantly,a positive correlation was found between parkin expression and the overall survival of patients with advanced colorectal cancer(P=0.019).Multivariate analysis showed that parkin expression was independent of any of the clinicopathological parameters evaluated in relation to patient survival.Conclusions:These results suggest that parkin expression status can be used as a potential independent prognostic marker of survival in advanced colorectal cancer. | Claudia Caroline Veloso da Silva-Camargo Rosimeri Kuhl Svoboda Baldin Nayanne Louise Costacurta Polli Amanda Pereira Agostinho Marcia Olandosk Lúcia de Noronha Vanessa Santos Sotomaior | 2018 | Cancer Biology & Medicine2018，15，1： | 1 |
| 9 | Sepuential single dose of cisapride,erythromycin,and metoclopramide in critically ill patients intolerant to enteral nutrition:a randomized,placebo controlled,crossover study显示文摘 | MacLaren R Kuhl DA Gervasio JM | 2000 | Crit Care Med2000，28，2： | 1 |
| 10 | Homozygous antithrom- bin deficiency type I1 (99 Leu to Phe mutation) and childhood thromboembolism 显示文摘 | Kuhle S Lane DA Jochmanns K | 2001 | Thromb Haemost2001，86，4： | 1 |
| 11 | Differential effects of environment on potato phenyl- propanoid and carotenoid expression 显示文摘 | Payyavula RS Navarre DA Kuhl JC Pantoja A Pillai SS | 2012 | BMC Plant Bi- ol2012，12，： | 1 |
| 12 | Predictors of mortality in adult trauma patients:the physiologie trauma score is equiv- alent to the Trauma and Injury Severity Score显示文摘 | Kuhls DA Malone DL MeCarter RJ | 2002 | J Am Coll Surg2002，194，6： | 1 |
| 13 | Tethefin restricts direct call-to-cell infection of HIV-1 显示文摘 | Kuhl BD Sloan RD Donahue DA | 2010 | Retrovirology2010，7，： | 1 |
| 14 | Predictors of mortality in adult trauma patients:the physiologic trauma score is equivalent to the Trauma and Injury Severity Score 显示文摘 | Kuhls DA Malone DL McCarter R J | 2002 | J Am Coil Surg2002，194，6： | 1 |
| 15 | Predictors of mortality in adult trauma patients: the physiologic trauma score is equivalent to the Trauma and Injury Severity Score显示文摘 | Kuhls DA Malone DL McCarter RJ | 2002 | J Am Coll Surg2002，194，6： | 1 |
| 16 | Variation of the CGG repeat at the fragile X site results in genetic instability:resolution of the Sherman paradox显示文摘 | Fu YH Kuhl DA Pizzuti A | 1991 | Cell1991，67，： | 1 |
| 17 | Homozygous antithrombin deficiency type Ⅱ (99 Leu to Phe mutation) and childhood thromboembolism显示文摘 | Kuhle S Lane DA Jochmanns K | 2001 | Thromb Haemost2001，86，4： | 1 |
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