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| 1 | Effect of serum γ-glutamyltranferase and albumin levels on the response to cardiac resynchronization therapy in the elderly显示文摘Background Several liver function tests have been identified as predictors of hospitalization for heart failure(HF) and death in patients with chronic HF. The relationship between serum γ-glutamyltranferase(GGT) and albumin(SA) levels with the response to cardiac resynchronization therapy(CRT) has not been reliably determined. The aim of the study was to evaluate the impact of liver function tests on the results of CRT in the elderly. Methods Baseline GGT and SA were assessed before CRT device implantation in the elderly(> 70-year-old) patients. The endpoints were:(1) CRT response defined as > 5% left ventricular ejection fraction improvement and no hospitalization for HF or cardiovascular death;(2) hospitalizations;and(3) mortality. Results Eighty of 138(58%) included patients were responders at nine months. Compared to responders, the SA levels were not significantly different(35.1 ± 5.4 vs. 33.6 ± 5.5 g/L, P = 0.103);but the GGT levels, higher(81.6 ± 69.3 vs. 54.7 ± 49.6 U/L, P = 0.013) in non-responders to CRT. GGT level was independently associated with non-response to CRT(P < 0.001, OR = 0.17;95% CI: 0.08–0.38, P < 0.001). GGT cut-off value ≥ 55 U/L was highly predictive of non-response [AUC = 0.65, 64% Sensitivity, 69% Specificity(95% CI: 0.56–0.74)]. GGT ≥ 55 U/L was also associated with higher risk of hospitalization for atrial fibrillation(AF)(95% vs. 83%, P = 0.024). Both SA and GGT had no impact on overall(P = 0.220, P = 0.723) mortality. Conclusions Higher level of GGT is an independent predictor of non-response to CRT in patients over age 70 years and is associated with higher risk of hospitalization for AF. Baseline serum levels of albumin and GGT and have no impact on mortality in elderly patients undergoing CRT. | Maciej Kubala Alexis Hermida Otilia Buiciuc Pierre-Marc Lallemand Geneviève Bertaina Frédéric Anselme Didier Klug Momar Diouf Jean-Sylvain Hermida | 2020 | Journal of Geriatric Cardiology2020，17，6： | 3 |
| 2 | Modeling of wavefront coded imaging systems显示文摘 | DOWSKI E R KUBALA K S | 2002 | SPIE2002，4736，： | 1 |
| 3 | The effect of (1 3)- beta Iglueans, carboxymethylglucan and sehizophyllan on human leukocytes in vitro显示文摘 | Kubala L Ruzickova J Nickova K | 2003 | Carbohydrate Research2003，338，： | 1 |
| 4 | Statistical models for shelf life failures显示文摘 | Me Gacula J R Kubala J J | 1975 | Journal of Food Science1975，40，2： | 1 |
| 5 | Design and optimization of computational imaging systems显示文摘 | DOWSKI E KUBALA K | 2004 | SPIE2004，5299，： | 1 |
| 6 | Normal pulmonary veins anatomy is associated with better AF-free survival after cryoablation as compared to atypical anatomy with common left pulmonary vein显示文摘 | Kubala M Hermida J S Nadji G | | 0，，07： | 1 |
| 7 | Atrial septal pacing to prevent atrial fibrillation in patients with sinus node dysfunc- tion: results of a randomized controlled study 显示文摘 | Hermida JS Kubala M Lescure FX | 2004 | Am Heart J2004，148，2： | 1 |
| 8 | Isolation and characterization of mesenchymal stem cell population entrapped in bone marrow collection sets显示文摘 | Jana Dvorakova Alena Hruba Vladimir Velebny Lukas Kubala | 2008 | Cell Biology International2008，，9： | 1 |
| 9 | Myeloperoxidase attracts neutrophils by physical forces 显示文摘 | Klinke A Nussbaum C Kubala L | 2011 | Blood2011，117，4： | 1 |
| 10 | Placental lipases in pregnancies complicated by gestational diabetes mellitus (GDM)显示文摘 | Barrett HL Kubala MH Scholz Romero K | 2014 | PLoS One2014，9，10： | 1 |
| 11 | Placental lipases in pregnancies complicated by gestational diabetes mellitus(GDM)显示文摘 | Barrett HL Kubala MH Scholz Romero K | 2014 | PLoS One2014，9，10： | 1 |
| 12 | Speech and language tech- nologies for audio indexing and retrieval显示文摘 | Kubala M F Leek T Liu D | 2000 | Proceedings of the IEEE2000，88，8： | 1 |
| 13 | Plasma-enhanced a- tomic layer deposition of anatase TiO2 using TIC14 显示文摘 | Kubala N G Row Wolden C A | 2009 | J Phys Chem C2009，113，16： | 1 |
| 14 | Atrial septal versus atrial appendage pacing:feasibility and effects on atrial conduction,interatrial synchronization,and atrioventricular sequence显示文摘 | Hermida JS Carpentier C Kubala M | 2003 | Pacing Clin Electrophysiol2003，26，11： | 1 |
| 15 | Thin pyrite (FeS2) films by molecular beam deposition显示文摘 | Bronold M Kubala S Pettenkofer C | 1997 | Thin Solid Films1997，304，12： | 1 |
| 16 | Pathogenic Cycle Between the Endogenous Nitric Oxide Synthase Inhibitor Asymmetrical Dimethylarginine and the Leukocyte-Derived Hemoprotein Myeloperoxidase显示文摘 | Eike-Christin von Leitner Anna Klinke Dorothee Atzler Jessica L. Slocum Natalie Lund Jan T. Kielstein Renke Maas Robin Schmidt-Haupt Michaela Pekarova Olaf Hellwinkel Dimitrios Tsikas Louis G. D?Alecy Denise Lau Stephan Willems Lukas Kubala Heimo Ehmke Th | 2011 | Circulation2011，，24： | 1 |
| 17 | Plasma levels of myeloperoxidase are not elevated in patients with stable coronary artery disease显示文摘 | Kubala L Lu G Baldus S | 2008 | Clin Chim Acta2008，394，12： | 1 |
| 18 | Fluorescenceof sang uinarine : Fundamental cHAracteristics andanalysis of interconversion between various forms 显示文摘 | Janovska M Kubala M Simanek V | 2009 | Anal Bioanal Chem2009，395，： | 1 |
| 19 | Statistical models for shelf life failures显示文摘 | GACULA M C KUBALA J J | 1975 | Journal of Food Science1975，40，： | 1 |
| 20 | Statistical models for shelf-life failures 显示文摘 | Gaculam C Kubala JJ | 1975 | Journal of Food Science1975，40，： | 1 |
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